利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

182 条记录 (耗时 0.042 秒)

    Programmable electromagnetic array for molecule transport
    61.
    发明授权
    Programmable electromagnetic array for molecule transport 有权
    用于分子运输的可编程电磁阵列

    公开(公告)号：US07820454B2

    公开(公告)日：2010-10-26

    申请号：US11647578

    申请日：2006-12-29

    申请人： Xing Su ,  Kenneth Swartz ,  Liming Wang ,  David Eric Schwartz ,  Mineo Yamakawa

    发明人： Xing Su ,  Kenneth Swartz ,  Liming Wang ,  David Eric Schwartz ,  Mineo Yamakawa

    IPC分类号： G01N33/553

    CPC分类号： B01L3/502761 ,  B01F11/0266 ,  B01F13/0059 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/1827 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0677

    摘要： An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

    摘要翻译： 本发明的实施例涉及一种装置，包括（1）包括线圈，金属芯和金属芯头的电磁元件阵列，以及（2）适于一个或多个线圈分别控制电流的控制器， 单独地改变所述一个或多个线圈的电流，以单独地反转一个或多个线圈的电流，并且跨越两个或更多个线圈产生特定的磁通分布和梯度; 其中所述金属芯头位于所述线圈的一端，并且所述金属芯头具有几何形状以在两个相邻线圈之间的感兴趣区域中产生期望的磁通量，强度和梯度; 其中所述装置在功能上耦合到流体装置以将流体中的磁性颗粒集中并输送到流体中而不流体流动。

    Composite organic inorganic nanoclusters
    64.
    发明申请
    Composite organic inorganic nanoclusters 审中-公开
    复合有机无机纳米团簇

    公开(公告)号：US20060234248A1

    公开(公告)日：2006-10-19

    申请号：US11081772

    申请日：2005-03-15

    申请人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    发明人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N21/658 ,  B82Y30/00 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供能够从其中并入的有机拉曼活性分子提供增强的拉曼信号的金属纳米团簇。 纳米团簇可以进一步官能化，例如具有涂层和层，例如吸附层，金属涂层，二氧化硅涂层，探针和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    DETECTION OF DNA METHYLATION USING RAMAN SPECTROSCOPY
    69.
    发明申请
    DETECTION OF DNA METHYLATION USING RAMAN SPECTROSCOPY 审中-公开
    使用拉曼光谱法检测DNA甲基化

    公开(公告)号：US20080241828A1

    公开(公告)日：2008-10-02

    申请号：US11694427

    申请日：2007-03-30

    申请人： Kai Wu ,  Xing Su ,  Mineo Yamakawa

    发明人： Kai Wu ,  Xing Su ,  Mineo Yamakawa

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6827 ,  C12Q2523/125 ,  C12Q2565/628

    摘要： Epigenetic events such as DNA methylation play important roles in the regulation of gene expression. DNA methylation patterns have been found to differ between healthy and diseased tissue, such as healthy and cancerous tissue, thereby allowing DNA methylation to serve as a biomarker for disease states. Embodiments of the invention provide methods for detecting methylation patterns in DNA polymers. Methylation patterns are detected, in part, through the use of surface enhanced Raman spectroscopy (SERS). SERS provides a sensitive structure-based technique for chemical analysis.

    摘要翻译： 表观遗传事件如DNA甲基化在调控基因表达中起重要作用。 已经发现DNA甲基化模式在健康和患病组织如健康和癌组织之间不同，从而允许DNA甲基化作为疾病状态的生物标志物。 本发明的实施方案提供了检测DNA聚合物中甲基化模式的方法。 甲基化模式部分地通过使用表面增强拉曼光谱（SERS）来检测。 SERS提供了一种敏感的基于结构的化学分析技术。

    Composite organic inorganic nanoclusters
    70.
    发明申请
    Composite organic inorganic nanoclusters 审中-公开
    复合有机无机纳米团簇

    公开(公告)号：US20080076119A9

    公开(公告)日：2008-03-27

    申请号：US11081772

    申请日：2005-03-15

    申请人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    发明人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N21/658 ,  B82Y30/00 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供能够从其中并入的有机拉曼活性分子提供增强的拉曼信号的金属纳米团簇。 纳米团簇可以进一步官能化，例如具有涂层和层，例如吸附层，金属涂层，二氧化硅涂层，探针和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。