公开(公告)号：US06416523B1

公开(公告)日：2002-07-09

申请号：US09678147

申请日：2000-10-03

申请人： Daniel M. Lafontaine

发明人： Daniel M. Lafontaine

IPC分类号： A61B1722

CPC分类号： A61B17/320758 ,  A61B17/3474 ,  A61B2017/00026 ,  A61B2017/0003 ,  A61B2017/22067 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61B2017/22094 ,  A61B2090/08021 ,  A61B2217/005 ,  A61B2217/007

摘要： A method and apparatus for creating a lumen through a total vascular occlusion. A directional cutter is advanced ahead of a number of proximal electrodes that engage a vessel wall. Blood in the vessel between the directional cutter and the proximal electrodes is removed by sealing the vessel with an occluding balloon and pumping a bio-compatible gas into the vessel to displace the blood. A signal source is applied to the directional cutter and used to measure the impedance between the directional cutter and each of the proximal electrodes. If the cutter engages a vessel wall, the impedance between the cutter and the proximal electrode decreases. A physician monitors the impedance to know when the vessel wall is engaged and turns the direction of the cutter away from the vessel wall such that the cutter continues creating a lumen within the occluding material. Once a lumen has been created in the occluding material, the cutter and electrodes are removed from the vessel and the vessel is treated with a conventional atherectomy device. In another embodiment of the invention, the signal source supplies a pacing signal to the directional cutter. If the cutter is embedded within an occlusion, the heart is not captured by the pacing signal. Once the cutter contact the vessel wall, the heart is captured and the physician changes the direction of the cutter to continue creating the lumen within the occlusion.

摘要翻译： 一种用于通过全血管闭塞产生内腔的方法和装置。 定向切割器在与血管壁接合的多个近端电极的前方前进。 通过用封闭气囊密封容器并将生物相容性气体泵入容器以置换血液来移除定向切割器和近端电极之间的血管中的血液。 将信号源施加到定向切割器，并用于测量定向切割器与每个近端电极之间的阻抗。 如果切割器接合血管壁，切割器和近端电极之间的阻抗减小。 医生监测阻抗以知道血管壁何时被接合并且使切割器的方向远离血管壁，使得切割器继续在闭塞材料内产生内腔。 一旦在封闭材料中产生内腔，则将切割器和电极从容器中取出，并用常规的粥样斑块切除装置处理血管。 在本发明的另一个实施例中，信号源向定向切割器提供起搏信号。 如果切割器嵌入在闭塞中，则心脏不被起搏信号捕获。 一旦切割器接触血管壁，就会捕获心脏，并且医师改变切割器的方向，以继续在闭塞内产生内腔。

公开(公告)号：US06343605B1

公开(公告)日：2002-02-05

申请号：US09634112

申请日：2000-08-08

申请人： Daniel M. Lafontaine

发明人： Daniel M. Lafontaine

IPC分类号： A61B1900

CPC分类号： A61B17/3207 ,  A61B10/0266 ,  A61B17/32053 ,  A61B17/3421 ,  A61B18/24 ,  A61B2017/00252 ,  A61B2017/00969 ,  A61B2017/22077 ,  A61B2017/306 ,  A61B2017/3488 ,  A61B2017/3492 ,  A61B2018/00291 ,  A61F2/02 ,  A61F2/2487 ,  A61M2025/0089 ,  A61M2025/009 ,  A61N1/36042

摘要： Devices and methods for increasing the volume of blood pumped by a heart muscle are disclosed. A therapeutic catheter in accordance with the present invention may comprise an elongate shaft having a proximal end, a distal end, and a lumen extending through at least a portion thereof. The therapeutic catheter may further include a cutter having a cutter lumen fixed to the distal end of the elongate shaft, and a mooring shaft slidingly disposed within the lumen of the elongate shaft. A method in accordance with the present invention may include the steps of engaging a muscle of a donor site with a portion of the mooring shaft, penetrating the muscle of the donor site with the cutter to form a muscle tendril, withdrawing the muscle tendril from the muscle of the donee site, positioning the distal end of the therapeutic catheter proximate a pit defined by the tissue of a donee site, inserting the muscle tendril into the tissue of the donee site, and disengaging the mooring shaft from the muscle tendril.

摘要翻译： 公开了用于增加由心脏肌肉泵送的血液体积的装置和方法。 根据本发明的治疗导管可以包括具有近端，远端和延伸穿过其至少一部分的内腔的细长轴。 治疗导管还可以包括具有固定到细长轴的远端的切割器内腔的切割器和滑动地设置在细长轴的内腔内的系泊轴。 根据本发明的方法可以包括以下步骤：将供体部位的肌肉与系泊轴的一部分接合，用切割器穿过供体部位的肌肉，以形成肌肉卷须，从肌肉卷起退出肌肉卷须 接合点位置的肌肉，将治疗导管的远端定位在由受精部位的组织限定的凹坑附近，将肌肉卷帘插入到受精部位的组织中，并使系泊轴与肌肉卷发脱离接触。

公开(公告)号：US6063082A

公开(公告)日：2000-05-16

申请号：US35738

申请日：1998-03-05

申请人： Lauri DeVore ,  Louis Ellis ,  Gary L. Hendrickson ,  Daniel M. Lafontaine ,  Zihong Guo ,  Ryan Kaveckis

发明人： Lauri DeVore ,  Louis Ellis ,  Gary L. Hendrickson ,  Daniel M. Lafontaine ,  Zihong Guo ,  Ryan Kaveckis

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/14 ,  A61B19/00 ,  A61F2/02 ,  A61M25/00

CPC分类号： A61F2/2493 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/1477 ,  A61B18/1492 ,  A61B17/32037 ,  A61B17/32056 ,  A61B17/3207 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/320084 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00136 ,  A61B2018/00148 ,  A61B2018/00196 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00279 ,  A61B2018/00351 ,  A61B2018/00392 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2090/3966 ,  A61B2218/002 ,  A61B90/39 ,  A61M2025/009

摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.

公开(公告)号：US5964782A

公开(公告)日：1999-10-12

申请号：US932990

申请日：1997-09-18

申请人： Daniel M. Lafontaine ,  Kent D. Harrison

发明人： Daniel M. Lafontaine ,  Kent D. Harrison

IPC分类号： A61B17/04 ,  A61B17/00 ,  A61B17/10 ,  A61B18/04 ,  A61B18/14

CPC分类号： A61B18/148 ,  A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/00668 ,  A61B2017/00672 ,  A61B2018/00196 ,  A61B2018/0022 ,  A61B2018/00273 ,  A61B2018/00279

摘要： An apparatus is provided for closing a perforation in a wall of a patient's blood vessel or other organs, and a method of introducing the apparatus and causing the closure are described. The apparatus includes an elongated support member having a distal end supporting one or more tissue engaging hooks configured to engage fibrous vessel tissue when moved in a first direction and to disengage the tissue when moved in a second direction, and a proximal end for applying rotational torque to the support member to cause the hooks to engage collagen fibrous tissue in the adventitia of the blood vessel or fibrous tissue in other body organs. The hooks engaging the collagen fiber causes the blood vessel tissue surrounding the perforation to be drawn into close proximity such that the perforation can be closed. The apparatus can be removed by applying reverse rotation of the support member, whereby the hooks are disengaged. The apparatus is deployed in an outer sheath with the hooks encased until a selected engaging location has been achieved. When positioned in the aperture to be closed, the hooks are exposed to allow interaction with the adventitia. Puncture closure can be accomplished by various techniques, including stasis, cauterizing, or by clamping. Various embodiments of the apparatus are described.

摘要翻译： 提供了用于封闭患者血管或其他器官的壁中的穿孔的装置，并且描述了引入该装置并引起闭合件的方法。 该装置包括细长的支撑构件，其具有支撑一个或多个组织接合钩的远端，所述组织接合钩构造成当沿第一方向移动时接合纤维血管组织，并且在沿第二方向移动时使组织脱离，以及用于施加旋转扭矩的近端 到支撑构件以引起钩将胶原纤维组织接合在血管的外膜或其他身体器官中的纤维组织中。 接合胶原纤维的钩使得穿孔周围的血管组织被拉近，使得穿孔可以闭合。 可以通过施加支撑构件的反向旋转来移除该装置，由此钩脱开。 该装置部署在外护套中，钩被包住，直到达到选定的接合位置。 当定位在要关闭的孔中时，钩暴露以允许与外膜相互作用。 穿刺闭合可以通过各种技术来实现，包括瘀斑，烧灼或夹紧。 描述该装置的各种实施例。

公开(公告)号：US5868735A

公开(公告)日：1999-02-09

申请号：US812804

申请日：1997-03-06

申请人： Daniel M. Lafontaine

发明人： Daniel M. Lafontaine

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/02 ,  A61M29/02 ,  C21B13/00 ,  C22B5/14 ,  C22B23/02 ,  A61B17/36

CPC分类号： A61B18/02 ,  C21B13/0033 ,  C22B23/021 ,  C22B5/14 ,  A61B2017/00088 ,  A61B2017/00292 ,  A61B2017/00557 ,  A61B2017/22002 ,  A61B2018/00101 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61M25/104

摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

公开(公告)号：US5695468A

公开(公告)日：1997-12-09

申请号：US586514

申请日：1996-01-16

申请人： Daniel M. Lafontaine ,  Chad J. Kugler ,  Matthew M. Burns

发明人： Daniel M. Lafontaine ,  Chad J. Kugler ,  Matthew M. Burns

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/00

CPC分类号： A61M25/10186 ,  A61M25/1018 ,  A61M25/10187 ,  A61M25/1025 ,  A61M2025/0063 ,  A61M2025/0098 ,  A61M2025/1056 ,  A61M2025/1077

摘要： A balloon catheter is disclosed which includes a fluid displacement rod at least partially and slidably disposed in an elongate tubular member with a balloon connected to the distal end of the tubular member. A seal connected to the proximal end of the tubular member creates a liquid tight seal between the inside of the tubular member and the displacement rod. Accordingly, longitudinal actuation of the displacement rod causes the balloon to expand and/or contract. The balloon catheter may be a fixed wire, an over-the-wire or a single-operator exchange type balloon catheter. In addition, a pressure gauge may be connected to the proximal end of the tubular member. A one-way valve is also disclosed which allows the balloon catheter to be prepped via the guide wire lumen. Accordingly, the present invention negates the need for both an inflation device and an inflation lumen which results in a significant improvement in catheter performance and cost savings.

摘要翻译： 公开了一种气囊导管，其包括至少部分且可滑动地设置在细长管状构件中的流体移动杆，其中球囊连接到管状构件的远端。 连接到管状构件的近端的密封件在管状构件的内部和位移杆之间形成液体密封。 因此，位移杆的纵向致动导致气囊膨胀和/或收缩。 球囊导管可以是固定线，线上或单操作者交换型球囊导管。 此外，压力计可以连接到管状构件的近端。 还公开了允许通过导丝管腔准备球囊导管的单向阀。 因此，本发明不需要充气装置和充气腔，这导致导管性能和成本节省的显着改善。

公开(公告)号：US5665103A

公开(公告)日：1997-09-09

申请号：US612158

申请日：1996-03-07

申请人： Daniel M. Lafontaine ,  Roger N. Hastings

发明人： Daniel M. Lafontaine ,  Roger N. Hastings

IPC分类号： A61B5/05 ,  A61B5/06 ,  A61B17/00 ,  A61F2/06 ,  A61F2/84 ,  A61M29/00

CPC分类号： A61F2/95 ,  A61B5/05 ,  A61B5/06 ,  A61B2017/00026 ,  A61B2017/0003

摘要： A method of detecting a metallic stent inside a living body wherein the method includes the steps of: (1) providing a stent locator device, (2) providing a metallic stent, (3) inserting the metallic stent into the living body, (4) inserting the stent locator into the living body and (5) locating the stent with the stent locator by detecting an electrical parameter affected by the position of the stent relative to the position of the locating device. The electrical parameter may be detected with a pair of electrodes or a coil mounted to the distal end of the stent locator. The stent locator may include one or more radiopaque markers mounted on the distal end such that the position of the stent may be radiographically correlated to the position of the stent locator device. Alternatively, the stent locator may include one or more visual markers mounted on the proximal end such that the position of the stent may be visually correlated to the position of the stent locator device. The stent locator may be in the form of virtually any intraluminal device such as a guide wire, a balloon catheter, an atherectomy catheter or a stent delivery catheter. In addition, the stent may be inserted prior to, subsequent to or simultaneously with the stent locator device.

摘要翻译： 一种在生物体内检测金属支架的方法，其中所述方法包括以下步骤：（1）提供支架定位装置，（2）提供金属支架，（3）将所述金属支架插入生物体中;（4） ）将支架定位器插入生物体中;（5）通过检测受到支架位置相对于定位装置的位置影响的电参数来定位具有支架定位器的支架。 可以用一对电极或安装在支架定位器的远端的线圈来检测电参数。 支架定位器可以包括安装在远端上的一个或多个不透射线的标记，使得支架的位置可以放射学地与支架定位器装置的位置相关。 或者，支架定位器可以包括安装在近端上的一个或多个视觉标记，使得支架的位置可以与支架定位器装置的位置视觉相关。 支架定位器可以是几乎任何管腔内装置的形式，例如导丝，气囊导管，动脉切除术导管或支架输送导管。 此外，支架可以在支架定位器装置之前，之后或同时插入。

公开(公告)号：US08617149B2

公开(公告)日：2013-12-31

申请号：US11541735

申请日：2006-10-02

申请人： Daniel M. Lafontaine ,  Gary L. Hendrickson

发明人： Daniel M. Lafontaine ,  Gary L. Hendrickson

IPC分类号： A61B18/18 ,  A61M29/00

CPC分类号： A61M25/1011 ,  A61B2018/0022 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M25/1034 ,  A61M2025/1013 ,  A61M2025/1079

摘要： A method of manufacturing a catheter can include assembling an inner balloon within a separate outer balloon. The inner and outer balloons can each be open on opposing longitudinal ends and have a central radially expandable portion, and proximal and distal reduced diameter portions on opposite longitudinal end portions of the balloon. The method can further include bonding a portion of an inner surface of the outer balloon proximal reduced diameter portion to a portion of an outer surface of the inner balloon proximal reduced diameter portion and bonding a distal end portion of an elongate catheter shaft to a proximal portion of the bonded inner and outer balloons.

摘要翻译： 制造导管的方法可以包括将内气囊组装在单独的外气囊中。 内部和外部气囊可以在相对的纵向端部上敞开，并且具有中心径向可膨胀部分，并且在气囊的相对的纵向端部上具有近端和远端缩径部分。 该方法还可以包括将外球囊近端缩小直径部分的内表面的一部分粘合到内球囊近直径部分的外表面的一部分，并将细长导管轴的远端部分接合到近端部分 的粘合内外气球。

公开(公告)号：US08512399B2

公开(公告)日：2013-08-20

申请号：US12648221

申请日：2009-12-28

申请人： Daniel M. Lafontaine

发明人： Daniel M. Lafontaine

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61M25/1011

摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.

摘要翻译： 一种心脏瓣膜，其具有第一锚架和第一锚架上的盖子，用于单向流动液体通过该阀。

公开(公告)号：US08080006B2

公开(公告)日：2011-12-20

申请号：US12104095

申请日：2008-04-16

申请人： Daniel M. Lafontaine ,  Boaz Avitall

发明人： Daniel M. Lafontaine ,  Boaz Avitall

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B90/39 ,  A61B2017/00101 ,  A61B2017/00243 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2090/3954

摘要： A method for performing cryotherapy on a target tissue region in a body includes positioning a first cooling element in a first location in a body adjacent a target tissue region, positioning a second cooling element in a second location in the body adjacent the target tissue region, and cooling the respective first and second cooling elements so as to cool the target tissue region.

摘要翻译： 用于在身体的目标组织区域上执行冷冻治疗的方法包括将第一冷却元件定位在邻近目标组织区域的身体的第一位置，将第二冷却元件定位在邻近目标组织区域的身体的第二位置， 并冷却相应的第一和第二冷却元件以冷却目标组织区域。