利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.028 秒)

    Capillary pins for high-efficiency microarray printing device
    1.
    发明授权
    Capillary pins for high-efficiency microarray printing device 有权
    用于高效微阵列打印设备的毛细管引脚

    公开(公告)号：US08283181B2

    公开(公告)日：2012-10-09

    申请号：US12169863

    申请日：2008-07-09

    申请人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    发明人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    IPC分类号： G01N1/10

    CPC分类号： B41J2/25 ,  B41J2/005 ,  C12Q1/6837 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575 ,  C12Q2565/507

    摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.

    摘要翻译： 本发明提供了用于微阵列打印装置的改进的组件（例如阵列引脚，打印头，基板压印板，打印头压板等）以及并入这些部件的微阵列印刷装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动 毛细血管

    Capillary pins for high-efficiency microarray printing device
    3.
    发明授权
    Capillary pins for high-efficiency microarray printing device 有权
    用于高效微阵列打印设备的毛细管引脚

    公开(公告)号：US07402286B2

    公开(公告)日：2008-07-22

    申请号：US11017625

    申请日：2004-12-15

    申请人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    发明人： Daniel Pinkel ,  Donna G. Albertson ,  Greg Hamilton ,  Nils W. Brown ,  Robert Nordmeyer

    IPC分类号： B01L3/02

    CPC分类号： B41J2/25 ,  B41J2/005 ,  C12Q1/6837 ,  C12Q2565/507

    摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.

    摘要翻译： 本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动 毛细血管

    High density array fabrication and readout method for a fiber optic biosensor
    6.
    发明授权
    High density array fabrication and readout method for a fiber optic biosensor 有权

    公开(公告)号：US06417506B1

    公开(公告)日：2002-07-09

    申请号：US09642243

    申请日：2000-08-17

    申请人： Daniel Pinkel ,  Joe Gray ,  Donna G. Albertson

    发明人： Daniel Pinkel ,  Joe Gray ,  Donna G. Albertson

    IPC分类号： C25D1300

    CPC分类号： G01N21/6452 ,  B01J2219/00513 ,  B01J2219/00524 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00659 ,  C12Q1/6825 ,  G01N21/648 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2201/0833 ,  G02B6/04

    摘要： The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its “sensor end” biological “binding partners” (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors—such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.

    High density array fabrication and readout method for a fiber optic biosensor
    7.
    发明授权
    High density array fabrication and readout method for a fiber optic biosensor 失效

    公开(公告)号：US5837196A

    公开(公告)日：1998-11-17

    申请号：US592779

    申请日：1996-01-26

    申请人： Daniel Pinkel ,  Richard L. Segraves ,  Ye Yz Zhai ,  Donna G. Albertson ,  Joe Gray

    发明人： Daniel Pinkel ,  Richard L. Segraves ,  Ye Yz Zhai ,  Donna G. Albertson ,  Joe Gray

    IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/77 ,  G01N33/53 ,  G01N33/543 ,  G01N37/00 ,  G02B6/04 ,  G01N21/00 ,  G01N15/06 ,  G01N21/29

    CPC分类号： G01N21/6452 ,  C12Q1/6825 ,  G01N21/7703 ,  G02B6/04 ,  B01J2219/00605 ,  B01J2219/00659 ,  G01N2201/0833

    摘要： The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors--such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.

    Detecting CYP24 expression level as a marker for predisposition to cancer
    8.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08173602B2

    公开(公告)日：2012-05-08

    申请号：US12633643

    申请日：2009-12-08

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01N61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    9.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US07648826B1

    公开(公告)日：2010-01-19

    申请号：US09285292

    申请日：1999-04-02

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N33/567 ,  G01N33/00 ,  G01N33/48 ,  G01N21/75 ,  G01N1/00 ,  A61K38/00

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。