公开(公告)号：US6143541A

公开(公告)日：2000-11-07

申请号：US16

申请日：1998-01-30

申请人： Akira Arisawa ,  Motoko Matsufuji ,  Takurou Tsuruta ,  Kazuyuki Dobashi ,  Takashi Nakashima ,  Kunio Isshiki ,  Takeo Yoshioka

发明人： Akira Arisawa ,  Motoko Matsufuji ,  Takurou Tsuruta ,  Kazuyuki Dobashi ,  Takashi Nakashima ,  Kunio Isshiki ,  Takeo Yoshioka

IPC分类号： C07D211/88 ,  C07D211/90 ,  C12N9/18 ,  C12N9/78 ,  C12N15/55 ,  C12P17/12 ,  C12P41/00 ,  C12N9/14 ,  C12N1/20 ,  C12N9/16 ,  C12P12/12

CPC分类号： C07D211/88 ,  C07D211/90 ,  C12N9/18 ,  C12N9/78 ,  C12P17/12 ,  C12P41/006

摘要： This invention provides DNA fragments for efficiently preparing a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, transformants obtained by using such a DNA fragment, and a process for preparing the aforesaid enzyme. Specifically, an isolated gene derived from the chromosome of Streptomyces viridosporus and encoding a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, plasmids having the aforesaid gene integrated thereinto, transformants obtained by using such a plasmid, and a process for preparing the aforesaid enzyme by using such a transformant are disclosed. A process for the enzymatic conversion of 4-substituted 1,4-dihydropyridine derivatives by using the aforesaid enzyme is also disclosed.

摘要翻译： PCT No.PCT / JP96 / 02147 Sec。 371日期1998年1月30日 102（e）1998年1月30日PCT PCT 1996年7月30日PCT公布。 公开号WO97 / 05243 日期1997年2月13日本发明提供了用于有效制备对4-取代的1,4-二氢吡啶衍生物具有不对称水解酶活性的蛋白质的DNA片段，以及通过使用该DNA片段得到的转化体及其制备方法。 具体来说，来源于链球菌链球菌的染色体的分离的基因，编码对4-取代的1,4-二氢吡啶衍生物具有不对称的水解酶活性的蛋白质，将上述基因整合到其中的质粒，使用这样的质粒获得的转化体， 公开了通过使用这种转化体制备上述酶的方法。 还公开了通过使用上述酶酶促转化4-取代的1,4-二氢吡啶衍生物的方法。

公开(公告)号：US5822235A

公开(公告)日：1998-10-13

申请号：US879216

申请日：1997-06-19

申请人： Takashi Nakashima

发明人： Takashi Nakashima

IPC分类号： H01L21/8234 ,  G06F7/50 ,  G06F7/501 ,  H01L27/07 ,  H01L27/088 ,  H03K17/687 ,  H03K19/0944 ,  H03K19/21

CPC分类号： G06F7/501 ,  H01L27/0727 ,  H03K19/09441 ,  H03K19/215 ,  G06F2207/3876

摘要： A rectifying transfer gate circuit includes first and second field effect transistors and one diode. The source of the first field effect transistor is coupled to a first input node and the gate thereof is coupled to a second input node. Meanwhile, the source of the second field effect transistor is coupled to the second input node and the gate thereof is coupled to the first input node. The diode is coupled between the common drain of the first and second field effect transistors and an output node, so as to increase the speed of the operation in the application circuit utilizing the above rectifying transfer gate circuit.

公开(公告)号：US5760238A

公开(公告)日：1998-06-02

申请号：US793283

申请日：1997-02-25

申请人： Kunio Isshiki ,  Naoki Matsumoto ,  Takashi Nakashima ,  Kazuyuki Dobashi ,  Takurou Tsuruta ,  Takeo Yoshioka

发明人： Kunio Isshiki ,  Naoki Matsumoto ,  Takashi Nakashima ,  Kazuyuki Dobashi ,  Takurou Tsuruta ,  Takeo Yoshioka

IPC分类号： C07D211/90 ,  C07D401/12 ,  C07D401/14 ,  C12P17/12

CPC分类号： C07D401/12 ,  C07D211/90 ,  C07D401/14

摘要： Disclosed are 1,4-dihydropyridine derivatives represented by the general formula (I) and salts thereof, as well as optical active 1,4-dihydropyridine derivatives represented by the general formula (II) and salts thereof which are obtained from the derivative by biochemical reactions using microorganisms or enzymes and useful as preventive and therapeutic agents for ischemic heart diseases and hypertension. ##STR1## (wherein x and Y are H, NO.sub.2, CN, halogen; R.sup.1 and R.sup.2 are H, CHO, substituted alkylcarbonyl, crotonyl, cinnamoyl, alkoxycarbonyl, aryloxycarbonyl, benzyloxycarbonyl, carboxybenzoyl, or R.sup.1 and R.sup.2 taken together represent phthaloyl; n is an integer of 1 to 3).

摘要翻译： PCT No.PCT / JP95 / 01606 Sec。 371日期1997年2月25日 102（e）日期1997年2月25日PCT提交1995年8月11日PCT公布。 公开号WO96 / 06829 日期：1996年3月7日公开了由通式（I）表示的1,4-二氢吡啶衍生物及其盐，以及由通式（II）表示的光学活性1,4-二氢吡啶衍生物及其盐， 通过使用微生物或酶的生物化学反应从衍生物中获得，并且可用作缺血性心脏病和高血压的预防和治疗剂。 （Ⅰ）（Ⅰ）（Ⅱ）（其中x和Y是H，NO2，CN，卤素; R1和R2是H，CHO，取代的烷基羰基，巴豆基，肉桂酰，烷氧羰基，芳氧羰基，苄氧基羰基，羧基苯甲酰基或 R1和R2一起代表邻苯二甲酰基; n是1至3的整数）。

公开(公告)号：US5635395A

公开(公告)日：1997-06-03

申请号：US387750

申请日：1995-02-21

申请人： Kunio Isshiki ,  Takashi Nakashima ,  Takeo Yoshioka ,  Hiroshi Tsunekawa ,  Takashi Adachi ,  Tomomi Ota

发明人： Kunio Isshiki ,  Takashi Nakashima ,  Takeo Yoshioka ,  Hiroshi Tsunekawa ,  Takashi Adachi ,  Tomomi Ota

IPC分类号： C07D211/90 ,  C12P17/12 ,  C12P41/00 ,  A01N43/40 ,  C07D213/803

CPC分类号： C07D211/90 ,  C12P17/12 ,  C12P41/005

摘要： (4R)-3-(Substituted aminoalkyl)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-5-carboxylic acids can be prepared efficiently, by reacting bis(substituted aminoalkyl) 1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-3,5-dicarboxylates with a microorganism capable of asymmetric hydrolysis and belonging to the genus Streptomyces, the genus Paecilomyces, the genus Botryodioplodia, the genus Alternaria or the genus Helminthosporium, or a treated product thereof. The compounds are extremely useful as important intermediates for preparation of pharmaceuticals useful for the prevention and treatment of angina pectoris, hypertension, etc.

摘要翻译： PCT No.PCT / JP93 / 01222 Sec。 371日期1995年2月21日 102（e）1995年2月21日PCT PCT 1993年8月31日PCT公布。 公开号WO94 / 05637 日期：1994年3月17日（4R）-3-（取代氨基烷基）氧羰基-1,4-二氢-2,6-二甲基-4-（硝基苯基）吡啶-5-羧酸可以通过双 取代的氨基烷基）1,4-二氢-2,6-二甲基-4-（硝基苯基）吡啶-3,5-二羧酸盐与能够不对称水解的微生物属于链霉菌属，拟青霉属，Botryodioplodia属， 链格孢属或Helminthosporium属，或其处理产物。 该化合物作为制备可用于预防和治疗心绞痛，高血压等的药物的重要中间体非常有用。

公开(公告)号：US5398240A

公开(公告)日：1995-03-14

申请号：US996592

申请日：1992-12-24

申请人： Takashi Nakashima ,  Yoshikazu Nobutoki ,  Osamu Michihira ,  Toshimichi Tokunaga

发明人： Takashi Nakashima ,  Yoshikazu Nobutoki ,  Osamu Michihira ,  Toshimichi Tokunaga

IPC分类号： H04L29/06 ,  H04L12/40

CPC分类号： H04L29/06

摘要： In a multiplex transmission apparatus and a multiplex transmission method when a control unit reads reception data while a status flag is set, it determines that the reception data is obtained before data in a transmission buffer is transmitted. When the control unit reads the reception data while the status flag is reset, it determines that the read data is response data to transmission data. Thus, the control unit precisely recognizes the time series of data on communication control.

摘要翻译： 在多路传输装置和复用传输方法中，当控制单元在设置状态标志时读取接收数据时，确定在发送缓冲器中的数据之前获得接收数据。 当控制单元在状态标志被复位时读取接收数据，确定读取的数据是发送数据的响应数据。 因此，控制单元精确地识别关于通信控制的数据的时间序列。

公开(公告)号：US5341294A

公开(公告)日：1994-08-23

申请号：US748838

申请日：1991-08-23

申请人： Hirotaka Kanazawa ,  Takeshi Edahiro ,  Hiroki Yoshioka ,  Nobuhiro Totoki ,  Hiroyuki Noda ,  Takashi Nakashima ,  Hiroshi Ohmura ,  Takeshi Murai ,  Ryuya Akita

发明人： Hirotaka Kanazawa ,  Takeshi Edahiro ,  Hiroki Yoshioka ,  Nobuhiro Totoki ,  Hiroyuki Noda ,  Takashi Nakashima ,  Hiroshi Ohmura ,  Takeshi Murai ,  Ryuya Akita

IPC分类号： B62D7/15 ,  B62D5/06 ,  B62D6/02

CPC分类号： B62D7/1545 ,  B62D7/1518 ,  B62D7/159

摘要： In a four wheel steering system, the rear wheel turning mechanism is connected to the front wheel turning mechanism by way of a rear wheel turning angle ratio changing mechanism which is mechanically connected to both the front wheel turning mechanism and the rear wheel turning mechanism and transmits the mechanical displacement input thereinto from the front wheel turning mechanism to the rear wheel turning mechanism to drive the same by an amount the ratio of which to the amount of mechanical displacement input into the rear wheel turning angle ratio changing mechanism gives a predetermined rear wheel turning angle ratio. The rear wheel turning angle ratio changing mechanism is controlled in such a way that, when the front wheels are turned from the neutral position in a middle vehicle speed range, makes the rear wheel turning angle ratio negative for a moment immediately after initiation of turning of the front wheels and thereafter turns the same positive.

摘要翻译： 在四轮转向系统中，后轮转向机构通过与后轮转向机构和后轮转动机构机械连接的后轮转角变更机构与前轮转向机构连接， 从前轮转向机构到后轮转向机构的机械位移输入，以将其相对于输入到后轮转向角比变更机构的机械位移量的比例驱动到后轮转向机构， 角度比。 控制后轮转向角变更机构，使得当前轮在中间车速范围内从中立位置转动时，使后轮转向角比率在开始转动之后立刻为负 前轮然后转动相同的正面。

公开(公告)号：US5201382A

公开(公告)日：1993-04-13

申请号：US677528

申请日：1991-03-29

申请人： Takeshi Edahiro ,  Ryuya Akita ,  Hiroshi Ohmura ,  Takashi Nakashima ,  Takeshi Murai

发明人： Takeshi Edahiro ,  Ryuya Akita ,  Hiroshi Ohmura ,  Takashi Nakashima ,  Takeshi Murai

IPC分类号： B62D6/00 ,  B60K28/16 ,  B60T8/175 ,  B60T8/1769 ,  B62D7/14 ,  B62D7/15 ,  B62D101/00 ,  B62D103/00 ,  B62D105/00 ,  B62D109/00 ,  F02D29/02

CPC分类号： B62D7/148 ,  B60K28/16 ,  B60T8/175 ,  B60T8/1769 ,  B62D7/159 ,  B60T2260/022

摘要： A front drive vehicle is provided with a four-wheel steering system and a traction control system. A control system for the vehicle detects whether a failure occurs in the traction control system, and causes the rear wheel turning mechanism to turn the rear wheels according to corrected rear wheel turning characteristics when it is determined that a failure occurs in the traction control system. The corrected rear wheel turning characteristics are shifted toward the reverse phase side with respect to the original rear wheel turning characteristics.

摘要翻译： 前驱车辆设有四轮转向系统和牵引力控制系统。 用于车辆的控制系统检测在牵引力控制系统中是否发生故障，并且当确定在牵引力控制系统中发生故障时，使后轮转向机构根据校正的后轮转向特性转动后轮。 校正后轮转向特性相对于原始后轮转向特性向相反侧移动。

公开(公告)号：US5176366A

公开(公告)日：1993-01-05

申请号：US592717

申请日：1990-10-04

申请人： Kenji Masumoto ,  Takashi Nakashima

发明人： Kenji Masumoto ,  Takashi Nakashima

IPC分类号： H01L23/50 ,  H01L21/48 ,  H01L23/495 ,  H01L23/498

CPC分类号： H01L21/4839 ,  H01L23/49558 ,  H01L23/49861 ,  H01L2924/0002

摘要： A semiconductor device in which outer leads adjoining in the direction of arrangement of said outer leads are connected by an insulating material with a predetermined width, locally provided only in the areas with said predetermined width along said direction of arrangement, and in which areas other than said outer leads and said insulating material are resin-sealed. A method for manufacturing a semiconductor device, which has the steps of connecting adjacent outer leads, with an insulating material with a predetermined width locally provided only in areas with said predetermined width along the direction of arrangement of outer leads, and of resin-sealing areas other than said outer leads and said insulating material while preventing the outflow of sealing resin by way of said insulating material.

公开(公告)号：US5078225A

公开(公告)日：1992-01-07

申请号：US689109

申请日：1991-04-24

申请人： Hiroshi Ohmura ,  Takashi Nakashima

发明人： Hiroshi Ohmura ,  Takashi Nakashima

IPC分类号： B62D5/04

CPC分类号： B62D5/0469

摘要： A system having a motor operatively connected to a steering system for reducing the steering effect is provided with a steering torque sensor for detecting steering torque in the steering system during a steering operation, an alternator output level sensor for detecting the output level of an engine driven alternator, and an ignition key switch sensor. In response to the output signal of the steering torque sensor, an assist signal is provided. In response to the output level of the alternator output level sensor and the position of the ignition key switch, an engine stall condition is detected. When engine stall occurs, the output torque of the motor is controlled in response to the assist signal for a predetermined period.

摘要翻译： 具有可操作地连接到用于减小转向效果的转向系统的电动机的系统设置有用于在转向操作期间检测转向系统中的转向转矩的转向转矩传感器，用于检测发动机驱动的输出水平的交流发电机输出电平传感器 交流发电机和点火钥匙开关传感器。 响应于转向转矩传感器的输出信号，提供辅助信号。 响应于交流发电机输出电平传感器的输出电平和点火开关的位置，检测到发动机失速状态。 当发动机失速时，响应于辅助信号控制电动机的输出转矩一段预定的时间。

公开(公告)号：US20130205861A1

公开(公告)日：2013-08-15

申请号：US13878275

申请日：2011-10-17

申请人： Takuya Hanada ,  Takashi Nakashima ,  Tetsuo Yokoyama ,  Kouichi Kuroda ,  Tatsuya Okui

发明人： Takuya Hanada ,  Takashi Nakashima ,  Tetsuo Yokoyama ,  Kouichi Kuroda ,  Tatsuya Okui

IPC分类号： B21C1/22

CPC分类号： B21C1/22 ,  B21C37/154 ,  F28F1/003

摘要： Provided is a method for producing a double-wall tube with braided wires at its interface in which the braided wires are interposed between an outer-wall and inner-wall blank tubes and then a drawing process is applied so as for the braided wires to be brought into close contact with the inner surface of the outer-wall tube and the outer surface of the inner-wall tube, the method comprising: polishing the inner surface of the outer-wall blank tube and the outer surface of the inner-wall blank tube so that a surface roughness thereof satisfies Ra

摘要翻译： 提供一种在其界面处制造具有编织线的双壁管的方法，其中编织线插入在外壁和内壁空白管之间，然后进行拉丝处理以使编织线为 与外壁管的内表面和内壁管的外表面紧密接触，该方法包括：抛光外壁空白管的内表面和内壁空白的外表面 使其表面粗糙度满足Ra <1.0μm，然后将编织线插入外壁和内壁空白管之间; 进行下沉拉伸处理，使得所得双壁管的外径相对于模孔直径的差异为0.1mm至0.3mm; 并进行热处理。 所生产的双壁管适合用作传热管。