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公开(公告)号：US20130046164A1
公开(公告)日：2013-02-21
申请号：US13643707
申请日：2011-05-04
CPC分类号： A61B5/14503 , A61B5/055 , A61B5/415 , A61B5/418 , A61K49/10 , G01R33/448 , G01R33/5601
摘要： A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
摘要翻译： 提供了一种传感器，用于在植入组织部位和离体应用时测量体内溶解氧浓度。 传感器包括通过透氧材料包含保持在可植入物品内的传感介质的制品。 感测介质包括用于氧气的MR造影剂。 该传感器被配置为当经历基于MR的方法时，指示流体的溶解氧浓度，例如在组织部位的体内溶解氧浓度。
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公开(公告)号：US20130020906A1
公开(公告)日：2013-01-24
申请号：US13542179
申请日：2012-07-05
IPC分类号： H01L41/09
CPC分类号： F03G7/005 , H01M10/052
摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example
摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置
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公开(公告)号：US08308707B2
公开(公告)日：2012-11-13
申请号：US13012426
申请日：2011-01-24
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
摘要翻译： 提供了将药物输送到眼睛的方法和系统。 该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。
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公开(公告)号：US20120175998A1
公开(公告)日：2012-07-12
申请号：US13328504
申请日：2011-12-16
IPC分类号： H02N11/00
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.
摘要翻译： 本文描述了用于提供电化学致动的装置和方法。 在一个实施例中，致动器装置包括包括负极和正极的电化学电池。负极的至少一部分由配制成插层，去插入，合金，氧化，还原的至少一种的材料形成 或者具有与正极的第二部分不同的程度的正极的第一部分的板，使得在正极的第一部分和第二部分之间施加微分应变，使得至少一部分 的电化学电池被移位。 电化学电池包括沿着电化学电池的轴线预弯曲以限定折叠轴线的部分，并且电化学电池的至少一部分的位移沿折叠轴线最大化。
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公开(公告)号：US20120146453A1
公开(公告)日：2012-06-14
申请号：US13316833
申请日：2011-12-12
IPC分类号： H02N11/00
CPC分类号： F03G7/005 , H01M2/16 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/587 , H01M6/30 , H01M2004/021 , H01M2010/4292
摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.
摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。
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66.发明申请公开(公告)号：US20110152839A1
公开(公告)日：2011-06-23
申请号：US12972364
申请日：2010-12-17
申请人： Michael J. Cima , Heejin Lee
发明人： Michael J. Cima , Heejin Lee
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61F2/042 , A61K9/0034 , A61K9/2072 , A61K31/00 , A61K31/167 , A61L31/16 , A61L31/18 , A61L2300/402 , A61L2300/602 , A61L2430/22 , A61M31/00
摘要： Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.
摘要翻译： 提供了可以在需要治疗的患者的膀胱内完全展开并且被患者良好耐受的膀胱内装置。 该装置可以包括具有保持形状的弹性体，其具有（i）提供膀胱内移动性的尺寸并且防止医疗装置通过尿道的排尿，以及（ii）排除医疗装置进入的尺寸，浮力或两者 输尿管孔。 当压缩到任何尺寸为3cm的最大尺寸的形状时，弹性体可发挥小于1N的最大作用力。 该装置可以包括用于膀胱内控制释放的药物，用于膀胱或区域组织的治疗。 还提供了治疗方法，包括在膀胱中选择需要治疗的患者，其中治疗的耐受性是主要关注的。
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公开(公告)号：US07918842B2
公开(公告)日：2011-04-05
申请号：US10783897
申请日：2004-02-20
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Implantable medical devices are provided for controlled release of drugs. In one embodiment, the device comprises a support structure; two or more discrete reservoirs provided in spaced positions across at least one surface of the support structure; and a release system loaded in each of the reservoirs, the release system including drug molecules dispersed in a degradable matrix material, wherein release of the drug molecules from the reservoir is controlled by in vivo disintegration of the matrix material. In another embodiment, the device comprises a support structure; two or more discrete reservoirs provided in spaced positions across at least one surface of the support structure; and a release system loaded in each of the reservoirs, the release system including drug molecules dispersed in a non-degradable matrix material, wherein release of the drug molecules from the reservoir is controlled by in vivo diffusion of the drug molecules from the matrix material.
摘要翻译： 提供可植入医疗器械用于药物的控制释放。 在一个实施例中，该装置包括支撑结构; 两个或多个离散的储存器设置在跨过支撑结构的至少一个表面的间隔位置; 以及装载在每个储存器中的释放系统，所述释放系统包括分散在可降解基质材料中的药物分子，其中药物分子从储存器的释放通过基质材料的体内分解来控制。 在另一个实施例中，该装置包括支撑结构; 两个或多个离散的储存器设置在跨过支撑结构的至少一个表面的间隔位置; 以及装载在每个储存器中的释放系统，所述释放系统包括分散在不可降解基质材料中的药物分子，其中通过药物分子从基质材料的体内扩散来控制药物分子从储存器的释放。
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公开(公告)号：US20110042204A1
公开(公告)日：2011-02-24
申请号：US12860771
申请日：2010-08-20
IPC分类号： C25B9/00
CPC分类号： F03G7/005 , H01M10/052
摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example
摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置
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公开(公告)号：US07892221B2
公开(公告)日：2011-02-22
申请号：US11041161
申请日：2005-01-21
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Reservoir-based medical devices are provided. In one embodiment, the medical device comprises a substrate; at least two discrete, microfabricated reservoirs provided in spaced positions across at least one surface of the substrate; discrete reservoir caps covering the at least two reservoirs; and control circuitry for selectively disintegrating the reservoir caps to open the reservoirs. The reservoirs of the device can include a diagnostic reagent or other molecules useful in medical diagnostics. In one embodiment, the reservoir cap comprises an anode and the control circuitry comprises a cathode and a power source for creating an electric potential between the cathode and the anode. Application of the electric potential causes the reservoir cap to disintegrate, thereby opening the reservoir.
摘要翻译： 提供了基于水库的医疗设备。 在一个实施例中，医疗装置包括基底; 至少两个离散的，微制造的储存器，跨过衬底的至少一个表面设置在间隔位置; 覆盖至少两个储存器的分立贮存器盖; 以及用于选择性地分解储存器盖以打开储存器的控制电路。 装置的储存器可以包括诊断试剂或用于医学诊断的其它分子。 在一个实施例中，储存器盖包括阳极，并且控制电路包括用于在阴极和阳极之间产生电位的阴极和电源。 施加电势会导致储存器盖分解，从而打开储存器。
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70.发明申请Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues 审中-公开可植入药物输送装置和处理男性泌尿生殖和周围组织的方法公开(公告)号：US20100003297A1
公开(公告)日：2010-01-07
申请号：US12538580
申请日：2009-08-10
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译： 提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。 在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。 药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。 在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。
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