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公开(公告)号：US11925226B2
公开(公告)日：2024-03-12
申请号：US16267242
申请日：2019-02-04
发明人： Yi Cui , Shanhui Fan , Lili Cai , Alex Y. Song , Wei Li , Po-Chun Hsu
CPC分类号： A41D31/32 , A41D31/14 , D01F1/10 , D01F1/106 , D01F6/04 , D04H13/00 , A41D2400/26 , A41D2500/20 , D10B2401/22 , D10B2501/04
摘要： A textile includes: (1) a matrix; and (2) particulate fillers dispersed within the matrix. The textile has a transmittance of infrared radiation at a wavelength of 9.5 μm of at least about 40%, and the textile has a weighted average reflectivity of radiation over a wavelength range of 0.3 μm to 2 μm of at least about 40%.
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公开(公告)号：US20240076637A1
公开(公告)日：2024-03-07
申请号：US18337160
申请日：2023-06-19
IPC分类号： C12N9/22 , C07K1/13 , C12N15/90 , C12Q1/6806
CPC分类号： C12N9/22 , C07K1/13 , C12N15/90 , C12Q1/6806 , C07K2319/60
摘要： Methods for labeling and imaging the accessible genome using a transposase are disclosed. In some embodiments, a bifunctional transposase complex or transposome is used to insert adaptors comprising chemical tags selectively at accessible sites in the genome where active regulatory DNA is located. Various chemical tags can be used for labeling DNA at insertion sites, including, for example, fluorescent dyes for fluorescence imaging, metal particles for electron microscopy or magnetic manipulation of DNA, isotopic labels, or biotin or other ligands, haptens, substrates, or inhibitors that are recognized by streptavidin, antibodies, enzymes, or receptors. Labeling DNA in this manner can be used to provide spatial information regarding the positioning of regulatory DNA in the genome and makes possible the imaging and sorting of cells based on the status of their regulatory DNA.
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公开(公告)号：US20240075167A1
公开(公告)日：2024-03-07
申请号：US18271618
申请日：2022-02-02
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Government as Represented by The Department of Veterans Affairs
发明人： Jeffrey L. Goldberg , Evan Cameron
CPC分类号： A61K48/0075 , A61K9/0048 , A61P27/02 , C12N9/22 , C12N15/86 , C12N2310/20 , C12N2750/14143
摘要： The present invention relates to a method for selectively transducing retinal and optic nerve head (ONH) astrocytes using adeno-associated virus serotype 5 (AAV5) in combination with a modified glial fibrillary acidic protein promoter (gfaABC1D) for delivery of gene therapies (recombinant DNA, shRNA, Crispr/Cas9) to treat glaucoma or other optic neuropathies
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公开(公告)号：US20240075155A1
公开(公告)日：2024-03-07
申请号：US18311023
申请日：2023-05-02
发明人： Russell Pachynski , Holbrook Kohrt , Jason Yonehiro , Brian Zabel
CPC分类号： A61K47/6813 , A61K45/06 , A61K47/6849 , A61K47/6869 , A61P35/00 , C07K14/4702 , C07K14/52 , C07K14/521 , A61K38/00
摘要： The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer.
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公开(公告)号：US20240074899A1
公开(公告)日：2024-03-07
申请号：US18376927
申请日：2023-10-05
发明人： Yang Hu
CPC分类号： A61F9/00781 , G09B23/306
摘要： Injection of silicon oil (SO) to the anterior chamber of an eye efficiently induces intraocular pressure (TOP) elevation. This effect occurs without causing overt ocular structural damage or inflammatory responses while simulating acute glaucomatous changes that human patients develop over years by inducing progressive RGC and ON degeneration and visual functional deficits within weeks. The anterior segments of the experimental eyes are not substantially affected, leaving clear ocular elements that allow easy and reliable assessment of in vivo visual function and morphology. More importantly, this is the only reversible ocular hypertension model by removing SO from the anterior chamber and particularly useful for testing neuroprotection treatment together with lowering TOP treatment. In summary, the acute ocular hypertension glaucoma model replicates secondary post-operative glaucoma. It is straightforward and reversible, does not require special equipment or repeat injections, and may be applicable to a range of animal species with only minor modifications.
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公开(公告)号：US11918550B2
公开(公告)日：2024-03-05
申请号：US17542145
申请日：2021-12-03
发明人： Jiangbin Ye , Haowen Jiang , Yang Li
IPC分类号： A61K31/167 , A61K31/06 , A61K31/203 , A61K31/225 , A61P35/00
CPC分类号： A61K31/167 , A61K31/06 , A61K31/203 , A61K31/225 , A61P35/00
摘要： Methods are provided for the treatment of cancer by administering a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells, which may be provided in a combination with a retinoic acid to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. The cancer may be resistant to retinoic acid.
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公开(公告)号：US20240066115A1
公开(公告)日：2024-02-29
申请号：US18271420
申请日：2022-02-01
发明人： Albert J. Wong
IPC分类号： A61K39/215 , C07K14/005 , G01N33/68 , H01J49/00 , H01J49/16
CPC分类号： A61K39/215 , C07K14/005 , G01N33/6848 , H01J49/004 , H01J49/164
摘要： Compositions and methods are provided for the identification of peptide sequences that are presented to T cells in an MHC context.
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68.发明公开公开(公告)号：US20240065999A1
公开(公告)日：2024-02-29
申请号：US18023839
申请日：2021-11-09
发明人： Ira Schachar , Cassie Ludwig , Stephen J. Smith
IPC分类号： A61K31/223 , A61K9/00 , A61K9/08 , A61K31/137 , A61P27/10
CPC分类号： A61K31/223 , A61K9/0048 , A61K9/08 , A61K31/137 , A61P27/10
摘要： The invention described herein relates to a prodrug that is converted into a dopamine agonist. The dopamine prodrug may be combined with one or more dopamine antagonists, dopamine receptor inhibitors, or vesicular monoamine transport inhibitors. A prodrug is a biologically inactive compound that can be metabolized by the body into its active form. For example, a prodrug placed on the ocular surface can undergo hydrolysis during penetration of the ocular surface, resulting in a biologically active drug. A prodrug allows for use of a lower concentration of the drug and protects against undesirable side effects. A prodrug can also help augment drug uptake into the target tissue.
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公开(公告)号：US11908690B2
公开(公告)日：2024-02-20
申请号：US17619514
申请日：2020-06-19
发明人： Alwin S. Daus , Sam Vaziri , Eric Pop
IPC分类号： H01L21/02 , H01L29/40 , H01L29/417 , H01L29/06
CPC分类号： H01L21/02568 , H01L21/02422 , H01L29/401 , H01L29/41775 , H01L29/0673
摘要： In certain examples, methods and semiconductor structures are directed to multilayered structures including TMD (transition metal dichalcogenide material or TMD-like material and a polymer-based layer which is characterized as exhibiting flexibility. A first layer including a TMD-based material (e.g., an atomic-thick layer including TMD) or TMD-like material is provided or grown on a surface which in certain instances may be a rigid platform or substrate. A plurality of electrodes are provided on or as part of the first layer, and another layer or film including polymer is applied to cover the first layer and the electrodes. The other layer is integrated with the TMD material or TMD-like material and the first layer, and the other layer provides a flexible substrate such as when released from the exemplary rigid platform or substrate.
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70.发明授权公开(公告)号：US11904589B2
公开(公告)日：2024-02-20
申请号：US17864505
申请日：2022-07-14
发明人： Stephen W. Tsai , Dan Wang , Antonio Miravete
CPC分类号： B32B38/1808 , B32B7/022 , B32B7/027 , B32B7/03 , B32B38/1833 , B32B2038/1891 , B32B2250/42 , B32B2250/44 , B32B2307/708 , B32B2309/06 , B32B2605/00
摘要： Square symmetric composite laminate structures, and sub-modules thereof, are provided, along with methods of forming the same. The square symmetric laminate structures include two or more sub-laminate modules, each comprising: a first ply set consisting of a first ply layer oriented at a first angle and a second ply layer oriented at a second angle, a first sum of the first and second angles being ninety degrees; and a second ply set consisting of a third ply layer oriented at a third angle and a fourth ply layer oriented at a fourth angle, a second sum of the third and fourth angles being ninety degrees; wherein the second ply layer is positioned adjacent the third ply layer and the second and third ply layers are both positioned intermediate the first and fourth ply layers, thereby defining a double-double helix arrangement of the respective ply layers. Associated methods are also provided.
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