公开(公告)号：US11324965B2

公开(公告)日：2022-05-10

申请号：US16511536

申请日：2019-07-15

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06 ,  A61K49/00 ,  A61N1/40 ,  A61N5/02 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61K41/00 ,  A61M5/00 ,  A61L2/00 ,  A61L2/08 ,  A61N5/067 ,  A61N5/10

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US11207409B2

公开(公告)日：2021-12-28

申请号：US15992852

申请日：2018-05-30

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Mark Dewhirst ,  Neil Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada ,  Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Harold Walder

IPC: A61K41/00 ,  A61K31/37 ,  A61K45/06 ,  A61K9/00 ,  A61N5/06 ,  A61N5/10 ,  A61K31/409 ,  A61P35/00

Abstract: A system (and associated method) for treating a human or animal body. The system has a photoactivatable drug for treating a first diseased site, a first pharmaceutically acceptable carrier including one or more phosphorescent or fluorescent agents which are capable of emitting an activation energy into the body which activates the photoactivatable drug, a first device which infuses the first diseased site with a photoactivatable drug and the first pharmaceutically acceptable carrier, a first energy source which irradiates the diseased site with an initiation energy to thereby initiate emission of the activation energy into the body, and a supplemental treatment device which administers one or both of a therapeutic drug or radiation to the body at a second diseased site or the first diseased site, to provide an immune system stimulation in the body.

公开(公告)号：US11103580B2

公开(公告)日：2021-08-31

申请号：US16514066

申请日：2019-07-17

Applicant: Immunolight, LLC

Inventor： Frederic A. Bourke, Jr.

IPC: A61K41/00 ,  A61K31/37 ,  A61K31/35 ,  A61K45/06 ,  A61N5/06 ,  A61K31/714 ,  A61K47/02 ,  A61F7/00 ,  A61H23/00 ,  A61K31/366 ,  A61N2/02 ,  A61N5/10

Abstract: Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US10899907B2

公开(公告)日：2021-01-26

申请号：US16674435

申请日：2019-11-05

Applicant: Immunolight, LLC

Inventor： Zakaryae Fathi ,  John Pacanovsky ,  Frederic A. Bourke, Jr.

IPC: B32B43/00 ,  C08J11/10 ,  B32B7/06 ,  B32B7/10 ,  B32B27/18 ,  B32B27/32 ,  B29B17/02 ,  B32B7/04 ,  B32B38/10 ,  B32B37/12 ,  B32B38/00

Abstract: A method is provided for decomposition of a polymeric article, wherein the polymeric article contains a polymer and one or more energy modulation agents, by applying an applied energy to the polymeric article, wherein the one or more energy modulation agents convert the applied energy into an emitted energy sufficient to cause bond destruction within the polymer.

公开(公告)号：US10717062B2

公开(公告)日：2020-07-21

申请号：US16238398

申请日：2019-01-02

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Tuan Vo-Dinh

IPC: B01J19/12 ,  A23L3/26 ,  A61L2/00 ,  C02F1/30 ,  C02F1/72 ,  A23L5/30 ,  B01J19/08 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  B01J23/50 ,  B01J23/52 ,  B01J31/02 ,  B01J31/22 ,  B01J35/00 ,  B01J37/00 ,  B01J37/02 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  A23L2/50 ,  A23L3/28 ,  C08J3/24 ,  C08J7/18 ,  G02B5/00 ,  A61M1/36 ,  C12H1/06 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

公开(公告)号：US10391330B2

公开(公告)日：2019-08-27

申请号：US15151642

申请日：2016-05-11

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Tuan Vo-Dinh ,  Harold Walder

IPC: A61N5/10 ,  A61N5/06 ,  A61K41/00 ,  A61N5/02 ,  A61K47/69

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US10283476B2

公开(公告)日：2019-05-07

申请号：US15459907

申请日：2017-03-15

Applicant: Immunolight, LLC

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: C09J9/02 ,  H01L23/00 ,  C09J11/02 ,  C09J163/00

Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US10272262B2

公开(公告)日：2019-04-30

申请号：US15874426

申请日：2018-01-18

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder

IPC: A61N5/06 ,  A61K41/00 ,  A61N5/10

Abstract: A system and method for light stimulation within a medium. Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US10029117B2

公开(公告)日：2018-07-24

申请号：US14729864

申请日：2015-06-03

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. Bourke, Jr.

IPC: C09K11/02 ,  C08L83/06 ,  C09J183/08 ,  A61K41/00 ,  B29C71/04 ,  A61N5/10 ,  A23L3/26 ,  A61L2/00 ,  B01J19/08 ,  B01J19/12 ,  C02F1/30 ,  C02F1/72 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61N5/06 ,  A23L5/30 ,  B82Y20/00

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US10026711B2

公开(公告)日：2018-07-17

申请号：US15382835

申请日：2016-12-19

Applicant: Immunolight, LLC

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: B32B27/26 ,  B32B27/18 ,  B32B27/16 ,  H01L23/00 ,  B32B38/00 ,  B32B37/12 ,  B32B37/18 ,  H01L25/065 ,  H01L25/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.