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    Detecting CYP24 expression level as a marker for predisposition to cancer
    64.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08685929B2

    公开(公告)日：2014-04-01

    申请号：US13443639

    申请日：2012-04-10

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01K61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
    65.
    发明申请
    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER 有权
    检测CYP24表达水平作为癌症预测标记

    公开(公告)号：US20100285023A1

    公开(公告)日：2010-11-11

    申请号：US12633643

    申请日：2009-12-08

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A61K39/395 ,  A61K48/00 ,  A61P35/00

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Wide field imager for quantitative analysis of microarrays
    66.
    发明授权
    Wide field imager for quantitative analysis of microarrays 有权
    宽幅成像仪用于定量分析微阵列

    公开(公告)号：US07499166B2

    公开(公告)日：2009-03-03

    申请号：US10850986

    申请日：2004-05-20

    申请人： Donna G. Albertson ,  Daniel Pinkel

    发明人： Donna G. Albertson ,  Daniel Pinkel

    IPC分类号： G01N21/64

    CPC分类号： G02B21/365 ,  C12M41/36 ,  G01N21/6452 ,  G01N2021/6463 ,  G02B21/08 ,  G02B27/0018 ,  G02B2207/113

    摘要： This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges from about 30 degrees to about 75 degrees from the normal to the microarray, and that has less than about ±25 percent variation in intensity over the array at all wavelengths ranging from 400 to 800 nm; a support for holding a microarray; a detection lens system that is chromatically corrected so the apparent position of the microarray or a feature comprising the microarray varies by less than 10 μm as the detection wavelength varies from about 400 to about 800 nm; and a detection device for detecting and optionally recording an image produced by said detection lens system.

    摘要翻译： 本发明提供了一种用于微阵列的高精度定量分析的成像系统。 在某些实施方案中，该系统包括宽带激发光源，其以距离微阵列法线约30度至约75度的入射角提供所述微阵列的科勒照明，并且具有小于约±25％ 在400至800 nm范围内的所有波长阵列上的强度变化; 支持持有微阵列; 检测透镜系统被校正为使得当检测波长从约400至约800nm变化时，微阵列的表观位置或包含微阵列的特征变化小于10um; 以及用于检测和可选地记录由所述检测透镜系统产生的图像的检测装置。

    Capillary pins for high-efficiency microarray printing device
    68.
    发明授权
    Capillary pins for high-efficiency microarray printing device 有权
    用于高效微阵列打印设备的毛细管引脚

    公开(公告)号：US07402286B2

    公开(公告)日：2008-07-22

    申请号：US11017625

    申请日：2004-12-15

    申请人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    发明人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    IPC分类号： B01L3/02

    CPC分类号： B41J2/25 ,  B41J2/005 ,  C12Q1/6837 ,  C12Q2565/507

    摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.

    摘要翻译： 本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动 毛细血管