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    Antineoplastic hydrogels, and enzyme-instructed preparations thereof
    61.
    发明授权
    Antineoplastic hydrogels, and enzyme-instructed preparations thereof 有权
    抗肿瘤水凝胶，及其酶制剂

    公开(公告)号：US08658600B2

    公开(公告)日：2014-02-25

    申请号：US13379801

    申请日：2010-06-24

    申请人： Yuan Gao ,  Yi Kuang ,  Bing Xu

    发明人： Yuan Gao ,  Yi Kuang ,  Bing Xu

    IPC分类号： A61K38/04 ,  A61K31/66 ,  C07F9/02

    CPC分类号： A61K47/48246 ,  A61K47/64 ,  C07D305/14 ,  C07F9/12 ,  C07F9/65512 ,  C07F9/6552 ,  C07K5/1016

    摘要： Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

    摘要翻译： 公开了一种制备具有双重作用的治疗分子的纳米纤维作为递送载体和药物本身的一般方法。 已经表明，通过适当的分子设计，酶反应和自组装的整合提供了一种有效的方法来产生临床使用的治疗剂的分子水凝胶而不损害其生物活性。 此外，本文公开的结果表明酶指导的自组装作为产生在水中固有地具有差的溶解度的分子的超分子水凝胶的简单策略。 例如，通过将紫杉醇与易于自组装的基序共价连接，可以形成紫杉醇的水凝胶而不损害紫杉醇的活性。

    Custom optimization of web pages
    62.
    发明授权
    Custom optimization of web pages 有权
    网页的自定义优化

    公开(公告)号：US08627204B2

    公开(公告)日：2014-01-07

    申请号：US13275346

    申请日：2011-10-18

    申请人： Mihai Octavian Coman ,  John Ronald Berkeley ,  Ethan Gur-esh ,  Oguz Mut ,  Adri Verlaan ,  Yuan Gao ,  Rahul Ramesh Deshpande

    发明人： Mihai Octavian Coman ,  John Ronald Berkeley ,  Ethan Gur-esh ,  Oguz Mut ,  Adri Verlaan ,  Yuan Gao ,  Rahul Ramesh Deshpande

    IPC分类号： G06F17/00 ,  G06F15/16 ,  H04B1/034

    CPC分类号： H04L41/0246 ,  G06F17/3089 ,  G06F17/30905 ,  H04N21/8586

    摘要： Web page optimization systems and methods are disclosed herein. In one implementation, a number of master pages and page layouts used to generate the web pages are defined. A number of channels are then defined to be associated with certain ones of the master pages and the page layouts. User device generating the request, a browser used to generate the request, and other suitable components of a user agent string in a web page request is then identified. A web page is rendered in response to the identified components of the user agent string using the master page and the page layout associated with a channel identified by such components of the web page request.

    摘要翻译： 本文公开了网页优化系统和方法。 在一个实现中，定义了用于生成网页的许多母版页和页面布局。 然后将多个通道定义为与某些主页面和页面布局相关联。 然后识别生成请求的用户设备，用于生成请求的浏览器以及网页请求中的用户代理字符串的其他合适的组件。 响应于所识别的用户代理字符串的组件，使用母版页和与由网页请求的这些组件标识的频道相关联的页面布局呈现网页。

    Phase Shift Keying Transmitter Circuit
    63.
    发明申请
    Phase Shift Keying Transmitter Circuit 有权
    相移键控变送器电路

    公开(公告)号：US20130163689A1

    公开(公告)日：2013-06-27

    申请号：US13699825

    申请日：2011-05-25

    申请人： Shengxi Diao ,  Yuan Gao ,  Yuanjin Zheng

    发明人： Shengxi Diao ,  Yuan Gao ,  Yuanjin Zheng

    IPC分类号： H04L27/20

    CPC分类号： H04L27/20 ,  H03B5/1215 ,  H03B5/1228 ,  H03B5/124 ,  H03C3/00 ,  H04B13/005 ,  H04L27/2046

    摘要： A phase shift keying transmitter circuit that includes: a variable frequency conversion stage adapted to receive a first data signal, wherein the variable frequency conversion stage comprises a plurality of frequency modulating elements, wherein the first data signal controls the number of the plurality of frequency modulating elements that are operated so as to control an operating frequency of the variable frequency conversion stage; and an output stage configured to switch between one of two possible outputs, the signals provided by one of the two possible outputs having an opposite polarity to the other, wherein the output stage is configured to receive a second data signal to control the switching between the two possible outputs, wherein the output stage is coupled to the variable frequency conversion stage and wherein the switching between the two possible outputs changes the phase of a signal from the variable frequency conversion stage by 180°.

    摘要翻译： 一种相移键控发送器电路，包括：适于接收第一数据信号的可变频率转换级，其中所述可变频率转换级包括多个频率调制元件，其中所述第一数据信号控制所述多个频率调制 操作以控制可变变频级的工作频率的元件; 以及输出级，被配置为在两个可能输出中的一个输出之间切换，由两个可能的输出之一提供的信号具有与另一个极性相反的极性，其中所述输出级被配置为接收第二数据信号以控制在 两个可能的输出，其中输出级耦合到可变频率转换级，并且其中两个可能输出之间的切换将来自可变频率转换级的信号的相位改变180°。

    TECHNIQUES FOR DETECTING INACTIVE BROWSER WINDOWS
    65.
    发明申请
    TECHNIQUES FOR DETECTING INACTIVE BROWSER WINDOWS 有权
    用于检测不活动浏览器窗口的技术

    公开(公告)号：US20120179744A1

    公开(公告)日：2012-07-12

    申请号：US12985805

    申请日：2011-01-06

    申请人： Blake Sullivan ,  Yuan Gao ,  Hongbing Wang

    发明人： Blake Sullivan ,  Yuan Gao ,  Hongbing Wang

    IPC分类号： G06F15/16

    CPC分类号： G06F3/0482 ,  G06F9/451 ,  G06F9/5022 ,  H04L67/02 ,  H04L67/22

    摘要： Embodiments of the present invention provide techniques for tracking the lifecycles of client-side browser windows in the context of a web application. In one set of embodiments, a server component of a web application can receive a notification that an application page in a first window has been unloaded/destroyed. In response, the server component can associate the first window with an expiration time and add the first window to an “expiration” list of windows that are potentially inactive. If a request is received by the server component from the first window while the first window is in the expiration list, the server component can identify the first window as active and remove it from the list. If a request is received by the server component from a second window after the expiration time associated with the first window, the server component can identify the first window as inactive and free all resources for the first window.

    摘要翻译： 本发明的实施例提供了用于在web应用的上下文中跟踪客户侧浏览器窗口的生命周期的技术。 在一组实施例中，web应用的服务器组件可以接收第一窗口中的应用页面已被卸载/销毁的通知。 作为响应，服务器组件可以将第一窗口与到期时间相关联，并将第一窗口添加到潜在不活动的窗口的“到期”列表。 如果服务器组件在第一个窗口处于到期列表时从第一个窗口接收到请求，则服务器组件可以将第一个窗口标识为活动状态，并将其从列表中移除。 如果服务器组件在与第一窗口相关联的到期时间之后从第二窗口接收到请求，则服务器组件可以将第一窗口识别为非活动状态并释放第一窗口的所有资源。

    System for streaming data from server to multiple slave browser windows in client computer through a master browser window
    66.
    发明授权
    System for streaming data from server to multiple slave browser windows in client computer through a master browser window 有权
    通过主浏览器窗口将数据从服务器传输到客户端计算机中的多个从属浏览器窗口的系统

    公开(公告)号：US07707513B2

    公开(公告)日：2010-04-27

    申请号：US12026819

    申请日：2008-02-06

    申请人： Tal Broda ,  Blake Sullivan ,  Xi Li ,  Edward J. Farrell ,  Yuan Gao

    发明人： Tal Broda ,  Blake Sullivan ,  Xi Li ,  Edward J. Farrell ,  Yuan Gao

    IPC分类号： G06F3/048

    CPC分类号： G06F17/30905 ,  H04L67/02

    摘要： A client computer has a master window and at least one slave window. The client computer receives streaming data at the master window. The master window includes a list of slave windows and the data includes an envelope that has a destination window identifier. The master window determines a destination window that corresponds to the window identifier. The master window dispatches the data to a slave window if the destination window is not the master window. Otherwise, the master window streams the data to the destination within the master window.

    摘要翻译： 客户端计算机具有主窗口和至少一个从属窗口。 客户端计算机在主窗口接收流数据。 主窗口包括从窗口列表，数据包括具有目的地窗口标识符的信封。 主窗口确定对应于窗口标识符的目标窗口。 如果目标窗口不是主窗口，则主窗口将数据分派到从窗口。 否则，主窗口将数据流传输到主窗口内的目的地。

    Novel strategy for selective regulation of background surface property in microarray fabrication and method to eliminated self quenching in micro arrays
    68.
    发明申请
    Novel strategy for selective regulation of background surface property in microarray fabrication and method to eliminated self quenching in micro arrays 审中-公开
    用于微阵列制备中背景表面性质的选择性调节的新策略以及在微阵列中消除自淬灭的方法

    公开(公告)号：US20080161202A1

    公开(公告)日：2008-07-03

    申请号：US11647580

    申请日：2006-12-29

    申请人： Edelmira Cabezas ,  Gunjan Tiwari ,  Jacqueline A. Fidanza ,  Yuan Gao

    发明人： Edelmira Cabezas ,  Gunjan Tiwari ,  Jacqueline A. Fidanza ,  Yuan Gao

    IPC分类号： C40B40/08 ,  C40B50/18 ,  C40B40/10 ,  C40B40/04

    CPC分类号： C40B40/10 ,  C40B40/06 ,  C40B50/18 ,  G01N33/54353 ,  G01N33/552

    摘要： A method for selective regulation of a background surface property of an array by adding a first building block molecule capable of forming a nucleotide or an amino acid bond on the spot and the background surface, adding a first protecting group to protect the first building block molecule on the spot and adding a second protecting group to protect the first building block molecule on the background surface, wherein the first protecting group is different from the second protecting group is disclosed. An array comprising a substrate comprising a substrate surface comprising a branched molecule wherein one end of branched molecule is attached to the substrate surface and the other end has many branches, further comprising a spacer in the branches to spread the branches and fluorophore molecules attached to the branches such that an average spacing between two fluorophore molecules is greater than 10 nm is disclosed.

    摘要翻译： 通过添加能够在现场和背景表面上形成核苷酸或氨基酸键的第一构建块分子，添加第一保护基以保护第一构建嵌段分子，选择性调节阵列的背景表面性质的方法 并且添加第二保护基以保护背景表面上的第一构建块分子，其中第一保护基与第二保护基不同。 一种包括基底的阵列，其包含基底表面，所述基底表面包含支链分子，其中支链分子的一端连接到基底表面，而另一端具有许多分支，还包括分支中的间隔物，以将分支和荧光团分子附着到 公开了两个荧光团分子之间的平均间隔大于10nm的分支。

    Fluorinated pentacene derivative and method of producing same
    69.
    发明申请
    Fluorinated pentacene derivative and method of producing same 有权
    氟化并五苯衍生物及其制备方法

    公开(公告)号：US20070083067A1

    公开(公告)日：2007-04-12

    申请号：US10578259

    申请日：2004-11-02

    申请人： Masafumi Kobayashi ,  Osamu Omae ,  Kimitaka Ohkubo ,  Yuan Gao

    发明人： Masafumi Kobayashi ,  Osamu Omae ,  Kimitaka Ohkubo ,  Yuan Gao

    IPC分类号： C07C25/13

    CPC分类号： C07C25/22 ,  C07C17/18 ,  C07C17/23 ,  C07C45/63 ,  C07C46/00 ,  C07C50/36 ,  C07C2603/52 ,  C07C49/697

    摘要： Fluorinated pentacene derivatives, for example, the novel compounds tetradecafluoropentacene, 5,6,7,12,13,14-hexafluoropentacene, 5,7,12,14-tetrafluoropentacene, and 6,13-difluoropentacene, and intermediates therefor are provided. And a method of producing fluorinated pentacene derivatives and intermediates therefor is also provided. Pentacene derivatives fluorinated at desired positions of the pentacene skeleton are obtained by introducing the oxo group, hydroxyl group, or alkoxyl group into the pentacene skeleton followed by fluorination with sulfur tetrafluoride and partial defluorination using a reducing agent.

    摘要翻译： 氟化并五苯衍生物，例如新化合物十四氟五苯，5,6,7,12,13,14-六氟戊烯，5,7,12,14-四氟戊并苯并咔唑和6,13-​​二氟戊烯及其中间体。 还提供了制备氟代并五苯衍生物的方法及其中间体。 通过将并入呋喃骨架中的氧代基，羟基或烷氧基引入到并五苯骨架的期望位置上氟化的并五苯衍生物，然后用四氟化硫进行氟化，并使用还原剂进行部分脱氟。