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91 条记录 (耗时 0.017 秒)

    Polymeric diffusion matrix containing propranolol
    61.
    发明授权
    Polymeric diffusion matrix containing propranolol 失效
    含普萘洛尔的聚合扩散基质

    公开(公告)号：US4482533A

    公开(公告)日：1984-11-13

    申请号：US479499

    申请日：1983-03-28

    申请人： Alec D. Keith

    发明人： Alec D. Keith

    IPC分类号： A61K9/70 ,  A61K31/135 ,  A61L15/03 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61K31/135

    摘要： A self-supporting polymeric diffusion matrix provides for the sustained release of propranolol in order to deliver said propranolol to a patient. The matrix comprises from about 1 to about 60% by weight of a polar plasticizer, from about 5 to about 20% by weight polyvinylalcohol having a molecular weight from about 50,000 to about 150,000, from about 10 to about 25% by weight polyvinylalcohol having a molecular weight from about 4,000 to about 15,000, from about 2 to about 30% by weight polyvinylpyrrolidone, and a pharmaceutically effective amount of the propanolol to provide a sustained release of said propranolol over a prolonged period.

    摘要翻译： 自支撑聚合物扩散基质提供普萘洛尔的持续释放，以将所述普萘洛尔输送给患者。 基质包含约1至约60重量％的极性增塑剂，约5至约20重量％的分子量为约50,000至约150,000的聚乙烯醇，约10至约25重量％的聚乙烯醇，其具有 分子量约4,000至约15,000，约2至约30重量％的聚乙烯吡咯烷酮，以及药学有效量的丙酰洛伦，以在延长的时间内提供所述普萘洛尔的持续释放。

    Polymeric diffusion matrix containing propranolol
    62.
    发明授权
    Polymeric diffusion matrix containing propranolol 失效
    含普萘洛尔的聚合扩散基质

    公开(公告)号：US4460562A

    公开(公告)日：1984-07-17

    申请号：US480368

    申请日：1983-03-30

    申请人： Alec D. Keith ,  Wallace Snipes

    发明人： Alec D. Keith ,  Wallace Snipes

    IPC分类号： A61K9/70 ,  A61K31/135 ,  A61L15/03 ,  A61F13/00 ,  A61K47/00

    CPC分类号： A61K9/7084 ,  A61K31/135 ,  C07K2319/02 ,  C07K2319/55 ,  C07K2319/74

    摘要： A self-supporting polymeric diffusion matrix provides for the sustained release of propranolol in order to deliver the propranolol to a patient. The matrix comprises from about 1 to about 60% of a polar plasticizer, from about 6 to about 30% by weight polyvinylalcohol, from about 2 to about 30% by weight polyvinylpyrrolidone, and a pharmaceutically effective amount of propranolol to provide a sustained release of propranolol over a prolonged period.

    摘要翻译： 自支撑聚合物扩散基质提供普萘洛尔的持续释放，以将普萘洛尔输送给患者。 基质包含约1至约60％的极性增塑剂，约6至约30重量％的聚乙烯醇，约2至约30重量％的聚乙烯吡咯烷酮和药学有效量的普萘洛尔，以提供持续释放 普萘洛尔在长时间内。

    Transdermal nitroglycerin pad
    64.
    发明授权
    Transdermal nitroglycerin pad 失效
    透皮硝酸甘油垫

    公开(公告)号：US4336243A

    公开(公告)日：1982-06-22

    申请号：US260517

    申请日：1981-05-04

    申请人： Dilip R. Sanvordeker ,  James G. Cooney ,  Ronald C. Wester

    发明人： Dilip R. Sanvordeker ,  James G. Cooney ,  Ronald C. Wester

    IPC分类号： A61K9/70 ,  A61K31/21 ,  A61L15/03 ,  A61F13/00

    CPC分类号： A61K9/7069 ,  A61K31/21 ,  A61K9/7092

    摘要： The present invention provides a trans-dermal delivery pad for nitroglycerin administration, specifically a microsealed, trans-dermal nitroglycerin pad having a backing which is impervious to nitroglycerin absorption and transport and a silicon matrix affixed thereto, said silicone polymer matrix being of cross-linked silicone rubber having from about 10 to 200 micron microsealed compartments being formed by in situ cross-linking of the silicone rubber after it is mixed with a hydrophilic solvent system containing the nitroglycerin and a hydrophobic solvent which enhances nitroglycerin dispersion and transport.

    摘要翻译： 本发明提供了一种用于硝酸甘油给药的透皮递送垫，特别是具有不渗透硝酸甘油吸收和转运的背衬的微密封反渗透硝酸甘油垫，以及固定在其上的硅基质，所述硅氧烷聚合物基质是交联的 在硅橡胶与含有硝酸甘油的亲水性溶剂体系和增强硝酸甘油分散和运输的疏水性溶剂混合后，通过硅橡胶的原位交联形成具有约10至200微米微密封隔室的硅橡胶。

    Antibacterial wound dressing
    66.
    发明授权
    Antibacterial wound dressing 失效
    抗菌伤口敷料

    公开(公告)号：US4191743A

    公开(公告)日：1980-03-04

    申请号：US847868

    申请日：1977-11-02

    申请人： Klaus Klemm ,  Helmut Wahlig

    发明人： Klaus Klemm ,  Helmut Wahlig

    IPC分类号： A61L15/44 ,  A61L15/46 ,  A61F13/00 ,  A61F7/02 ,  A61L15/03

    CPC分类号： A61L15/46 ,  A61L2300/406

    摘要： Antibiotics can be effectively administered to wounds over long time periods by a wound dressing which comprises at least two layers of synthetic resin arranged one above the other and an intermediate layer composed of a synthetic resin granulate (particle size: 0.5-3mm) having an antibiotic incorporated therein.

    摘要翻译： 通过伤口敷料可以有效地对伤口施用抗生素，所述伤口敷料包括至少两层合成树脂层叠在一起的中间层和由具有抗生素的合成树脂颗粒（粒径：0.5-3mm）组成的中间层 并入其中。

    Polymeric sheets as synthetic medical dressings or coverings for wounds
    67.
    发明授权
    Polymeric sheets as synthetic medical dressings or coverings for wounds 失效
    聚合物片作为合成医用敷料或伤口覆盖物

    公开(公告)号：US4034751A

    公开(公告)日：1977-07-12

    申请号：US634908

    申请日：1975-11-24

    申请人： John Hui-hsiung Hung

    发明人： John Hui-hsiung Hung

    IPC分类号： A61F13/00 ,  A61F13/15 ,  A61L15/26 ,  A61L15/01 ,  A61L15/03

    CPC分类号： A61F13/00017 ,  A61F13/00046 ,  A61L15/26 ,  A61F13/534 ,  A61F2013/00119 ,  A61F2013/00157 ,  A61F2013/00182 ,  A61F2013/00263 ,  A61F2013/00519 ,  A61F2013/00744 ,  A61F2013/00846 ,  A61F2013/00876 ,  A61F2013/0091 ,  A61F2013/53445 ,  Y10T428/24744 ,  Y10T428/2935

    摘要： Polymeric sheets having on one or both sides a fabric texture and a network of elongated channels in the interior of the structural framework of the sheet. In one embodiment, the sheets comprise a plurality of interbonded continuous polymeric ribs extending in a direction parallel to the plane of the sheet. The ribs impart a fabric texture to both sides of the sheet and define between them recessed portions on each surface of the sheet. The elongated channels extend throughout the ribs. The open area between the ribs can vary from zero to 60%. In another embodiment, the sheets have an ultra-thin, pinhole-free silicone rubber membrane on one side and a fabric texture on the other side. The sheets are useful as burn coverings where they serve as synthetic temporary replacements for damaged or missing skin. The sheets have physiologic properties similar to human skin, excellent drapability characteristics, recessed portions which provide a reservoir for wound debris and, in certain embodiments, a dermal surface which permits wound adherence by fibroblastic ingrowth.

    摘要翻译： 在一个或两侧具有织物结构的聚合片材和片材结构框架内部的细长通道网络。 在一个实施例中，片材包括在平行于片材平面的方向上延伸的多个相互连接的连续聚合物肋条。 这些肋条将织物纹理赋予片材的两侧，并且在片材的每个表面上在它们之间限定凹陷部分。 细长的通道贯穿肋条延伸。 肋骨之间的开放面积可以从零变化到60％。 在另一个实施例中，片材在一侧具有超薄的无针孔硅橡胶膜，另一侧具有织物纹理。 这些床单可用作烧伤覆盖物，其中它们用作合成的临时替代物，用于损坏或缺少皮肤。 这些片材具有类似于人类皮肤的生理学特性，优异的悬垂性特征，为伤口碎片提供储存器的凹部，在某些实施方案中，允许通过成纤维细胞向内生长的伤口粘附的皮肤表面。