利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

87 条记录 (耗时 0.053 秒)

    Apparatus and methods for clot dissolution
    64.
    发明授权
    Apparatus and methods for clot dissolution 有权
    用于凝块溶解的装置和方法

    公开(公告)号：US07763010B2

    公开(公告)日：2010-07-27

    申请号：US10142005

    申请日：2002-05-08

    申请人： Michael A. Evans ,  Denise Demarais ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

    发明人： Michael A. Evans ,  Denise Demarais ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0021 ,  A61B17/22 ,  A61B17/320725 ,  A61B17/320758 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61M25/007 ,  A61M25/0105

    摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

    摘要翻译： 使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。 任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。 导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。 在一些实施例中，输注，抽吸和导丝通过共同内腔。 血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。 以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

    Apparatus and methods for compression of endoluminal prostheses
    68.
    发明授权
    Apparatus and methods for compression of endoluminal prostheses 失效
    用于压缩腔内假体的装置和方法

    公开(公告)号：US5749921A

    公开(公告)日：1998-05-12

    申请号：US603755

    申请日：1996-02-20

    申请人： Jay A. Lenker ,  Michael A. Evans ,  Steven W. Kim ,  Edward V. Kinney

    发明人： Jay A. Lenker ,  Michael A. Evans ,  Steven W. Kim ,  Edward V. Kinney

    IPC分类号： A61F2/06 ,  A61F2/84

    CPC分类号： A61F2/95 ,  A61F2/07 ,  A61F2002/9511 ,  A61F2002/9522 ,  A61F2002/9528

    摘要： The present invention provides devices and methods to promote the compression and/or recapture of endoluminal prostheses. An endoluminal prosthesis system generally comprises a tubular body and a radially compressible endoluminal prosthesis. The tubular body includes a lumen, while the prosthesis has a proximal end with a plurality of engageable structures radially disbursed thereabout. Each of a plurality of filaments extends distally from the lumen of the tubular body to an engageable structure so that tensioning of the filaments radially compresses the proximal end of the prosthesis. Preferably, a sheath then slides over the prosthesis, the sheath ideally having a plurality of axially oriented runners which form a radially flared structure to smoothly compress the prosthesis therebetween.

    摘要翻译： 本发明提供了用于促进腔内假体的压缩和/或再捕获的装置和方法。 腔内假体系统通常包括管状体和径向可压缩的腔内假体。 管状体包括内腔，而假体具有近端，多个可接合结构在其周围径向分布。 多根细丝中的每一根从管状体的内腔向远端延伸到可接合的结构，使得细丝的张紧径向地压缩假体近端。 优选地，护套然后在假体上滑动，护套理想地具有多个轴向定向的流道，其形成径向展开的结构以在其间平滑地压缩假体。

    Method and device for thermal ablation having improved heat transfer
    69.
    发明授权
    Method and device for thermal ablation having improved heat transfer 失效
    热消融的方法和装置具有改善的热传递

    公开(公告)号：US5542928A

    公开(公告)日：1996-08-06

    申请号：US266037

    申请日：1994-06-27

    申请人： Michael A. Evans ,  Colin J. Nichols ,  Laura Kemp ,  William R. Dubrul ,  Robert S. Behl

    发明人： Michael A. Evans ,  Colin J. Nichols ,  Laura Kemp ,  William R. Dubrul ,  Robert S. Behl

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61B17/22 ,  A61B18/00 ,  A61B18/04 ,  A61B18/08 ,  A61B19/00 ,  A61F7/00 ,  A61F7/12 ,  A61M1/00 ,  A61B17/36

    CPC分类号： A61B18/082 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/00292 ,  A61B2017/22038 ,  A61B2017/4216 ,  A61B2018/00095 ,  A61B2018/00422 ,  A61B2018/044 ,  A61B2018/046 ,  A61B2090/3933 ,  A61B2218/002 ,  A61F2007/0059 ,  A61F7/12 ,  A61M1/0084

    摘要： A thermal ablation catheter includes an elongate body member having a heating element disposed over a predetermined length of its distal end or within an axial lumen. The heating element is suspended away from an exterior surface of the elongate member to form a circulation region thereunder. Alternatively, the heating element is distributed over some or all of the axial lumen. Thermally conductive fluid can be introduced through the lumen in the elongate member and into the circulation region to effect heat transfer. The catheter is used to introduce the thermally conductive medium to a hollow body organ where the heating element raises the temperature of the medium sufficiently to induce injury to the lining of the organ. Optionally, an expandable cage in the catheter or on an associated introducer sheath may be used in combination with a thermal ablation catheter. The expandable cage helps center the heating element on the catheter within the body organ and prevents direct contact between the heating element and the wall of the organ. When disposed on the catheter, the cage can be useful to position a flow directing element attached to the flow delivery lumen of the catheter. Heat transfer and temperature uniformity can be enhanced by inducing an oscillatory flow of the heat transfer medium through the catheter while heat is being applied.

    摘要翻译： 热消融导管包括细长本体构件，其具有设置在其远端的预定长度上或在轴向腔内的加热元件。 加热元件从细长构件的外表面悬挂以形成其下的循环区域。 或者，加热元件分布在轴向内腔的一些或全部上。 导热流体可以通过细长构件中的内腔引入循环区域以实现热传递。 导管用于将导热介质引入中空体器官，其中加热元件足以使培养基的温度升高以引起对器官衬里的损伤。 任选地，导管中或相关导引鞘上的可膨胀笼可以与热消融导管结合使用。 可膨胀笼可帮助将加热元件放置在身体器官内的导管上，并防止加热元件与器官壁之间的直接接触。 当设置在导管上时，保持架可用于定位附接到导管的流动输送腔的流动引导元件。 通过在施加热量时通过导管引导传热介质的振荡流，可以增强热传递和温度均匀性。

    Vibrating catheter
    70.
    发明授权
    Vibrating catheter 失效
    振动导管

    公开(公告)号：US5498236A

    公开(公告)日：1996-03-12

    申请号：US320184

    申请日：1994-10-07

    申请人： Will R. Dubrul ,  Michael A. Evans

    发明人： Will R. Dubrul ,  Michael A. Evans

    IPC分类号： A61B17/22 ,  A61B17/32

    CPC分类号： A61B17/22 ,  A61B17/22012 ,  A61B2017/22084

    摘要： The present invention describes a catheter suitable for introduction into a tubular tissue for dissolving blockages in such tissue. The catheter is particularly useful for removing thrombi within blood vessels. In accordance with the preferred embodiments, a combination of vibrating motion and injection of a lysing agent is utilized to break up blockages in vessels. The vessels may be veins, arteries, ducts, intestines, or any lumen within the body that may become blocked from the material that flows through it. As a particular example, dissolution of vascular thrombi is facilitated by advancing a catheter through the occluded vessel, the catheter causing a vibrating stirring action in and around the thrombus usually in combination with the dispensing of a thrombolytic agent such as urokinase into the thrombus. The catheter has an inflatable or expandable member near the distal tip which, when inflated or expanded, prevents the passage of dislodged thrombus around the catheter. The dislodged portions of thrombus are directed through a perfusion channel in the catheter, where they are removed by filtration means housed within the perfusion channel before the blood exits the tip of the catheter. Catheters that allow both low frequency (1-1000 Hz) vibratory motion and delivery of such agents to a blockage and a method for using such catheters are disclosed.

    摘要翻译： 本发明描述了一种适于引入管状组织中以将阻塞物溶解在这种组织中的导管。 导管特别适用于去除血管内的血栓。 根据优选实施方案，利用振动运动和裂解剂注射的组合来分解血管中的阻塞。 血管可以是静脉，动脉，管道，肠道或身体内可能被流过其的物质阻塞的任何内腔。 作为一个具体实例，通过使导管穿过闭塞血管促进血管血栓的溶解，导管在血栓内和周围引起振动的搅拌作用，通常结合血栓溶解剂如尿激酶分配到血栓中。 导管在远侧末端附近具有可膨胀或可扩张的构件，当充气或膨胀时，其可以防止移位的血栓在导管周围通过。 血栓的脱落部分被引导通过导管中的灌注通道，在血液离开导管末端之前，通过过滤装置将其置于灌注通道内。 公开了允许低频（1-1000Hz）振动运动和这种试剂传递到阻塞的导管，以及使用这种导管的方法。