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    Methods and systems for re-evaluating assembly consensus sequences
    64.
    发明授权
    Methods and systems for re-evaluating assembly consensus sequences 失效
    重新评估组装共识序列的方法和系统

    公开(公告)号：US6047109A

    公开(公告)日：2000-04-04

    申请号：US126006

    申请日：1998-07-29

    Applicant: Alex J. Whittaker

    Inventor： Alex J. Whittaker

    IPC: G06F19/22 ,  G06F15/18

    CPC classification number: G06F19/22

    Abstract: A computational method maximizing open reading frame length in an assembly consensus sequence is provided. Systems employing the method are also provided.

    Abstract translation: 提供了一种在组合共识序列中最大化开放阅读框长度的计算方法。 还提供了采用该方法的系统。

    Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT.sub.1D receptor antagonists
    69.
    发明授权
    Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT.sub.1D receptor antagonists 失效

    公开(公告)号：US5972935A

    公开(公告)日：1999-10-26

    申请号：US11338

    申请日：1998-04-24

    Applicant: Laramie Mary Gaster

    Inventor： Laramie Mary Gaster

    IPC: C07D491/048 ,  A61K31/00 ,  A61K31/47 ,  A61K31/4738 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5383 ,  A61P1/00 ,  A61P3/00 ,  A61P3/04 ,  A61P9/00 ,  A61P9/12 ,  A61P15/00 ,  A61P15/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D491/04 ,  C07D491/052 ,  C07D498/04 ,  A61K31/44 ,  C07D413/00 ,  C07D491/00

    CPC classification number: C07D491/04

    Abstract: The invention relates to novel heterocyclic compounds of formula (I) or a salt or N-oxide thereof, in which R is a group of formulae (i), (ii) or (iii), where R.sup.1 is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, COC.sub.1-6 akyl, C.sub.1-6 alkoxy, hydroxy, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkoxy, acyle, nitro, trifluoromethyl, cyano, SR.sup.9, SOR.sup.9, SO.sub.2 R.sup.9, NR.sup.9 CONR.sup.10 R.sup.11, NR.sup.10 SO.sub.2 R.sup.11, SO.sub.2 NR.sup.11 r.sup.11, SO.sub.2 NR.sup.10 R.sup.11, CO.sub.2 R.sup.10, CONR.sup.10 R.sup.11, CO.sub.2 NR.sup.10 R.sup.11, CONR.sup.10 (CH.sub.2).sub.a CO.sub.2 R.sup.11, (CH.sub.2).sub.a NR.sup.10 R.sup.11, ##STR1## (CH.sub.2).sub.a CONR.sup.10 R.sup.11, (CH.sub.2).sub.a COR.sup.11, (CH.sub.2).sub.a CO.sub.2 C.sub.1-6 alkyl, CO.sub.2 (CH.sub.2).sub.a OR.sup.10, NR.sup.10 R.sup.11, N.dbd.CNR.sup.9 NR.sup.10 R.sup.11, NR.sup.10 CO(CH.sub.2).sub.a NR.sup.10 R.sup.11, NR.sup.10 CO.sub.2 R.sup.11, CONHNR.sup.10 R.sup.11, CR.sup.10 .dbd.NOR.sup.11, CNR.sup.10 .dbd.NOR.sup.11, where R.sup.9, R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 alkyl and a is 1 to 4; or R.sup.1 is a group --X--R.sup.12 where R.sup.12 is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur and X is a bond, O, S, CH.sub.2, C.dbd.O, NR.sup.13 CO or NR.sup.13 where R.sup.13 is hydrogen or C.sub.1-6 alkyl; R.sup.4 and R.sup.5 are independently hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkenyl, C.sub.1-6 alkoxy, hydroxyC.sub.1-6 alkyl, C.sub.1-6 alkylOC.sub.1-6 alkyl, acyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO.sub.2 R.sup.10, CONR.sup.10 R.sup.11, NR.sup.10 R.sup.11 where R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 alkyl, or R.sup.4 and R.sup.5 together form a group --CH.sub.2).sub.r --R.sup.14 --(CH.sub.2).sub.s -- where R.sup.14 is O, S, CH.sub.2 or NR.sup.15 where R.sup.15 is hydrogen or C.sub.1-6 alkyl and r and s are independently 0, 1 or 2; R.sup.2 is hydrogen, C.sub.1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl; R.sup.3 is hydrogen or C.sub.1-6 alkyl or together with R.sup.8 forms a group (CH.sub.2).sub.q where q is 2, 3 or 4; Z is oxygen or sulphur, p is 1 or 2; P is an optionally substituted bicyclic ring optionally containing one to four heteroatoms; or P is an optionally substituted 5- to 7-membered saturated or partially saturated ring optionally containing one to three heteroatoms; and B is oxygen or sulphur, D is nitrogen, carbon or a CH group; R.sup.6 is hydrogen or C.sub.1-6 alkyl and R.sup.7 is C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen, or R.sup.6 together with R.sup.7 forms a group --A-- where A is (CR.sup.16 R.sup.17).sub.t where t is 1, 2 or 3 and R.sup.16 and R.sup.17 are independently hydrogen or C.sub.1-6 alkyl or A is (CR.sup.16 R.sup.17).sub.u --J where u is 0, 1, or 2 and J is oxygen, sulphur, CR.sup.16 .dbd.C.sup.17, CR.sup.16 .dbd.N, CR.sup.16 NR.sup.17 or N.dbd.N; R.sup.18 and R.sup.19 are independently hydrogen or C.sub.1-6 alkyl; R.sup.20 and R.sup.21 are independently hydrogen, C.sub.1-6 alkyl, aralkyl, or together with the nitrogen atom to which they are attached form an optionally substituted 5- to 7-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, nitrogen or sulphur, m is 0 to 4; and Q is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur, processes for their preparation, and their use as 5-HT.sub.1D receptor antagonists.

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