公开(公告)号：US08646053B2

公开(公告)日：2014-02-04

申请号：US12967956

申请日：2010-12-14

申请人： Stephan Laertz ,  Peter Fischer ,  Carsten Leue ,  Thomas Schaeck

发明人： Stephan Laertz ,  Peter Fischer ,  Carsten Leue ,  Thomas Schaeck

IPC分类号： G06F7/04

CPC分类号： H04L63/0281 ,  H04L63/12

摘要： The present invention provides a security module for Web application, especially a portal application, using a rewriter proxy. The security module ensures that the rewritten URIs are appended by an authentication identifier for determining whether the rewritten URI has not been changed. Preferably, the authentication identifier can be generated by applying a secure hash algorithm and/or secret key to the original URIs of the remote resource or the entire rewritten URIs. When a client activates those URIs, a request is sent to the rewriter proxy. Before a connection to the access protected remote resource is established, the security module validates whether the URIs contained in the user client request have been changed by the user.

摘要翻译： 本发明提供了一种用于Web应用的安全模块，特别是使用重写器代理的门户应用。 安全模块确保重写的URI由用于确定重写的URI是否未被改变的认证标识符附加。 优选地，可以通过将安全散列算法和/或秘密密钥应用于远程资源的原始URI或整个重写的URI来生成认证标识符。 当客户端激活这些URI时，请求将被发送到重写代理。 在建立与访问受保护的远程资源的连接之前，安全模块验证用户客户端请求中包含的URI是否已被用户更改。

公开(公告)号：US20110046518A1

公开(公告)日：2011-02-24

申请号：US12542746

申请日：2009-08-18

申请人： Peter Fischer

发明人： Peter Fischer

IPC分类号： A61B5/103

CPC分类号： A61B5/103 ,  A61B5/11 ,  A61B5/1116 ,  A61B5/6823 ,  A61B5/6831 ,  A63B21/0004 ,  A63B23/0244 ,  A63B2225/50

摘要： A posture assessment and feedback instrument (FIG. 1A and FIG. 1B) all contained within a single housing (1). The output of a capacitive sensor (4) within the housing (1) varies in response to the distance between the sensor and the body of a user. The housing (1) is strapped to the body of a user (FIG. 3, FIG. 4, FIG. 5A, and FIG. 5B) with a belt (2). The application area is chosen such that the distance between the sensor (4) and the body varies in response to a defined posture change (FIG. 5A and FIG. 5B). Thus the sensor output will vary in response to the defined posture change. The output is compared to a stored threshold value and triggers a feedback signal when the threshold is exceeded.

摘要翻译： 姿势评估和反馈仪器（图1A和图1B）都包含在单个壳体（1）内。 壳体（1）内的电容传感器（4）的输出响应于传感器和用户身体之间的距离而变化。 壳体（1）用带（2）捆扎到使用者的身体（图3，图4，图5A和图5B）。 选择应用区域使得传感器（4）和身体之间的距离响应于定义的姿势变化而变化（图5A和图5B）。 因此，传感器输出将根据定义的姿势变化而变化。 将输出与存储的阈值进行比较，并在超过阈值时触发反馈信号。

公开(公告)号：US20080319156A1

公开(公告)日：2008-12-25

申请号：US12117798

申请日：2008-05-09

申请人： Peter Fischer ,  Wilfried Haese ,  Alexander Meyer

发明人： Peter Fischer ,  Wilfried Haese ,  Alexander Meyer

IPC分类号： C08G64/30 ,  C08G64/00

CPC分类号： C08G64/307 ,  Y10T428/31667

摘要： The invention provides a process for the preparation of polycarbonate by the melt transesterification process, polycarbonate having a low electrostatic charge obtainable by this process, and mouldings or extrudates, in particular optical data storage media or light-diffusing plates, made from this polycarbonate.

摘要翻译： 本发明提供了一种通过熔融酯交换法制备聚碳酸酯的方法，具有通过该方法可获得的低静电电荷的聚碳酸酯，以及由该聚碳酸酯制成的模制品或挤出物，特别是光学数据存储介质或光扩散板。

公开(公告)号：US07396417B2

公开(公告)日：2008-07-08

申请号：US11662846

申请日：2005-09-20

申请人： Peter Fischer ,  Hanspeter Brunner

发明人： Peter Fischer ,  Hanspeter Brunner

IPC分类号： C23G1/00

CPC分类号： C23G1/088 ,  B23K26/38 ,  B23K37/08 ,  C11D1/44 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/33 ,  C11D11/0029

摘要： A degreasing method for descaling or removing laser scales from iron-containing metal part surface by treating the iron-containing metal part surfaces that is optionally tainted with laser scales with an aqueous solution containing at least one type of highly water-soluble and complexed with Fe ions carboxylic acid, at least one type of salt of at least one type of carboxylic acid exhibiting the same action and at least one type of fatty amine ethoxylate, wherein the solution is buffered, the Fe ions are carried into the solution and at least partially complexed, increasing the pH value of the solution for descaling with respect to at least one type of carboxylic acid. The entire concentration of carboxylic acids and the salts thereof is increased for descaling by 2 to 20% by weight.

摘要翻译： 一种脱脂方法，用于通过用含有至少一种高度水溶性且与Fe络合的水溶液处理任选地用激光鳞片去除的含铁金属部分表面，从含铁金属部件表面去除或除去激光鳞片 离子羧酸，表现出相同作用的至少一种类型的羧酸的至少一种盐和至少一种类型的脂肪胺乙氧基化物，其中所述溶液被缓冲，所述Fe离子被运送到溶液中并且至少部分地 络合，增加溶液相对于至少一种类型的羧酸除垢的pH值。 羧酸及其盐的全部浓度由于除垢2〜20重量％而增加。

公开(公告)号：US20080011323A1

公开(公告)日：2008-01-17

申请号：US11662846

申请日：2005-09-20

申请人： Peter Fischer ,  Hanspeter Brunner

发明人： Peter Fischer ,  Hanspeter Brunner

IPC分类号： C23G1/08 ,  B23K26/00 ,  C11D1/44 ,  C11D11/00 ,  C11D3/20 ,  C11D3/33

CPC分类号： C23G1/088 ,  B23K26/38 ,  B23K37/08 ,  C11D1/44 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/33 ,  C11D11/0029

摘要： A degreasing method for descaling or removing laser scales from iron-containing metal part surface by treating the iron-containing metal part surfaces that is optionally tainted with laser scales with an aqueous solution containing at least one type of highly water-soluble and complexed with Fe ions carboxylic acid, at least one type of salt of at least one type of carboxylic acid exhibiting the same action and at least one type of fatty amine ethoxylate, wherein the solution is buffered, the Fe ions are carried into the solution and at least partially complexed, increasing the pH value of the solution for descaling with respect to at least one type of carboxylic acid. The entire concentration of carboxylic acids and the salts thereof is increased for descaling by 2 to 20% by weight.

摘要翻译： 一种脱脂方法，用于通过用含有至少一种高度水溶性且与Fe络合的水溶液处理任选地用激光鳞片去除的含铁金属部分表面，从含铁金属部件表面去除或除去激光鳞片 离子羧酸，表现出相同作用的至少一种类型的羧酸的至少一种盐和至少一种类型的脂肪胺乙氧基化物，其中所述溶液被缓冲，所述Fe离子被运送到溶液中并且至少部分地 络合，增加溶液相对于至少一种类型的羧酸除垢的pH值。 羧酸及其盐的全部浓度由于除垢2〜20重量％而增加。

公开(公告)号：US20070021419A1

公开(公告)日：2007-01-25

申请号：US11339058

申请日：2006-01-25

申请人： Shudong Wang ,  Janice McLachlan ,  Darren Gibson ,  Ashley Causton ,  Nicholas Turner ,  Peter Fischer

发明人： Shudong Wang ,  Janice McLachlan ,  Darren Gibson ,  Ashley Causton ,  Nicholas Turner ,  Peter Fischer

IPC分类号： A61K31/5377 ,  A61K31/506 ,  C07D413/14 ,  C07D403/14

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10

摘要： The present invention relates to compounds of formula I, or pharmaceutically acceptable salt thereof, wherein: Z is CR10 or N; one of R1 and R2 is selected from (CH2)mR11, (CH2)mR12, (CH2)mNR12R13, (CH2)mOR12, (CH2)mNR13CO(CH2)nR11, (CH2)mNR13COR12, (CH2)mCONR13(CH2)nR11, (CH2)mCONR12R13, (CH2)mCO(CH2)nR11 and (CH2)mCOR12; where m is 0, 1, 2, 3 or 4 and n is 1, 2, 3 or 4; the other of R1 and R2 is H or R11; R3 and R5 are both H; R4 is H or R11; R6is H or (CH2)pR11, where p is 0 or 1; R7, R9 and R10 are each independently H or R11; R8 is selected from H, halogen, NO2, CN, OR13, NR13R14, NHCOR13, CF3, COR13, R13, CONR13R15, SO2NR13R14, SO2R13, NR13SO2R14, OCH2CH2OH, OCH2CH2OMe, morpholine, piperidine, and piperazine; each R11 is independently halogen, NO2, CN, (CH2)qOR13(CH2)rNR13R14, NHCOR13, CF3, COR13, R13, CONR13R14, SO2NR13R14, SO2R13, OR12, NR13SO2R14, OCH2CH2OH, OCH2CH2OMe, NR13SO2R12, (CH2)sNR12R13, morpholine, piperidine or piperazine, where q, r and s are each independently 0, 1, 2, 3 or 4; each R12 is independently a hydrocarbyl group optionally containing one or more heteroatoms and optionally substituted with one or more R11 groups; each R13 and each R14 is independently H or an alkyl group; and R15 is an alkyl group; providing that when Z is CR10 and R9 is H, at least one of R7, R8 and R10 is other than OMe; and Z is CR10 and R7-9 are all H, R10 is other than OCF2CHF2.

公开(公告)号：US06986816B2

公开(公告)日：2006-01-17

申请号：US10484179

申请日：2002-07-08

申请人： Claus-Peter Reisinger ,  Sven Michael Hansen ,  Peter Fischer ,  Konrad Triebeneck ,  Joachim Helbig

发明人： Claus-Peter Reisinger ,  Sven Michael Hansen ,  Peter Fischer ,  Konrad Triebeneck ,  Joachim Helbig

IPC分类号： B08B7/00

CPC分类号： B08B9/057 ,  B01J19/002 ,  B01J2219/00247 ,  B08B9/08

摘要： The invention relates to a process for the removal of deposits formed in a reaction apparatus by the precipitation of solids from a liquid reaction mixture, which process is characterized in that particles of a material that is inert under the reaction conditions are introduced into the reaction apparatus, which particles, by suitable mechanical circulation of the reaction mixture, are so moved through the reactor that, during the reaction, by striking the walls or other built-in elements, they abrasively remove precipitates adhered thereto.

摘要翻译： 本发明涉及一种通过从液体反应混合物中沉淀固体而去除在反应装置中形成的沉积物的方法，该方法的特征在于在反应条件下将惰性物质的颗粒引入反应装置 通过反应混合物的适当的机械循环将颗粒移动通过反应器，在反应过程中，通过撞击壁或其它内置元件，它们可以磨蚀地去除附着在其上的沉淀物。

公开(公告)号：US20050256142A1

公开(公告)日：2005-11-17

申请号：US11033692

申请日：2005-01-11

申请人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

发明人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC分类号： A61K31/52 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P17/14 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  C07D473/16 ,  C07D473/12

CPC分类号： C07D473/16 ,  A61K31/52 ,  Y02A50/411

摘要： The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

摘要翻译： 本发明涉及式1化合物或其药学上可接受的盐，其中R 1和R 2之一是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或非支链C 1 -C 6烷基或芳基 并且其中R 3和R 4中的至少一个不是H; R 5是支链或非支链C 1 -C 5烷基或C 1 -C 3亚烷基 其中每一个可以任选地被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 3， 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2， / SUB>。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中枢神经系统疾病，糖尿病，中风，脱发或神经变性疾病中的用途。

公开(公告)号：US20050198332A1

公开(公告)日：2005-09-08

申请号：US11027121

申请日：2004-12-30

申请人： Stephan Laertz ,  Peter Fischer ,  Carsten Leue ,  Thomas Schaeck

发明人： Stephan Laertz ,  Peter Fischer ,  Carsten Leue ,  Thomas Schaeck

IPC分类号： G06F15/16

CPC分类号： H04L63/0281 ,  H04L63/12

摘要： The present invention provides a security module for Web application, especially a portal application, using a rewriter proxy. The security module ensures that the rewritten URIs are appended by an authentication identifier for determining whether the rewritten URI has not been changed. Preferably, the authentication identifier can be generated by applying a secure hash algorithm and/or secret key to the original URIs of the remote resource or the entire rewritten URIs. When a client activates those URIs, a request is sent to the rewriter proxy. Before a connection to the access protected remote resource is established, the security module validates whether the URIs contained in the user client request have been changed by the user.

摘要翻译： 本发明提供了一种用于Web应用的安全模块，特别是使用重写器代理的门户应用。 安全模块确保重写的URI由用于确定重写的URI是否未被改变的认证标识符附加。 优选地，可以通过将安全散列算法和/或秘密密钥应用于远程资源的原始URI或整个重写的URI来生成认证标识符。 当客户端激活这些URI时，请求将被发送到重写代理。 在建立与访问受保护的远程资源的连接之前，安全模块验证用户客户端请求中包含的URI是否已被用户更改。

公开(公告)号：US20050153894A1

公开(公告)日：2005-07-14

申请号：US10771242

申请日：2004-04-13

申请人： Daniella Zheleva ,  Peter Fischer ,  Campbell Mclnnes ,  Martin Andrews ,  Weng Chan ,  Gail Atkinson

发明人： Daniella Zheleva ,  Peter Fischer ,  Campbell Mclnnes ,  Martin Andrews ,  Weng Chan ,  Gail Atkinson

IPC分类号： A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  G01N33/573 ,  G01N33/574

CPC分类号： G01N33/573 ,  A61K38/00 ,  G01N33/574

摘要： The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.

摘要翻译： 本发明涉及通过改变与其底物的相互作用能够抑制CDK /细胞周期蛋白复合物，特别是细胞周期蛋白A或E / CDK2的p21衍生肽。 肽衍生自p21的C末端区域，并显示细胞周期蛋白/ CDK2抑制对细胞周期蛋白/ CDK4抑制的选择性。 特别涉及某些丙氨酸替代物的这些肽的变体显示特别有效。