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公开(公告)号：US20090312365A1
公开(公告)日：2009-12-17
申请号：US12350094
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20090306127A1
公开(公告)日：2009-12-10
申请号：US12350114
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20070219192A1
公开(公告)日：2007-09-20
申请号：US11592737
申请日：2006-11-02
IPC分类号： A61K31/5383 , A61K31/426 , A61K31/4745 , A61K31/4172 , A61K31/4184
CPC分类号： C07D233/61 , A61K31/4172 , A61K31/4184 , A61K31/426 , A61K31/4745 , A61K31/5383 , C07C217/70 , C07C235/34 , C07C237/22 , C07C275/24 , C07C307/06 , C07D233/14 , C07D233/64
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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64.发明授权Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer 有权喹喔啉的苯磺酰胺衍生物及其药物组合物及其在治疗癌症的方法中的用途公开(公告)号：US09295671B2
公开(公告)日：2016-03-29
申请号：US13594634
申请日：2012-08-24
申请人： Yong-Liang Zhu , Xiangping Qian
发明人： Yong-Liang Zhu , Xiangping Qian
IPC分类号： A61K31/498 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D413/04 , C07D241/42 , C07D241/44 , A61K31/18 , A61P35/00 , A61P35/02 , G01N33/574 , C12Q1/68
CPC分类号： A61K31/498 , A61K31/18 , A61K31/5377 , A61K45/06 , C07D241/42 , C07D241/44 , C07D401/04 , C07D403/04 , C07D413/04 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/5748 , G01N2333/47
摘要： Chemical entities that are benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions and methods of treatment of cancer are described.
摘要翻译： 描述了喹喔啉的苯磺酰胺衍生物，药物组合物和癌症治疗方法的化学实体。
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![Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use](/abs-image/US/2015/04/28/US09018197B2/abs.jpg.150x150.jpg)
65.发明授权Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use 有权十四氢-1H-环戊二烯并[a]菲化合物，组合物和相关使用方法公开(公告)号：US09018197B2
公开(公告)日：2015-04-28
申请号：US13219372
申请日：2011-08-26
申请人： Xiangping Qian
发明人： Xiangping Qian
IPC分类号： A61K31/585 , C07J19/00 , C07J17/00 , C07J41/00 , C07J43/00
CPC分类号： A61K31/585 , C07J19/00 , C07J41/0055 , C07J43/003
摘要： Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
摘要翻译： 描述了蟾毒灵衍生物的化学实体，药物组合物和癌症治疗方法。
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公开(公告)号：US20090264466A1
公开(公告)日：2009-10-22
申请号：US12359193
申请日：2009-01-23
IPC分类号： A61K31/4545 , C07D401/12 , A61K31/454 , A61P21/00
CPC分类号： C07D401/12
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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公开(公告)号：US07582668B2
公开(公告)日：2009-09-01
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/4178 , C07D403/10
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。
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公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20070066591A1
公开(公告)日：2007-03-22
申请号：US10553987
申请日：2004-05-12
申请人： Xiangping Qian , Xianping Qian , Gustave Bergnes
发明人： Xiangping Qian , Xianping Qian , Gustave Bergnes
IPC分类号： A61K31/554 , A61K31/553 , A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4245 , C07D413/02 , C07D417/02
CPC分类号： C07D271/07
摘要： Compounds useful for treating cellular proliferative diseases and disorders by inhibiting the activity of KSP are disclosed.
摘要翻译： 公开了通过抑制KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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70.发明授权Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use 有权某些氨基吡啶和氨基三嗪，其组合物及其使用方法公开(公告)号：US09133123B2
公开(公告)日：2015-09-15
申请号：US13642227
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D253/07 , C07D401/12 , C07D401/14 , C07D417/14 , A61K31/53 , A61K31/427 , A61K31/4427 , A61P21/00 , A61P21/04 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/48 , C07D403/04 , C07D417/04 , C07D213/74 , C07D215/38 , C07D403/10
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 2，R 4，R 5，R 6，R 7，R 8，R 9，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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