公开(公告)号：US09120067B2

公开(公告)日：2015-09-01

申请号：US13395592

申请日：2010-12-13

Applicant: Kenichi Miyata ,  Takahiro Mohri ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Masashi Nishikado ,  Gou Yanagihara

Inventor： Kenichi Miyata ,  Takahiro Mohri ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Masashi Nishikado ,  Gou Yanagihara

IPC: B81B1/00 ,  B01F15/00 ,  B01F5/00 ,  B01F11/00 ,  B01J19/00 ,  B01L3/00

CPC classification number: B01F15/00876 ,  B01F5/0065 ,  B01F11/0074 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0867 ,  B01L2400/049

Abstract: There are provided a micro mixer capable of efficiently mixing at least two types of liquids in a simple structure and a microfluidic chip provided with the micro mixer. In order to achieve the object, the micro mixer includes a minute passage through which first and second liquids are caused to flow respectively, and a mixing vessel in which a liquid injecting port caused to communicate with the minute passage is provided in a bottom part, and the liquid injecting port is provided in a shifted position from a center of the bottom part in the bottom part. Moreover, the liquid injecting port may be provided in a shifted position from a center line of the mixing vessel.

Abstract translation: 提供了能够以简单结构有效地混合至少两种类型的液体的微型混合器和设置有微型混合器的微流体芯片。 为了实现该目的，微型混合器包括分别使第一和第二液体流过的微小通道，并且在底部设置有与微通道连通的液体注入口的混合容器， 并且液体注入口设置在从底部的底部的中心移位的位置。 此外，液体注入口可以设置在从混合容器的中心线移动的位置。

公开(公告)号：US08257974B2

公开(公告)日：2012-09-04

申请号：US12803060

申请日：2010-06-18

Applicant: Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki ,  Kohsuke Tanimoto

Inventor： Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki ,  Kohsuke Tanimoto

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N35/1095 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44756 ,  G01N2035/00158 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).

Abstract translation: 在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为 有效地传递到反应物中，从而促进反应的进行。 在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动 ）。 反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道 （10），同时在其前缘侧提供气体。 在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。

公开(公告)号：US07906318B2

公开(公告)日：2011-03-15

申请号：US11121096

申请日：2005-05-04

Applicant: Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

Inventor： Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

IPC: C12M1/34

CPC classification number: B01L3/50273 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/024 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0633 ,  B01L2400/0677

Abstract: A micro-reactor for analyzing a sample, comprises (1) a plate-shaped chip; (2) a plurality of regent storage sections each having a chamber to store respective agents; (3) a regent mixing section to mix plural regents fed from the plurality of regent storage sections so as to produce a mixed reagent; (4) a sample receiving section having an injection port through which a sample is injected from outside; and (5) a reacting section to mix and react the mixed regent fed from the reagent mixing section and the sample fed from the sample receiving section. The plurality of regent storage sections, the regent mixing section, the sample receiving section and the reacting section are incorporated in the chip and are connected through flow paths, and the regent mixing section includes a feed-out preventing mechanism to prevent an initially-mixed regent from being fed out to the reacting section.

Abstract translation: 用于分析样品的微反应器包括（1）板状芯片; （2）多个存储部分，每个存储部分具有用于存储相应代理的室; （3）注射混合部，混合从多个摄取储存部供给的多个药剂，以制备混合试剂; （4）具有从外部注入样品的注入口的样本接收部分; 和（5）反应部分，用于混合并反应从试剂混合部分供给的混合注射器和从样品接收部分供给的样品。 多个摄取储存部分，摄取混合部分，样品接收部分和反应部分结合在芯片中并通过流动路径连接，并且摄像机混合部分包括防止初始混合的送出机构 摄政从被送到反应部分。

公开(公告)号：US20090155927A1

公开(公告)日：2009-06-18

申请号：US12092116

申请日：2006-10-18

Applicant: Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

Inventor： Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

IPC: G01N1/10 ,  B01J19/00 ,  G01N35/08 ,  G01N37/00

CPC classification number: B01L3/502738 ,  B01F5/0602 ,  B01F5/0647 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00891 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/084 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0084 ,  Y10T436/2575

Abstract: A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and reagents and realizes high-precision controlling of the timing of mixing of reagents and other liquids, the mixing ratio of liquids, the pressure for liquid feeding, etc. Further, there is provided a method of liquid feeding making use of the same. Accordingly, a flow path branched at the position of an inlet from a flow path through which an opening communicating with an external pump communicates with the inlet is provided with an air evacuation flow path with its terminal open outward. Further, the flow path resistance of the air evacuation flow path for a liquid is made greater than the flow path resistance, for the liquid, of a flow channel from the reagent storage chamber to a reagent feed-out flow path.

Abstract translation: 能够在样品和含有多种试剂的混合物的混合试剂之间反应的微反应器，该微反应器避免在驱动溶液和试剂之间插入空气，并实现对试剂和其它液体的混合时间的高精度控制，混合 液体的比例，液体供给的压力等。此外，提供了一种使用该液体的方法。 因此，在与从外部泵连通的开口与流路连通的流路的入口位置分支的流路设置有使其端子向外侧开口的排气流路。 此外，使液体的排气流路的流路阻力大于液体对从试剂储存室到试剂送出流路的流路的流路阻力。

公开(公告)号：US20060263914A1

公开(公告)日：2006-11-23

申请号：US11434253

申请日：2006-05-16

Applicant: Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

Inventor： Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

IPC: H01L21/66 ,  H01L23/58

CPC classification number: B01L3/565 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0439 ,  G01N2035/00158 ,  Y10T137/87877

Abstract: A testing chip includes (1) a first chip having a micro flow path that stores reagent; upstream-side opening provided on upstream-side of the micro flow path; downstream-side opening provided on downstream-side of the micro flow path; and one or more sealing members in a small thickness stuck to at least one surface of the first chip to seal the upstream-side opening and the downstream-side opening until the testing chip is used and (2) a second chip having a micro flow path for mixing and reaction between reagent and a specimen and detecting the reaction; and an opening provided on upstream-side of the micro flow path, wherein, when the testing chip is used, the first and second chips are superimposed on each other so that the downstream-side opening of the first chip and the opening of the second chip are positioned on each other.

公开(公告)号：US20060213291A1

公开(公告)日：2006-09-28

申请号：US11378516

申请日：2006-03-17

Applicant: Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

Inventor： Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

IPC: G01D21/00

CPC classification number: G01N35/00029 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502715 ,  B01L2200/146 ,  B01L2200/147 ,  Y10T436/2575

Abstract: An analyzer for analysis of a specimen in a testing chip that includes a micropump connecting section that is connected with a micropump to take in liquid from the micropump and includes a micro flow channel in which a reagent and the specimen are mixed so as to react with each other, the analyzer including: a mounting section for mounting the testing chip attachably and detachably thereto; a micropump unit that has a testing chip connecting section to be connected with the micropump connecting section of the testing chip which is mounted on the mounting section, and feeds liquid to the testing chip through the testing chip connecting section; and a pressing mechanism that presses the micropump connecting section and the testing chip connecting section against each other, the connecting sections being connected with each other.

Abstract translation: 一种用于分析测试芯片中的样本的分析器，其包括与微型泵连接以从微型泵吸取液体的微泵连接部分，并且包括微流道，其中将试剂和样品混合以便与 彼此分离器包括：安装部分，用于将测试芯片可安装和可拆卸地安装在其上; 微型泵单元，具有与安装在安装部上的测试用芯片的微型泵连接部连接的测试芯片连接部，并通过测试芯片连接部将液体供给到测试芯片; 以及将微型泵连接部和测试用芯片连接部彼此按压的按压机构，连接部彼此连接。

公开(公告)号：US07094040B2

公开(公告)日：2006-08-22

申请号：US10387946

申请日：2003-03-13

Applicant: Kusunoki Higashino ,  Yasuhisa Fujii ,  Shunichi Hayamizu ,  Yasuhiro Sando

Inventor： Kusunoki Higashino ,  Yasuhisa Fujii ,  Shunichi Hayamizu ,  Yasuhiro Sando

IPC: F04B17/00

CPC classification number: F16K99/0001 ,  B01L3/5027 ,  F04B43/043 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0048 ,  F16K2099/0074 ,  F16K2099/0094 ,  Y10T137/2224 ,  Y10T137/2273

Abstract: Disclosed herein is a micro fluid transferring system that comprises a micropump having a chamber, a first fluid transferring portion connected to the chamber, and a second fluid transferring portion connected to the chamber. This system is characterized in that at least one of the first and second fluid transferring portions comprises a pressure absorbing section for absorbing or alleviating a liquid vibrational pressure therein.

公开(公告)号：US20060088451A1

公开(公告)日：2006-04-27

申请号：US11254210

申请日：2005-10-19

Applicant: Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

Inventor： Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

IPC: B01J19/00

CPC classification number: B01L3/50273 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0439 ,  B01L2400/0655 ,  B01L2400/086 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The object of the present invention is to provide a micro-reactor, equipped with a high-precision liquid feed system of simple structure, capable of high-precision analysis of at least one item. The present invention provides a micro-reactor for biological substance inspection including a sample storage section, a reagent storage section, a sample pre-processing section, a micro-pump connecting section and a branched minute flow path. And a sample pre-processed by the sample pre-processing section is fed into the minute flow path branched off into at least two parts by a micro-pump and a liquid dividing section, and on the downstream side of each of the branched minute flow paths, the sample is fed to a flow path constituting a reaction site, and then to a flow path constituting the detection site, thereby providing simultaneous measurement of a plurality of items of a sample.

Abstract translation: 本发明的目的是提供一种微型反应器，其具有结构简单的高精度液体供给系统，能够对至少一个物品进行高精度分析。 本发明提供了一种用于生物物质检查的微反应器，包括样品存储部分，试剂储存部分，样品预处理部分，微泵连接部分和分支的微小流路。 并且由样品预处理部分预处理的样品通过微型泵和分液部分被分配到至少两部分的微小流路中，并且在每个分支微流量的下游侧 将样品送入构成反应部位的流路，然后送入构成检测部位的流路，从而同时测量多个样品。

公开(公告)号：US06309056B1

公开(公告)日：2001-10-30

申请号：US09298510

申请日：1999-04-22

Applicant: Yasuhiro Sando ,  Kusunoki Higashino ,  Hisashi Takata ,  Yasuhisa Fujii ,  Hideo Hotomi

Inventor： Yasuhiro Sando ,  Kusunoki Higashino ,  Hisashi Takata ,  Yasuhisa Fujii ,  Hideo Hotomi

IPC: B41J2045

CPC classification number: B41J2/14314 ,  B41J2202/18

Abstract: An ink jet head for a printer wherein an ink drop is ejected from a nozzle to fly and land on the recording paper to form an image. The ink jet head includes the nozzle for ejecting ink, an ink channel that communicates with the nozzle, a pair of oscillating plates that are opposing to each other on walls of the ink channel, a pair of electrodes disposed in contact with the oscillating plates, an ink chamber for holding the ink, and an inlet for supplying the ink from the ink chamber to the ink channel. A gap between the electrodes is filled with the ink having a relative dielectric constant higher than air. A voltage is applied between the electrodes.

Abstract translation: 一种用于打印机的喷墨头，其中墨滴从喷嘴喷射以飞行并落在记录纸上以形成图像。 喷墨头包括用于喷射墨水的喷嘴，与喷嘴连通的墨水通道，在墨水通道的壁上彼此相对的一对振动板，设置成与振动板接触的一对电极， 用于保持墨水的墨水室和用于将墨水从墨水室供给到墨水通道的入口。 电极之间的间隙用比空气高的相对介电常数的墨水填充。 在电极之间施加电压。

公开(公告)号：US20130242298A1

公开(公告)日：2013-09-19

申请号：US13989498

申请日：2011-09-12

Applicant: Tomoko Miyaura ,  Yasuhiro Sando

Inventor： Tomoko Miyaura ,  Yasuhiro Sando

IPC: G02B1/12 ,  G02B5/00

CPC classification number: G02B1/12 ,  G01N21/553 ,  G01N21/648 ,  G01N2035/00158 ,  G02B5/008

Abstract: The invention relates to a prism part included in an analysis chip for use in an analysis device for analyzing a specimen utilizing surface plasmon resonance, and being cooperative with a channel member to form a channel for flowing a sample solution containing the specimen. The prism part includes a prism main body into which excitation light for generating surface plasmon is incident, and a gold film formed on a specified surface of the prism main body. The prism main body includes a mixed layer having a predetermined thickness from the specified surface toward the inner side. The mixed layer is formed by ions of gold for the gold film to enter from the specified surface in the formation of the gold film on the specified surface.

Abstract translation: 本发明涉及一种棱镜部件，其包括在用于分析利用表面等离子体共振的样品的分析装置中的分析芯片中，并且与通道部件协作以形成用于使含有样品的样品溶液流动的通道。 棱镜部分包括棱镜主体，用于产生表面等离子体激元的激发光入射到该棱镜主体中，以及形成在棱镜主体的特定表面上的金膜。 棱镜主体包括从指定表面朝向内侧具有预定厚度的混合层。 混合层由金的离子形成，以使金膜从指定的表面进入指定表面上形成金膜。