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    RUPTURE DISKS FOR BIOREACTORS AND METHODS OF USING SAME
    61.
    发明申请
    RUPTURE DISKS FOR BIOREACTORS AND METHODS OF USING SAME 审中-公开

    公开(公告)号：US20180163882A1

    公开(公告)日：2018-06-14

    申请号：US15836646

    申请日：2017-12-08

    申请人： LONZA LTD

    发明人： Michael Mietzner

    IPC分类号： F16K17/16 ,  C12M1/00

    CPC分类号： F16K17/16 ,  C12M1/00 ,  C12M23/00

    摘要： A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.

    REGULATABLE PROMOTER
    65.
    发明申请
    REGULATABLE PROMOTER 审中-公开
    可调节的促销者

    公开(公告)号：US20170037418A1

    公开(公告)日：2017-02-09

    申请号：US15335132

    申请日：2016-10-26

    申请人： LONZA LTD.

    发明人： DIETHARD MATTANOVICH ,  BRIGITTE GASSER ,  MICHAEL MAURER ,  ROLAND PRIELHOFER ,  JOACHIM KLEIN ,  JANA WENGER

    IPC分类号： C12N15/81 ,  C12N9/02 ,  C07K16/00 ,  C12N15/67 ,  C07K14/39 ,  C12N15/63 ,  C12P21/00

    CPC分类号： C12N15/815 ,  C07K14/39 ,  C07K16/00 ,  C07K2317/55 ,  C12N9/0008 ,  C12N15/635 ,  C12N15/67 ,  C12N15/81 ,  C12P21/00 ,  C12Y102/01012

    摘要： A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate or at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.

    摘要翻译： 一种通过培养包含表达构建体的重组真核生物细胞系（包括可调节启动子和编码所述启动子的转录控制下的POI的核酸分子）的重组真核生物细胞系的方法，包括以下步骤：a）培养细胞 与抑制启动子的基础碳源连接，b）用有限量的补充碳源培养细胞系，抑制启动子以与转录因子相比以转录速率或至少15％产生POI pGAP启动子，和c）生产和回收POI; 并进一步分离可调节的启动子和相应的表达系统。

    Methods for decolorizing compositions comprising betaines
    66.
    发明授权
    Methods for decolorizing compositions comprising betaines 有权
    包含甜菜碱的组合物脱色方法

    公开(公告)号：US09550726B2

    公开(公告)日：2017-01-24

    申请号：US14431861

    申请日：2013-11-13

    申请人： Lonza Ltd.

    发明人： Thomas Büchner ,  Gesa Paradies ,  Justin Yang

    IPC分类号： C07C227/40

    CPC分类号： C07C227/40 ,  C07C229/22

    摘要： The invention relates to a process for decolorizing a composition comprising a betaine comprising the steps of (a) providing a solution of the composition in an organic solvent, (b) contacting the solution with a decolorant, wherein the decolorant is a polar solid decolorant. The invention also relates to uses of ion exchange materials and decolorized solutions and compositions obtainable by the inventive process.

    摘要翻译： 本发明还涉及离子交换材料和脱色溶液以及通过本发明方法可获得的组合物的用途。

    LIQUID LAUNDRY DETERGENT COMPOSITION FOR CLOTHING
    68.
    发明申请
    LIQUID LAUNDRY DETERGENT COMPOSITION FOR CLOTHING 审中-公开
    液体洗衣洗涤剂组合物

    公开(公告)号：US20160355761A1

    公开(公告)日：2016-12-08

    申请号：US15117838

    申请日：2015-02-06

    申请人： LONZA LTD

    发明人： Mutsumi NAKANISHI ,  Kazuhiko SAKATA

    IPC分类号： C11D3/48 ,  C11D3/37

    CPC分类号： C11D3/48 ,  C11D3/3723 ,  C11D3/3769 ,  C11D3/3773

    摘要： [Problem to be Solved] To provide a liquid laundry detergent composition for clothing which can remove bacteria from the clothing effectively during washing and also impart an excellent antibacterial effect to the clothing after washing.[Solution] A liquid laundry detergent composition for clothing comprising: a bacteria-eliminating active agent, at least one cationic polymer selected from the following components (a), (b) and (c), and a surfactant: the component (a): diallylamine hydrochloride polymers, diallylamine polymers, methylallylamine hydrochloride polymers, diallyldimethylammonium chloride polymers, diallylmethylethyl sulfate polymers, diallylamine hydrochloride-sulfur dioxide copolymers, diallylamine acetate-sulfur dioxide copolymers and the like; the component (b) acrylamide-diallylamine hydrochloride copolymers, acrylamide-diallyldimethylammonium chloride copolymers and the like; the component (c) allylamine hydrochloride polymers, allylamine polymers, allylamine hydrochloride-diallylamine hydrochloride copolymers, allylamine acetate-diallylamine acetate copolymers and the like.

    摘要翻译： [解决方案]一种衣物用液体衣物洗涤剂组合物，其特征在于，含有除去细菌的活性剂，至少一种选自下述成分（a），（b）和（c）的阳离子性聚合物和表面活性剂：成分（a） ：二烯丙基胺盐酸盐聚合物，二烯丙基胺聚合物，甲基烯丙基胺盐酸盐聚合物，二烯丙基二甲基氯化铵聚合物，二烯丙基甲基乙基硫酸盐聚合物，二烯丙基胺盐酸盐 - 二氧化硫共聚物，二烯丙基胺乙酸盐 - 二氧化硫共聚物等; 组分（b）丙烯酰胺 - 二烯丙基胺盐酸盐共聚物，丙烯酰胺 - 二烯丙基二甲基氯化铵共聚物等; 组分（c）烯丙胺盐酸盐聚合物，烯丙胺聚合物，烯丙胺盐酸盐 - 二烯丙基胺盐酸盐共聚物，烯丙基胺乙酸盐 - 二烯丙基胺乙酸盐共聚物等。