Deuterated cyclosporin analogs and their use as immunomodulating agents
    61.
    发明申请
    Deuterated cyclosporin analogs and their use as immunomodulating agents 有权
    氘代环孢菌素类似物及其作为免疫调节剂的用途

    公开(公告)号:US20050176628A1

    公开(公告)日:2005-08-11

    申请号:US11105897

    申请日:2005-04-13

    摘要: Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives.

    摘要翻译: 公开了与天然存在的和其他目前已知的环孢菌素和环孢菌素衍生物相比具有增强的功效和降低的毒性的环孢菌素衍生物。 本发明的环孢菌素衍生物通过以下方式通过环孢菌素A(CsA)分子的化学和同位素取代产生:(1)氨基酸1的化学取代和任选的氘取代; 和(2)在环孢菌素A分子的代谢关键位置的氘代替,例如氨基酸1,4,9。还公开了产生环孢菌素衍生物的方法和与所公开的环孢菌素衍生物一起产生具有降低的毒性的免疫抑制的方法。

    Data processing system for complex pricing and transactional analysis
    62.
    发明申请
    Data processing system for complex pricing and transactional analysis 失效
    用于复杂定价和事务分析的数据处理系统

    公开(公告)号:US20050165676A1

    公开(公告)日:2005-07-28

    申请号:US10996892

    申请日:2004-11-23

    申请人: Robert Foster

    发明人: Robert Foster

    摘要: The present invention provides methods and systems for defining financial transaction components; defining mapping rules for taking individual financial transactions and breaking them down into their components, such as production services, billing services and settlement services. A data processing system in accordance with one embodiment of the present invention, creates a transaction instance corresponding to a financial transaction, creates a production service instance linked to the transaction instance by a first relation instance, and creates a billing service instance linked to the production service instance by a second relation instance. The data processing system, may also create other production service instances linked to the transaction instance using other relation instances, as well as, other billing service instances linked to the production service instances.

    摘要翻译: 本发明提供了用于定义金融交易组件的方法和系统; 定义用于采取个人金融交易并将其分解为组件的映射规则,如生产服务,计费服务和结算服务。 根据本发明的一个实施例的数据处理系统,创建与金融交易对应的交易实例,通过第一关系实例创建与交易实例链接的生产服务实例,并创建与生产相关联的计费服务实例 服务实例由第二关系实例。 数据处理系统还可以使用其他关系实例以及链接到生产服务实例的其他计费服务实例来创建链接到事务实例的其他生产服务实例。

    Diffusion balloon aortic cannula
    63.
    发明申请
    Diffusion balloon aortic cannula 审中-公开
    扩散气囊主动脉插管

    公开(公告)号:US20050010172A1

    公开(公告)日:2005-01-13

    申请号:US10734729

    申请日:2003-12-12

    申请人: Robert Foster

    发明人: Robert Foster

    摘要: An aortic cannula (10) includes an enclosure (12) which may be affixed to the end of the cannula (10) by means of adhesive or may be embedded in the cannula during layered construction thereof. The enclosure (12) expands with flow through the lumen of the cannula (10) such that the flow area through the material of the enclosure is several times the flow cross-sectional area of the cannula lumen.

    摘要翻译: 主动脉插管(10)包括可以通过粘合剂固定到套管(10)的端部的外壳(12),或者可以在其分层结构期间嵌入插管中。 外壳(12)随着流过套管(10)的内腔而膨胀,使得通过外壳材料的流动面积是套管内腔的流动横截面面积的几倍。

    Rapid thermal CVD apparatus
    64.
    发明授权
    Rapid thermal CVD apparatus 失效
    快速热切割设备

    公开(公告)号:US4796562A

    公开(公告)日:1989-01-10

    申请号:US3516

    申请日:1987-01-15

    摘要: In a chemical vapor deposition apparatus for coating semiconductor wafers, the wafer is held face down in the reaction chamber. A radiant heat source above the wafer and outside the reaction chamber. The wafer is held on a ring chuck by means of a retractable clamp heats the wafer from its backside to a temperature in excess of 1000.degree. C. rapidly. The radiant heat source includes cylindrical lamps placed in a radial pattern to improve heating uniformity. In the selective tungsten process the temperature of the wafer is raised from ambient to about 600.degree. C. while flowing process gases. At the upper temperature range the heating source can be rapidly cycled on and off to improve the uniformity of coating.

    摘要翻译: 在用于涂覆半导体晶片的化学气相沉积设备中,将晶片面朝下地保持在反应室中。 在晶片上方和反应室外部的辐射热源。 通过可伸缩夹具将晶片保持在环形卡盘上,将晶片从背面快速加热至超过1000℃的温度。 辐射热源包括以放射状图案放置以提高加热均匀性的圆柱形灯。 在选择性钨工艺中,流动工艺气体时,晶片的温度从环境温度升至约600℃。 在较高温度范围内,加热源可以快速循环开启和关闭,以提高涂层的均匀性。