公开(公告)号：US09562086B2

公开(公告)日：2017-02-07

申请号：US13701472

申请日：2011-06-03

Applicant: Zee Upton

Inventor： Zee Upton

IPC: C07K14/50 ,  C07K14/475 ,  C07K14/435 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/50 ,  A61K38/00 ,  C07K14/435 ,  C07K14/475 ,  C07K16/2839 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/50

Abstract: Isolated protein complexes are provided comprising keratinocyte growth factor and vitronectin, or at least domains thereof that enable binding to and activation of both a keratinocyte growth factor receptor and an integrin receptor for vitronectin. These protein complexes include synthetic proteins where the keratinocyte growth factor and vitronectin sequences are joined by a linker sequence. In particular forms, vitronectin sequences do not include a C-terminal heparin binding domain. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement, skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.

Abstract translation: 提供分离的蛋白质复合物，其包含角质形成细胞生长因子和玻连蛋白，或至少其结构域，其能够与角质形成细胞生长因子受体和玻连蛋白的整联蛋白受体结合和活化。 这些蛋白质复合物包括合成蛋白质，其中角质形成细胞生长因子和玻连蛋白序列通过接头序列连接。 在特定形式中，玻连蛋白序列不包括C末端肝素结合结构域。 还提供了这些蛋白质复合物用于刺激或诱导伤口愈合，组织工程，化妆品和治疗性处理如皮肤置换，皮肤补充和治疗需要上皮细胞迁移的灼伤的细胞迁移和/或增殖的用途。 在其它实施方案中，本发明提供对癌细胞转移的抑制，特别是与乳腺癌相关。

公开(公告)号：US20160144020A1

公开(公告)日：2016-05-26

申请号：US14899538

申请日：2014-06-18

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Janet Davies ,  Bradley Campbell

IPC: A61K39/36 ,  G01N33/68

CPC classification number: A61K39/36 ,  C07K14/415 ,  C07K16/16 ,  G01N33/6893 ,  G01N2333/415 ,  G01N2800/24

Abstract: Allergenic Johnson Grass proteins, antibodies thereto and encoding nucleic acids are provided, which may be used for the diagnosis and/or therapy of sensitivity to these allergenic proteins or to immunologically cross-reactive allergenic proteins. In particular, the allergenic Johnson grass proteins and nucleic acids may be used for environmental testing for airborne allergens and/or for batch standardization of diagnostic and therapeutic compositions.

Abstract translation: 提供过敏性约翰逊草蛋白，其抗体和编码核酸，其可用于诊断和/或治疗对这些变应原蛋白或免疫交叉反应性变应原蛋白的敏感性。 特别地，过敏性约翰逊草蛋白和核酸可用于空气传播过敏原的环境测试和/或用于诊断和治疗组合物的批量标准化。

公开(公告)号：US09254288B2

公开(公告)日：2016-02-09

申请号：US13889337

申请日：2013-05-07

Applicant: Pamela Michelle Pollock

Inventor： Pamela Michelle Pollock

IPC: A61K31/495 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/496 ,  A61K31/4709 ,  C12Q1/68 ,  A61K31/497 ,  A61K31/51

CPC classification number: A61K31/506 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/51 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2800/52 ,  A61K2300/00

Abstract: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR2 variants, which are linked to drug resistance. The disclosure further provides methods of diagnosis and theranosis, using these molecules and fragments thereof, and kits for employing these methods and compositions.

Abstract translation: 本公开提供与耐药性相关的酪氨酸激酶蛋白和核酸变体，特别是FGFR2变体。 本公开进一步提供了使用这些分子及其片段的诊断和治疗方法以及使用这些方法和组合物的试剂盒。

公开(公告)号：US20150347918A1

公开(公告)日：2015-12-03

申请号：US14294000

申请日：2014-06-02

Applicant: Disney Enterprises, Inc. ,  Queensland University of Technology

Inventor： Patrick LUCEY ,  Xinyu WEI

IPC: G06N5/04 ,  G06N99/00

CPC classification number: G06N5/048 ,  G06N7/005 ,  G06N20/00

Abstract: Systems and methods are disclosed for a future event prediction. Embodiments include capturing spatiotemporal data pertaining to activities, wherein the activities include a plurality of events, and employing an augmented-hidden-conditional-random-field (a-HCRF) predictor to generate a future event prediction based on a parameter-vector input, hidden states, and the spatiotemporal data. Methods therein utilize a graph including a first node associated with random variables corresponding to a future event state, a second node associated with random variables corresponding to spatiotemporal input data, a first group of nodes, each node therein associated with random variables corresponding to a subset of the spatiotemporal input data, a second group of nodes, each node therein associated with random variables corresponding to a hidden-state; wherein the edges connect the first node with the second node, the first node with the second group of nodes, and the first group of nodes with the second group of nodes.

Abstract translation: 公开了用于未来事件预测的系统和方法。 实施例包括捕获与活动相关的时空数据，其中活动包括多个事件，并且采用增强隐藏条件随机场（a-HCRF）预测器，以基于参数向量输入生成未来事件预测， 隐藏状态和时空数据。 其中的方法使用包括与对应于未来事件状态的随机变量相关联的第一节点的图形，与对应于时空输入数据的随机变量相关联的第二节点，第一组节点，其中每个节点与对应于子集的随机变量相关联 的时空输入数据，第二组节点，其中的每个节点与对应于隐藏状态的随机变量相关联; 其中所述边缘将所述第一节点与所述第二节点，所述第一节点与所述第二组节点连接，所述第一节点与所述第二组节点连接。

公开(公告)号：US20140045749A1

公开(公告)日：2014-02-13

申请号：US14032848

申请日：2013-09-20

Applicant: Queensland University of Technology

Inventor： Zee Upton ,  Jennifer Ann Kricker

IPC: A61K47/48

CPC classification number: A61K47/48246 ,  A61K38/1709 ,  A61K38/30 ,  A61K38/39 ,  C07K14/71 ,  C07K14/78 ,  A61K2300/00

Abstract: A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.

Abstract translation: 提供了一种治疗以异常上皮细胞增殖和/或迁移为特征的疾病或病症的方法。 该方法的一个步骤可以包括向哺乳动物施用破坏分离的蛋白质复合物的试剂，包括：胰岛素样生长因子I（IGF-I）; 选自IGFBP-3和IGFBP-5的胰岛素样生长因子结合蛋白（IGFBP）; 和玻连蛋白; 或其防止分离的蛋白质复合物的形成，从而治疗哺乳动物的疾病或病症。 所述试剂选自通过至少一个氨基酸残基的取代与IGF-II区分的多肽，其中多肽破坏分离的蛋白质复合物。

公开(公告)号：US20130243843A1

公开(公告)日：2013-09-19

申请号：US13701472

申请日：2011-06-03

Applicant: Zee Upton

Inventor： Zee Upton

IPC: C07K14/50 ,  C07K14/435

CPC classification number: C07K14/50 ,  A61K38/00 ,  C07K14/435 ,  C07K14/475 ,  C07K16/2839 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/50

Abstract: Isolated protein complexes are provided comprising keratinocyte growth factor and vitronectin, or at least domains thereof that enable binding to and activation of both a keratinocyte growth factor receptor and an integrin receptor for vitronectin. These protein complexes include synthetic proteins where the keratinocyte growth factor and vitronectin sequences are joined by a linker sequence. In particular forms, vitronectin sequences do not include a C-terminal heparin binding domain. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement, skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.

Abstract translation: 提供分离的蛋白质复合物，其包含角质形成细胞生长因子和玻连蛋白，或至少其结构域，其能够与角质形成细胞生长因子受体和玻连蛋白的整联蛋白受体结合和活化。 这些蛋白质复合物包括合成蛋白质，其中角质形成细胞生长因子和玻连蛋白序列通过接头序列连接。 在特定形式中，玻连蛋白序列不包括C末端肝素结合结构域。 还提供了这些蛋白质复合物用于刺激或诱导伤口愈合，组织工程，化妆品和治疗性处理如皮肤置换，皮肤补充和治疗需要上皮细胞迁移的灼伤的细胞迁移和/或增殖的用途。 在其它实施方案中，本发明提供对癌细胞转移的抑制，特别是与乳腺癌相关。

公开(公告)号：US20110269716A1

公开(公告)日：2011-11-03

申请号：US13121666

申请日：2009-09-30

Applicant: Steven Bottle ,  Kathryn Fairfull-Smith ,  Farina Schill

Inventor： Steven Bottle ,  Kathryn Fairfull-Smith ,  Farina Schill

IPC: A61K31/675 ,  A61P39/06 ,  C07D209/44 ,  C07F9/572 ,  C12N5/071 ,  A61K31/4035

CPC classification number: C07D209/44 ,  A61K31/4035 ,  A61K31/4155

Abstract: The invention relates to antioxidant substituted isoindoline nitroxide compounds and their use in methods of treating or preventing diseases or disorders related to oxidative stress, methods of reducing oxidative stress and methods of protecting a subject from oxidative stress upon exposure to ionising radiation. Pharmaceutical compositions comprising the antioxidant compounds are also described.

Abstract translation: 本发明涉及抗氧化剂取代的异吲哚啉氮氧化物及其在治疗或预防与氧化应激有关的疾病或病症的方法中的用途，减少氧化应激的方法以及在暴露于电离辐射时保护受试者免受氧化应激的方法。 还描述了包含抗氧化剂化合物的药物组合物。

公开(公告)号：US07659367B2

公开(公告)日：2010-02-09

申请号：US10544796

申请日：2004-02-05

Applicant: Zee Upton ,  Christopher Luke Towne

Inventor： Zee Upton ,  Christopher Luke Towne

IPC: C07K14/00 ,  C07K14/65 ,  C07K14/78

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/65 ,  C07K2319/00 ,  C07K2319/50

Abstract: Isolated protein complexes are provided comprising growth factors such as IGF-I, IGF-II, VEGF or PDGF, or at least domains thereof that enable binding to and activation of both a growth factor receptor, and an integrin receptor-binding domain of vitronectin or fibronectin. These protein complexes may be in the form of oligo-protein complexes or single, synthetic proteins where the growth factor and vitronectin or fibronectin sequences are joined by a linker sequence. In particular forms, vitronectin or fibronectin sequences do not include a heparin binding domain and/or polyanionic domain. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation which may have use in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement and skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.

Abstract translation: 提供了分离的蛋白质复合物，其包含生长因子如IGF-I，IGF-II，VEGF或PDGF，或至少其结构域，其能够结合并激活玻连蛋白的生长因子受体和整联蛋白受体结合结构域 纤连蛋白。 这些蛋白质复合物可以是寡蛋白复合物或单一合成蛋白质的形式，其中生长因子和玻连蛋白或纤连蛋白序列通过接头序列连接。 在特定形式中，玻连蛋白或纤连蛋白序列不包括肝素结合结构域和/或聚阴离子结构域。 还提供了这些蛋白质复合物用于刺激或诱导细胞迁移和/或增殖的用途，其可用于伤口愈合，组织工程，化妆品和治疗处理如皮肤替换和皮肤补充以及治疗需要上皮细胞迁移的灼伤 。 在其它实施方案中，本发明提供对癌细胞转移的抑制，特别是与乳腺癌相关。

公开(公告)号：US07601887B2

公开(公告)日：2009-10-13

申请号：US10573372

申请日：2004-09-23

Applicant: James Langham Dale ,  Santy Peraza Echeverria

Inventor： James Langham Dale ,  Santy Peraza Echeverria

IPC: C12N15/09 ,  C12N15/82 ,  A01H5/00

CPC classification number: C12N15/8282 ,  C07K14/415 ,  C12N15/8279

Abstract: The present invention relates to two banana resistant genes, RGA5 and RGA2, and methods of producing transgenic plants having resistance to fusarium by transforming the plants with RGA5 or RGA2 polynucleotide sequences. The invention also relates to plants transformed with the RGA5 or RGA2 polynucleotide sequences, and methods of breeding plants for fusarium resistance by crossing transformed plants expressing RGA5 or RGA2 polypeptides with fusarium susceptible plants.

Abstract translation: 本发明涉及两种香蕉抗性基因RGA5和RGA2，以及通过用RGA5或RGA2多核苷酸序列转化植物来产生具有抗镰刀菌抗性的转基因植物的方法。 本发明还涉及用RGA5或RGA2多核苷酸序列转化的植物，以及通过将表达RGA5或RGA2多肽的转化植物与镰孢敏感植物杂交来繁殖镰刀菌抗性的植物的方法。

公开(公告)号：US20060141444A1

公开(公告)日：2006-06-29

申请号：US10715926

申请日：2003-11-18

Applicant: Christine Knox ,  Peter Timms

Inventor： Christine Knox ,  Peter Timms

IPC: C12Q1/00

CPC classification number: G01N33/5091 ,  A61K39/00 ,  C07K14/195 ,  C07K14/30 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/56933 ,  G01N33/689 ,  G01N2500/02 ,  G01N2500/20 ,  G01N2800/367 ,  G01N2800/368

Abstract: The present invention is directed to reproductive function-modulating organisms especially of the genera Ureaplasma and Mycoplasma, which adhere more strongly to spermatozoa than other organisms and which correlate with the presence or risk of a condition selected from male infertility, an adverse pregnancy outcome or an adverse assisted reproductive technology outcome. More particularly, the invention is directed to the detection of these reproductive function-modulating organisms (also referred to herein as adherovars), and to various therapeutic and prophylactic strategies for enhancing or otherwise improving inter alia fertility and especially male fertility.

Abstract translation: 本发明涉及生殖功能调节生物体，尤其是解脲支原体和支原体属，它们比其他生物体更强烈地粘附于精子，并且与选自男性不育症，不良妊娠结局或 不利辅助生殖技术成果。 更具体地，本发明涉及这些生殖功能调节生物体（本文中也称为粘附物）的检测，以及用于增强或以其它方式改善生育力，特别是雄性生育力的各种治疗和预防策略。