公开(公告)号：US20190239958A1

公开(公告)日：2019-08-08

申请号：US16343369

申请日：2017-09-18

Applicant: INSTITUT MINES-TÉLÉCOM ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT-ETIENNE

Inventor： David PERRIN ,  Stéphane AVRIL ,  Pierre BADEL ,  Jean-Noël ALBERTINI

IPC: A61B34/10 ,  G06T7/12 ,  G06T7/00 ,  A61F2/07

CPC classification number: A61B34/10 ,  A61B2017/00526 ,  A61B2017/00778 ,  A61B2034/102 ,  A61B2034/105 ,  A61B2034/108 ,  A61B2090/367 ,  A61F2/06 ,  A61F2/07 ,  A61F2002/065 ,  A61F2240/002 ,  G06T7/0012 ,  G06T7/12

Abstract: The method of assisting the production of an implantable unfurlable made to measure device comprises: three-dimensional reconstruction of a complex surface of the cavity in which the device will be implanted; Production of a first finite element mesh of this complex surface; Choosing of generic components of the device; Production of a second finite element mesh of these assembled generic components; Determination of the morphosis parameters for morphosing from the first mesh to a mesh of a set of simple linked volumes which is representative of the part of the cavity, and then deformation of the first mesh by this morphosis; Simulation of a deformation of the second mesh, by inverse morphosis dependent on the determined parameters, to the complex surface, simulating unfurling of the device; Determination of dimensioning of points of interest by projection onto the second deformed mesh; and Generation of a production blueprint plan of the device.

公开(公告)号：US20190187567A1

公开(公告)日：2019-06-20

申请号：US16311293

申请日：2017-06-21

Applicant: H.E.F. ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Maxime BICHOTTE ,  Yves JOURLIN ,  Laurent DUBOST

IPC: G03F7/20 ,  G03F9/00 ,  G03F1/76 ,  G03F1/80

CPC classification number: G03F7/70216 ,  B82Y30/00 ,  G03F1/00 ,  G03F1/68 ,  G03F1/76 ,  G03F1/80 ,  G03F7/2026 ,  G03F7/7035 ,  G03F9/70

Abstract: The invention relates to a system (2) for producing an optical mask (35) for surface microtexturing, said system (2) comprising: a substrate (10) having a surface (11) that is to be textured; a layer of material (20) which covers the surface (11) of the substrate (10) and has an outer surface (21) that is exposed to the outside environment; and a generating and depositing device for generating and depositing droplets (30) on the outer surface (21) of the layer of material (20), in a specific arrangement (31) under condensation, forming the optical mask (35) on the outer surface (21) of the layer of material (20). The invention also relates to a treatment plant comprising a system (2) of said type. The invention further relates to a method for producing a mask as well as to a surface microtexturing method.

公开(公告)号：US20170343564A1

公开(公告)日：2017-11-30

申请号：US15660456

申请日：2017-07-26

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  HOSPICES CIVILS DE LYON ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE

Inventor： Jerome Marc Claude HONNORAT ,  Jean-Christophe ANTOINE ,  Jean-Philippe CAMDESSANCHE ,  Nadia BOUTAHAR ,  Veronique Annie ROGEMOND

IPC: G01N33/68 ,  A61K31/365 ,  A61K31/436 ,  A61K31/519 ,  C07K16/28 ,  A61K31/137 ,  A61K31/675 ,  A61K31/52 ,  A61K38/13 ,  G01N33/564

CPC classification number: G01N33/6896 ,  A61K31/137 ,  A61K31/365 ,  A61K31/436 ,  A61K31/519 ,  A61K31/52 ,  A61K31/675 ,  A61K38/13 ,  C07K16/2887 ,  G01N33/564 ,  G01N2333/71 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present invention relates to the diagnosis of acquired sensory neuronopathies (SNN), and to the treatment of these disorders.

公开(公告)号：US09623044B2

公开(公告)日：2017-04-18

申请号：US14414994

申请日：2013-07-16

Applicant: UNIVERSITE CLAUDE BERNARD LYON I ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET, SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

Inventor： Fatiha Nothias ,  Sylvia Soares ,  Laurent David ,  Alexandra Montembault

IPC: A61K31/722 ,  A61L27/20 ,  A61L27/52 ,  A61L27/38 ,  A61L27/50 ,  A61K9/16 ,  A61K45/06

CPC classification number: A61K31/722 ,  A61K9/16 ,  A61K45/06 ,  A61L27/20 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/32 ,  C08L5/08

Abstract: The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses.It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.