公开(公告)号：US10059726B2

公开(公告)日：2018-08-28

申请号：US15166405

申请日：2016-05-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  Kerry Betz ,  Alexey Fedorov ,  Brian M. Stoltz ,  Robert H. Grubbs

IPC: C07F7/08

CPC classification number: C07F7/0829

Abstract: The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic C—H bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. The systems associated with these methods are also disclosed.

公开(公告)号：US10040784B2

公开(公告)日：2018-08-07

申请号：US15454198

申请日：2017-03-09

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Masaki Hayashi ,  Satoshi Hashimoto

IPC: C07D409/06 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277

Abstract: This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide.

公开(公告)号：US20160176773A1

公开(公告)日：2016-06-23

申请号：US14972475

申请日：2015-12-17

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Yoshitaka Numajiri ,  Beau P. Pritchett ,  Koji Chiyoda

IPC: C07B53/00 ,  C07C269/06 ,  C07C225/18 ,  C07C221/00 ,  C07D209/88 ,  C07C303/30 ,  C07D211/74 ,  C07D211/76 ,  C07D265/32 ,  C07C271/18 ,  C07C309/63

Abstract: This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.

Abstract translation: 本发明提供了具有四元立体中心的富集的曼尼希加成物和制备该化合物的新方法。 方法包括制备式（I）化合物的方法：包括在烷基化条件下用过渡金属催化剂处理式（II）化合物。

公开(公告)号：US20130267699A1

公开(公告)日：2013-10-10

申请号：US13797736

申请日：2013-03-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D265/32 ,  C07D207/16 ,  C07D223/10 ,  C07D211/60

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

Abstract translation: 本发明提供具有季中心的杂环化合物和制备化合物的方法。 方法包括制备式（II）化合物的方法：包括用过渡金属催化剂处理式（I）化合物，并且在化合价和稳定性允许的烷基化条件下进行。