公开(公告)号：US09277970B2

公开(公告)日：2016-03-08

申请号：US13946661

申请日：2013-07-19

申请人： Tommaso Mansi ,  Olivier Ecabert ,  Saikiran Rapaka ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Olivier Ecabert ,  Saikiran Rapaka ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06K9/00 ,  A61B19/00 ,  G06T19/20 ,  G06T7/00 ,  A61N7/02 ,  G06F19/00 ,  A61B18/14 ,  A61B5/042 ,  A61B18/02 ,  A61N1/362 ,  A61B18/00 ,  A61N1/39

CPC分类号： A61B34/10 ,  A61B5/042 ,  A61B18/02 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2090/364 ,  A61B2090/3764 ,  A61N1/362 ,  A61N1/39 ,  A61N7/022 ,  G06T7/12 ,  G06T7/149 ,  G06T19/20 ,  G06T2207/10072 ,  G06T2207/20081 ,  G06T2207/20124 ,  G06T2207/30048 ,  G16H50/50

摘要： A method and system for patient-specific planning and guidance of an ablation procedure for cardiac arrhythmia is disclosed. A patient-specific anatomical heart model is generated based on pre-operative cardiac image data. The patient-specific anatomical heart model is registered to a coordinate system of intra-operative images acquired during the ablation procedure. One or more ablation site guidance maps are generated based on the registered patient-specific anatomical heart model and intra-operative patient-specific measurements acquired during the ablation procedure. The ablation site guidance maps may include myocardium diffusion and action potential duration maps. The ablation site guidance maps are generated using a computational model of cardiac electrophysiology which is personalized by fitting parameters of the cardiac electrophysiology model using the intra-operative patient-specific measurements. The ablation site guidance maps are displayed by a display device during the ablation procedure.

摘要翻译： 公开了一种用于患者特异性规划和指导心律失常消融手术的方法和系统。 基于手术前心脏图像数据生成患者特异性解剖心脏模型。 将患者特异性解剖心脏模型记录到在消融过程期间获取的手术中图像的坐标系。 基于注册的患者特异性解剖心脏模型和在消融过程期间获得的术中患者特异性测量来生成一个或多个消融部位引导图。 消融部位引导图可以包括心肌扩散和动作电位持续时间图。 使用心脏电生理学的计算模型产生消融部位指导图，其通过使用手术中患者特异性测量来拟合心脏电生理学模型的参数进行个性化。 在消融过程中，消融部位引导图由显示装置显示。

公开(公告)号：US20130197881A1

公开(公告)日：2013-08-01

申请号：US13754174

申请日：2013-01-30

申请人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06F17/50

CPC分类号： G06F17/5009 ,  A61B5/0044 ,  A61B5/055 ,  A61B8/0883 ,  A61B2576/023 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36585 ,  G06T17/00 ,  G06T2210/41 ,  G09B23/30 ,  G16H50/50

摘要： A method and system for patient-specific planning of cardiac therapy, such as cardiac resynchronization therapy (CRT), based on preoperative clinical data and medical images, such as ECG data, magnetic resonance imaging (MRI) data, and ultrasound data, is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image data of a patient. A patient-specific computational heart model, which comprises cardiac electrophysiology, biomechanics and hemodynamics, is generated based on the patient-specific anatomical model of the left and right ventricles and clinical data. Simulations of cardiac therapies, such as CRT at one or more anatomical locations are performed using the patient-specific computational heart model. Changes in clinical cardiac parameters are then computed from the patient-specific model, constituting predictors of therapy outcome useful for therapy planning and optimization.

摘要翻译： 公开了基于术前临床数据和医学图像（例如ECG数据，磁共振成像（MRI）数据和超声数据）的心脏治疗的患者特异性规划的方法和系统，例如心脏再同步治疗（CRT） 。 从患者的医学图像数据产生左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和临床数据生成包括心脏电生理学，生物力学和血液动力学的患者特异性计算心脏模型。 使用患者特异性计算心脏模型进行心脏治疗的模拟，例如在一个或多个解剖位置处的CRT。 然后从患者特异性模型计算临床心脏参数的变化，构成对治疗计划和优化有用的治疗结果的预测因子。

公开(公告)号：US10311978B2

公开(公告)日：2019-06-04

申请号：US13754174

申请日：2013-01-30

申请人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06F17/50 ,  A61B5/055 ,  A61N1/362 ,  A61N1/365 ,  G06F19/00 ,  G06T17/00 ,  G09B23/30 ,  G16H50/50 ,  A61B5/00 ,  A61B8/08

CPC分类号： G06F17/5009 ,  A61B5/0044 ,  A61B5/055 ,  A61B8/0883 ,  A61B2576/023 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36585 ,  G06T17/00 ,  G06T2210/41 ,  G09B23/30 ,  G16H50/50

摘要： A method and system for patient-specific planning of cardiac therapy, such as cardiac resynchronization therapy (CRT), based on preoperative clinical data and medical images, such as ECG data, magnetic resonance imaging (MRI) data, and ultrasound data, is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image data of a patient. A patient-specific computational heart model, which comprises cardiac electrophysiology, biomechanics and hemodynamics, is generated based on the patient-specific anatomical model of the left and right ventricles and clinical data. Simulations of cardiac therapies, such as CRT at one or more anatomical locations are performed using the patient-specific computational heart model. Changes in clinical cardiac parameters are then computed from the patient-specific model, constituting predictors of therapy outcome useful for therapy planning and optimization.

公开(公告)号：US09375195B2

公开(公告)日：2016-06-28

申请号：US13905939

申请日：2013-05-30

申请人： Ali Kamen ,  Tommaso Mansi ,  Bogdan Georgescu ,  Dorin Comaniciu

发明人： Ali Kamen ,  Tommaso Mansi ,  Bogdan Georgescu ,  Dorin Comaniciu

IPC分类号： G06K9/00 ,  A61B8/08 ,  A61B8/13 ,  A61B10/02 ,  A61B5/00 ,  G06T7/00 ,  A61B5/05 ,  A61B5/055 ,  A61B8/14 ,  A61B8/00

CPC分类号： A61B8/0841 ,  A61B5/055 ,  A61B5/7425 ,  A61B8/13 ,  A61B8/14 ,  A61B8/4254 ,  A61B8/463 ,  A61B8/483 ,  A61B8/485 ,  A61B8/5261 ,  A61B10/0233 ,  A61B10/0241 ,  G06T7/33 ,  G06T2207/10136 ,  G06T2207/30081

摘要： A method and system for real-time ultrasound guided prostate needle biopsy based on a biomechanical model of the prostate from 3D planning image data, such as magnetic resonance imaging (MRI) data, is disclosed. The prostate is segmented in the 3D ultrasound image. A reference patient-specific biomechanical model of the prostate extracted from planning image data is fused to a boundary of the segmented prostate in the 3D ultrasound image, resulting in a fused 3D biomechanical prostate model. In response to movement of an ultrasound probe to a new location, a current 2D ultrasound image is received. The fused 3D biomechanical prostate model is deformed based on the current 2D ultrasound image to match a current deformation of the prostate due to the movement of the ultrasound probe to the new location.

摘要翻译： 公开了一种基于3D规划图像数据（如磁共振成像（MRI））数据的前列腺生物力学模型的实时超声引导前列腺穿刺活检的方法和系统。 前列腺在3D超声图像中被分割。 从计划图像数据中提取的前列腺特异性参考生物力学模型融合到3D超声图像中分割的前列腺的边界，产生融合的3D生物力学前列腺模型。 响应于超声探头移动到新位置，接收当前的2D超声图像。 融合的3D生物力学前列腺模型基于当前的2D超声图像而变形，以匹配由于超声探头移动到新位置而导致的前列腺的当前变形。

公开(公告)号：US10325686B2

公开(公告)日：2019-06-18

申请号：US13928430

申请日：2013-06-27

申请人： Tommaso Mansi ,  Wei Keat Lim ,  Vanessa King ,  Andreas Kremer ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Andreas Keller ,  Cord Friedrich Staehler ,  Emil Wirsz ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Wei Keat Lim ,  Vanessa King ,  Andreas Kremer ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Andreas Keller ,  Cord Friedrich Staehler ,  Emil Wirsz ,  Dorin Comaniciu

IPC分类号： G16H50/50 ,  G16B5/00

摘要： A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode.

公开(公告)号：US20140022250A1

公开(公告)日：2014-01-23

申请号：US13946661

申请日：2013-07-19

申请人： Tommaso Mansi ,  Olivier Ecabert ,  Saikiran Rapaka ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Olivier Ecabert ,  Saikiran Rapaka ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： A61B19/00 ,  G06T19/20

CPC分类号： A61B34/10 ,  A61B5/042 ,  A61B18/02 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2090/364 ,  A61B2090/3764 ,  A61N1/362 ,  A61N1/39 ,  A61N7/022 ,  G06T7/12 ,  G06T7/149 ,  G06T19/20 ,  G06T2207/10072 ,  G06T2207/20081 ,  G06T2207/20124 ,  G06T2207/30048 ,  G16H50/50

摘要： A method and system for patient-specific planning and guidance of an ablation procedure for cardiac arrhythmia is disclosed. A patient-specific anatomical heart model is generated based on pre-operative cardiac image data. The patient-specific anatomical heart model is registered to a coordinate system of intra-operative images acquired during the ablation procedure. One or more ablation site guidance maps are generated based on the registered patient-specific anatomical heart model and intra-operative patient-specific measurements acquired during the ablation procedure. The ablation site guidance maps may include myocardium diffusion and action potential duration maps. The ablation site guidance maps are generated using a computational model of cardiac electrophysiology which is personalized by fitting parameters of the cardiac electrophysiology model using the intra-operative patient-specific measurements. The ablation site guidance maps are displayed by a display device during the ablation procedure.

摘要翻译： 公开了一种用于患者特异性规划和指导心律失常消融手术的方法和系统。 基于手术前心脏图像数据生成患者特异性解剖心脏模型。 将患者特异性解剖心脏模型记录到在消融过程期间获取的手术中图像的坐标系。 基于注册的患者特异性解剖心脏模型和在消融过程期间获得的术中患者特异性测量来生成一个或多个消融部位引导图。 消融部位引导图可以包括心肌扩散和动作电位持续时间图。 使用心脏电生理学的计算模型产生消融部位指导图，其通过使用手术中患者特异性测量来拟合心脏电生理学模型的参数进行个性化。 在消融过程中，消融部位引导图由显示装置显示。

公开(公告)号：US20130324841A1

公开(公告)日：2013-12-05

申请号：US13905939

申请日：2013-05-30

申请人： Ali Kamen ,  Tommaso Mansi ,  Bogdan Georgescu ,  Dorin Comaniciu

发明人： Ali Kamen ,  Tommaso Mansi ,  Bogdan Georgescu ,  Dorin Comaniciu

IPC分类号： A61B8/08 ,  A61B10/02 ,  A61B5/055 ,  A61B8/13

CPC分类号： A61B8/0841 ,  A61B5/055 ,  A61B5/7425 ,  A61B8/13 ,  A61B8/14 ,  A61B8/4254 ,  A61B8/463 ,  A61B8/483 ,  A61B8/485 ,  A61B8/5261 ,  A61B10/0233 ,  A61B10/0241 ,  G06T7/33 ,  G06T2207/10136 ,  G06T2207/30081

摘要： A method and system for real-time ultrasound guided prostate needle biopsy based on a biomechanical model of the prostate from 3D planning image data, such as magnetic resonance imaging (MRI) data, is disclosed. The prostate is segmented in the 3D ultrasound image. A reference patient-specific biomechanical model of the prostate extracted from planning image data is fused to a boundary of the segmented prostate in the 3D ultrasound image, resulting in a fused 3D biomechanical prostate model. In response to movement of an ultrasound probe to a new location, a current 2D ultrasound image is received. The fused 3D biomechanical prostate model is deformed based on the current 2D ultrasound image to match a current deformation of the prostate due to the movement of the ultrasound probe to the new location.

摘要翻译： 公开了一种基于3D规划图像数据（如磁共振成像（MRI））数据的前列腺生物力学模型的实时超声引导前列腺穿刺活检的方法和系统。 前列腺在3D超声图像中被分割。 从计划图像数据中提取的前列腺特异性参考生物力学模型融合到3D超声图像中分割的前列腺的边界，产生融合的3D生物力学前列腺模型。 响应于超声探头移动到新位置，接收当前的2D超声图像。 融合的3D生物力学前列腺模型基于当前的2D超声图像而变形，以匹配由于超声探头移动到新位置而导致的前列腺的当前变形。

公开(公告)号：US20190197199A9

公开(公告)日：2019-06-27

申请号：US13754174

申请日：2013-01-30

申请人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Bogdan Georgescu ,  Xudong Zheng ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06F17/50

CPC分类号： G06F17/5009 ,  A61B5/0044 ,  A61B5/055 ,  A61B8/0883 ,  A61B2576/023 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36585 ,  G06T17/00 ,  G06T2210/41 ,  G09B23/30 ,  G16H50/50

摘要： A method and system for patient-specific planning of cardiac therapy, such as cardiac resynchronization therapy (CRT), based on preoperative clinical data and medical images, such as ECG data, magnetic resonance imaging (MRI) data, and ultrasound data, is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image data of a patient. A patient-specific computational heart model, which comprises cardiac electrophysiology, biomechanics and hemodynamics, is generated based on the patient-specific anatomical model of the left and right ventricles and clinical data. Simulations of cardiac therapies, such as CRT at one or more anatomical locations are performed using the patient-specific computational heart model. Changes in clinical cardiac parameters are then computed from the patient-specific model, constituting predictors of therapy outcome useful for therapy planning and optimization.

公开(公告)号：US10296809B2

公开(公告)日：2019-05-21

申请号：US13780230

申请日：2013-02-28

申请人： Saikiran Rapaka ,  Tommaso Mansi ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

发明人： Saikiran Rapaka ,  Tommaso Mansi ,  Bogdan Georgescu ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G16H50/50 ,  G06F17/50 ,  G06K9/62 ,  G06T7/143 ,  G06T7/149 ,  G06K9/00

摘要： A method and system for patient-specific cardiac electrophysiology is disclosed. Particularly, a patient-specific anatomical model of a heart is generated from medical image data of a patient, a level-set representation of the patient-specific anatomical model is generated of the heart on a Cartesian grid; and a transmembrane action potential at each node of the level-set representation of the of the patient-specific anatomical model of the heart is computed on a Cartesian grid.

公开(公告)号：US09463072B2

公开(公告)日：2016-10-11

申请号：US14455803

申请日：2014-08-08

申请人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Tiziano Passerini ,  Saikiran Rapaka

发明人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Tiziano Passerini ,  Saikiran Rapaka

IPC分类号： A61B5/0402 ,  G06T17/20 ,  G06T7/00 ,  A61B5/00 ,  A61B6/00 ,  G06F19/00 ,  A61B34/10 ,  A61N1/362 ,  A61B19/00

CPC分类号： A61B34/10 ,  A61B5/04028 ,  A61B5/7278 ,  A61B5/743 ,  A61B6/4441 ,  A61B6/486 ,  A61B6/503 ,  A61B6/5247 ,  A61B2034/101 ,  A61B2034/105 ,  A61B2576/023 ,  A61N1/3627 ,  G06F19/00 ,  G06F19/321 ,  G06T7/12 ,  G06T17/20 ,  G06T2200/08 ,  G06T2207/30048 ,  G16H50/50

摘要： A method and system for patient-specific planning and guidance of electrophysiological interventions is disclosed. A patient-specific anatomical heart model is generated from cardiac image data of a patient. A patient-specific cardiac electrophysiology model is generated based on the patient-specific anatomical heart model and patient-specific electrophysiology measurements. Virtual electrophysiological interventions are performed using the patient-specific cardiac electrophysiology model. A simulated electrocardiogram (ECG) signal is calculated in response to each virtual electrophysiological intervention.

摘要翻译： 公开了一种用于患者特异性规划和指导电生理干预的方法和系统。 从患者的心脏图像数据生成患者特异性解剖心脏模型。 基于患者特异性解剖心脏模型和患者特异性电生理学测量产生患者特异性心脏电生理学模型。 使用患者特异性心脏电生理模型进行虚拟电生理干预。 根据每个虚拟电生理干预计算模拟心电图（ECG）信号。