公开(公告)号：US20150182691A1

公开(公告)日：2015-07-02

申请号：US14418441

申请日：2013-07-29

Applicant: UCB Biopharma SPRL

Inventor： Martin John McLoughlin ,  Michael James David Heald ,  Ilario Melzi ,  Stefan Verlaak ,  Tatiana Palombi

IPC: A61M5/145 ,  A61M5/158

CPC classification number: A61M5/1456 ,  A61M5/002 ,  A61M5/158 ,  A61M5/20 ,  A61M5/3134 ,  A61M5/31505 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2477 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/583 ,  A61M2205/586 ,  A61M2205/8206

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. The plunger slaving part is arranged such that when a drive load is applied to its rear drive-receiving face to bring the front plunger-contacting face into contact with the plunger the drive load is evenly transmitted. The circumferential wall is provided with slide restrictors that restrict frictional sliding movement thereof in relation to the inner wall of the barrel.

Abstract translation: 提供了适用于具有电动驱动单元的自动注射器的盒单元。 盒单元包括限定盒单元容纳腔和针突起孔的盒单元壳体。 容纳腔可以接收注射器。 在注射器的筒体内可轴向移动以向前运动以与注射器柱塞接触，存在一个柱塞从动部件，其限定周向壁布置成与筒体的内壁摩擦滑动关系，后驱动接收面和前部 柱塞接触面。 柱塞从动部件布置成使得当驱动负载施加到其后驱动接收面以使前柱塞接触面与柱塞接触时，驱动负载被均匀地传递。 圆周壁上设有滑动限制器，其限制了相对于筒体的内壁的摩擦滑动运动。

公开(公告)号：US11517676B2

公开(公告)日：2022-12-06

申请号：US16679661

申请日：2019-11-11

Applicant: Bespak Europe Limited ,  UCB Biopharma SPRL

Inventor： Martin John McLoughlin ,  Ian Darnell ,  Matt Ekman ,  Ian Anderson ,  Neil Bentley Cammish

IPC: A61M5/31 ,  A61M5/24 ,  A61M5/20

Abstract: An assembly for an autoinjector device, the assembly including a syringe support for supporting a syringe by limiting forward axial movement of the syringe relative to the syringe support, and a guard element attachable to the syringe support by an attachment so that the guard element is axially restrained both axially forwardly and axially rearwardly relative to the syringe support by the attachment. Forwardly directed axial loads received by the guard element are transmitted to the syringe support via the attachment.

公开(公告)号：US11384148B2

公开(公告)日：2022-07-12

申请号：US16271086

申请日：2019-02-08

Applicant: UCB Biopharma SPRL

Inventor： Helene Margaret Finney ,  Alastair David Griffiths Lawson ,  Stevan Graham Shaw ,  Bryan John Smith ,  Kerry Louise Tyson ,  Lara Kevorkian ,  Christoph Meier ,  Kaushik Sarkar ,  Paul Alan Atherfold

IPC: A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  G01N33/50 ,  G01N33/564 ,  G01N33/68 ,  A61K47/60 ,  A61K47/64 ,  C07K16/00 ,  A61K39/00

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US11331438B2

公开(公告)日：2022-05-17

申请号：US16608465

申请日：2018-04-25

Applicant: UCB Biopharma SPRL

Inventor： Barry Alan Knight ,  Marko Frederik Plevnik ,  Norihiko Inoue ,  Jamie Buckley ,  Lisa Hornsey

IPC: A61M5/32

Abstract: Provided is a cap for an injector comprising a syringe with a needle cover. The cap comprises a first cap body part in the form of a sleeve having forward and rear openings; a second cap body part in the form of a plug arranged for receipt by said forward opening of said sleeve form first cap body part, wherein said plug form second body part defines a plug top and an inner plug body, and wherein said inner plug body defines a protruding pocket; and arranged for receipt within said protruding pocket of the inner plug body, a metal connector defining plural needle cover gripping elements arranged around a central hub, wherein each gripping element is provided with one or more barbs for gripping the needle cover. The first cap body part, second cap body part and connector are provided as separate parts. In the assembled cap, the plug top of the plug form second cap body part forms a cover for the forward opening of the sleeve form first cap body part, and the needle cover gripping elements of the connector extend into the sleeve form first cap body part.

公开(公告)号：US20210371547A1

公开(公告)日：2021-12-02

申请号：US17151911

申请日：2021-01-19

Applicant: UCB BIOPHARMA SPRL

Inventor： Simon Peter TICKLE ,  Heather Margaret LADYMAN

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

公开(公告)号：US20210301012A1

公开(公告)日：2021-09-30

申请号：US16342800

申请日：2017-10-23

Applicant: UCB Biopharma SPRL

Inventor： Michael John Wright ,  Ralph Adams ,  Rebecca Burnley ,  Anna Ettorre

IPC: C07K16/24

Abstract: The invention is in the field of protein:protein interactions, in particular the stabilisation of protein:protein interactions. Binding proteins are provided for stabilising the interactions, together with compositions comprising the binding proteins. Methods using the binding proteins are also provided, including targeting of cells and also medical uses.

公开(公告)号：USRE48622E1

公开(公告)日：2021-07-06

申请号：US16517969

申请日：2019-07-22

Applicant: UCB Biopharma SPRL ,  KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.Leuven R&D

Inventor： Daniel James Ford ,  Richard Jeremy Franklin ,  Anant Ramrao Ghawalkar ,  Helen Tracey Horsley ,  Qiuya Huang ,  James Thomas Reuberson ,  Bart Vanderhoydonck

IPC: C07D487/04 ,  A61K31/519 ,  C07D471/04

Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

公开(公告)号：US20210079120A1

公开(公告)日：2021-03-18

申请号：US17078130

申请日：2020-10-23

Applicant: UCB BIOPHARMA SPRL

Inventor： SAM PHILIP HEYWOOD ,  GAVIN BARRY WILD ,  CHRISTOPHER JOHN LE PAGE ,  RAZWAN HANIF

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

公开(公告)号：US20210069328A1

公开(公告)日：2021-03-11

申请号：US17078127

申请日：2020-10-23

Applicant: UCB BIOPHARMA SPRL

Inventor： SAM PHILIP HEYWOOD ,  GAVIN BARRY WILD ,  RAZWAN HANIF ,  CHRISTOPHER JOHN LE PAGE

IPC: A61K39/395 ,  C07K1/113 ,  C07K16/28 ,  C07K16/18

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

公开(公告)号：US10752676B2

公开(公告)日：2020-08-25

申请号：US14344637

申请日：2012-09-10

Applicant: David Paul Humphreys ,  Daniel John Lightwood ,  Kerry Louise Tyson ,  David Edward Ormonde Knight ,  Karine Jeannine Madeleine Hervé ,  Joanne Elizabeth Compson ,  Matthew Jon Timothy Page ,  Andrew Charles Payne ,  Nicola Louise Fisher ,  Brendon Mackenzie ,  Matthew Cox

Inventor： David Paul Humphreys ,  Daniel John Lightwood ,  Kerry Louise Tyson ,  David Edward Ormonde Knight ,  Karine Jeannine Madeleine Hervé ,  Joanne Elizabeth Compson ,  Matthew Jon Timothy Page ,  Andrew Charles Payne ,  Nicola Louise Fisher ,  Brendon Mackenzie ,  Matthew Cox

IPC: C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  A61K39/00 ,  G01N33/569 ,  G01N33/573 ,  G01N33/68

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.