公开(公告)号：US20100087673A1

公开(公告)日：2010-04-08

申请号：US12523440

申请日：2008-01-08

申请人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Yuzuru Morino ,  Mikihiro Takahashi

发明人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Yuzuru Morino ,  Mikihiro Takahashi

IPC分类号： C07C67/00

CPC分类号： C07C67/307 ,  C07B2200/07 ,  C07C69/63

摘要： An optically active α-fluorocarboxylate is produced by reacting an optically active α-hydroxycarboxylate with sulfuryl fluoride (SO2F2), trifluoromethanesulfonyl fluoride (CF3SO2F) or nonafluorobutanesulfonyl fluoride (C4F9SO2F) in the presence of organic base and in the absence of reaction solvent. More preferably, a distillation purification is conducted after adding acid to the reaction-terminated liquid. With this, it is possible to produce an optically active α-fluorocarboxylate of a still higher purity. It is possible by this process to advantageously produce an optically active α-fluorocarboxylate on a large-amount scale.

摘要翻译： 光学活性的α-氟代羧酸酯是通过光学活性的α-羟基羧酸酯与硫酰氟（SO 2 F 2），三氟甲磺酰氟（CF 3 SO 2 F）或九氟丁磺酰氟（C 4 F 9 SO 2 F）在有机碱的存在下和不存在反应溶剂下反应制备的。 更优选地，在向反应终止的液体中加入酸之后进行蒸馏纯化。 由此，可以生产出更高纯度的光学活性α-氟代羧酸酯。 通过该方法可以有利地大量生产光学活性的α-氟代羧酸酯。

公开(公告)号：US20090312574A1

公开(公告)日：2009-12-17

申请号：US12519959

申请日：2007-12-18

申请人： Koichi Mikami ,  Kohsuke Aikawa ,  Akihiro Ishii ,  Kaori Mogi ,  Takashi Ootsuka

发明人： Koichi Mikami ,  Kohsuke Aikawa ,  Akihiro Ishii ,  Kaori Mogi ,  Takashi Ootsuka

IPC分类号： C07C51/04

CPC分类号： C07C67/347 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/343 ,  C07C69/732

摘要： An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost.

摘要翻译： 在具有光学活性配体的过渡金属络合物的存在下，通过使含氟α-酮酯与烯烃反应制备光学活性的含氟羰基产物。 在没有反应溶剂的情况下进行该反应的方式1，在相对介电常数低的溶剂中进行该反应的方式2，以及在卤代烃系溶剂中进行该反应的方式3。 在这三种模式中的每一种中，可以以低成本制造光学活性的含氟羰基产物。

公开(公告)号：US5382589A

公开(公告)日：1995-01-17

申请号：US90136

申请日：1993-07-21

申请人： Akihiro Ishii ,  Yasunobu Nishimura ,  Hirotsune Kondoh ,  Yoshiyuki Kikuchi

发明人： Akihiro Ishii ,  Yasunobu Nishimura ,  Hirotsune Kondoh ,  Yoshiyuki Kikuchi

IPC分类号： C07D401/12 ,  A61K31/445

CPC分类号： C07D401/12

摘要： The present invention relates to phthalimide compounds represented by the following general formula (I) and their acid-added salts and to methods of producing the same: ##STR1## wherein Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--. The present invention provides phthalimide compounds represented by the above general formula (I) and their acid-added salts, which are useful compounds as intermediates of medicines such as anti-ulcers based on histamine H.sub.2 receptor antagonism. In particular, acid-added salts of the phthalimide compounds can be easily refined by the recrystallization method. Therefore, there is provided an advantage that purity of the anti-ulcers which are derived from phthalimide compounds and their acid-added salts according to the present invention can be improved.

摘要翻译： 本发明涉及由以下通式（I）表示的邻苯二甲酰亚胺化合物及其加酸盐及其制备方法：其中Y表示-CH 2 -CH 2 - 或-CH = CH- 。 本发明提供由上述通式（I）表示的邻苯二甲酰亚胺化合物及其加酸盐，它们是作为药物中间体的有用化合物，例如基于组胺H 2受体拮抗作用的抗溃疡。 特别地，邻苯二甲酰亚胺化合物的酸加成盐可以通过重结晶法容易地精制。 因此，提供了可以提高根据本发明的衍生自邻苯二甲酰亚胺化合物及其加酸盐的抗溃疡的纯度的优点。

公开(公告)号：US5013828A

公开(公告)日：1991-05-07

申请号：US342350

申请日：1989-04-21

申请人： Yoshiyuki Kikuchi ,  Akihiro Ishii

发明人： Yoshiyuki Kikuchi ,  Akihiro Ishii

IPC分类号： C07H19/06

CPC分类号： C07H19/06

摘要： 2'-Deoxy-3',5'-diacyl-5-fluorouridines useful as antitumor medicines or intermediates thereof are easily and efficiently obtained by first fluorinating 2'-deoxyuridine in aqueous solution with fluorine gas to thereby form 2'-deoxy-5,6-dihydro-5-fluoro-6-hydroxyuridine, which is a novel compound, and reacting this compound with a carboxylic acid anhydride or halide R--CO--X, where R is an aliphatic group having not more than 20 carbon atoms or a substituted or unsubstituted phenyl group, and X is an acyloxy group RCO.sub.2 or a halogen atom. In the initial fluorination reaction the aqueous solution may contain a carbonate (or a hydrogen carbonate) or a lower fatty acid or its salt to capture hydrogen fluoride formed by the reaction. The next acylating reaction can be promoted by carrying out the reaction in the presence of an organic base such as pyridine.

摘要翻译： 可用作抗肿瘤药物的2'-脱氧-3'，5'-二酰基-5-氟尿嘧啶或其中间体通过首先用氟气氟化2'-脱氧尿苷水溶液，从而形成2'-脱氧-5 ，6-二氢-5-氟-6-羟基尿苷，其为新化合物，并使该化合物与羧酸酐或卤化物R-CO-X反应，其中R为不大于20个碳原子的脂族基团或 取代或未取代的苯基，X为酰氧基RCO 2或卤素原子。 在初始氟化反应中，水溶液可含有碳酸盐（或碳酸氢盐）或低级脂肪酸或其盐以捕获通过反应形成的氟化氢。 可以通过在有机碱如吡啶存在下进行反应来促进下一个酰化反应。

公开(公告)号：US20130005007A1

公开(公告)日：2013-01-03

申请号：US13519058

申请日：2011-02-14

申请人： Yasuhisa Asano ,  Kenichi Fuhshuku ,  Tetsuro Nishii ,  Akihiro Ishii

发明人： Yasuhisa Asano ,  Kenichi Fuhshuku ,  Tetsuro Nishii ,  Akihiro Ishii

IPC分类号： C12P7/04

CPC分类号： C12P7/04 ,  C12N1/16 ,  C12N15/81

摘要： Disclosed is a method for producing (S)-1,1,1-trifluoro-2-propanol with high optical purity and high yield by having at least one kind of microorganism, which is selected from the group consisting of Hansenula polymorpha, Pichia anomala, Candida parapsilosis, Candida mycoderma, Pichia naganishii, Candida saitoana, Cryptococcus curvatus, Saturnospora dispora, Saccharomyces bayanus and Pichia membranaefaciens, act on 1,1,1-trifluoroacetone. Since microorganisms found in nature are made to act in a natural state, the problems to be raised when a transformant or the like is used can be avoided in this method. Consequently, the method can be easily put in industrial practice.

摘要翻译： 公开了具有高光学纯度和高产率的（S）-1,1,1-三氟-2-丙醇的方法，该方法具有至少一种微生物，其选自多形汉逊酵母（Hansenula polymorpha），异形毕赤酵母 ，奇异假丝酵母（Candida parapsilosis），真菌念珠菌（Candida mycoderma），日本毕赤酵母（Pichia naganishii），蚕豆假丝酵母（Candida saitoana），曲霉隐球菌（Cryptococcus curvatus），土星孢子（Saturnospora dispora），巴豆酵母（Saccharomyces bayanus）和毕赤酵母（Pichia membranaefaciens），作用于1,1,1-三氟丙酮。 由于在自然界中发现的微生物使自然状态发生作用，所以在这种方法中可以避免使用转化体等引起的问题。 因此，该方法可以轻松投入工业实践。

公开(公告)号：US07985880B2

公开(公告)日：2011-07-26

申请号：US12306837

申请日：2007-06-25

申请人： Akihiro Ishii ,  Kaori Mogi ,  Hideyuki Tsuruta ,  Kenjin Inomiya

发明人： Akihiro Ishii ,  Kaori Mogi ,  Hideyuki Tsuruta ,  Kenjin Inomiya

IPC分类号： C07C209/00

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C209/26 ,  C07C209/62 ,  C07C211/29

摘要： There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optically active secondary amine and a formaldehyde (including an equivalent thereof) or lower aldehyde in the presence of a transition metal catalyst under a hydrogen gas atmosphere, thereby converting the secondary amine to an optically active tertiary amine of the formula, and subjecting the tertiary amine to hydrogenolysis. The target optically active compound can be produced efficiently by this production method.

摘要翻译： 提供光学活性1-（氟 - ，三氟甲基 - 或三氟甲氧基 - 取代的苯基）烷基胺N-单烷基衍生物的制备方法，该方法包括以下步骤：进行光学活性仲胺和甲醛的还原性烷基化（包括 等同物）或低级醛在过渡金属催化剂存在下在氢气气氛下反应，由此将仲胺转化为下式的光学活性叔胺，并对叔胺进行氢解。 可以通过该制造方法有效地制造目标光学活性化合物。

公开(公告)号：US20090326272A1

公开(公告)日：2009-12-31

申请号：US12306837

申请日：2007-06-25

申请人： Akihiro Ishii ,  Kaori Mogi ,  Hideyuki Tsuruta ,  Kenjin Inomiya

发明人： Akihiro Ishii ,  Kaori Mogi ,  Hideyuki Tsuruta ,  Kenjin Inomiya

IPC分类号： C07C211/26

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C209/26 ,  C07C209/62 ,  C07C211/29

摘要： There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optically active secondary amine and a formaldehyde (including an equivalent thereof) or lower aldehyde in the presence of a transition metal catalyst under a hydrogen gas atmosphere, thereby converting the secondary amine to an optically active tertiary amine of the formula, and subjecting the tertiary amine to hydrogenolysis. The target optically active compound can be produced efficiently by this production method.

摘要翻译： 提供光学活性1-（氟 - ，三氟甲基 - 或三氟甲氧基 - 取代的苯基）烷基胺N-单烷基衍生物的制备方法，该方法包括以下步骤：进行光学活性仲胺和甲醛的还原性烷基化（包括 等同物）或低级醛在过渡金属催化剂存在下在氢气气氛下反应，由此将仲胺转化为下式的光学活性叔胺，并对叔胺进行氢解。 可以通过该制造方法有效地制造目标光学活性化合物。

公开(公告)号：US6041758A

公开(公告)日：2000-03-28

申请号：US205229

申请日：1998-12-04

申请人： Akihiro Ishii

发明人： Akihiro Ishii

IPC分类号： F02D45/00 ,  F02D41/04 ,  F02D41/10 ,  F02D41/12 ,  F02D41/30 ,  F02D41/34 ,  F02D41/14

CPC分类号： F02D41/307 ,  F02D41/34 ,  F02D2200/0406 ,  F02D2250/21 ,  Y02T10/44

摘要： A fuel injection amount controller for engines capable of decreasing the shocks caused by the correction of increasing or decreasing the amount of fuel at the time of changing over the operation mode. The fuel injection amount controller includes an operation condition detector for detecting the operation conditions of an engine inclusive of an intake pipe pressure and a crank angle. An air-to-fuel ratio controller controls the air-to-fuel ratio of the engine to a ratio more lean than stoichiometric when operation conditions represent a predetermined operation condition. A pressure deviation detector calculates a pressure deviation in the intake pipe pressure within a predetermined period of time or between predetermined crank angles. A fuel amount correction device injects the fuel in an amount corresponding to the pressure deviation when the deviation is not smaller than a predetermined value. A correction coefficient change-over device changes a correction coefficient for the amount of fuel over to a suppressing direction in response to a timing for changing the operation condition at the stoichiometric air-to-fuel ratio and the operation condition at the lean air-to-fuel ratio over to each other.

摘要翻译： 一种用于发动机的燃料喷射量控制器，其能够减少在改变操作模式时增加或减少燃料量导致的冲击。 燃料喷射量控制器包括用于检测包括进气管压力和曲柄角的发动机的操作条件的操作条件检测器。 当操作条件表示预定的操作条件时，空燃比控制器将发动机的空燃比控制在比化学计量更稀的比率。 压力偏差检测器计算预定时间段内或预定曲柄角之间的进气管压力的压力偏差。 当偏差不小于预定值时，燃料量校正装置以与压力偏差相对应的量喷射燃料。 校正系数转换装置响应于将理论空燃比的操作条件和稀空燃比的操作条件改变为正时，将燃料量的校正系数改变为抑制方向 - 燃料比率相互之间。

公开(公告)号：US6004860A

公开(公告)日：1999-12-21

申请号：US705956

申请日：1996-08-30

申请人： Tadashi Ogawa ,  Akihiro Ishii ,  Yuichi Nakayoshi

发明人： Tadashi Ogawa ,  Akihiro Ishii ,  Yuichi Nakayoshi

IPC分类号： H01L21/304 ,  H01L21/02 ,  H01L21/20 ,  H01L21/306 ,  H01L21/762 ,  H01L27/12 ,  H01L21/76

CPC分类号： H01L21/76251 ,  H01L21/2007 ,  H01L21/30625 ,  Y10S148/012 ,  Y10S148/135

摘要： An SOI substrate and a method for fabricating the same are provided to sharpen the departing angle at the circumference of the active substrate, and provide the active substrate with a uniform thickness. An attached wafer of the present invention is formed by processing the upper side of the base substrate so that its thickness increases from the center to the circumference, and attaching the active substrate to the processed side of the base substrate. The unattached portion of the attached wafer is removed. Then mirror processing is performed to provide the active substrate with a substantially uniform thickness along the processed side of the base substrate.

摘要翻译： 提供了一种SOI衬底及其制造方法，用于在有源衬底的圆周上锐化出角，并为活性衬底提供均匀的厚度。 通过对基底基板的上侧进行处理，使其厚度从中心向周向增加，将活性基板附着到基底基板的被处理侧，形成附着的晶片。 去除附着的晶片的未附着部分。 然后进行镜面加工，以使得活性基底沿着基底基底的经处理侧具有基本上均匀的厚度。

公开(公告)号：US5863829A

公开(公告)日：1999-01-26

申请号：US748406

申请日：1996-11-13

申请人： Yuichi Nakayoshi ,  Hiroaki Yamamoto ,  Akihiro Ishii

发明人： Yuichi Nakayoshi ,  Hiroaki Yamamoto ,  Akihiro Ishii

IPC分类号： H01L21/306 ,  H01L21/02 ,  H01L21/20 ,  H01L21/304 ,  H01L21/336 ,  H01L27/12 ,  H01L29/786 ,  H01L21/302

CPC分类号： H01L21/2007 ,  Y10S438/977

摘要： The present invention provides a process for fabricating an SOI substrate with no peripheral scratches and with enhanced fabrication efficiency. The present process includes bonding a semiconductor wafer of an active substrate 1 and a semiconductor base wafer 2 to form a bonded wafer 4; surface-grinding the active substrate 1; spin etching the surface-ground active substrate 1; and PACE processing the etched active substrate 1 to form the active substrate into a thin film and simultaneously, to remove the non-bonded peripheral portion of the bonded wafer 4.

摘要翻译： 本发明提供了一种制造SOI衬底的方法，该SOI衬底没有外围划伤并具有增强的制造效率。 本工艺包括将有源衬底1的半导体晶片和半导体基底晶片2接合以形成接合晶片4; 对活性基板1进行表面研磨; 旋转蚀刻表面 - 地面活性衬底1; 并且PACE处理蚀刻的有源衬底1以将活性衬底形成薄膜并且同时移除键合晶片4的未结合的外围部分。