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公开(公告)号:US07542803B2
公开(公告)日:2009-06-02
申请号:US11081873
申请日:2005-03-16
申请人: Kenneth T. Heruth , Keith A. Miesel
发明人: Kenneth T. Heruth , Keith A. Miesel
IPC分类号: A61N1/00
CPC分类号: A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241 , G06F19/00
摘要: Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.
摘要翻译: 用于通过医疗装置(例如可植入医疗装置(IMD))控制对患者的治疗递送的技术涉及对性能度量的灵敏度分析。 性能指标可能与治疗的功效或副作用有关。 例如,性能度量可以包括睡眠质量度量,活动水平度量,帕金森病患者的运动障碍度量等。 灵敏度分析确定定义性能度量的基本上最大或最小值的治疗参数的值。 所确定的治疗参数是基线治疗参数组,并且医疗装置可以基于基线治疗参数集来控制治疗的递送。
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公开(公告)号:US07513884B2
公开(公告)日:2009-04-07
申请号:US11112219
申请日:2005-04-22
申请人: Keith A. Miesel , Justin A. Blanco
发明人: Keith A. Miesel , Justin A. Blanco
IPC分类号: A61M31/00
CPC分类号: A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
摘要: Branching catheter systems with diagnostic components for detecting and isolating fluid flow problems (e.g., leaks, occlusions, etc.) and methods for detecting and isolating fluid flow problems are disclosed. Among the fluid flow problems that may potentially be detected are leaks in the branching catheter systems (e.g., cuts, disconnected components, etc.). Another fluid flow problem that may be detected using the diagnostic systems of the present invention is the presence of occlusions or other blockages that prevent fluid flow within the catheter systems. In addition to identifying that a problem exists, the diagnostic components may preferably also be used to identify the location of the fluid flow problem as discussed herein. Connectors for use in the branching catheter systems are also disclosed. Among the diagnostic components that may be used in branching catheter systems of the present are valves to control fluid flow through the various sections of the branching catheter system, fluid flow detectors to detect flow through the one or more sections of the branching catheter system and a control system for operating the diagnostic components.
摘要翻译: 公开了具有用于检测和分离流体流动问题(例如泄漏,闭塞等)的诊断部件的分支导管系统以及用于检测和分离流体流动问题的方法。 在可能潜在检测的流体流动问题中,分支导管系统中的泄漏(例如,切割,断开的部件等)。 可以使用本发明的诊断系统检测的另一个流体流动问题是存在妨碍导管系统内的流体流动的闭塞或其它阻塞物。 除了确定存在问题之外,诊断部件还可以优选地用于识别本文所讨论的流体流动问题的位置。 还公开了用于分支导管系统的连接器。 在本发明的分支导管系统中可以使用的诊断部件中的阀是控制通过分支导管系统的各个部分的流体流动的流体流动检测器,用于检测通过分支导管系统的一个或多个部分的流动,以及 用于操作诊断部件的控制系统。
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公开(公告)号:US20090030263A1
公开(公告)日:2009-01-29
申请号:US12248622
申请日:2008-10-09
申请人: Kenneth T. Heruth , Keith A. Miesel
发明人: Kenneth T. Heruth , Keith A. Miesel
CPC分类号: A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241
摘要: Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.
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公开(公告)号:US07447545B2
公开(公告)日:2008-11-04
申请号:US11081872
申请日:2005-03-16
申请人: Kenneth T. Heruth , Keith A. Miesel
发明人: Kenneth T. Heruth , Keith A. Miesel
IPC分类号: A61N1/362
CPC分类号: A61N1/36071 , A61B5/103 , A61B5/1116 , A61M5/14276 , A61N1/02 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557
摘要: A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译: 医疗设备向患者传递治疗。 识别姿势事件,例如,周期性地确定患者的姿势和/或患者的姿势转换,并且每个确定的姿势事件与当前治疗参数组相关联。 基于与该治疗参数组相关联的姿势事件,为多个治疗参数组中的每一个确定至少一个姿势度量的值。 将治疗参数组的列表呈现给诸如临床医师的用户,用于评估治疗参数组的相对功效。 可以根据一个或多个姿势度量值对列表进行排序,以帮助评估治疗参数组。 在针对多个姿势度量确定值的情况下,可以根据用户选择的姿势度量中的一个排序列表。
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65.
公开(公告)号:US6077227A
公开(公告)日:2000-06-20
申请号:US221547
申请日:1998-12-28
申请人: Keith A. Miesel , Lee Stylos
发明人: Keith A. Miesel , Lee Stylos
IPC分类号: A61B5/00 , A61B5/0215 , A61B5/022 , A61B5/02 , A61B19/00
CPC分类号: A61B5/02152 , A61B5/022 , A61B5/0031 , A61B5/418
摘要: A method for construction ond delivery of a novel implantable medical device provides for use of a kit having sizeable fixture components for holding a blood vessel and a sensor portion connectable during surgery to the appropriately sized fixture.
摘要翻译: 用于构建新型可植入医疗装置的递送方法提供使用具有用于保持血管的相当大的固定部件和在手术期间可连接到适当尺寸的夹具的传感器部分的试剂盒。
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公开(公告)号:US09192719B2
公开(公告)日:2015-11-24
申请号:US12916720
申请日:2010-11-01
申请人: Charles R. Rogers , Irfan Z. Ali , Ronald L. Mezera , Keith A. Miesel , Scott A. Sarkinen , Nicholas R. Whitehead
发明人: Charles R. Rogers , Irfan Z. Ali , Ronald L. Mezera , Keith A. Miesel , Scott A. Sarkinen , Nicholas R. Whitehead
CPC分类号: A61M5/16809 , A61M5/14216 , A61M5/14276 , A61M2005/16863 , A61M2005/16868 , A61M2005/16872
摘要: A method of detecting a fault condition within an implantable medical pump comprises delivering therapeutic fluid using a medical pump comprising an actuation mechanism configured to be energized to provide a pump stroke, detecting a property associated with energizing the actuation mechanism, and determining whether the property associated with energizing the actuation mechanism indicates that a fault condition exists with the medical pump.
摘要翻译: 检测可植入医疗泵内的故障状况的方法包括使用医用泵递送治疗流体,所述医疗泵包括致动机构,所述致动机构被配置为通电以提供泵行程,检测与致动机构通电相关联的属性,以及确定属性是否相关联 通过致动机构通电,指示医疗泵存在故障状况。
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公开(公告)号:US08561460B2
公开(公告)日:2013-10-22
申请号:US13269088
申请日:2011-10-07
申请人: Keith A. Miesel
发明人: Keith A. Miesel
CPC分类号: A61M5/1684 , A61M5/14 , A61M5/14276 , A61M2205/3317 , G01F17/00 , G01F23/14
摘要: A volume sensing system for use in determining a volume of a variable volume reservoir can include a lower plunger that can have a first end adapted to move with a bottom of the reservoir. An upper plunger can be slidable relative to the lower plunger. A lower biasing member can be positioned substantially between a base of the reservoir and the upper plunger, and the upper biasing member can be positioned between the upper plunger and an interference member. The upper biasing member can have a predetermined stiffness relative to the lower biasing member such that upon movement of the lower plunger, the upper plunger can move at a predetermined fraction of the amount of movement of the lower plunger, where the predetermined fraction can be determined at least in part by the predetermined stiffness of the upper biasing member relative to the lower biasing member.
摘要翻译: 用于确定可变体积储存器的体积的体积感测系统可以包括下部柱塞,其可以具有适于与储存器的底部一起移动的第一端。 上柱塞可相对于下柱塞滑动。 下偏压构件可以基本上位于储存器的底部和上柱塞之间,并且上偏压构件可以定位在上柱塞和干涉构件之间。 上偏置构件可以具有相对于下偏压构件的预定刚度,使得在下柱塞移动时,上柱塞可以以下柱塞移动量的预定分数移动,其中可确定预定分数 至少部分地由上偏置构件相对于下偏置构件的预定刚度。
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68.
公开(公告)号:US08337431B2
公开(公告)日:2012-12-25
申请号:US12351414
申请日:2009-01-09
申请人: Kenneth T. Heruth , Keith A. Miesel
发明人: Kenneth T. Heruth , Keith A. Miesel
CPC分类号: A61B5/1116 , A61B5/1118 , A61B5/4519 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61N1/36135 , A61N1/36542
摘要: A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.
摘要翻译: 诸如可植入医疗装置(IMD)或编程装置之类的装置确定患者何时试图睡觉。 当设备确定患者正在尝试睡眠时,设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。 当设备确定患者没有尝试睡眠时,设备周期性地确定患者的活动水平。 活动度量值可以基于确定的活动水平来确定。 临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息,以例如评估由医疗设备递送给患者的治疗的有效性。
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公开(公告)号:US08335568B2
公开(公告)日:2012-12-18
申请号:US12544727
申请日:2009-08-20
申请人: Kenneth T. Heruth , Keith A. Miesel
发明人: Kenneth T. Heruth , Keith A. Miesel
IPC分类号: A61N1/18
CPC分类号: A61M5/14276 , A61B5/02 , A61B5/04 , A61B5/4815 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要: A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译: 诸如可植入医疗装置(IMD)的医疗设备确定指示患者睡眠质量的一个或多个指标的值,并且基于睡眠质量量度值控制治疗的递送。 例如,医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较,并且基于比较来调整治疗。 在一些实施例中,医疗装置基于比较来调整治疗的强度,例如当比较表明患者的睡眠质量差时,增加治疗强度。 在一些实施例中,医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值,自动选择可用于递送治疗的多个治疗参数集中的一个。
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公开(公告)号:US08246573B2
公开(公告)日:2012-08-21
申请号:US12768336
申请日:2010-04-27
CPC分类号: A61M5/14276 , A61B5/1116 , A61M5/14212 , A61M5/172 , A61M2205/18 , A61M2205/3317 , A61M2205/50
摘要: A medical device system comprises a reservoir configured to store a therapeutic fluid and a medical pump configured to deliver the therapeutic fluid from the reservoir to a patient. The system also comprises a sensor that can detect a characteristic associated with the pump and a processor to determine if the characteristic detected indicates the reservoir is empty or near empty. The characteristic may comprise a property associated with the energization of an actuation mechanism configured to be energized to provide a pump stroke. The characteristic may also comprise a characteristic of a noise made by an actuator within the pump at the end of a pump stroke.
摘要翻译: 医疗设备系统包括被配置为存储治疗流体的储存器和被配置为将治疗流体从储存器输送到患者的医用泵。 该系统还包括可以检测与泵相关联的特征的传感器和处理器,以确定检测到的特征是否指示储存器为空或接近空。 特征可以包括与致动机构的通电相关联的特性,该致动机构配置成被激励以提供泵冲程。 特征还可以包括在泵冲程结束时由泵内的致动器产生的噪声的特性。
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