-
公开(公告)号：US20090011038A1
公开(公告)日：2009-01-08
申请号：US12090754
申请日：2006-10-25
IPC分类号： A61K9/14
CPC分类号： A61K9/146 , A61K9/1641 , A61K47/34 , A61K47/59 , A61K47/595 , A61K47/62
摘要： The invention relates to novel particulate drug-delivery systems based on a polymer support containing at least one linear, branched or cross-linked polymer in a fraction of over 50 percent by weight in relation to the total weight of the support. The system is characterised in that at least one signal substance for transport through a biological barrier and at least one active ingredient are stored, the support, signal substance and active ingredient having no covalent links and no active-ingredient specific and signal substance specific coordinative links between one another.
摘要翻译： 本发明涉及基于聚合物载体的新型颗粒药物递送系统，其包含至少一种相对于载体总重量超过50重量％的直链，支链或交联聚合物。 该系统的特征在于，存储用于传输通过生物屏障和至少一种活性成分的至少一种信号物质，所述载体，信号物质和没有共价连接并且没有活性成分特异性和信号物质特异性协调链接的信号物质和活性成分 在彼此之间
-
62.发明申请Method for Producing Coated Drugs Having a Stable Profile for the Release of Active Ingredients 审中-公开用于生产具有用于释放活性成分的稳定分布的涂布药物的方法公开(公告)号：US20070231397A1
公开(公告)日：2007-10-04
申请号：US11570050
申请日：2005-07-09
IPC分类号： A61K9/00
CPC分类号： A61K9/5089 , A61K9/5026
摘要： The invention relates to methods for producing drugs having a stable profile for the release of active ingredients, said drugs exhibiting a controlled release characteristic as a result of the coating of vinyl (co)polymers. The inventive methods are characterised in that the coated drugs are conditioned in a fluidised bed coating appliance or a drum coating appliance for at least 10 minutes until a stable profile for the release of active ingredients is reached at a temperature of between 30 and 70° C. A humidity of between 5 and 30% is regulated during the conditioning process.
摘要翻译： 本发明涉及用于生产具有稳定的释放活性成分的药物的药物的方法，所述药物由于乙烯基（共）聚合物的涂覆而表现出控制释放特征。 本发明的方法的特征在于，将涂覆的药物在流化床包衣器具或鼓包衣器中调理至少10分钟，直到在30至70℃的温度下达到用于释放活性成分的稳定曲线 在调理过程中调节5至30％的湿度。
-
63.发明申请Method for producing an immediately decomposing oral form of administration which releases active ingredients 有权用于产生释放活性成分的立即分解口服给药形式的方法公开(公告)号：US20060051412A1
公开(公告)日：2006-03-09
申请号：US10542283
申请日：2003-11-21
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/146 , A61K9/1647 , A61K9/2054 , A61K31/192
摘要： The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
摘要翻译： 本发明涉及一种生产口服给药方法，该方法立即分解并释放口腔内的活性成分。 根据所述方法，（a）阴离子药物活性成分与（b）由丙烯酸的自由基聚合的C 1 -C 4 -C 4酯的共聚物密集混合 或甲基丙烯酸和其它含有官能叔氨基的（甲基）丙烯酸酯单体，和（c）5-50wt。 ％）相对于（b）相对于熔融物质中的C 12 -C 22 -C 22羧酸; 将混合物固化并研磨形成含有平均粒径为200μm或更小的活性成分的粉末; 并将粉末包封在由药学上标准的佐剂组成的水溶性基质中，条件是不超过3wt。 相对于共聚物，HLB值至少为14的乳化剂的％必须包含在其中。 本发明还涉及含有活性成分的粉末及其用途。
-
公开(公告)号：US20050084925A1
公开(公告)日：2005-04-21
申请号：US10501140
申请日：2003-10-16
IPC分类号： C12P35/04 , C12P35/00 , C07D501/14
CPC分类号： C12P35/04
摘要： The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands having nucleophilic groups and is in bead form.
摘要翻译： 本发明涉及一种借助于固定在交联的亲水共聚物上的青霉素酰胺酶来制备头孢氨苄的方法，所述交联的亲水共聚物对具有亲核基团的配体具有结合活性且呈珠粒形式。
-
公开(公告)号：US06878387B1
公开(公告)日：2005-04-12
申请号：US09787438
申请日：1999-09-28
IPC分类号： A61K47/32 , A61K9/22 , A61K9/32 , A61K9/50 , A61K9/52 , A61K9/58 , A61K9/64 , A61K31/522 , A61K47/12 , A61P11/06 , C08F220/18 , C08L33/04 , A61K9/14 , A61K9/16 , A61K9/46 , A61K9/48
CPC分类号： A61K9/5078 , A61K9/5026 , A61K31/522
摘要： The invention relates to a pharmaceutical preparation consisting of: (a) a core containing an active substance, optionally an excipient and common pharmaceutical additives in addition to the salt of an inorganic acid whose proportion in the weight of the core ranges from 2.5 to 97% by weight and (b) and outer film coating consisting of one or more (meth)acrylate copolymers and optionally common pharmaceutical adjuvants, wherein 40 to 100% by weight of the (meth)acrylate copolymers consist of 93 to 98% by weight of radically polymerized C1- to C4-alkylesters of acrylic or methacrylic acid and 7 to 2% by weight of (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical and that may be optionally present in a mixture consisting of 1 to 60% by weight of one or more additional (meth)acrylate copolymers different from the above-mentioned (meth)acrylate copolymers, consisting of 85 to 100% by weight of a radically polymerized C1- to C4-alkylesters of acrylic orethacrylic acid and optionally and optionally up to 15% by weight of additional (meth)acrylate monomers with basic groups or acid groups in the alkyl radical.
摘要翻译： 本发明涉及一种药物制剂，其包含：（a）含有活性物质的核心，任选的赋形剂和常见的药用添加剂，除了无机酸的盐，其核心重量的比例为2.5至97％ （b）和由一种或多种（甲基）丙烯酸酯共聚物和任选的普通药用佐剂组成的外膜包衣，其中40至100重量％的（甲基）丙烯酸酯共聚物由93至98重量％ 聚合丙烯酸或甲基丙烯酸的C 1至C 4 - 烷基酯和7至2重量％的在烷基中具有季铵基团的（甲基）丙烯酸酯单体，并且其可以任选地存在于由1至60％ 一种或多种与上述（甲基）丙烯酸酯共聚物不同的另外的（甲基）丙烯酸酯共聚物的重量，其由85至100重量％的丙烯酸类聚丙烯酸酯的自由基聚合的C 1 -C 4烷基酯 酸和任选地和任选地至多15重量％的在烷基中具有碱性基团或酸基团的另外的（甲基）丙烯酸酯单体。
-
66.发明申请Multi-particulate form of medicament, comprising at least two differently coated forms of pellet 有权多颗粒形式的药物，包含至少两种不同的包衣形式的丸剂公开(公告)号：US20050053660A1
公开(公告)日：2005-03-10
申请号：US10949323
申请日：2004-09-27
IPC分类号： A61K9/16 , A61K9/20 , A61K9/26 , A61K9/50 , A61K9/54 , A61K9/58 , A61K9/62 , A61K31/573 , A61K31/58 , A61K31/606 , A61K31/635 , A61K47/32 , A61K47/36 , A61K47/38 , A61P1/00
CPC分类号： A61K31/58 , A61K9/2081 , A61K9/5026 , A61K9/5073 , A61K9/5084 , A61K31/573 , A61K31/606 , A61K31/635
摘要： The invention relates to a multiparticulate drug form suitable for uniform release of an active pharmaceutical ingredient in the small intestine and in the large intestine, comprising at least two forms of pellets A and B which comprise an active pharmaceutical ingredient in the core and have different polymer coatings which determine the release of the active ingredient at different pH values, characterized in that pellet form A is provided with an inner polymer coating which enables continuous release of active ingredient, and has an outer enteric coating which rapidly dissolves above about pH 5.5, and pellet form B is provided with a polymer coating which, in the USP release test, releases less than 20% of the active ingredient at pH 6.8 in 6 hours and releases more than 50% of the active ingredient at pH 7.2 in 6 hours. The invention additionally relates to a process for producing the multiparticulate drug form and to the use of pellet forms A and B for producing the drug form.
摘要翻译： 本发明涉及适于在小肠和大肠中均匀释放活性药物成分的多颗粒药物形式，其包含至少两种形式的颗粒A和B，其包含芯中的活性药物成分并具有不同的聚合物 确定在不同pH值下释放活性成分的涂层，其特征在于，颗粒形式A具有能够连续释放活性成分的内部聚合物涂层，并且具有快速溶解在约pH 5.5以上的外部肠溶衣，以及 颗粒形式B具有聚合物涂层，其在USP释放试验中在6小时内在pH 6.8下释放少于20％的活性成分，并在6小时内在pH 7.2下释放超过50％的活性成分。 本发明还涉及生产多颗粒药物形式的方法以及用于制备药物形式的颗粒形式A和B的用途。
-
公开(公告)号：US06624210B1
公开(公告)日：2003-09-23
申请号：US09764993
申请日：2001-01-23
申请人： Hans-Ulrich Petereit , Christian Meier , Erna Roth
发明人： Hans-Ulrich Petereit , Christian Meier , Erna Roth
IPC分类号： C08K904
CPC分类号： A61K9/2846 , Y10S524/904
摘要： The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having functional tertiary ammonium groups and (b) 1-50% by weight of a softener and 1-15% by weight of an emulgator with an HLB value of less than 14, wherein constituents (a), (b) and (c) are mixed with or without adding water and optionally adding a pharmaceutical active substance and other conventional additives and the coating and excipient agent is produced by melting, casting, spreading or spraying. The invention is characterized in that the copolymer (a) is applied in powder form with a mean particle size of 1-40 &mgr;m.
摘要翻译： 本发明涉及一种生产用于口服或皮肤剂型的包衣和赋形剂的方法，由（a）35-98重量％的由丙烯酸或甲基丙烯酸的自由基聚合的C1-C4酯组成的共聚物和 具有功能性叔铵基团的另外的（甲基）丙烯酸酯单体和（b）1-50重量％的软化剂和1-15重量％的HLB值小于14的乳化剂，其中组分（a），（ b）和（c）与或不加入水混合，并且任选地加入药物活性物质和其它常规添加剂，并且通过熔融，浇铸，铺展或喷涂制备涂层和赋形剂。 本发明的特征在于共聚物（a）以平均粒径为1-40μm的粉末形式施用。
-
公开(公告)号：US06306428B1
公开(公告)日：2001-10-23
申请号：US09058951
申请日：1998-04-13
IPC分类号： A61K900
CPC分类号： A61K9/2095 , A61K9/2072 , A61K9/2086 , A61K9/7007
摘要： A time-release laminar pharmaceutical composition, comprised of rolled or folded layers of a polymer film, that contain a pharmaceutically active substance, in which the outer surface area of the polymer film which contains the active substance, and which is accessible to the digestive juices, amounts to at most 25% of the entire surface area in the rolled or folded state, and the rolled or folded layers adhere to one another in such a way that the laminar form of medication maintains its rolled or folded form for a period of at least one hour in the release test according to USP 23, Method A, apparatus 2, at 37° C. and 50 rpm, in artificial gastric juice, and at least 30% of the active substance contained in it is released in the rolled or folded state.
摘要翻译： 包含聚合物膜的卷曲或折叠层的时间释放层状药物组合物，其含有药物活性物质，其中含有活性物质的聚合物膜的外表面积并且可被消化液接触 相当于轧制或折叠状态下整个表面积的至多25％，并且卷起或折叠的层彼此粘合，使得层状形式的药物保持其卷曲或折叠形式一段时间 根据USP 23，方法A，装置2在37℃和50rpm，在人造胃液中的释放试验中至少1小时，其中含有的至少30％的活性物质被释放在轧制或 折叠状态。
-
公开(公告)号：US5133970A
公开(公告)日：1992-07-28
申请号：US550991
申请日：1990-07-11
申请人： Hans-Ulrich Petereit , Erna Roth
发明人： Hans-Ulrich Petereit , Erna Roth
IPC分类号： A61K9/70 , A61L15/58 , C08F8/44 , C08L33/04 , C08L33/06 , C08L33/14 , C09J7/02 , C09J133/00 , C09J133/04 , C09J133/06 , C09J133/14
CPC分类号： A61K9/7061 , A61L15/58 , C08F8/44 , C09J133/14 , Y10T428/31511
摘要： A water-soluble salt of a copolymer containing a monoethylenically unsaturated monomer containing amino groups that can be radically polymerized and at least one alkyl ester of acrylic and/or methacrylic acid, is used as a flexible pressure-sensitive adhesive for application to the skin.
摘要翻译： 使用含有可自由基聚合的氨基的单烯属不饱和单体和至少一种丙烯酸和/或甲基丙烯酸的烷基酯的共聚物的水溶性盐作为用于皮肤的柔性压敏粘合剂。
-
公开(公告)号：US4904469A
公开(公告)日：1990-02-27
申请号：US10983
申请日：1987-02-05
CPC分类号： A61L15/425 , A61L15/28 , A61L15/38
摘要： The invention relates to a wound covering made from a polysaccharide base, particularly cellulose, which is formed as a fabric, which has a high absorbency due to its sponge-like structure and contains non-immobilized enzymes for wound therapy.
摘要翻译： 本发明涉及由多糖基质，特别是纤维素制成的伤口覆盖物，其由织物形成，其由于其海绵状结构而具有高吸收性并且含有用于伤口治疗的非固定化酶。
-
-
-
-
-
-
-
-
-
搜索结果
99 条记录 (耗时 0.046 秒)
