公开(公告)号：US20060216201A1

公开(公告)日：2006-09-28

申请号：US11385525

申请日：2006-03-21

Applicant: Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

Inventor： Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

IPC: G01N33/00

CPC classification number: B01L3/502723 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0688 ,  Y10T137/0318 ,  Y10T137/2076 ,  Y10T137/2082 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A testing microchip includes a specimen storage section; a reagent storage section; a reaction section; a testing section for a test of a reaction product obtained from the reaction; a liquid feed control section; and a gas bubble trapping structure. The sections are connected continuously by a series of flow channels. The liquid feed control section stops passing of liquid until a liquid feeding pressure reaches a predetermined pressure, and passes the liquid when the liquid feeding pressure becomes higher than the predetermined pressure; and the gas bubble trapping structure traps a gas bubble in the liquid that flows in the flow channel so that the gas bubble does not flow to the downstream side and only the liquid passes to the downstream side. A testing apparatus that performs testing in the testing section of the testing microchip, wherein the testing microchip is attachably and detachably mounted to the apparatus.

Abstract translation: 测试微芯片包括样本存储部分; 试剂储存部; 反应部分 用于从反应获得的反应产物的试验的试验部分; 液体供给控制部; 和气泡捕获结构。 这些部分通过一系列流动通道连续连接。 液体供给控制部停止液体通过，直到液体供给压力达到规定压力，并且当液体供给压力变得高于预定压力时使液体通过; 并且气泡捕获结构捕获在流动通道中流动的液体中的气泡，使得气泡不流到下游侧，并且仅液体流到下游侧。 一种在测试微芯片的测试部分进行测试的测试设备，其中测试微芯片可附接和可拆卸地安装在该设备上。

公开(公告)号：US20060204381A1

公开(公告)日：2006-09-14

申请号：US11416532

申请日：2006-05-03

Applicant: Kusunoki Higashino ,  Yasuhisa Fujii ,  Shunichi Hayamizu ,  Yasuhiro Sando

Inventor： Kusunoki Higashino ,  Yasuhisa Fujii ,  Shunichi Hayamizu ,  Yasuhiro Sando

IPC: F04B17/00

CPC classification number: F16K99/0001 ,  B01L3/5027 ,  F04B43/043 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0048 ,  F16K2099/0074 ,  F16K2099/0094 ,  Y10T137/2224 ,  Y10T137/2273

Abstract: Disclosed herein is a micro fluid transferring system that comprises a micropump having a chamber, a first fluid transferring portion connected to the chamber, and a second fluid transferring portion connected to the chamber. This system is characterized in that at least one of the first and second fluid transferring portions comprises a pressure absorbing section for absorbing or alleviating a liquid vibrational pressure therein.

公开(公告)号：US06851846B2

公开(公告)日：2005-02-08

申请号：US10171920

申请日：2002-06-14

Applicant: Yasuhisa Fujii ,  Shigeo Yamashita ,  Yasuhiro Sando ,  Koji Yamamoto ,  Shunichi Hayamizu

Inventor： Yasuhisa Fujii ,  Shigeo Yamashita ,  Yasuhiro Sando ,  Koji Yamamoto ,  Shunichi Hayamizu

IPC: G01N37/00 ,  B01F3/08 ,  B01F5/00 ,  B01F5/04 ,  B01F13/00 ,  B01L3/00 ,  B01F15/02 ,  B81B7/04

CPC classification number: B01F13/0062 ,  B01F5/0453 ,  B01F5/0458 ,  B01F13/0066 ,  B01F13/0093 ,  B01F2215/0431 ,  B01L3/5027 ,  Y10T137/87652

Abstract: Disclosed herewith is a microchip having a micromixer therein. The mixromixer employs a mixing or extracting structure having (1) a first flow pass provided at a first level of the microchip; (2) a second flow pass provided at a second level of the microchip, which is different from the first level; (3) a third flow pass having a plurality of sub flow passes separately layered at the first level and each having a first end and second end thereof, each sub flow pass being connected to one of the first and second flow passes at the first end thereof; and (4) a fourth flow pass, provided at the first level, connected to the second ends of the sub flow passes so that, at least connecting portions between the fourth flow pass and the sub flow passes of the third flow pass, an extending direction of the fourth flow pass is substantially identical to those of the sub flow passes. By allowing the first liquid to flow from the first flow pass to the fourth flow pass through the third flow pass while the second liquid to flow from the second flow pass to the fourth flow pass through the third flow pass, the first and second liquids are mixed at the fourth flow pass.

Abstract translation: 本文公开的是其中具有微混合器的微芯片。 混合混合器采用混合或提取结构，其具有（1）设置在微芯片的第一级的第一流动通道; （2）设置在不同于第一级的微芯片的第二级的第二流程; （3）第三流程，其具有在第一水平处分开层叠的多个子流通道，每个具有第一端和第二端，每个子流通道在第一端连接到第一和第二流动通道之一 的; 和（4）设置在第一级的第四流道，连接到副流通道的第二端，使得至少第四流通和次流之间的连接部分通过第三流道，延伸 第四流程的方向基本上与副流程相同。 通过使第一液体从第一流通流动到第三流动通道，而第二液体从第二流量流动到第四流动通过第三流动通道，第一和第二液体是 在第四个流程中混合。

公开(公告)号：US06838055B2

公开(公告)日：2005-01-04

申请号：US09988492

申请日：2001-11-20

Applicant: Yasuhiro Sando ,  Yasuhisa Fujii

Inventor： Yasuhiro Sando ,  Yasuhisa Fujii

IPC: G01N33/49 ,  B01F5/02 ,  B01F13/00 ,  B01L3/00 ,  B81B1/00 ,  G01N27/447 ,  G01N33/86 ,  G01N35/08 ,  G01N37/00 ,  B01L3/02 ,  G01N15/06 ,  G01N21/47 ,  G01N33/00 ,  G01N33/48

CPC classification number: B01F5/0256 ,  B01F13/0059 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0439 ,  B81B1/00 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339

Abstract: Disclosed herein is a microchip provided with a specimen flow pass, a reagent flow pass, a confluence flow pass all of which are fine flow passes. The specimen flow pass allows specimen to flow toward one end thereof. The reagent flow pass is connected to that end of the specimen flow pass and allows at least one reagent to flow for reaction with the specimen. The confluence flow pass extends from that end of the specimen flow pass and allows the confluent specimen and reagent to flow. A sensing portion is assigned near or at the confluence flow pass, and the reaction of the specimen and the reagent is capable of being detected or observed there. Further to this, the microchip comprises a force applying means for reciprocally moving the specimen and the reagent at the sensing portion. Since the reaction of the specimen and the reagent is occurred while they are reciprocally moved within the sensing portion, a length of confluence flow pass required for the reaction can be shortened, and therefore, a size of the microchip can be made compact.