公开(公告)号：US20240165313A1

公开(公告)日：2024-05-23

申请号：US18429963

申请日：2024-02-01

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Carnegie Mellon University ,  Mississippi State University

Inventor： Shalv Madhani ,  Brian Joseph Frankowski ,  William J. Federspiel ,  Gregory Burgreen ,  James F. Antaki

IPC: A61M1/36 ,  A61M1/16 ,  A61M60/113 ,  A61M60/232 ,  A61M60/38 ,  A61M60/419 ,  A61M60/422 ,  A61M60/82 ,  A61M60/824 ,  A61M60/825

CPC classification number: A61M1/3667 ,  A61M1/1625 ,  A61M1/1698 ,  A61M1/3666 ,  A61M60/113 ,  A61M60/232 ,  A61M60/38 ,  A61M60/419 ,  A61M60/422 ,  A61M60/82 ,  A61M60/824 ,  A61M60/825 ,  A61M2205/7536

Abstract: An extracorporeal system for lung assist includes a housing having a blood flow inlet in fluid connection with a pressurizing stator compartment within the housing. A fiber bundle compartment within the housing is above and in fluid connection with the pressurizing stator compartment via a flow channel formed within the housing and extending from the pressurizing stator compartment to an inlet manifold of the fiber bundle compartment. A blood flow outlet in is fluid connection with an outlet man fold of the fiber bundle compartment. The blood flow inlet extends through the housing parallel to a plane of rotation of an impeller in the pressurizing stator compartment. The blood flow inlet turns to deliver blood into a central portion of the impeller. A has inlet is in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers of a cylindrical fiber bundle positioned within the fiber bundle compartment. A gas outlet is in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

公开(公告)号：US11986493B2

公开(公告)日：2024-05-21

申请号：US17540965

申请日：2021-12-02

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Mark Thomas Gladwin ,  Edwin Parsley ,  Hunter Clay Champion

IPC: A61K33/00 ,  A61K9/00 ,  A61K31/04

CPC classification number: A61K33/00 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/04

Abstract: Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. The method includes administering to a subject in need of treatment a therapeutically effective amount of inorganic nitrite. The nitrite may be administered by inhalation and may be nebulized. The nitrite may be administered at an emitted dose or in an escalated titrated dose. The nitrite may be a liquid formulation or a dry powder formulation.

公开(公告)号：US20240157059A1

公开(公告)日：2024-05-16

申请号：US18418661

申请日：2024-01-22

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Jeffrey A. Gusenoff ,  Beth R. Gusenoff

IPC: A61M5/315

CPC classification number: A61M5/31583 ,  A61M5/31526 ,  A61M5/31528 ,  A61M2202/08 ,  A61M2202/09 ,  A61M2210/086

Abstract: Provided herein are devices useful in processing fat for fat grafting and for delivering fat tissue grafts to a patient. Also provided are devices and methods for fat grafting and for treatment of plantar fasciitis.

公开(公告)号：US20240156779A1

公开(公告)日：2024-05-16

申请号：US18277765

申请日：2022-03-09

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Ieva Sutkeviciute ,  Jean-Pierre Vilardaga ,  Jiyoung Lee ,  Ivet Bahar ,  Burak Kaynak

IPC: A61K31/401

CPC classification number: A61K31/401

Abstract: Disclosed herein are methods for treating hyperparathyroidism, osteoporosis, or cancer cachexia, or inhibiting abnormally increased white adipose tissue browning, or decreasing the risk of a kidney stone in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a negative allosteric modulator of parathyroid hormone (PTH) type 1 receptor (PTHR) signaling.

公开(公告)号：US20240150520A1

公开(公告)日：2024-05-09

申请号：US18546039

申请日：2022-02-10

Applicant: Cornell University ,  University of Pittsburgh - of the Commonwealth System of Higher Education

Inventor： Geoffrey W. Coates ,  Yiye Lu ,  Tara Y. Meyer

IPC: C08G63/08 ,  C08G63/84

CPC classification number: C08G63/08 ,  C08G63/84

Abstract: Methods for regioselective ring-opening polymerization of unsymmetrical cyclic diester monomers, polymers, which may be made by the methods, and uses of same. Monomers may include cyclic hydroxy-acid dimers, such as, for example, 3-methyl glycolide and the like. Polymerization initiators may include chiral metal alkoxide initiators, such as, for example, (SalBinam)Al-01Pr initiators and the like. Polymers may include polyesters, such as, for example, poly(lactic-co-glycolic acid) (PLGA) and the like, with 90% or greater regioselectivity for alternating ester units (e.g., glycolic unit-lactic unit (G—L) linkages). Polymers may be utilized for substained or targeted drug delivery vehicles, scaffolding for tissue engineering, bioabsorbable sutures, or the like.

公开(公告)号：US20240141285A1

公开(公告)日：2024-05-02

申请号：US18495903

申请日：2023-10-27

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Jennifer M. Bomberger ,  Ananya Kapur

IPC: C12N1/20 ,  C12N5/00

CPC classification number: C12N1/20 ,  C12N5/0018 ,  C12R2001/445

Abstract: An airway model for culturing microbes such as bacteria Pseudomonas aeruginosa, is provided, comprising culturing the microbes in synthetic sputum media on an air-liquid interface culture of airway epithelial cells. The bacteria may be Pseudomonas aeruginosa, and the epithelial cells may be from a cystic fibrosis (CF) patient and/or comprise a mutation in CFTR found in CF patients.

公开(公告)号：US20240118289A1

公开(公告)日：2024-04-11

申请号：US18321405

申请日：2023-05-22

Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education

Inventor： Kai Singbartl ,  John A. Kellum

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/495 ,  G01N2333/70578 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/50

Abstract: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.

公开(公告)号：US20240102836A1

公开(公告)日：2024-03-28

申请号：US18474469

申请日：2023-09-26

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： HENG BAN ,  GREGORY E.J. KINZLER

IPC: G01F1/46

CPC classification number: G01F1/46

Abstract: A linear variable differential pitot tube includes a primary solenoid, a first secondary solenoid, a second secondary solenoid, wherein the primary solenoid is positioned in between the first secondary solenoid and the second secondary solenoid, wherein the first secondary solenoid and the first secondary solenoid have identical geometries, and a high permeability magnetic core, the high permeability magnetic core being structured to move relative to the primary solenoid, the first secondary solenoid, and the second secondary solenoid. Also, a system and method for measuring the localized velocity of a flow of a fluid using the linear variable differential pitot tube.

公开(公告)号：US11938248B2

公开(公告)日：2024-03-26

申请号：US17001177

申请日：2020-08-24

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Eric M. Jeffries ,  Yadong Wang ,  James H. Clampffer

IPC: A61L27/56 ,  A61F2/06 ,  A61F2/07 ,  A61L27/18 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L33/06 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  D01D5/00 ,  D01F6/62 ,  D01F6/74

CPC classification number: A61L27/507 ,  A61F2/06 ,  A61F2/07 ,  A61L27/18 ,  A61L27/3679 ,  A61L27/3808 ,  A61L27/3886 ,  A61L27/50 ,  A61L27/54 ,  A61L33/068 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  D01D5/0007 ,  D01F6/62 ,  D01F6/74 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0026 ,  A61F2240/001 ,  A61F2240/004 ,  A61F2240/005 ,  A61F2250/0067 ,  A61L27/3804 ,  A61L2300/42 ,  A61L2300/606 ,  D10B2509/06

Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.

公开(公告)号：US20240058283A1

公开(公告)日：2024-02-22

申请号：US18336712

申请日：2023-06-16

Applicant: West Virginia University Board of Governors on Behalf of West Virginia University ,  Temple University-Of the Commonwealth System of Higher Education ,  University of Pittsburgh-Of the Commonwealth System of Higher Education ,  The United States Government as represented by the Department of Veterans Affairs

Inventor： John B. Barnett ,  Werner Geldenhuys ,  Jonathan Soboloff ,  Harry C. Blair

IPC: A61K31/167

CPC classification number: A61K31/167

Abstract: A method of restoring the balance of osteoclast to osteoblast activity in a patient having rheumatoid arthritis comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. A method for treating arthritis-induced bone erosion in a patient comprising administering to a patient a therapeutically effective amount of the compound N-(3,4-dichlorophenyl)-N-methylpropanamide is provided. The compound N-(3,4-dichlorophenyl)-N-methylpropanamide is administered in a pharmaceutically acceptable composition to said patient. A mode of action of N-(3,4-dichlorophenyl)-N-methyl propanamide comprising targeting transient receptor potential channels is provided.