摘要:
A method for fabricating an SOI substrate is provided, which has an active substrate formed as a thin film. The method comprises the steps of: using a both-side polishing apparatus to polish both sides of a supporting substrate 1; bonding an active substrate 2 onto the supporting substrate 1. to form a bonded-wafer; removing an unbonded portion formed at the circumference of the bonded-wafer; flat grinding the active substrate 2 to reduce the thickness thereof; etching the active substrate 2 by spin etching; and processing the active substrate to be a thin film by PACE processing.
摘要:
An SOI substrate and a method for fabricating the same are provided to sharpen the departing angle at the circumference of the active substrate, and provide the active substrate with a uniform thickness. An attached wafer of the present invention is formed by processing the upper side of the base substrate so that its thickness increases from the center to the circumference, and attaching the active substrate to the processed side of the base substrate. The unattached portion of the attached wafer is removed. Then mirror processing is performed to provide the active substrate with a substantially uniform thickness along the processed side of the base substrate.
摘要:
The present invention provides a process for fabricating an SOI substrate with no peripheral scratches and with enhanced fabrication efficiency. The present process includes bonding a semiconductor wafer of an active substrate 1 and a semiconductor base wafer 2 to form a bonded wafer 4; surface-grinding the active substrate 1; spin etching the surface-ground active substrate 1; and PACE processing the etched active substrate 1 to form the active substrate into a thin film and simultaneously, to remove the non-bonded peripheral portion of the bonded wafer 4.
摘要:
Disclosed is a method for producing (S)-1,1,1-trifluoro-2-propanol with high optical purity and high yield by having at least one kind of microorganism, which is selected from the group consisting of Hansenula polymorpha, Pichia anomala, Candida parapsilosis, Candida mycoderma, Pichia naganishii, Candida saitoana, Cryptococcus curvatus, Saturnospora dispora, Saccharomyces bayanus and Pichia membranaefaciens, act on 1,1,1-trifluoroacetone. Since microorganisms found in nature are made to act in a natural state, the problems to be raised when a transformant or the like is used can be avoided in this method. Consequently, the method can be easily put in industrial practice.
摘要:
A production process of a fluorosulfuric acid aromatic-ring ester according to the present invention includes reaction of an aromatic-ring hydroxyl compound with sulfuryl fluoride (SO2F2) in the presence of a tertiary amine except pyridine and methylpyridine. The sulfuryl fluoride, used as the reactant in the production process according to the present invention, is widely adapted as a fumigant and is easily available on a large scale. Further, the target compound can be obtained rapidly with a high yield under moderate reaction conditions in the production process according to the present invention. In this way, all of the prior art problems can be solved in the production process according to the present invention. The production process according to the present invention is thus particularly useful for industrial production of the fluorosulfuric acid aromatic-ring ester.
摘要翻译:根据本发明的氟代硫酸芳环酯的制备方法包括在除吡啶和甲基吡啶之外的叔胺存在下,芳环羟基化合物与硫酰氟(SO 2 F 2)的反应。 在根据本发明的生产方法中用作反应物的硫酰氟被广泛地用作熏蒸剂,并且容易获得大量。 此外,在本发明的制造方法中,在中等反应条件下,可以快速获得目标化合物。 以这种方式,可以在根据本发明的制造方法中解决所有现有技术问题。 因此,本发明的制造方法特别适用于氟代硫酸芳香环酯的工业化生产。
摘要:
In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO2F2) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is useful as an important intermediate for the synthesis of 2′-deoxy-2′-fluoro-2′-C-methylcytidine with antivirus activity.
摘要翻译:在本发明的存在下,通过1,2-二醇与(II)的反应制备开环氟化合物的形式的(2R)-2-氟-2-C-甲基-D-内罗糖-γ-内酯前体 硫酰氟(SO 2 F 2)在有机碱和任选的氟离子源存在下进行。 本发明的制造方法与现有的制造方法(缩短三个步骤:环状亚硫酸酯化,氧化和开环氟化至一步)相比确保了较少的工艺步骤,并且满足了工业生产的要求(高产率 和高繁殖力)。 由此获得的(2R)-2-氟-2-C-甲基-D-内克隆-γ-内酯前体可用作合成2'-脱氧-2'-氟-2'-C 甲基胞苷具有抗病毒活性。
摘要:
By reacting a β-hydroxy-α-amino acid with sulfuryl fluoride (SO2F2) in the presence of an organic base, it is possible to produce an α-fluoro-β-amino acid of the formula [2]. By using a C8-12 tertiary amine having two or more alkyl groups of C3 or higher, and especially diisopropylethylamine, as the organic base, by-production of quantery ammonium salts is effectively suppressed. By applying the production process of the present invention, it is possible to very easily produce (2R)-3-(dibenzylamino)-2-fluoropropionic acid methyl ester, which is extremely important as a pharmaceutical intermediate, with high positional selectivity even on an industrial scale.
摘要:
In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO2F2) in the presence of an organic base and a nucleophile (X−). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active α-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.
摘要翻译:在本发明中,通过在有机碱和亲核体(X)的存在下,通过醇与硫酰氟(SO 2 F 2)的反应制备羟基取代产物。 因此,本发明作为工业制造方法是有效的,其使用适合于大规模应用的相对便宜的试剂,并且可以在简单的方法中实现,容易的纯化操作和较少的废物产生,并且适用于制造光学活性羟基 取代产物,特别是光学活性的α-羟基取代酯和光学活性的4-羟基取代脯氨酸。 本发明的制造方法解决了所有现有技术的问题,可以应用于工业用途。
摘要:
There is provided a process for producing an α-substituted ester by reaction of a fluorosulfuric acid ester of α-hydroxyester with a Grignard reagent in the presence of a zinc catalyst. It is newly found that the reaction for production of α-substituted esters, in which the raw reaction substrate is limited to expensive trifluoromethanesulfonic acid esters, can proceed favorably with the use of fluorosulfuric acid esters suitable for mass-production uses. By the use of the fluorosulfuric acid ester high in optical purity, it is possible to obtain the α-substituted ester with high optical purity upon inversion of the asymmetric carbon configuration. The process of the present invention can solve all of the prior art problems and can be applied for industrial uses.
摘要:
An in-vehicle electronic control apparatus, having a monitoring control circuit, according to the present invention is configured in such a way that serial interface circuits 27a and 37a are connected between a main control circuit unit 20A and a monitoring control circuit unit 30A, high-speed full-duplex block communication is performed by use of a communication permission signal ALT and a communication synchronization signal CLK, the same question information included in uplink communication information UPD is recurrently transmitted in a plurality times of communication and updated after being transmitted a predetermined times, and the main control circuit unit 20A returns answer information by use of downlink communication information DND, within a predetermined duration after the update of the question information; because the question update period is prolonged, the control load on the main control circuit unit 20A is reduced.