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72 条记录 (耗时 0.059 秒)

    Chk1 and uses thereof
    61.
    发明授权
    Chk1 and uses thereof 失效
    Chk1及其用途

    公开(公告)号：US06723498B1

    公开(公告)日：2004-04-20

    申请号：US09340264

    申请日：1999-06-30

    申请人： Andrew W. Shyjan ,  Mark Williamson ,  Shengfang Jin

    发明人： Andrew W. Shyjan ,  Mark Williamson ,  Shengfang Jin

    IPC分类号： C12Q100

    CPC分类号： C12Q1/6809 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/573 ,  G01N2333/9108 ,  G01N2333/9121

    摘要： Increased expression of Chk1 is associated with drug resistance of certain cells (e.g., cancer cells). The invention provides methods for identifying drug resistant cells by measuring the expression or activity of Chk1, methods for identifying modulators of drug resistance, and methods for modulating drug resistance by modulating the expression or activity of Chk1.

    摘要翻译： Chk1的增加的表达与某些细胞（例如癌细胞）的耐药性相关。 本发明提供了通过测量Chk1的表达或活性，鉴定药物抗性调节剂的方法和通过调节Chk1的表达或活性来调节药物抗性的方法来鉴定耐药性细胞的方法。

    Methods for using 22045, a human cyclic nucleotide phosphodiesterase
    62.
    发明授权
    Methods for using 22045, a human cyclic nucleotide phosphodiesterase 失效
    使用22045的人类环状核苷酸磷酸二酯酶的方法

    公开(公告)号：US06673564B2

    公开(公告)日：2004-01-06

    申请号：US09420190

    申请日：1999-10-18

    申请人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Mark Williamson

    发明人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Mark Williamson

    IPC分类号： C12Q144

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The present invention relates to methods for using a human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to methods for using polynucleotides encoding the phosphodiesterase. The invention relates to methods using the phosphodiesterase polypeptides and polynucleotides as a target for diagnosis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to agonists and antagonists identifiefd by drug screening methods with the phosphodiesterase polypeptides and polynucleotides as a target.

    摘要翻译： 本发明涉及使用属于哺乳动物磷酸二酯酶超家族的人环状核苷酸磷酸二酯酶的方法。 本发明还涉及使用编码磷酸二酯酶的多核苷酸的方法。 本发明涉及使用磷酸二酯酶多肽和多核苷酸作为磷酸二酯酶介导的或相关疾病中的诊断和治疗的靶标的方法。 本发明还涉及使用磷酸二酯酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于磷酸二酯酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及用磷酸二酯酶多肽和多核苷酸作为靶标的药物筛选方法鉴定的激动剂和拮抗剂。

    22012, human carboxypeptidase
    63.
    发明授权
    22012, human carboxypeptidase 失效
    22012，人羧肽酶

    公开(公告)号：US06369210B1

    公开(公告)日：2002-04-09

    申请号：US09345469

    申请日：1999-06-30

    申请人： Rosana Kapeller-Libermann ,  Kyle J. MacBeth ,  Mark Williamson

    发明人： Rosana Kapeller-Libermann ,  Kyle J. MacBeth ,  Mark Williamson

    IPC分类号： C07H2104

    CPC分类号： C12N9/48 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention relates to a newly identified human carboxypeptidase. The invention also relates to polynucleotides encoding the carboxypeptidase. The invention further relates to methods using the carboxypeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in carboxypeptidase-related disorders. The invention further relates to drug-screening methods using the carboxypeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the carboxypeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the carboxypeptidase polypeptides and polynucleotides.

    摘要翻译： 本发明涉及一种新鉴定的人类羧肽酶。 本发明还涉及编码羧肽酶的多核苷酸。 本发明还涉及使用羧肽酶多肽和多核苷酸作为羧肽酶相关病症诊断和治疗的靶标的方法。 本发明还涉及使用羧肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于羧肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生羧肽酶多肽和多核苷酸的方法。

    Flange assembly
    64.
    发明授权
    Flange assembly 有权
    法兰组装

    公开(公告)号：US09366369B2

    公开(公告)日：2016-06-14

    申请号：US13683728

    申请日：2012-11-21

    申请人： Mark Williamson

    发明人： Mark Williamson

    IPC分类号： F16L23/18 ,  F16L23/16

    CPC分类号： F16L23/16 ,  F16L23/003 ,  F16L23/02 ,  F16L23/18

    摘要： A flange assembly (10 comprising a flange (12) in the form of a disk shaped rim formed on a pipe section (14) for connection to a hose or pipe. The pipe section (14) defines a hollow bore (16) through which flowable material may flow and the flange (12) defines a contact face (18) for engagement, in use, with an opposing flange. The flange (12) defines a gasket seat (20) about an opening of the bore (16) to receive a gasket (22) and the flange assembly (10) further includes a gasket clamp (24a,24b) to releasably retain the gasket (22) in position on the gasket seat (20).

    摘要翻译： 一种凸缘组件（10），其包括形成在管段（14）上的盘形边缘形式的凸缘（12），用于连接到软管或管道。管段（14）限定一个中空孔（16） 可流动的材料可以流动并且凸缘（12）限定接触面（18），用于在使用中与相对的凸缘接合。凸缘（12）围绕孔（16）的开口限定密封垫座（20） 接收垫圈（22）并且所述凸缘组件（10）还包括垫圈夹具（24a，24b），以将垫圈（22）可释放地保持在垫圈座（20）上的适当位置。

    Integrated circuit chips, apparatuses for obtaining backscatter data from samples, methods of backscatter analysis, and methods of forming alpha particle emission and detection systems
    68.
    发明申请
    Integrated circuit chips, apparatuses for obtaining backscatter data from samples, methods of backscatter analysis, and methods of forming alpha particle emission and detection systems 失效
    集成电路芯片，用于从样本获得反向散射数据的装置，反向散射分析的方法和形成α粒子发射和检测系统的方法

    公开(公告)号：US20080258057A1

    公开(公告)日：2008-10-23

    申请号：US11787852

    申请日：2007-04-18

    申请人： Mark Williamson ,  Gurtej S. Sandhu

    发明人： Mark Williamson ,  Gurtej S. Sandhu

    IPC分类号： G01T1/24 ,  H01L21/00 ,  H01L31/115

    CPC分类号： H01L31/115

    摘要： Some embodiments include methods for fabricating an alpha particle emitter and detector associated with an integrated circuit chip. Some embodiments include an integrated circuit chip comprising an alpha particle emitter and detector supported by a semiconductor substrate. Some embodiments include an apparatus for obtaining backscatter data from a sample utilizing an alpha particle emission and detection system supported by a semiconductor substrate. Some embodiments include methods of backscatter analysis utilizing a semiconductor substrate containing an alpha particle emitter and an alpha particle sensor.

    摘要翻译： 一些实施例包括用于制造与集成电路芯片相关联的α粒子发射器和检测器的方法。 一些实施例包括集成电路芯片，其包括由半导体衬底支撑的α粒子发射器和检测器。 一些实施例包括用于利用由半导体衬底支持的α粒子发射和检测系统从样本获得反向散射数据的装置。 一些实施例包括使用含有α粒子发射器和α粒子传感器的半导体衬底的后向散射分析的方法。

    Human protein kinase, phosphatase, and protease family members and uses thereof
    69.
    发明授权
    Human protein kinase, phosphatase, and protease family members and uses thereof 失效
    新型人类蛋白激酶，磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号：US07282360B2

    公开(公告)日：2007-10-16

    申请号：US11636948

    申请日：2006-12-11

    申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    IPC分类号： C12N9/20 ,  C12N15/00 ,  C12N1/20 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C12N9/12 ,  C12N9/16 ,  C12N9/48 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    17867, a novel human aminopeptidase
    70.
    发明授权
    17867, a novel human aminopeptidase 失效

    公开(公告)号：US07034111B2

    公开(公告)日：2006-04-25

    申请号：US10039073

    申请日：2001-12-31

    申请人： Rosana Kapeller-Libermann ,  Mark Williamson

    发明人： Rosana Kapeller-Libermann ,  Mark Williamson

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00 ,  C07K5/00

    CPC分类号： C12Q1/37 ,  A61K38/00 ,  C12N9/48 ,  G01N2500/00 ,  Y02A50/475

    摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.