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公开(公告)号：US06719775B2
公开(公告)日：2004-04-13
申请号：US09766938
申请日：2001-01-22
IPC分类号： A61M2902
CPC分类号： A61M25/1006 , A61B17/22031 , A61B17/22032 , A61B2017/320044 , A61B2017/320048 , A61B2017/320741 , A61B2017/3435 , A61M25/0119 , A61M2025/109
摘要： Methods and devices for separating plaque from vessel walls using everting membranes. Everting tubes disposed on catheters are used in one embodiment of the invention to separate plaque from blood vessel walls. One embodiment of the invention utilizes a single everting membrane including a fixed portion, a leading edge, and an advancing portion. The everting tube can have an interior which can be pressurized to propel the everting tube distal edge distally onward, so as to separate the plaque from the vessel inner wall. One device has double everting membranes fixedly attached to a tubular member and having facing advancing membrane portions which may be proximally fixed relative to one another, but are preferably both free to travel distally. The outermost tube can be laid down over the vessel inner wall and the innermost tube laid down over the plaque, with the advancing surfaces of each everting membrane facing each other. Fluid can be supplied under pressure to fill the interior of the everting tubes and thereby distally advance the tube leading edges. The present invention may be used in conjunction with distal emboli capturing filter or distal occlusion devices.
摘要翻译： 用永久膜分离血管壁的方法和装置。 在本发明的一个实施方案中使用设置在导管上的Everting管将斑块与血管壁分开。 本发明的一个实施例使用包括固定部分，前缘和前进部分的单个过渡膜。 转管可以具有内部，其可以被加压以向远侧向前推动脱开管远侧边缘，以便从容器内壁分离斑块。 一个装置具有固定连接到管状构件并且具有相对于彼此可以近端固定的面向前进的膜部分的双重过渡膜，但优选地是两个自由地向远侧行进。 最外面的管可以放置在容器内壁上方，并且最内侧的管放置在斑块上，其中每个过渡膜的前进表面彼此面对。 可以在压力下提供流体以填充出口管的内部，从而使管前缘向远侧前进。 本发明可以与远端栓塞捕获过滤器或远端闭塞装置结合使用。
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公开(公告)号：US06500186B2
公开(公告)日：2002-12-31
申请号：US09836957
申请日：2001-04-17
IPC分类号： A61B1722
CPC分类号： A61B17/320725 , A61B17/3207 , A61B17/320758 , A61B2017/22061 , A61B2017/320004 , A61B2017/320716 , A61B2017/320733 , A61F2/82
摘要： A system for removing matter from a partially or totally occluded stent includes a cutter that is urged radially outward toward the inner surface of the stent. Preferably, the cutter has a hardness that is less than or equal to the hardness of the material used to make the stent. Aspiration may be provided to remove portions of the occluding material from the vessel.
摘要翻译： 用于从部分或完全闭塞的支架中去除物质的系统包括朝向支架的内表面径向向外推动的切割器。 优选地，切割器具有小于或等于用于制造支架的材料的硬度的硬度。 可以提供吸入以从容器中除去阻塞材料的部分。
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63.发明授权公开(公告)号：US06416523B1
公开(公告)日：2002-07-09
申请号：US09678147
申请日：2000-10-03
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B1722
CPC分类号： A61B17/320758 , A61B17/3474 , A61B2017/00026 , A61B2017/0003 , A61B2017/22067 , A61B2017/22077 , A61B2017/22082 , A61B2017/22094 , A61B2090/08021 , A61B2217/005 , A61B2217/007
摘要： A method and apparatus for creating a lumen through a total vascular occlusion. A directional cutter is advanced ahead of a number of proximal electrodes that engage a vessel wall. Blood in the vessel between the directional cutter and the proximal electrodes is removed by sealing the vessel with an occluding balloon and pumping a bio-compatible gas into the vessel to displace the blood. A signal source is applied to the directional cutter and used to measure the impedance between the directional cutter and each of the proximal electrodes. If the cutter engages a vessel wall, the impedance between the cutter and the proximal electrode decreases. A physician monitors the impedance to know when the vessel wall is engaged and turns the direction of the cutter away from the vessel wall such that the cutter continues creating a lumen within the occluding material. Once a lumen has been created in the occluding material, the cutter and electrodes are removed from the vessel and the vessel is treated with a conventional atherectomy device. In another embodiment of the invention, the signal source supplies a pacing signal to the directional cutter. If the cutter is embedded within an occlusion, the heart is not captured by the pacing signal. Once the cutter contact the vessel wall, the heart is captured and the physician changes the direction of the cutter to continue creating the lumen within the occlusion.
摘要翻译： 一种用于通过全血管闭塞产生内腔的方法和装置。 定向切割器在与血管壁接合的多个近端电极的前方前进。 通过用封闭气囊密封容器并将生物相容性气体泵入容器以置换血液来移除定向切割器和近端电极之间的血管中的血液。 将信号源施加到定向切割器，并用于测量定向切割器与每个近端电极之间的阻抗。 如果切割器接合血管壁，切割器和近端电极之间的阻抗减小。 医生监测阻抗以知道血管壁何时被接合并且使切割器的方向远离血管壁，使得切割器继续在闭塞材料内产生内腔。 一旦在封闭材料中产生内腔，则将切割器和电极从容器中取出，并用常规的粥样斑块切除装置处理血管。 在本发明的另一个实施例中，信号源向定向切割器提供起搏信号。 如果切割器嵌入在闭塞中，则心脏不被起搏信号捕获。 一旦切割器接触血管壁，就会捕获心脏，并且医师改变切割器的方向，以继续在闭塞内产生内腔。
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公开(公告)号：US06343605B1
公开(公告)日：2002-02-05
申请号：US09634112
申请日：2000-08-08
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B1900
CPC分类号： A61B17/3207 , A61B10/0266 , A61B17/32053 , A61B17/3421 , A61B18/24 , A61B2017/00252 , A61B2017/00969 , A61B2017/22077 , A61B2017/306 , A61B2017/3488 , A61B2017/3492 , A61B2018/00291 , A61F2/02 , A61F2/2487 , A61M2025/0089 , A61M2025/009 , A61N1/36042
摘要： Devices and methods for increasing the volume of blood pumped by a heart muscle are disclosed. A therapeutic catheter in accordance with the present invention may comprise an elongate shaft having a proximal end, a distal end, and a lumen extending through at least a portion thereof. The therapeutic catheter may further include a cutter having a cutter lumen fixed to the distal end of the elongate shaft, and a mooring shaft slidingly disposed within the lumen of the elongate shaft. A method in accordance with the present invention may include the steps of engaging a muscle of a donor site with a portion of the mooring shaft, penetrating the muscle of the donor site with the cutter to form a muscle tendril, withdrawing the muscle tendril from the muscle of the donee site, positioning the distal end of the therapeutic catheter proximate a pit defined by the tissue of a donee site, inserting the muscle tendril into the tissue of the donee site, and disengaging the mooring shaft from the muscle tendril.
摘要翻译： 公开了用于增加由心脏肌肉泵送的血液体积的装置和方法。 根据本发明的治疗导管可以包括具有近端，远端和延伸穿过其至少一部分的内腔的细长轴。 治疗导管还可以包括具有固定到细长轴的远端的切割器内腔的切割器和滑动地设置在细长轴的内腔内的系泊轴。 根据本发明的方法可以包括以下步骤：将供体部位的肌肉与系泊轴的一部分接合，用切割器穿过供体部位的肌肉，以形成肌肉卷须，从肌肉卷起退出肌肉卷须 接合点位置的肌肉，将治疗导管的远端定位在由受精部位的组织限定的凹坑附近，将肌肉卷帘插入到受精部位的组织中，并使系泊轴与肌肉卷发脱离接触。
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公开(公告)号：US5964782A
公开(公告)日：1999-10-12
申请号：US932990
申请日：1997-09-18
CPC分类号： A61B18/148 , A61B17/0057 , A61B2017/00637 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2018/00196 , A61B2018/0022 , A61B2018/00273 , A61B2018/00279
摘要： An apparatus is provided for closing a perforation in a wall of a patient's blood vessel or other organs, and a method of introducing the apparatus and causing the closure are described. The apparatus includes an elongated support member having a distal end supporting one or more tissue engaging hooks configured to engage fibrous vessel tissue when moved in a first direction and to disengage the tissue when moved in a second direction, and a proximal end for applying rotational torque to the support member to cause the hooks to engage collagen fibrous tissue in the adventitia of the blood vessel or fibrous tissue in other body organs. The hooks engaging the collagen fiber causes the blood vessel tissue surrounding the perforation to be drawn into close proximity such that the perforation can be closed. The apparatus can be removed by applying reverse rotation of the support member, whereby the hooks are disengaged. The apparatus is deployed in an outer sheath with the hooks encased until a selected engaging location has been achieved. When positioned in the aperture to be closed, the hooks are exposed to allow interaction with the adventitia. Puncture closure can be accomplished by various techniques, including stasis, cauterizing, or by clamping. Various embodiments of the apparatus are described.
摘要翻译： 提供了用于封闭患者血管或其他器官的壁中的穿孔的装置，并且描述了引入该装置并引起闭合件的方法。 该装置包括细长的支撑构件，其具有支撑一个或多个组织接合钩的远端，所述组织接合钩构造成当沿第一方向移动时接合纤维血管组织，并且在沿第二方向移动时使组织脱离，以及用于施加旋转扭矩的近端 到支撑构件以引起钩将胶原纤维组织接合在血管的外膜或其他身体器官中的纤维组织中。 接合胶原纤维的钩使得穿孔周围的血管组织被拉近，使得穿孔可以闭合。 可以通过施加支撑构件的反向旋转来移除该装置，由此钩脱开。 该装置部署在外护套中，钩被包住，直到达到选定的接合位置。 当定位在要关闭的孔中时，钩暴露以允许与外膜相互作用。 穿刺闭合可以通过各种技术来实现，包括瘀斑，烧灼或夹紧。 描述该装置的各种实施例。
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公开(公告)号：US5868735A
公开(公告)日：1999-02-09
申请号：US812804
申请日：1997-03-06
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/02 , A61M29/02 , C21B13/00 , C22B5/14 , C22B23/02 , A61B17/36
CPC分类号： A61B18/02 , C21B13/0033 , C22B23/021 , C22B5/14 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.
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公开(公告)号：US5695468A
公开(公告)日：1997-12-09
申请号：US586514
申请日：1996-01-16
CPC分类号： A61M25/10186 , A61M25/1018 , A61M25/10187 , A61M25/1025 , A61M2025/0063 , A61M2025/0098 , A61M2025/1056 , A61M2025/1077
摘要： A balloon catheter is disclosed which includes a fluid displacement rod at least partially and slidably disposed in an elongate tubular member with a balloon connected to the distal end of the tubular member. A seal connected to the proximal end of the tubular member creates a liquid tight seal between the inside of the tubular member and the displacement rod. Accordingly, longitudinal actuation of the displacement rod causes the balloon to expand and/or contract. The balloon catheter may be a fixed wire, an over-the-wire or a single-operator exchange type balloon catheter. In addition, a pressure gauge may be connected to the proximal end of the tubular member. A one-way valve is also disclosed which allows the balloon catheter to be prepped via the guide wire lumen. Accordingly, the present invention negates the need for both an inflation device and an inflation lumen which results in a significant improvement in catheter performance and cost savings.
摘要翻译： 公开了一种气囊导管，其包括至少部分且可滑动地设置在细长管状构件中的流体移动杆，其中球囊连接到管状构件的远端。 连接到管状构件的近端的密封件在管状构件的内部和位移杆之间形成液体密封。 因此，位移杆的纵向致动导致气囊膨胀和/或收缩。 球囊导管可以是固定线，线上或单操作者交换型球囊导管。 此外，压力计可以连接到管状构件的近端。 还公开了允许通过导丝管腔准备球囊导管的单向阀。 因此，本发明不需要充气装置和充气腔，这导致导管性能和成本节省的显着改善。
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公开(公告)号：US5665103A
公开(公告)日：1997-09-09
申请号：US612158
申请日：1996-03-07
CPC分类号： A61F2/95 , A61B5/05 , A61B5/06 , A61B2017/00026 , A61B2017/0003
摘要： A method of detecting a metallic stent inside a living body wherein the method includes the steps of: (1) providing a stent locator device, (2) providing a metallic stent, (3) inserting the metallic stent into the living body, (4) inserting the stent locator into the living body and (5) locating the stent with the stent locator by detecting an electrical parameter affected by the position of the stent relative to the position of the locating device. The electrical parameter may be detected with a pair of electrodes or a coil mounted to the distal end of the stent locator. The stent locator may include one or more radiopaque markers mounted on the distal end such that the position of the stent may be radiographically correlated to the position of the stent locator device. Alternatively, the stent locator may include one or more visual markers mounted on the proximal end such that the position of the stent may be visually correlated to the position of the stent locator device. The stent locator may be in the form of virtually any intraluminal device such as a guide wire, a balloon catheter, an atherectomy catheter or a stent delivery catheter. In addition, the stent may be inserted prior to, subsequent to or simultaneously with the stent locator device.
摘要翻译： 一种在生物体内检测金属支架的方法，其中所述方法包括以下步骤：（1）提供支架定位装置，（2）提供金属支架，（3）将所述金属支架插入生物体中;（4） ）将支架定位器插入生物体中;（5）通过检测受到支架位置相对于定位装置的位置影响的电参数来定位具有支架定位器的支架。 可以用一对电极或安装在支架定位器的远端的线圈来检测电参数。 支架定位器可以包括安装在远端上的一个或多个不透射线的标记，使得支架的位置可以放射学地与支架定位器装置的位置相关。 或者，支架定位器可以包括安装在近端上的一个或多个视觉标记，使得支架的位置可以与支架定位器装置的位置视觉相关。 支架定位器可以是几乎任何管腔内装置的形式，例如导丝，气囊导管，动脉切除术导管或支架输送导管。 此外，支架可以在支架定位器装置之前，之后或同时插入。
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公开(公告)号：US08644934B2
公开(公告)日：2014-02-04
申请号：US11854844
申请日：2007-09-13
IPC分类号： A61N1/362
CPC分类号： A61N1/059 , A61N1/365 , A61N1/372 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3756
摘要： An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.
摘要翻译： 可植入心脏组织激励系统包括具有脉冲发生电路的可植入起搏控制器单元。 该系统还包括引线，引线体在可附接到起搏控制器单元的近端引导端与被配置为植入心脏内的远端引线端之间延伸。 引线导体在引线体内延伸。 该系统还包括位于远端引导端附近的发射器组件，其通过引线导体电连接到脉冲发生电路，以无线地发送起搏控制信息和起搏能量。 该系统还包括被配置成植入心脏内的无引线电极组件，其包括用于接收无线传输的接收器，用于存储充电能量的电荷存储单元，以及电刺激电路，以使用 起搏控制信息和充电能量。
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公开(公告)号：US08512399B2
公开(公告)日：2013-08-20
申请号：US12648221
申请日：2009-12-28
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61M25/1011
摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.
摘要翻译： 一种心脏瓣膜，其具有第一锚架和第一锚架上的盖子，用于单向流动液体通过该阀。
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