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公开(公告)号：US07238358B2
公开(公告)日：2007-07-03
申请号：US11028898
申请日：2005-01-03
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US07122196B2
公开(公告)日：2006-10-17
申请号：US11082005
申请日：2005-03-15
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
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公开(公告)号：US06949246B2
公开(公告)日：2005-09-27
申请号：US10193002
申请日：2002-07-10
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/04 , A61K39/395 , A61P31/06 , C07H21/02 , C07H21/04 , C07K7/00 , C07K14/35 , C07K16/12 , C07K17/00 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/04 , C12Q1/68 , C12R1/19 , G01N33/68 , A61K39/21 , A61K39/38 , C07K14/00
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。
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64.发明授权公开(公告)号：US06861506B1
公开(公告)日：2005-03-01
申请号：US09534825
申请日：2000-03-23
申请人： Tony N. Frudakis , John M. Smith , Steven G. Reed , Lynda E. Misher , Marc W. Retter , Davin C. Dillon
发明人： Tony N. Frudakis , John M. Smith , Steven G. Reed , Lynda E. Misher , Marc W. Retter , Davin C. Dillon
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/47 , C07K14/82 , C12Q1/68 , C07K1/00 , C07K14/00 , C07K17/00 , C07K2/00
CPC分类号： C07K14/005 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/53 , A61K2039/57 , C07K14/47 , C07K14/82 , C07K2319/00 , C12N2740/12022 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。
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65.发明授权公开(公告)号：US06673356B1
公开(公告)日：2004-01-06
申请号：US09693542
申请日：2000-10-20
IPC分类号： A61K3902
CPC分类号： C07K14/29 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/403
摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, inparticular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containingsuch polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断和治疗艾氏杆菌感染的特异性人粒细胞性肝炎的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 也提供了包含这种多肽或DNA序列的药物组合物和疫苗。 含有该多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 还提供了针对这种多肽的抗体。
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公开(公告)号：US06607728B2
公开(公告)日：2003-08-19
申请号：US09159469
申请日：1998-09-23
IPC分类号： A61K3902
CPC分类号： C07K14/29 , A61K38/00 , C07K2319/00 , Y02A50/401
摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
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67.发明授权Compounds and methods for the diagnosis and treatment of B. microti infection 有权用于诊断和治疗微生物感染的化合物和方法公开(公告)号：US06451315B1
公开(公告)日：2002-09-17
申请号：US09528784
申请日：2000-03-17
IPC分类号： A61K39002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00 , Y10S530/822
摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen, DNA sequences encoding such polypeptides, and fusion proteins comprising such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences, fusion proteins or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences, fusion proteins or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 提供的化合物包括含有微生物抗原的至少一个抗原部分的多肽，编码这种多肽的DNA序列和包含这些多肽的融合蛋白。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列，融合蛋白或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列，融合蛋白或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。
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68.发明授权Compounds for immunotherapy and diagnosis of breast cancer and methods for their use 失效乳腺癌免疫治疗和诊断用化合物及其使用方法公开(公告)号：US06410507B1
公开(公告)日：2002-06-25
申请号：US09346327
申请日：1999-07-02
申请人： Steven G. Reed , Jiangchun Xu , Davin C. Dillon
发明人： Steven G. Reed , Jiangchun Xu , Davin C. Dillon
IPC分类号： A61K3818
CPC分类号： C12N9/0077 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/47 , C07K14/82 , C07K2319/00
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided, together with polynucleotides for preparing the inventive polypeptides.
摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 包含此类多肽的乳腺癌的免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸也与制备本发明多肽的多核苷酸一起提供。
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69.发明授权公开(公告)号：US06375955B1
公开(公告)日：2002-04-23
申请号：US09022765
申请日：1998-02-12
申请人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Peter Probst
发明人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Peter Probst
IPC分类号： A61K39008
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
摘要翻译： 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供包含这些多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。
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70.发明授权Compounds and methods for the diagnosis and treatment of EHRLICHIA infection 失效用于诊断和治疗EHRLICHIA感染的化合物和方法公开(公告)号：US06306402B1
公开(公告)日：2001-10-23
申请号：US09106582
申请日：1998-06-29
IPC分类号： A61K3902
CPC分类号： C07K14/29 , A61K38/00 , C07K2319/00 , Y02A50/401
摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断和治疗埃里巴病毒感染，特别是人粒细胞性肾病的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 也提供了包含这种多肽或DNA序列的药物组合物和疫苗。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 还提供了针对这种多肽的抗体。
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