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61.发明申请COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS (AS AMENDED) 审中-公开包含丝氨酸蛋白酶变体（如修订）的组合物和方法公开(公告)号：US20130260438A1
公开(公告)日：2013-10-03
申请号：US13696512
申请日：2011-05-05
申请人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译： 本发明提供了丝氨酸蛋白酶变体。 具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。 此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。 在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。
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公开(公告)号：US08530219B2
公开(公告)日：2013-09-10
申请号：US13128836
申请日：2009-11-10
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38681 , C11D3/3942 , C12N9/54 , C12Y304/21062
摘要： The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides compositions comprising this serine protease variant. In some embodiments, the present invention provides laundry and other non-automatic (i.e., hand) dishwashing cleaning compositions comprising this serine protease variant.
摘要翻译： 本发明提供芽孢杆菌属 枯草杆菌蛋白酶变体。 此外，本发明提供包含该丝氨酸蛋白酶变体的组合物。 在一些实施方案中，本发明提供了包含该丝氨酸蛋白酶变体的衣物和其它非自动（即，手）餐具清洗组合物。
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公开(公告)号：US20120178143A1
公开(公告)日：2012-07-12
申请号：US13351155
申请日：2012-01-16
申请人： David A. Estell
发明人： David A. Estell
CPC分类号： C11D3/386 , A23K20/189 , C11D3/38 , C12N9/14
摘要： The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the hydrolase of the present invention.
摘要翻译： 本发明涉及革兰氏阳性微生物中新型水解酶的鉴定。 本发明提供水解酶的氨基酸序列。 本发明提供了包含编码水解酶的核酸的宿主细胞。 本发明还提供了用于处理包括本发明的水解酶的纺织品的清洁组合物，动物饲料和组合物。
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公开(公告)号：US20120107907A1
公开(公告)日：2012-05-03
申请号：US13345547
申请日：2012-01-06
申请人： Andrew Shaw , Louise Wallace , David A. Estell , Ronald W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
发明人： Andrew Shaw , Louise Wallace , David A. Estell , Ronald W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
CPC分类号： C12N9/54 , C11D1/02 , C11D3/386 , C11D3/38663 , C12Y304/24
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
摘要翻译： 本发明提供包含至少一种具有改善的储存稳定性的中性金属蛋白酶的方法和组合物。 在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。 在一些特别优选的实施方案中，本发明提供了包含从芽孢杆菌属芽孢杆菌获得的中性金属蛋白酶的方法和组合物。 在一些更特别优选的实施方案中，中性金属蛋白酶从解淀粉芽孢杆菌获得。 在另外的优选实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的变体。 在另外的实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的同系物。 本发明特别用于包括但不限于清洁，漂白和消毒的应用。
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公开(公告)号：US20120067373A1
公开(公告)日：2012-03-22
申请号：US13079126
申请日：2011-04-04
申请人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
发明人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
CPC分类号： C12N9/54 , C11D3/33 , C11D3/378 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38645 , C11D3/38681 , C11D17/043 , C11D17/044 , C11D17/045
摘要： The present invention is in the field of automatic dishwashing detergent compositions, as well as methods of making and using same. In particular, it relates to an automatic dishwashing detergent composition comprising a new protease. The automatic dishwashing detergent composition provides improved cleaning and finishing. In particular the composition of the invention provides better proteinaceous removal at the same level of other proteases available in the market. This also alternatively allows for the use of a lower level of the protease of the invention and therefore a more cost effective composition.
摘要翻译： 本发明涉及自动餐具洗涤剂组合物领域，以及制造和使用它们的方法。 特别地，本发明涉及一种包含新蛋白酶的自动餐具洗涤剂组合物。 自动洗碗洗涤剂组合物提供改进的清洁和整理。 特别地，本发明的组合物在市场上可获得的相同水平的其它蛋白酶中提供更好的蛋白质去除。 这也可以允许使用较低水平的本发明的蛋白酶，因此使用更具成本效益的组合物。
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公开(公告)号：US20110281327A1
公开(公告)日：2011-11-17
申请号：US13085392
申请日：2011-04-12
申请人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
发明人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
CPC分类号： C12N9/54
摘要： The present invention provides variant proteases, compositions comprising such variant proteases, and methods of cleaning comprising such variant proteases.
摘要翻译： 本发明提供了变体蛋白酶，包含这种变体蛋白酶的组合物和包含这种变体蛋白酶的清洁方法。
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公开(公告)号：US20110256608A1
公开(公告)日：2011-10-20
申请号：US13082979
申请日：2011-04-08
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
CPC分类号： C07K14/811 , A61K8/64 , A61Q7/02
摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。
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公开(公告)号：US20110251116A1
公开(公告)日：2011-10-13
申请号：US13162104
申请日：2011-06-16
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W.J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A.H. Van der Kley , Leonardus P.M. Van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W.J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A.H. Van der Kley , Leonardus P.M. Van Marrewijk
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译： 本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。 特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。 本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。 在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。 这些变体蛋白酶也可用于许多应用。
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公开(公告)号：US07947475B2
公开(公告)日：2011-05-24
申请号：US12779793
申请日：2010-05-13
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC分类号： C12P21/00
CPC分类号： C07K14/811 , A61K8/64 , A61Q7/02
摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。
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公开(公告)号：US20110098184A1
公开(公告)日：2011-04-28
申请号：US11662050
申请日：2005-10-14
CPC分类号： C40B30/04 , G01N2333/811
摘要： The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the present invention provides methods for competitive differential screening that facilitate the identification of tight binders. In some preferred embodiments, the agents used in the methods of the present invention comprise tight and weak binders. In other embodiments, the present invention provides methods that utilize competitive binders that recognize and bind targets, but with binding that is less strong than that of binders of interest.
摘要翻译： 本发明涉及一种可用于筛选的新方法。 特别地，本发明提供了用于竞争性差异筛选的方法。 在一些优选的实施方案中，本发明提供了有助于识别紧密粘合剂的竞争性差异筛选方法。 在一些优选的实施方案中，在本发明的方法中使用的试剂包括紧和弱的粘合剂。 在其它实施方案中，本发明提供利用竞争性结合物识别和结合靶标但具有比目标结合物强的结合的方法。
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