公开(公告)号：US09957166B2

公开(公告)日：2018-05-01

申请号：US15044041

申请日：2016-02-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond Archer ,  Mark E. Davis

IPC: C01B39/04 ,  B01J29/70 ,  C01B39/48 ,  B01J29/87 ,  B01J29/86 ,  B01J29/04 ,  B01J29/89 ,  B01J29/88 ,  C01B37/00 ,  C01B37/02 ,  C01B39/08 ,  C01B39/12 ,  B01J20/18 ,  B01J20/30 ,  B01J37/00

CPC classification number: C01B39/48 ,  B01J20/18 ,  B01J20/3057 ,  B01J29/047 ,  B01J29/70 ,  B01J29/7007 ,  B01J29/86 ,  B01J29/87 ,  B01J29/88 ,  B01J29/89 ,  B01J37/0018 ,  C01B37/005 ,  C01B37/007 ,  C01B37/02 ,  C01B39/04 ,  C01B39/08 ,  C01B39/12

Abstract: Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one source of at least one oxide of a tetravalent element, optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements, pentavalent elements, and mixtures thereof, optionally, at least one source of an element selected from Groups 1 and 2 of the Periodic Table; and optionally, hydroxide ions or fluoride ions, and maintaining the reaction mixture under conditions sufficient to form crystals of the molecular sieve. In the method, various imidazolium cations are used as the structure directing element.

公开(公告)号：US09901909B2

公开(公告)日：2018-02-27

申请号：US15050885

申请日：2016-02-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Michiel J. Dusselier ,  Mark E. Davis

IPC: B01J29/85 ,  C01B39/54 ,  B01D53/86 ,  B01J37/08 ,  B01J29/04 ,  C01B39/48 ,  C07C67/37 ,  C07C29/48 ,  C07C209/14 ,  C01B21/04 ,  C07C7/13 ,  C01B39/06 ,  C07C29/50 ,  C07C1/20 ,  B01D53/94

CPC classification number: B01J29/048 ,  B01D53/8628 ,  B01D53/9418 ,  B01D2251/2062 ,  B01D2255/20792 ,  B01D2255/50 ,  B01J2229/186 ,  C01B21/0411 ,  C01B39/06 ,  C01B39/48 ,  C07C1/20 ,  C07C7/13 ,  C07C29/48 ,  C07C29/50 ,  C07C67/37 ,  C07C209/14 ,  C07C2521/12 ,  C07C2523/06 ,  C07C2529/70 ,  Y02C20/10 ,  Y02C20/30 ,  Y02P20/52 ,  C07C69/14 ,  C07C31/04 ,  C07C11/02

Abstract: The present disclosure is directed to methods of producing zincoaluminosilicate structures with AEI, CHA, and GME topologies using organic structure directing agents (OSDAs), and the compositions and structures resulting from these methods.

公开(公告)号：US20170049903A1

公开(公告)日：2017-02-23

申请号：US15222669

申请日：2016-07-28

Applicant: California Institute of Technology ,  Calando Pharmaceuticals, Inc.

Inventor： Suzie Hwang Pun ,  Hector Gonzalez ,  Mark E. Davis ,  Nathalie C. Bellocq ,  Jianjun Cheng

IPC: A61K47/48 ,  A61K38/44 ,  A61K48/00 ,  C08G65/333

CPC classification number: A61K48/0041 ,  A61K38/44 ,  A61K47/555 ,  A61K47/6949 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015 ,  C08G65/33396 ,  C08G65/48 ,  C08G2650/04 ,  C08G2650/38 ,  C12N15/87 ,  C12Y113/12007

Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

Abstract translation: 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：

公开(公告)号：US09468681B2

公开(公告)日：2016-10-18

申请号：US13782458

申请日：2013-03-01

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K45/06 ,  A61K31/337 ,  A61K31/727 ,  A61K47/48 ,  A61K9/51

CPC classification number: A61K45/06 ,  A61K9/5161 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/60 ,  A61K47/6935 ,  A61K2300/00

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US09446149B2

公开(公告)日：2016-09-20

申请号：US14805640

申请日：2015-07-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K47/48 ,  A61K31/337 ,  A61K9/51 ,  A61K31/713 ,  A61K31/4745 ,  A61K31/427 ,  C08G81/00 ,  C12N15/113 ,  A61K9/19

CPC classification number: A61K47/48907 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K47/6935 ,  C08G81/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

Abstract: Described herein are polymer conjugates comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic acid.

Abstract translation: 本文描述的是包含含有与含有硝基硼酸的聚合物偶合的多元醇的聚合物的聚合物共轭物。

公开(公告)号：US09289757B2

公开(公告)日：2016-03-22

申请号：US14034386

申请日：2013-09-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond Archer ,  Mark E. Davis

IPC: B01J29/70 ,  C01B39/48 ,  B01J29/87 ,  B01J29/86 ,  B01J29/04 ,  B01J29/89 ,  C01B37/00 ,  C01B37/02 ,  C01B39/04

CPC classification number: C01B39/48 ,  B01J20/18 ,  B01J20/3057 ,  B01J29/047 ,  B01J29/70 ,  B01J29/7007 ,  B01J29/86 ,  B01J29/87 ,  B01J29/88 ,  B01J29/89 ,  B01J37/0018 ,  C01B37/005 ,  C01B37/007 ,  C01B37/02 ,  C01B39/04 ,  C01B39/08 ,  C01B39/12

Abstract: Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one source of at least one oxide of a tetravalent element, optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements, pentavalent elements, and mixtures thereof, optionally, at least one source of an element selected from Groups 1 and 2 of the Periodic Table; and optionally, hydroxide ions or fluoride ions, and maintaining the reaction mixture under conditions sufficient to form crystals of the molecular sieve. In the method, various imidazolium cations are used as the structure directing element.

公开(公告)号：US20150025126A1

公开(公告)日：2015-01-22

申请号：US14185409

申请日：2014-02-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Hector Gonzalez ,  Suzie Hwang Pun

IPC: A61K47/48 ,  A61K31/337

CPC classification number: A61K31/337 ,  A61K31/724 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6951 ,  A61K48/00 ,  B82Y5/00

Abstract: A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents.

Abstract translation: 描述了制备含有至少一种治疗剂和多维聚合物网络的超分子复合物的方法。 描述通过本发明的方法制备的超分子复合物。 还描述了通过施用治疗有效量的本发明的超分子复合物的治疗方法。 这样的超分子复合物可以用作各种治疗剂的递送载体。

公开(公告)号：US20140249203A1

公开(公告)日：2014-09-04

申请号：US13782486

申请日：2013-03-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mark E. Davis ,  Han Han

IPC: A61K9/51 ,  A61K31/4745 ,  A61K31/427 ,  A61K31/713

CPC classification number: A61K47/48907 ,  A61K9/19 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/427 ,  A61K31/4745 ,  A61K31/713 ,  A61K47/6935 ,  C08G81/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。

公开(公告)号：US08746999B2

公开(公告)日：2014-06-10

申请号：US13852397

申请日：2013-03-28

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Akinleye Alabi

IPC: A61K9/14

CPC classification number: A61K47/6935 ,  A61K9/14 ,  A61K9/5146 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/713 ,  A61K47/545 ,  A61K47/549 ,  A61K47/595 ,  A61K47/644 ,  C08G59/4078 ,  C08G65/337 ,  C08G69/40 ,  C08G69/48 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Abstract translation: 载体纳米颗粒包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物呈现到纳米颗粒外部的环境以及相关组合物，方法和系统。

公开(公告)号：US20240261755A1

公开(公告)日：2024-08-08

申请号：US18638805

申请日：2024-04-18

Applicant: California Institute of Technology

Inventor： Donglong Fu ,  Mark E. Davis

IPC: B01J20/18 ,  B01D53/02 ,  B01J20/28 ,  B01J20/30

CPC classification number: B01J20/186 ,  B01D53/02 ,  B01J20/28014 ,  B01J20/2808 ,  B01J20/3085 ,  B01D2253/1085 ,  B01D2253/308 ,  B01D2257/80 ,  B01D2258/06

Abstract: The present disclosure is directed to metal ion-containing zeolitic compositions, preferably transition metal ion-containing, more preferably zinc ion containing zeolitic compositions, that are useful for reversibly scavenging water from humid gaseous feed streams, including air, and method of making and using the same. In some embodiments, the compositions comprise zinc-ion-doped zeolites have LTA, FAU, or EMT topologies.