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公开(公告)号：US10106479B2
公开(公告)日：2018-10-23
申请号：US15081157
申请日：2016-03-25
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
IPC: C07D211/94 , C07C45/65 , C07D223/10 , C07D317/72 , B01J31/04
Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
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2.发明授权Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof 有权手性烯胺酮的合成及其衍生物及其生物活性研究公开(公告)号：US09518034B2
公开(公告)日：2016-12-13
申请号：US14514001
申请日：2014-10-14
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Dennis A. Dougherty , Douglas Duquette , Noah Duffy
IPC: C07D295/116 , C07D209/88
CPC classification number: C07D295/116 , C07D209/88
Abstract: This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
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公开(公告)号：US20170137382A1
公开(公告)日：2017-05-18
申请号：US15366590
申请日：2016-12-01
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D207/277 , C07D207/27 , C07D265/32 , C07D211/90 , C07D211/76 , C07D211/96 , C07D223/10
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号：US20230098847A1
公开(公告)日：2023-03-30
申请号：US17867233
申请日：2022-07-18
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号：US20200157049A1
公开(公告)日：2020-05-21
申请号：US16427629
申请日：2019-05-31
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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Patent Agency Ranking
公开(公告)号：US20180339968A1
公开(公告)日：2018-11-29
申请号：US16049434
申请日：2018-07-30
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D223/10 , C07D309/04 , C07D207/16 , C07D211/60 , C07D211/90 , C07D207/277 , C07D207/273 , C07D207/267 , C07D309/30 , C07D211/96 , C07D211/94 , C07D211/88 , C07D211/76 , C07D211/38 , C07D211/34 , C07D211/22 , C07D211/18 , C07D211/16 , C07D207/46 , C07D207/27 , C07D207/263 , C07D207/26 , C07D207/10 , C07D207/08 , C07D265/30 , C07D207/06 , C07D241/52 , C07D241/08 , C07D241/04 , C07D223/04 , C07D265/32
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号：US10906875B2
公开(公告)日：2021-02-02
申请号：US16427629
申请日：2019-05-31
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D207/06 , C07D207/08 , C07D207/10 , C07D201/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30 , C07D207/16
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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8.发明申请公开(公告)号：US20190055182A1
公开(公告)日：2019-02-21
申请号：US16166893
申请日：2018-10-22
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
IPC: C07C45/65 , C07D211/94 , C07D223/10 , B01J31/04 , C07D317/72 , C07C49/647 , C07C49/683
Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
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公开(公告)号：US10035769B2
公开(公告)日：2018-07-31
申请号：US15366590
申请日：2016-12-01
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D207/27 , C07D207/277 , C07D211/76 , C07D211/78 , C07D211/90 , C07D211/96 , C07D223/10 , C07D265/32
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号：US20210155592A1
公开(公告)日：2021-05-27
申请号：US17164204
申请日：2021-02-01
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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