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公开(公告)号：US20190276513A1
公开(公告)日：2019-09-12
申请号：US16357340
申请日：2019-03-19
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
IPC: C07K14/655 , A61K47/69 , A61K38/08 , A61K47/62 , A61K38/12
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20190217125A1
公开(公告)日：2019-07-18
申请号：US16331459
申请日：2017-09-05
Applicant: Board of Regents, The University of Texas System , TEL-HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. AT THE CHAIM SHEBA MEDICAL CENTER
Inventor： Dirk BARTKOSKI , Dror ALEZRA , Mohammad SALEHPOUR , Thomas BUCHHOLZ
CPC classification number: A61N5/1043 , A61N2005/1089 , G21K1/093
Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.
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公开(公告)号：US20190216603A1
公开(公告)日：2019-07-18
申请号：US16313166
申请日：2017-06-29
Inventor： Boris ORLOV , Ehud RAANANI
CPC classification number: A61F2/2466 , A61B17/00 , A61B17/11 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/3423 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/1107 , A61B2017/1139 , A61F2/2427 , A61F2/2433
Abstract: A method of accessing the ascending aorta via the superior vena cava (SVC) comprising puncturing the adjacent wall regions of the SVC and AA to provide passage from the SVC into the AA.
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公开(公告)号：US20190183360A1
公开(公告)日：2019-06-20
申请号：US16272616
申请日：2019-02-11
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady Kostenich , Arie Orenstein , Michael Belkin
CPC classification number: A61B5/0261 , A61B1/041 , A61B3/12 , A61B3/1241 , A61B5/0075 , A61B5/0077 , A61B5/0084 , A61B5/489 , F04C2270/041
Abstract: Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.
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公开(公告)号：US10264962B2
公开(公告)日：2019-04-23
申请号：US15971292
申请日：2018-05-04
Inventor： Ygal Rotenstreich , Mordecai Rosner
Abstract: A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.
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Patent Agency Ranking
公开(公告)号：US10173056B2
公开(公告)日：2019-01-08
申请号：US14413898
申请日：2013-07-11
Inventor： Gil Raviv , David Shashar , Yoram Shadmi , Itzchak Shvitlowsky , David Castel
Abstract: The present invention is directed to methods for improving male fertility inter alia by increasing sperm count in a male subject. The methods of the invention comprise applying a positive electrical current below sensation level to at least one site of a scrotum of a subject in need thereof.
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公开(公告)号：US10113170B2
公开(公告)日：2018-10-30
申请号：US15328602
申请日：2015-07-23
Inventor： Yechezkel Sidi , Dror Avni , Gali Lerman
IPC: A61K48/00 , C12N15/113 , A61K31/7105 , A61K31/713 , A61K9/00 , A61K41/00 , A61P17/06 , A61P17/00
Abstract: The present invention relates to methods of treating, preventing, reducing the severity of, reducing the incidence of, delaying the onset of, or reducing pathogenesis of an inflammatory skin disease, condition or lesion in a human subject, which include the step of administering to the subject a therapeutically effective amount of mi RNA compositions. In addition, methods of this invention may be used to treat symptoms of inflammatory skin diseases and reduce and/or inhibit keratinocyte proliferation.
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公开(公告)号：US10028999B2
公开(公告)日：2018-07-24
申请号：US15309195
申请日：2015-05-11
Inventor： Joab Chapman , Efrat Shavit-Stein
IPC: A61K38/57 , A61K38/17 , C07K14/72 , C07K5/083 , C07K5/093 , C07K5/103 , C07K5/117 , A61K45/06 , A61K38/00
Abstract: The present invention is directed to a peptide conjugate comprising an alpha-amino protecting moiety, a peptide comprising the amino acid sequence at least 3 amino-acid long derived from the C′-terminus of PAR-1, or an active variant thereof and a protease-disabling moiety. The present invention is further directed to pharmaceutical compositions comprising the peptide conjugate and use thereof for treating diseases and disorder associated with excessive PAR-1 activity.
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公开(公告)号：US20180193374A1
公开(公告)日：2018-07-12
申请号：US15744086
申请日：2016-07-14
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Avital GlLAM , Noam SHOMRON , Eitan FRIEDMAN
IPC: A61K31/7105 , C12N15/113 , A61P35/04
CPC classification number: A61K31/7105 , A61K31/713 , A61P35/04 , C12N15/113 , C12N2310/141 , C12N2310/14 , C12N2310/531
Abstract: Provided are compositions and methods for treating cancer, particularly solid tumors, and cancer metastasis, using micro-RNAs mi R-96 and/or mi R-182.
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公开(公告)号：US20180016338A1
公开(公告)日：2018-01-18
申请号：US15715386
申请日：2017-09-26
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Gal MARKEL , Rona ORTENBERG , Jacob SCHACHTER
IPC: C07K16/28 , G01N33/574 , A61K39/395 , A61K45/06 , A61K39/00
CPC classification number: C07K16/2803 , A61K35/17 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/14 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57473 , G01N33/57492 , G01N2333/70503
Abstract: A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
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