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公开(公告)号：US10324311B2
公开(公告)日：2019-06-18
申请号：US15168697
申请日：2016-05-31
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Ryan DeSousa
IPC: G02C7/10 , B29D11/00 , C08F2/48 , C08F2/50 , G02B1/04 , C07F7/30 , C07F9/09 , C08F26/06 , G02C7/04 , C08F220/54 , B29K83/00 , B29K105/00
Abstract: Described herein are acyl germanium photoinitiator for cost-effective and time-efficient method for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a method for making UV-absorbing contact lenses made by using an acyl germanium photoinitiator of the invention.
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公开(公告)号：US10227435B2
公开(公告)日：2019-03-12
申请号：US15376702
申请日：2016-12-13
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Jinyu Huang
IPC: C08L101/14 , C08L83/04 , C08F290/06 , G02B1/04 , C08G77/20 , C08G77/14 , C08G77/38 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20190061293A1
公开(公告)日：2019-02-28
申请号：US16114528
申请日：2018-08-28
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Ryan DeSousa
Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.
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公开(公告)号：US20180362697A1
公开(公告)日：2018-12-20
申请号：US16110194
申请日：2018-08-23
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , C08G77/20 , C08G77/16
CPC classification number: C08F290/068 , C08G77/12 , C08G77/16 , C08G77/20 , C08G77/392 , G02B1/043 , C08L83/04 , C08L101/14
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20180100053A1
公开(公告)日：2018-04-12
申请号：US15727666
申请日：2017-10-09
Applicant: Novartis AG
Inventor： Feng Jing , Frank Chang
IPC: C08K5/00 , C08K5/5419 , C08G77/14
CPC classification number: C08K5/0025 , C08F2810/20 , C08G77/14 , C08G77/20 , C08G77/38 , C08G77/388 , C08G77/392 , C08K5/5419 , G02C7/04
Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.
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Patent Agency Ranking
公开(公告)号：US20170242275A1
公开(公告)日：2017-08-24
申请号：US15434105
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , John Dallas Pruitt , Jared Nelson
IPC: G02C7/10 , C07D249/20 , B29D11/00 , C08F230/08 , G02B1/04 , G02C7/04 , C07C237/20 , C08F220/70
CPC classification number: G02C7/108 , B29D11/00134 , B29K2105/0002 , C07C233/38 , C07D249/20 , C08F20/36 , C08F220/70 , C08F230/08 , G02B1/043 , G02B5/208 , G02B5/223 , G02C7/049
Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
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公开(公告)号：US09720139B2
公开(公告)日：2017-08-01
申请号：US15446057
申请日：2017-03-01
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Venkat Shankar
IPC: C08L83/04 , C08F230/08 , C08G77/42 , C08G77/442 , G02C7/04 , G02B1/04 , C08G77/28 , C08G77/26 , B29D11/00 , B29K83/00 , B29K105/00
CPC classification number: G02B1/043 , B29D11/00134 , B29D11/00192 , B29K2083/00 , B29K2105/0061 , C08F220/00 , C08F220/58 , C08F230/08 , C08F290/068 , C08F2220/585 , C08G77/20 , C08G77/26 , C08G77/28 , C08G77/38 , C08G77/42 , C08G77/442 , C08G77/445 , C08G77/48 , C08G2210/00 , C08J3/03 , C08J3/075 , C08J3/28 , C08L51/085 , C08L83/06 , C08L83/10 , C08L83/14 , G02C7/04 , C08L83/04 , C08L101/14
Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
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公开(公告)号：US20170176643A1
公开(公告)日：2017-06-22
申请号：US15446057
申请日：2017-03-01
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Venkat Shankar
CPC classification number: G02B1/043 , B29D11/00134 , B29D11/00192 , B29K2083/00 , B29K2105/0061 , C08F220/00 , C08F220/58 , C08F230/08 , C08F290/068 , C08F2220/585 , C08G77/20 , C08G77/26 , C08G77/28 , C08G77/38 , C08G77/42 , C08G77/442 , C08G77/445 , C08G77/48 , C08G2210/00 , C08J3/03 , C08J3/075 , C08J3/28 , C08L51/085 , C08L83/06 , C08L83/10 , C08L83/14 , G02C7/04 , C08L83/04 , C08L101/14
Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
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公开(公告)号：US20170166674A1
公开(公告)日：2017-06-15
申请号：US15376702
申请日：2016-12-13
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Jinyu Huang
IPC: C08F290/06 , C08G77/20 , G02B1/04
CPC classification number: C08F290/068 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/38 , C08G2210/00 , G02B1/043 , C08L101/14 , C08L83/04
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US09568645B2
公开(公告)日：2017-02-14
申请号：US14496492
申请日：2014-09-25
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Ryan DeSousa
IPC: G02B1/04 , B29D11/00 , B29K83/00 , B29K105/00 , B29K105/24
CPC classification number: G02B1/043 , B29D11/00134 , B29K2083/005 , B29K2105/0005 , B29K2105/0061 , B29K2105/24 , C08L83/04 , C08L33/26
Abstract: The invention provides silicone hydrogel ophthalmic lenses (in particular contact lenses) having relatively-long thermal stability and methods for making such ophthalmic lenses.
Abstract translation: 本发明提供具有相当长的热稳定性的硅酮水凝胶眼用透镜（特别是隐形眼镜）以及制造这种眼科镜片的方法。
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