LIVE ATTENUATED EDWARDSIELLA ICTALURI VACCINE AND METHOD OF USING THE SAME
    63.
    发明申请
    LIVE ATTENUATED EDWARDSIELLA ICTALURI VACCINE AND METHOD OF USING THE SAME 审中-公开
    活化的EDWARDSIELLA ICTALURI疫苗及其使用方法

    公开(公告)号:US20170065695A1

    公开(公告)日:2017-03-09

    申请号:US15257607

    申请日:2016-09-06

    IPC分类号: A61K39/02 C12N1/20

    摘要: A live attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional evpB protein and a method of using the same to protect fish against infection from virulent Edwardsiella ictaluri. The methods and compositions for protecting fish against infection from virulent Edwardsiella ictaluri comprising administering to a fish a therapeutically effective amount of an attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional EvpB protein. The bacterium may include an insertion and/or deletion mutation in the evpB gene. The fish include catfish, preferably catfish fingerling or a catfish fry. The composition may be delivered via immersion delivery, an injection delivery, an oral delivery, or combinations thereof.

    摘要翻译: 缺乏编码功能性evpB蛋白的活基因的活的减毒爱德华肝炎细菌,以及使用该活性基因的方法来保护鱼免受毒性爱德华氏菌感染。 用于保护鱼免受毒性爱德华氏菌感染的方法和组合物,其包括向鱼施用治疗有效量的缺乏编码功能性EvpB蛋白的活的基因的减毒爱德华肝炎细菌。 细菌可能包括evpB基因中的插入和/或缺失突变。 鱼类包括鲶鱼,优选鲶鱼鱼苗或鲶鱼鱼苗。 组合物可以通过浸没递送,注射递送,口服递送或其组合递送。

    Change analyst
    67.
    发明授权
    Change analyst 有权
    变更分析师

    公开(公告)号:US09047678B2

    公开(公告)日:2015-06-02

    申请号:US13506384

    申请日:2012-04-16

    摘要: A method of determining change in a state of an object using images of the object, the method including providing a first image and a second image of the object, the first image and the second image being spaced apart in time, performing a plurality of pixel-based change detection algorithms to obtain a plurality of output difference products/images containing change information and pseudo change information, combining the plurality of output difference products to form a hybrid output difference product, and thresholding the output difference product to detect changes in the object.

    摘要翻译: 一种使用对象的图像确定对象的状态变化的方法,所述方法包括提供对象的第一图像和第二图像,第一图像和第二图像在时间上间隔开,执行多个像素 的变化检测算法,以获得包含变化信息和伪变化信息的多个输出差分产物/图像,组合多个输出差分积以形成混合输出差分积,以及阈值输出差分积以检测对象中的变化 。

    SYSTEM AND METHOD FOR CELL-TYPE SPECIFIC COMPARATIVE ANALYSES OF DIFFERENT GENOTYPES TO IDENTIFY RESISTANCE GENES
    69.
    发明申请
    SYSTEM AND METHOD FOR CELL-TYPE SPECIFIC COMPARATIVE ANALYSES OF DIFFERENT GENOTYPES TO IDENTIFY RESISTANCE GENES 审中-公开
    不同基因型细胞型特异性比较分析系统与方法鉴定抗性基因

    公开(公告)号:US20140296086A1

    公开(公告)日:2014-10-02

    申请号:US13993886

    申请日:2011-12-13

    申请人: Vincent P. Klink

    发明人: Vincent P. Klink

    IPC分类号: C12Q1/68

    摘要: Glycine max L. Merr. (soybean) resistance to Heterodera glycines Ichinohe is classified into two cytologically-defined responses, the G. max [Peking]- and G. max[PI 88788]-types. Microarray analyses comparing these cytologically and developmentally distinct resistant reactions reveal differences in gene expression in pericycle and surrounding cells even before infection. Gene pathway analyses compare the two genotypes (1) before, (2) at various times during, (3) constitutively throughout the resistant reaction and (4) at all time points prior to and during the resistant reaction. The amplified levels of transcriptional activity of defense genes may explain the rapid and potent reaction in G. Max[Peking/PI 548402] as compared to G. max[PI 88788].

    摘要翻译: Glycine max L. Merr (大豆)对异养甘氨酸的抗性ichchinohe被分为两个细胞定义的响应,即G.max [Peking]和G.max [PI 88788]型。 比较这些细胞学和发育不同的抗性反应的微阵列分析揭示了即使在感染之前,周期和周围细胞基因表达的差异。 基因途径分析比较了(2)在(3)组成型的整个抗性反应中的两种基因型(1)和(4)在抗性反应之前和期间的所有时间点。 与G.max [PI 88788]相比,防御基因的转录活性的扩增水平可以解释G.Max [Peking / PI 548402]中快速有效的反应。