公开(公告)号：US11901331B2

公开(公告)日：2024-02-13

申请号：US17647275

申请日：2022-01-06

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC分类号： C08K3/00 ,  H01L23/00 ,  B41J2/175 ,  C09J4/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77 ,  H01L25/065 ,  H01L25/00 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  H01L23/522

CPC分类号： H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/777 ,  C09K11/7769 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2924/07811 ,  H01L2924/00 ,  H01L2924/1461 ,  H01L2924/00 ,  H01L2224/92125 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US11345833B2

公开(公告)日：2022-05-31

申请号：US16121043

申请日：2018-09-04

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC分类号： C09J5/00 ,  B32B7/12 ,  B32B25/08 ,  B32B27/28 ,  B32B27/30 ,  B32B27/32 ,  B32B27/36 ,  B41J2/175 ,  C08F2/46 ,  C08F2/48 ,  C08F2/54 ,  C09J5/02 ,  C09J7/10 ,  C09J11/04 ,  C09J107/00 ,  C09J109/00 ,  C09J121/00 ,  H01L21/683 ,  H01L23/29 ,  H01L23/00 ,  C08K3/30

摘要： A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

公开(公告)号：US11278042B2

公开(公告)日：2022-03-22

申请号：US17135479

申请日：2020-12-28

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC分类号： A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  A61M1/34 ,  C23C16/458 ,  C02F1/30

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US11260129B2

公开(公告)日：2022-03-01

申请号：US16074707

申请日：2017-02-02

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Harold Walder ,  Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Wayne Beyer ,  Mark Oldham ,  Justus Adamson ,  Michael Nolan

IPC分类号： A61K9/00 ,  A61K41/00 ,  A61K31/37 ,  A61N5/06 ,  A61N5/10 ,  A61K45/06

摘要： A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+ and (3Ca3 (PO4)2Ca(F, Cl)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.

公开(公告)号：US10748868B2

公开(公告)日：2020-08-18

申请号：US16103355

申请日：2018-08-14

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC分类号： H01L23/00 ,  C08K3/00 ,  B41J2/175 ,  C09J4/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77 ,  H01L25/065 ,  H01L25/00 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  H01L23/522

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US10575541B2

公开(公告)日：2020-03-03

申请号：US15895231

申请日：2018-02-13

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC分类号： A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  C23C16/458 ,  C02F1/30

摘要： A phosphor composition, containing one or more phosphors having on a surface thereof a coating selected from silica, diamond, and diamond-like carbon, wherein the one or more phosphors are configured to emit radiation upon interaction with an initiation energy.

公开(公告)号：US10232190B2

公开(公告)日：2019-03-19

申请号：US15649917

申请日：2017-07-14

申请人： IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

发明人： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Michael J. Therien ,  Mark W. Dewhirst ,  Ian N. Stanton ,  Jennifer Ann Ayres ,  Diane Renee Fels ,  Joseph A. Herbert

IPC分类号： A61N5/06 ,  A61K41/00 ,  A61N5/10

摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：US10093784B2

公开(公告)日：2018-10-09

申请号：US15590181

申请日：2017-05-09

申请人： Immunolight, LLC.

发明人： Zakaryae Fathi ,  John Pacanovsky ,  Frederic A. Bourke, Jr.

IPC分类号： C08J11/00 ,  C08J11/10 ,  B32B38/10 ,  B32B43/00 ,  B32B7/04 ,  B32B38/00

摘要： A method is provided for decomposition of a polymeric article, wherein the polymeric article contains a polymer and one or more energy modulation agents, by applying an applied energy to the polymeric article, wherein the one or more energy modulation agents convert the applied energy into an emitted energy sufficient to cause bond destruction within the polymer.

公开(公告)号：US10087343B2

公开(公告)日：2018-10-02

申请号：US15126834

申请日：2015-03-18

申请人： IMMUNOLIGHT, LLC

发明人： Zakaryae Fathi ,  Frederic Avery Bourke, Jr. ,  Harold Walder

IPC分类号： C09J5/00 ,  C09J107/00 ,  C09J109/00 ,  C09J11/04 ,  B32B7/12 ,  B41J2/175 ,  H01L23/29 ,  H01L23/00 ,  H01L21/683

摘要： A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

公开(公告)号：US09649832B2

公开(公告)日：2017-05-16

申请号：US14593049

申请日：2015-01-09

申请人： Immunolight, LLC ,  Duke University

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

IPC分类号： B32B38/00 ,  C09J4/00 ,  C09J133/08 ,  B41J2/175 ,  C08K3/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18

CPC分类号： H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.