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公开(公告)号:US20100272647A1
公开(公告)日:2010-10-28
申请号:US12612267
申请日:2009-11-04
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
CPC分类号: C07K14/705
摘要: We disclose BACH G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof Nucleic acids capable of encoding BACH polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4 or a mouse BACH genomic sequence (SEQ ID NO: 10).
摘要翻译: 我们公开了包含SEQ ID NO:1所示氨基酸序列的BACH G蛋白偶联受体(GPCR)多肽。 3或SEQ ID NO:5及其同源物,变体和衍生物还能够公开能够编码BACH多肽的核酸,特别是包含SEQ ID No.1,SEQ ID No.2或SEQ所示的核酸序列的核酸 SEQ ID NO:4或小鼠BACH基因组序列(SEQ ID NO:10)。
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公开(公告)号:US20090187996A1
公开(公告)日:2009-07-23
申请号:US11926693
申请日:2007-10-29
申请人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Isabelle Malinge , Dirk Zahn
IPC分类号: G01N33/483 , G01N33/68 , A61K49/00 , C12Q1/68 , A01K67/027 , A01K67/00 , C07K14/47 , A61K39/395
CPC分类号: C07K14/705 , A61K49/0008
摘要: The present invention relates to a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of pain, the method comprising determining whether a candidate molecule is an agonist or antagonist, including a opener, blocker or modulator, of Kv9.2 polypeptide, in which the Kv9.2 polypeptide comprises the amino acid sequence shown in SEQ ID NO:3 or SEQ ID NO:5, or a sequence which is at least 90% identical thereto.
摘要翻译: 本发明涉及鉴定适于治疗,预防或缓解疼痛的分子的方法,所述方法包括确定候选分子是否是Kv9.2多肽的激动剂或拮抗剂,包括开启剂,阻断剂或调节剂, 其中Kv9.2多肽包含SEQ ID NO:3或SEQ ID NO:5所示的氨基酸序列,或与其至少90%相同的序列。
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公开(公告)号:USPP19943P2
公开(公告)日:2009-04-21
申请号:US12075634
申请日:2008-03-12
申请人: John Dixon
发明人: John Dixon
IPC分类号: A01H5/00
CPC分类号: A01H5/02
摘要: A new cultivar of Gaillardia named ‘FRENZY’ that is distinguishable by compact dwarf habit, medium-green foliage, and large red tubular flowers with bright yellow petal tips, blooming from early through late summer. In combination these traits set ‘FRENZY’ apart from all other existing varieties of Gaillardia known to the inventor.
摘要翻译: 一种新颖的盖拉迪亚品种被称为“FRENZY”,由紧凑的矮人习惯,中绿色的叶子和大型的红色管状花朵与明亮的黄色花瓣提示区分开来,从早到晚。 结合这些特征将“FRENZY”与发明家已知的所有其他现有品种的Gaillardia相比。
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公开(公告)号:US20090048200A1
公开(公告)日:2009-02-19
申请号:US12090741
申请日:2006-10-30
申请人: Alan Hendrick , John Dixon , Tere Michelle Tait , Rosa Fradley , Malcolm Sheardown , Haiping Liu , Kok Siu Foo
发明人: Alan Hendrick , John Dixon , Tere Michelle Tait , Rosa Fradley , Malcolm Sheardown , Haiping Liu , Kok Siu Foo
IPC分类号: A61K31/7088 , G01N33/00 , C12Q1/02 , A61P25/00 , A01K67/027 , C12Q1/68
CPC分类号: C07K14/723 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K48/00 , C07K14/705 , C12N15/8509 , G01N33/6896 , G01N2333/726 , G01N2500/04 , G01N2800/30
摘要: We disclose GPR26 G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding GPR26 polypeptide are also disclosed. The GPR26 receptor is useful in the diagnosis and therapy of mental illness.
摘要翻译: 我们公开了包含SEQ ID NO:1所示的氨基酸序列的GPR26G-蛋白偶联受体(GPCR)多肽。 3或SEQ ID NO:5,及其同源物,变体和衍生物。 还公开了能够编码GPR26多肽的核酸。 GPR26受体可用于精神疾病的诊断和治疗。
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公开(公告)号:US20070248545A1
公开(公告)日:2007-10-25
申请号:US11644011
申请日:2006-12-21
申请人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
发明人: Nicola Brice , Mark Carlton , John Dixon , Alan Hendrick , Isabelle Malinge , Sophie Messager , Dirk Zahn
CPC分类号: G01N33/566 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K49/0008 , C07K14/70571 , C12N15/8509 , G01N33/6893 , G01N2333/726 , G01N2500/00 , G01N2800/24 , G01N2800/52
摘要: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.
摘要翻译: 我们描述了鉴定适于治疗,预防或减轻GPR86相关疾病,特别是炎性疾病或疼痛的分子的方法,该方法包括确定候选分子是否是GPR86多肽的激动剂或拮抗剂,其中GPR86 多肽包含SEQ ID NO:3或SEQ ID NO:5或SEQ ID NO:7所示的氨基酸序列,其片段或与其至少90%相同的序列。
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公开(公告)号:US20070115082A1
公开(公告)日:2007-05-24
申请号:US11538251
申请日:2006-10-03
申请人: Mark Schirmer , John Dixon
发明人: Mark Schirmer , John Dixon
IPC分类号: H01H51/22
CPC分类号: H01H59/0009 , H01H1/0036 , H01H1/0237 , H01H2001/0052
摘要: A MEMS switch has 1) a first contact, and 2) a second contact that is movable relative to the first contact. At least one of the contacts is electrically conductive and has a platinum-series based material.
摘要翻译: MEMS开关具有1)第一触点,以及2)可相对于第一触点移动的第二触点。 触点中的至少一个是导电的并且具有基于铂系的材料。
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公开(公告)号:US20070101444A1
公开(公告)日:2007-05-03
申请号:US11529048
申请日:2006-09-28
申请人: Nicola Brice , John Dixon , Sophie Messager , Dirk Zahn
发明人: Nicola Brice , John Dixon , Sophie Messager , Dirk Zahn
IPC分类号: A01K67/027
CPC分类号: C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , A01K2267/0356 , C07K14/705 , G01N33/6872 , G01N2500/02 , G01N2800/2842
摘要: Provided are screens for identifying compounds capable of binding to TrpM8 polypeptide. Theses compounds can be antagonists of TrpM8 polypeptide activity. Also provided is a transgenic non-human animal having a functionally disrupted endogenous TrpM8 gene.
摘要翻译: 提供了用于鉴定能够结合TrpM8多肽的化合物的筛选。 这些化合物可以是TrpM8多肽活性的拮抗剂。 还提供了具有功能性破坏的内源TrpM8基因的转基因非人动物。
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公开(公告)号:US20060211903A1
公开(公告)日:2006-09-21
申请号:US10539137
申请日:2003-12-19
申请人: Kevin Blann , Annette Bollmann , John Dixon , Arno Neveling , David Morgan , Hulisani Maumela , Esna Killian , Fiona Hess , Stefanus Otto , Matthew overett
发明人: Kevin Blann , Annette Bollmann , John Dixon , Arno Neveling , David Morgan , Hulisani Maumela , Esna Killian , Fiona Hess , Stefanus Otto , Matthew overett
CPC分类号: C07C2/36 , B01J2531/0238 , B01J2531/62 , C07C2531/24 , C07C11/02
摘要: The invention describes a process for trimerisation olefins, which process includes the step of contacting an olefinic feedstream with a catalyst system which includes a transition metal compound and a heteroatomic ligand and wherein the trimer is an olefin and wherein the heteroatomic ligand is described by the following general formula (R)nA-B-C(R)m.
摘要翻译: 本发明描述了一种三烯化烯烃的方法,该方法包括使烯烃进料流与包含过渡金属化合物和杂原子配体的催化剂体系接触的步骤,其中三聚体是烯烃,其中杂原子配体由以下描述 通式(R)N(C)N(A)
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公开(公告)号:US20060173226A1
公开(公告)日:2006-08-03
申请号:US10539237
申请日:2003-12-19
申请人: Kevin Blann , Annette Bollmann , John Dixon , Arno Neveling , David Morgan , Hulisani Maumela , Esna Killian , Fiona Hess , Stefanus Otto , Matthew Overett , Michael Green
发明人: Kevin Blann , Annette Bollmann , John Dixon , Arno Neveling , David Morgan , Hulisani Maumela , Esna Killian , Fiona Hess , Stefanus Otto , Matthew Overett , Michael Green
CPC分类号: B01J31/188 , B01J31/1608 , B01J31/1616 , B01J31/165 , B01J31/18 , B01J31/1875 , B01J31/2204 , B01J31/2409 , B01J2231/20 , B01J2531/46 , B01J2531/48 , B01J2531/56 , B01J2531/58 , B01J2531/62 , B01J2531/64 , B01J2531/66 , C07C2/36 , C07C2531/24
摘要: The invention describes a process for tetramerisation of olefins wherein the product stream of the process contains more than 30% of the tetramer olefin. The process includes the step of contacting an olefinic feedstream with a catalyst system containing a transition metal compound and a heteroatomic ligand.
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公开(公告)号:US20050160486A1
公开(公告)日:2005-07-21
申请号:US10900930
申请日:2004-07-27
申请人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
发明人: Samuel Aparicio , Mark Carlton , John Dixon , Sophie Messager , Andreas Russ , Rosemary Thresher
IPC分类号: C07K14/705 , A01K67/027 , A61K38/17 , A61K39/395 , A61K48/00
CPC分类号: C07K14/705
摘要: We disclose a method of treating or preventing a disease selected from the group consisting of: a bladder disease, a bladder disorder, benign prostatic hyperplasia, bladder outlet obstruction, incontinence, including overflow and urge incontinence, urinary urge, cystitis, including interstitial cystitis and overactive bladder.
摘要翻译: 我们公开了一种治疗或预防选自以下的疾病的方法:膀胱疾病,膀胱病,良性前列腺增生,膀胱出口阻塞,失禁,包括溢流和急迫性尿失禁,尿急,膀胱炎,包括间质性膀胱炎和 膀胱过度活动
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