公开(公告)号：US6043271A

公开(公告)日：2000-03-28

申请号：US510213

申请日：1995-08-02

申请人： Michael T. Flavin ,  Ze-Qi Xu ,  John D. Rizzo ,  Alla Kucherenko ,  Albert Khilevich ,  Abram Kivovich Sheinkman ,  Vilayphone Vilaychack ,  Lin Lin ,  Wei Chen ,  William A. Boulanger

发明人： Michael T. Flavin ,  Ze-Qi Xu ,  John D. Rizzo ,  Alla Kucherenko ,  Albert Khilevich ,  Abram Kivovich Sheinkman ,  Vilayphone Vilaychack ,  Lin Lin ,  Wei Chen ,  William A. Boulanger

IPC分类号： C07D311/58 ,  A61K31/365 ,  A61K45/06 ,  A61P31/12 ,  A61P37/04 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  A61K31/35 ,  C07D407/00

CPC分类号： C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

摘要： A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing a viral infections using (.+-.)-calanolide or (-)-calanolide is provided.

摘要翻译： 提供了从色烯4制备（+/-） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。 还提供了制备（+/-） - 丙内酰脲A及其衍生物的有用中间体。 根据所公开的方法，在酸催化剂的存在下，将色烯4中间体与乙醛二乙基缩醛或对甲醛反应，或者在酸性条件或中性Mitsunobu条件下，包括醛醇与乙醛反应和醛化反应的两步反应， 产生苯并二氢吡喃酮7.在三氯化铈的存在下，用硼氢化钠还原色酮7.产生（+/-） - 甘露糖苷A。一种通过手性拆分（+/-） - 卡立拉内酯A至其光学活性形式的方法 还公开了HPLC系统或通过酶酰化和水解。 最后，提供了使用（+/-） - 蒎烯内酯或（ - ） - 蒎烯内酯治疗或预防病毒感染的方法。

公开(公告)号：US5892060A

公开(公告)日：1999-04-06

申请号：US609537

申请日：1996-03-01

申请人： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychak ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

发明人： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychak ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

IPC分类号： A61K45/06 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  C07D407/14

CPC分类号： C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

摘要翻译： 提供了从色烯4制备（+） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。 根据所公开的方法，将色烯4中间体与乙醛进行氯代钛介导的醛醇缩合反应以选择性地产生（+/-） - 8a。 （+） - 8a的（+/-） - 8a的分离和酶介导的分辨率。 （+） - 8a在中性Mitsunobu条件下循环，然后以高产率和对映异构体纯度，（+） - 7产生（+） - 卡立拉内酯A的Luche还原。 已经扩展了本发明的方法，以产生强效的抗病毒性甘露糖苷A类似物。

公开(公告)号：US5874591A

公开(公告)日：1999-02-23

申请号：US925707

申请日：1997-09-09

申请人： Michael T. Flavin ,  Ze-Qi Xu ,  Vilayphone Vilaychack ,  Lin Lin

发明人： Michael T. Flavin ,  Ze-Qi Xu ,  Vilayphone Vilaychack ,  Lin Lin

IPC分类号： C07D311/58 ,  A61K31/365 ,  A61K45/06 ,  A61P31/12 ,  A61P37/04 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  C07D493/00

CPC分类号： C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

摘要： A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (.+-.)-calanolide A or (-)-calanolide A is provided.

公开(公告)号：US5872264A

公开(公告)日：1999-02-16

申请号：US924803

申请日：1997-09-05

申请人： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychack ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

发明人： Michael T. Flavin ,  Ze-Qi Xu ,  Albert Khilevich ,  David Zembower ,  John D. Rizzo ,  Shuyuan Liao ,  Aye Mar ,  Lin Lin ,  Vilayphone Vilaychack ,  Darko Brankovic ,  Sergey Dzekhster ,  Jinjun Liu

IPC分类号： A61K45/06 ,  C07D311/16 ,  C07D493/04 ,  C07D493/14 ,  C07D493/22

CPC分类号： C07D493/04 ,  A61K45/06 ,  C07D311/16 ,  C07D493/14

摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (.+-.)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

摘要翻译： 提供了从色烯4制备（+） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。 根据所公开的方法，将色烯4中间体与乙醛进行氯代钛介导的醛醇缩合反应以选择性地产生（+/-） - 8a。 （+） - 8a的（+/-） - 8a的分离和酶介导的分辨率。 在中性Mitsunobu条件下环化（+） - 8a，然后以高产率和对映体纯度，（+/-） - 7产生（+） - 卡立拉内酯A的Luche还原。 已经扩展了本发明的方法，以产生强效的抗病毒性甘露糖苷A类似物。

公开(公告)号：US10302876B2

公开(公告)日：2019-05-28

申请号：US13398312

申请日：2012-02-16

申请人： Soren Grinderslev ,  Lin Lin

发明人： Soren Grinderslev ,  Lin Lin

IPC分类号： G02B6/36 ,  G02B6/38 ,  G02B6/32

摘要： A connector comprising a first outer housing defining at least one cavity, the cavity being cylindrical, a first insert disposed in the cavity, the first insert comprising at least a first housing, the housing being cylindrical, a first ferrule in the first housing, the first ferrule configured with arcuate sides to be received in the cavity, the first ferule comprising an end face, at least one alignment hole for receiving an alignment pin defined in the end face, and at least one fiber-receiving channel for receiving an optical fiber, an optical fiber disposed in the fiber-receiving channel of the first ferrule.

公开(公告)号：US09844728B2

公开(公告)日：2017-12-19

申请号：US14358967

申请日：2011-12-16

申请人： Jinming Cao ,  Lin Hou ,  Chao Guo ,  Xingguang Yu ,  Huiqiang Liu ,  Kerry Yang ,  Lin Lin

发明人： Jinming Cao ,  Lin Hou ,  Chao Guo ,  Xingguang Yu ,  Huiqiang Liu ,  Kerry Yang ,  Lin Lin

IPC分类号： A63F9/24 ,  A63F13/00 ,  G06F17/00 ,  G06F19/00 ,  A63F13/79 ,  H04L12/58 ,  A63F13/30

CPC分类号： A63F13/79 ,  A63F13/12 ,  A63F13/34 ,  A63F2300/5546 ,  A63F2300/57 ,  H04L51/32

摘要： An apparatus and method for providing social network content in an online game is disclosed herein. Content is obtained from a social network site and is displayed within the game. The game also provides a mechanism for the user of the game to generate content to the posted within the social network from within the game. Such generated content is automatically posted in the social network for a recipient specified by the user.

公开(公告)号：US09082409B2

公开(公告)日：2015-07-14

申请号：US12200384

申请日：2008-08-28

申请人： Lin Lin ,  Ping Lin

发明人： Lin Lin ,  Ping Lin

IPC分类号： G10L21/00 ,  G10L25/00 ,  G06F17/00 ,  G06F17/20 ,  G06F3/00 ,  G06F17/21 ,  G06F17/22 ,  G06F17/24 ,  G06F17/25 ,  G06F17/26 ,  G06F17/27 ,  G06F17/28

CPC分类号： G06F3/167 ,  G06F17/00 ,  G06F17/2247 ,  G10L21/00 ,  G10L2015/228

摘要： A method, system and voice browser execute voice applications to perform a voice-based function. A document is retrieved and parsed to create a parse tree. Script code is created from the parse tree, thereby consuming part of the parse tree to create a reduced parse tree. The reduced parse tree is stored in a cache for subsequent execution to perform the voice-based function.

摘要翻译： 一种方法，系统和语音浏览器执行语音应用来执行基于语音的功能。 检索并解析文档以创建解析树。 脚本代码是从解析树创建的，从而消耗部分解析树以创建一个简化的分析树。 缩减的分析树被存储在高速缓存中以便随后执行以执行基于语音的功能。

公开(公告)号：US08964029B2

公开(公告)日：2015-02-24

申请号：US11919541

申请日：2005-04-29

申请人： Alan M. Finn ,  Pengju Kang ,  Ziyou Xiong ,  Lin Lin ,  Pei-Yuan Peng ,  Meghna Misra ,  Christian Maria Netter

发明人： Alan M. Finn ,  Pengju Kang ,  Ziyou Xiong ,  Lin Lin ,  Pei-Yuan Peng ,  Meghna Misra ,  Christian Maria Netter

IPC分类号： H04N7/18 ,  G06K9/36 ,  G08B13/196

CPC分类号： G08B13/19652 ,  G06K9/00771 ,  G08B13/1963 ,  G08B13/19689

摘要： The present invention describes a system and method for surveillance cameras that maintain proper mapping of a mapped region of interest with an imaged region of interest based on feedback received regarding the current orientation of a surveillance camera. The system or method first determines the location of the imaged region of interest within the surveillance camera's imaged current field of view based on mechanical or imaged feedback, or a combination of both. The system or method then remaps the mapped region of interest within the surveillance camera's imaged current field of view such that the mapped region of interest is coextensive with the imaged region of interest.

公开(公告)号：US20130216189A1

公开(公告)日：2013-08-22

申请号：US13398312

申请日：2012-02-16

申请人： Soren Grinderslev ,  Lin Lin

发明人： Soren Grinderslev ,  Lin Lin

IPC分类号： G02B6/36

CPC分类号： G02B6/3879 ,  G02B6/32 ,  G02B6/3672 ,  G02B6/3825 ,  G02B6/3885

摘要： A connector comprising a first outer housing defining at least one cavity, the cavity being cylindrical, a first insert disposed in the cavity, the first insert comprising at least a first housing, the housing being cylindrical, a first ferrule in the first housing, the first ferrule configured with arcuate sides to be received in the cavity, the first ferule comprising an end face, at least one alignment hole for receiving an alignment pin defined in the end face, and at least one fiber-receiving channel for receiving an optical fiber, an optical fiber disposed in the fiber-receiving channel of the first ferrule.

摘要翻译： 一种连接器，包括限定至少一个空腔的第一外壳，所述空腔是圆柱形的，设置在所述空腔中的第一插入件，所述第一插入件包括至少第一壳体，所述壳体是圆柱形的，所述第一壳体中的第一套圈， 第一套圈构造成具有弓形侧面以容纳在空腔中，第一微细小孔包括端面，用于接收限定在端面中的对准销的至少一个对准孔以及用于接收光纤的至少一个光纤接收通道 ，设置在第一套圈的光纤接收通道中的光纤。

公开(公告)号：US20130202616A1

公开(公告)日：2013-08-08

申请号：US13749499

申请日：2013-01-24

申请人： Brad J. Spellberg ,  Lin Lin

发明人： Brad J. Spellberg ,  Lin Lin

IPC分类号： C12N9/86 ,  C07K16/40

CPC分类号： C12N9/86 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/40 ,  C12Y305/02006

摘要： The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.

摘要翻译： 本发明提供用于治疗或预防细菌发明的疫苗和药物组合物。 本发明的疫苗组合物包括碳青霉烯酶如丝氨酸碳青霉烯酶，金属β-内酰胺酶或其免疫原性片段。 药物组合物包括抗碳青霉烯酶抗体或其片段。 还提供了使用本发明的疫苗和药物组合物治疗和预防细菌感染的方法。 本发明还提供了抗体缀合物，其包括与铁载体或其类似物缀合的抗体或其片段。