-
公开(公告)号:US10589077B2
公开(公告)日:2020-03-17
申请号:US15532836
申请日:2015-12-04
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Makoto Ogura , Naoki Yamamoto , Takashi Kumon
IPC: A61M37/00
Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.
-
公开(公告)号:US20200061359A1
公开(公告)日:2020-02-27
申请号:US16668066
申请日:2019-10-30
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Shinpei NISHIMURA , Seiji TOKUMOTO
Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.
-
公开(公告)号:US20200000737A1
公开(公告)日:2020-01-02
申请号:US16471692
申请日:2017-12-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Naoko FUJITA , Takito SHIMA , Kazuya KOMINAMI , Naoyuki UCHIDA
IPC: A61K9/70 , A61K31/485 , A61K47/14 , A61K47/10 , A61K47/34
Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.
-
公开(公告)号:US20190388668A1
公开(公告)日:2019-12-26
申请号:US16471290
申请日:2017-12-15
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Takuya TAJIMA , Naoki YAMAMOTO , Seiji TOKUMOTO
IPC: A61M37/00
Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
-
公开(公告)号:US20190350874A1
公开(公告)日:2019-11-21
申请号:US16474213
申请日:2017-12-26
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Ryo TANAKA , Hideaki OHASHI , Naruhide MIYOSHI , Takito SHIMA , Naoko FUJITA , Yasunari MICHINAKA
IPC: A61K9/70 , A61K31/192 , A61K31/196 , A61K31/405 , A61K47/12 , A61K47/20 , A61K47/32
Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.
-
公开(公告)号:US20190083770A1
公开(公告)日:2019-03-21
申请号:US15756234
申请日:2016-08-19
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Shinpei NISHIMURA , Seiji TOKUMOTO , Masafumi ONO
IPC: A61M37/00
Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.
-
公开(公告)号:US20190000775A1
公开(公告)日:2019-01-03
申请号:US15745266
申请日:2017-07-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Takashi YASUKOCHI , Atsushi SONOBE , Satoshi AMANO
IPC: A61K9/70 , A61K31/407 , A61K47/18 , A61K47/14
Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
-
公开(公告)号:US20180289631A1
公开(公告)日:2018-10-11
申请号:US16008704
申请日:2018-06-14
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Atsushi Sonobe , Takashi Yasukochi , Yasunori Takada
IPC: A61K9/70 , A61K47/10 , A61K47/12 , A61K47/14 , A61K31/407
Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
-
公开(公告)号:US10086183B2
公开(公告)日:2018-10-02
申请号:US15032709
申请日:2014-11-04
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Shunsuke Arami , Shinpei Nishimura , Seiji Tokumoto , Makoto Ogura
IPC: A61M37/00
Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
-
公开(公告)号:US09993549B2
公开(公告)日:2018-06-12
申请号:US15032718
申请日:2014-10-30
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Seiji Tokumoto , Kazuya Machida , Nao Kurokawa , Rie Namiki
CPC classification number: A61K39/39 , A61K9/0014 , A61K9/0021 , A61K9/08 , A61K9/7023 , A61K39/0008 , A61K47/10 , A61K2039/54 , A61K2039/55511
Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.
-
-
-
-
-
-
-
-
-