公开(公告)号：US20090088830A1

公开(公告)日：2009-04-02

申请号：US12031787

申请日：2008-02-15

申请人： Ashraf Mohamed ,  Chenyang Xu ,  Frank Sauer ,  Marcus Pfister ,  Andrew F. Hall ,  Klaus Klingenbeck-Regn

发明人： Ashraf Mohamed ,  Chenyang Xu ,  Frank Sauer ,  Marcus Pfister ,  Andrew F. Hall ,  Klaus Klingenbeck-Regn

IPC分类号： A61F2/06 ,  G06K9/00

CPC分类号： G06T19/006 ,  A61B6/4423 ,  A61B6/487 ,  A61B6/504 ,  A61B34/10 ,  A61B2034/102 ,  A61B2034/108 ,  A61B2090/365 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2310/0097 ,  G06T7/344 ,  G06T7/38 ,  G06T2207/10121 ,  G06T2207/30101 ,  G06T2207/30204

摘要： A method for guiding stent deployment during an endovascular procedure includes providing a virtual stent model of a real stent that specifies a length, diameter, shape, and placement of the real stent. The method further includes projecting the virtual stent model onto a 2-dimensional (2D) DSA image of a target lesion, manipulating a stent deployment mechanism to navigate the stent to the target lesion while simultaneously acquiring real-time 2D fluoroscopic images of the stent navigation, and overlaying each fluoroscopic image on the 2D DSA image having the projected virtual stent model image, where the 2D fluoroscopic images are acquired from a C-arm mounted X-ray apparatus, and updating the projection of the virtual stent model onto the fluoroscopic images whenever a new fluoroscopic image is acquired or whenever the C-arm is moved, where the stent is aligned with the virtual stent model by aligning stent end markers with virtual end markers.

摘要翻译： 用于在血管内手术期间引导支架展开的方法包括提供实际支架的虚拟支架模型，其指定真实支架的长度，直径，形状和位置。 该方法还包括将虚拟支架模型投影到目标损伤的二维（2D）DSA图像上，操纵支架展开机构以将支架导航到目标病变，同时获取支架导航的实时2D透视图像 并且将每个透视图像叠加在具有投射的虚拟支架模型图像的2D DSA图像上，其中从C臂安装的X射线装置获取2D透视图像，并且将虚拟支架模型的投影更新到荧光图像上 每当获取新的荧光透视图像或每当C形臂移动时，通过将支架终点标记与虚拟末端标记对齐，支架与虚拟支架模型对准。

公开(公告)号：US20090020985A1

公开(公告)日：2009-01-22

申请号：US12216922

申请日：2008-07-11

申请人： Frank Sauer

发明人： Frank Sauer

IPC分类号： B60R21/20

CPC分类号： B60R21/217 ,  B60R21/203

摘要： An airbag fastening system in an airbag module has a clamping connection and includes a retaining ring for an injection orifice of the airbag in an airbag receptacle surrounding both the airbag module and the retaining ring. The retaining ring has a reducing width on an outer face in a main pulling direction when the airbag unfolds. At least a portion of the airbag receptacle or a component associated with the airbag receptacle has a smaller width above the retaining ring than a greatest width of the retaining ring. A lower end of the airbag forms the injection orifice, is folded over the retaining ring, and extends between the retaining ring and the airbag receptacle or the component. The retaining ring includes at least one portion having a conically tapered cross-section on the outer face in the main pulling direction when the airbag unfolds.

摘要翻译： 安全气囊模块中的气囊紧固系统具有夹紧连接，并且包括用于安全气囊插入件中的用于安全气囊的注射孔的保持环，围绕安全气囊模块和保持环。 当气囊展开时，保持环在主拉动方向上具有在外表面上的减小宽度。 安全气囊插座的至少一部分或与安全气囊插座相关联的部件在保持环之上具有比保持环的最大宽度更小的宽度。 气囊的下端形成喷射孔，折叠在保持环上，并且在保持环和气囊插座或部件之间延伸。 当气囊展开时，保持环包括在主拉动方向上的外表面上具有锥形锥形横截面的至少一个部分。

公开(公告)号：US20090014987A1

公开(公告)日：2009-01-15

申请号：US12230845

申请日：2008-09-05

申请人： Steffen Weigand ,  Frank Sauer ,  Stefan Hamels ,  Ralf Glaab

发明人： Steffen Weigand ,  Frank Sauer ,  Stefan Hamels ,  Ralf Glaab

IPC分类号： B60R21/20

CPC分类号： B60R21/2035 ,  B60R21/217

摘要： An airbag module including a gas generator with at least one laterally projecting fastening portion; a generator support; an airbag with an inflation opening; a cover cap; and latching elements for connecting the generator support to the cover cap. The airbag has a plate proximate to the inflation opening, the plate including an opening for the gas generator. Latching elements are provided to hold the plate and the airbag connected thereto, and to hold the fastening portion of the gas generator situated between the generator support and the plate. The plate, at least in the region of these latching elements, is larger than the external dimensioning of the folded airbag in the region of the inflation opening.

摘要翻译： 一种安全气囊模块，包括具有至少一个横向突出的紧固部分的气体发生器; 发电机支架; 具有充气开口的气囊; 盖帽; 以及用于将发电机支撑件连接到盖帽的闭锁元件。 气囊具有靠近充气开口的板，该板包括用于气体发生器的开口。 提供锁定元件以保持连接到其上的板和气囊，并且保持位于发电机支撑件和板之间的气体发生器的紧固部分。 至少在这些闩锁元件的区域中，该板大于在充气开口区域中折叠的气囊的外部尺寸。

公开(公告)号：US20080233101A1

公开(公告)日：2008-09-25

申请号：US11520494

申请日：2006-09-12

申请人： Frank Sauer

发明人： Frank Sauer

IPC分类号： A61K38/47 ,  C12N5/06 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N15/63

摘要： The invention provides a method of regulating transcription of a gene that is a target for an epigenetic regulator; a method of characterizing the transcriptional activity of such a gene; a method of screening for a chromosomal element (CE) for an epigenetic regulator of a target gene; an isolated complex including an epigenetic regulator for a target gene, wherein the epigenetic regulator is specifically bound to a non-coding polynucleotide; and a method of screening for a modulator of transcription of a gene that is a target for an epigenetic regulator.

摘要翻译： 本发明提供了调节作为表观遗传调节物靶标的基因的转录的方法。 表征该基因的转录活性的方法; 筛选靶基因的表观遗传调节剂的染色体元件（CE）的方法; 包括靶基因的表观遗传调节剂的分离的复合物，其中所述表观遗传调节子特异性结合于非编码多核苷酸; 以及筛选作为表观遗传调节物的靶基因的转录调节物的方法。

公开(公告)号：US20080095421A1

公开(公告)日：2008-04-24

申请号：US11874266

申请日：2007-10-18

申请人： Yiyong Sun ,  Rui Liao ,  Chenyang Xu ,  Frank Sauer

发明人： Yiyong Sun ,  Rui Liao ,  Chenyang Xu ,  Frank Sauer

IPC分类号： A61B5/00

CPC分类号： A61B6/487 ,  A61B5/06 ,  A61B5/062 ,  A61B6/12 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5247 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4254 ,  A61B8/4416

摘要： A fluoroscopy image is registered with data representing a volume, identifying a catheter position relative to a volume represented by preoperative volume data. The catheter position relative to a patient volume represented by data acquired without scanning the catheter is displayed. For example, a 2D fluoroscopy image is registered with respect to coordinates of a 3D preoperative CT or MRI volume by registering the fluoroscopy image and the preoperative volume to 3D ultrasound coordinates.

摘要翻译： 用表示体积的数据记录荧光透视图像，识别相对于由术前体积数据表示的体积的导管位置。 显示相对于由不扫描导管获取的数据表示的患者体积的导管位置。 例如，通过将荧光透视图像和术前体积登记到3D超声坐标，相对于3D术前CT或MRI体积的坐标登记2D透视图像。

公开(公告)号：US20080007037A1

公开(公告)日：2008-01-10

申请号：US11812987

申请日：2007-06-22

申请人： Frank Sauer

发明人： Frank Sauer

IPC分类号： B60R21/231 ,  B60R21/26

CPC分类号： B60R21/217 ,  B60R21/205 ,  B60R21/206

摘要： An airbag module including a gas generator and an airbag. The gas generator and the airbag are arranged in the module housing one behind the other in the direction of a longitudinal axis of the airbag module so that the dimension of the airbag module is greater in the direction of the longitudinal axis than the dimension of the airbag module in a direction transversely to the longitudinal axis. The module housing is divided in the direction of the longitudinal axis of the airbag module and includes two housing shells. The airbag is connected to the module housing by a clamping frame which includes at least one gas conduction element.

摘要翻译： 一种气囊组件，包括气体发生器和气囊。 气体发生器和气囊沿着安全气囊模块的纵向轴线的方向一个接一个地布置在模块壳体中，使得气囊模块的尺寸在纵轴方向上大于气囊的尺寸 在横向于纵向轴线的方向上模块化。 模块壳体沿着安全气囊模块的纵向轴线的方向分开并且包括两个壳体壳体。 气囊通过包括至少一个气体传导元件的夹紧框架连接到模块壳体。

公开(公告)号：US20070287902A1

公开(公告)日：2007-12-13

申请号：US10569957

申请日：2004-08-24

申请人： Kristine Fuimaono ,  Gal Hayam ,  Yuval Karmi ,  Reinmar Killmann ,  Assaf Preiss ,  Norbert Rahn ,  Frank Sauer ,  Chenyang Xu

发明人： Kristine Fuimaono ,  Gal Hayam ,  Yuval Karmi ,  Reinmar Killmann ,  Assaf Preiss ,  Norbert Rahn ,  Frank Sauer ,  Chenyang Xu

IPC分类号： A61B18/14

CPC分类号： A61B6/032 ,  A61B5/055 ,  A61B5/7285 ,  A61B6/541 ,  A61B8/14 ,  A61B8/543 ,  A61B18/1492 ,  A61B2018/00375 ,  A61B2018/00839 ,  G01R33/5608

摘要： The invention relates to a device and to a method for visual assistance during the electrophysiological use of a catheter in the heart, enabling electroanatomic 3D mapping data relating to an area of the heart to be treated to be visualised during the use of the catheter. Before the catheter is used, 3D image data of a body region containing the area to be treated is detected by means of a method for tomographic 3D imaging. The area to be treated or significant parts thereof are extracted from said 3D image data, in order to obtain selected 3D image data. The electroanatomic 3D mapping data and the selected 3D image data obtained are then classed in terms of position and dimension, and are adjacently visualised, for example, during the catheter ablation. The inventive method and associated device enable the orientation of the operator to be improved during the use of a catheter in the heart.

摘要翻译： 本发明涉及一种用于在心脏中电生理使用导管期间的视觉辅助的装置和方法，使得在使用导管期间能够使待处理的心脏区域的电解剖3D图映射数据被可视化。 在使用导管之前，通过用于断层3D成像的方法来检测包含待处理区域的身体区域的3D图像数据。 从所述3D图像数据中提取要处理的区域或其重要部分，以便获得所选择的3D图像数据。 然后根据位置和尺寸对所获得的电解剖3D图像数据和所选择的3D图像数据进行分类，并且例如在导管消融期间相邻地可视化。 本发明的方法和相关装置使得在使用心脏中的导管时能够改善操作者的取向。

公开(公告)号：US20060159323A1

公开(公告)日：2006-07-20

申请号：US11330633

申请日：2006-01-12

申请人： Yiyong Sun ,  Fred Azar ,  Chenyang Xu ,  Frank Sauer ,  Norbert Rahn

发明人： Yiyong Sun ,  Fred Azar ,  Chenyang Xu ,  Frank Sauer ,  Norbert Rahn

IPC分类号： G06K9/00 ,  G06K9/32

CPC分类号： A61B5/0035 ,  A61B5/042 ,  A61B5/055 ,  A61B6/03 ,  G06T7/33 ,  G06T2207/30048

摘要： A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.

摘要翻译： 公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。 术前图像显示在第一支持视图中。 术中EA图像映射显示在第二支持视图中。 通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。 基于对齐，将术前图像的视图与EA图集成。

公开(公告)号：US06916876B2

公开(公告)日：2005-07-12

申请号：US10091640

申请日：2002-03-06

申请人： Peter Manshausen ,  Frank Sauer ,  Thomas Steinhoff ,  Jan Mazanek ,  Christian Wamprecht ,  Christel Spinger ,  Uwe Priesnitz ,  Peter Happe

发明人： Peter Manshausen ,  Frank Sauer ,  Thomas Steinhoff ,  Jan Mazanek ,  Christian Wamprecht ,  Christel Spinger ,  Uwe Priesnitz ,  Peter Happe

IPC分类号： C08G18/10 ,  C08J3/12 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K3/36 ,  C08K5/21 ,  C08L1/00 ,  C08L5/00 ,  C08L33/02 ,  C08L75/04 ,  C09D7/00 ,  C09D7/12 ,  C09D175/04 ,  C09D201/00 ,  C08J3/00 ,  C08K3/20 ,  C08L75/00

CPC分类号： C08J3/12 ,  C08G18/10 ,  C08J2375/04 ,  C08L75/04 ,  C09D7/43 ,  C09D7/69 ,  C08G18/283

摘要： The invention relates to a powdered thickener preparation based on polyurethane, which can be incorporated particularly well into water-based paints and lacquers and into other aqueous systems, and to their use as rheological additives for thickening preferably aqueous systems.

摘要翻译： 本发明涉及一种基于聚氨酯的粉末增稠剂制剂，其可以特别好地掺入到水基油漆和漆中并进入其它含水体系中，以及它们作为流变添加剂用于增稠优选含水体系的用途。

公开(公告)号：US06787750B1

公开(公告)日：2004-09-07

申请号：US09607116

申请日：2000-06-29

申请人： Frank Sauer

发明人： Frank Sauer

IPC分类号： H01L2700

CPC分类号： G06T7/73 ,  G06T2207/30244

摘要： A method for optical tracking in a video sequence comprises the steps of placing optical markers in a 3-dimensional scene for viewing by a camera from a given camera pose. Certain preselected markers are designated optical beacons and are configured for ready location of images thereof in an image of the camera. Others of the markers are placed in positions having known relative spatial relationship to the optical beacons. Images of the optical beacons are found in the image. Images of a plurality of others of the optical markers are found by using existing knowledge of their relationship to the beacons, optionally via an approximate camera pose corresponding thereto that is derived from the image information, precise locations of optical markers are obtained, and information of the precise locations of optical markers is uses to obtain a precise camera pose.

摘要翻译： 一种用于视频序列中的光学跟踪的方法包括以下步骤：将光学标记放置在三维场景中，以从相机从给定的相机姿态观看。 某些预先选择的标记被指定为光信标，并且被配置用于在相机的图像中准备好其图像的位置。 其他标记被放置在与光信标已知的相对空间关系的位置。 光学信标的图像在图像中找到。 通过使用与信标的关系的现有知识，可选地通过从图像信息导出的与其对应的近似相机姿态，获得光学标记的多个其他的图像，获得光学标记的精确位置，以及信息 光学标记的精确位置用于获得精确的相机姿态。