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61.发明申请公开(公告)号：US20080090290A1
公开(公告)日：2008-04-17
申请号：US11668256
申请日：2007-01-29
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Isolated nucleic acids encoding an anti-IL-12 antibody or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
摘要翻译： 编码抗IL-12抗体或抗体部分的分离的核酸，载体，宿主细胞和制备方法可用于产生抗体或用于治疗和/或诊断IL-12相关病症和疾病的部分。
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公开(公告)号：US20070003548A1
公开(公告)日：2007-01-04
申请号：US11180219
申请日：2005-07-13
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
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公开(公告)号：US20060257407A1
公开(公告)日：2006-11-16
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
发明人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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64.发明申请Anti-IL-12/23p40 Antibodies, Epitopes, Formulations, Compositions, Methods and Uses 审中-公开抗IL-12 / 23p40抗体，表位，制剂，组合物，方法和用途公开(公告)号：US20090181027A1
公开(公告)日：2009-07-16
申请号：US12238804
申请日：2008-09-26
申请人： Paul Dal Monte , Jill Giles-Komar , George Heavner , David Knight , Mehrnaz Khossravi , Jinquan Luo , David Shealy , David Volkin
发明人： Paul Dal Monte , Jill Giles-Komar , George Heavner , David Knight , Mehrnaz Khossravi , Jinquan Luo , David Shealy , David Volkin
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： A61K47/26 , A61K47/183 , A61K2039/505 , C07K16/244 , C07K2317/34 , C07K2317/76
摘要： An anti-IL-12/23p40 antibody that binds to a portion of the IL-12 or IL-23 protein corresponding to the p40 subunit of IL-12 or IL-23, including compositions, formulations, and methods of administration have applications in diagnostic and/or therapeutic uses and devices.
摘要翻译： 结合与IL-12或IL-23的p40亚基相对应的IL-12或IL-23蛋白的一部分的抗IL-12 / 23p40抗体，包括组合物，制剂和施用方法，可应用于 诊断和/或治疗用途和装置。
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65.发明申请公开(公告)号：US20070160606A1
公开(公告)日：2007-07-12
申请号：US11240275
申请日：2005-09-30
IPC分类号： A61K39/395 , A61K38/19 , A61K38/17
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/92
摘要： The present invention relates to at least one novel anti-TNF antibody, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices, including the treatment of renal cell carcinoma.
摘要翻译： 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置，包括治疗肾细胞癌。
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公开(公告)号：US20050123541A1
公开(公告)日：2005-06-09
申请号：US10954900
申请日：2004-09-30
IPC分类号： C12N15/09 , A61K20060101 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P20060101 , A61P35/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C07K16/42 , C12N20060101 , C12N5/10 , C12N15/13 , C12P21/08 , G01N20060101 , A61K31/573 , A61K31/473 , A61K31/137
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.
摘要翻译： 本发明涉及使用至少一种抗TNF抗体治疗癌或腺癌的方法。
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67.发明授权公开(公告)号：US08329170B2
公开(公告)日：2012-12-11
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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68.发明申请公开(公告)号：US20120207670A1
公开(公告)日：2012-08-16
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , A61P29/00 , A61P23/00 , A61P37/00 , A61P37/04 , A61P5/00 , A61P37/06 , A61P23/02 , A61K51/00 , A61P21/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P31/00
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US20090202549A1
公开(公告)日：2009-08-13
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12N5/10 , C12N5/02 , C12N15/63 , C07K16/24 , C07H21/04
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20050214293A1
公开(公告)日：2005-09-29
申请号：US10975708
申请日：2004-10-28
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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