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137 条记录 (耗时 0.028 秒)

    Substituted Imidazoline Compounds
    62.
    发明申请
    Substituted Imidazoline Compounds 有权
    取代的咪唑啉化合物

    公开(公告)号：US20090156830A1

    公开(公告)日：2009-06-18

    申请号：US12247524

    申请日：2008-10-08

    申请人： Jetze Tepe ,  James Hamby

    发明人： Jetze Tepe ,  James Hamby

    IPC分类号： C07D233/28 ,  C07D233/22 ,  C07D233/24

    CPC分类号： C07D233/28

    摘要： The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.

    摘要翻译： 本发明涉及包含取代的咪唑啉化合物（包括前药）及其盐的组合物。 在一些实施方案中，本发明涉及这些组合物作为治疗剂的用途，优选用于治疗关节炎或癌症。 在进一步的实施方案中，本发明涉及具有有效量的本文公开的取代咪唑啉化合物的药物组合物，其作为基因表达的激动剂或拮抗剂或与转录因子NF-κB的相互作用。

    Imidazolyl derivatives as corticotropin releasing factor inhibitors
    67.
    发明申请
    Imidazolyl derivatives as corticotropin releasing factor inhibitors 有权
    咪唑衍生物作为促肾上腺皮质激素释放因子抑制剂

    公开(公告)号：US20040235924A1

    公开(公告)日：2004-11-25

    申请号：US10772027

    申请日：2004-02-04

    发明人： Xiaojun Han ,  Gene M. Dubowchik ,  John E. Macor

    IPC分类号： A61K031/4172 ,  C07D233/28

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (nullCRF receptornull) 1 useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.

    摘要翻译： 本发明涉及式（I）的新型杂环拮抗剂和包含可用于治疗抑郁症，焦虑症，情感障碍，进食障碍，创伤后应激的促皮质激素释放因子受体（“CRF受体”）的所述拮抗剂的药物组合物 疾病，头痛，药物成瘾，炎性疾病，药物或酒精戒断症状和其它治疗可由CRF-1受体拮抗作用的其他病症。

    Method for the continuous production of acetylene diurea
    68.
    发明申请
    Method for the continuous production of acetylene diurea 有权
    连续生产乙炔二脲的方法

    公开(公告)号：US20040054191A1

    公开(公告)日：2004-03-18

    申请号：US10614556

    申请日：2003-07-07

    发明人： Dirk Franke ,  Klaus Horchler ,  Vilmos Czikkely

    IPC分类号： C07D233/28

    CPC分类号： C07D487/04 ,  Y02P20/582

    摘要： The continuous production of acetylene diurea takes place by means of the reaction of glyoxal with urea in the presence of mineral acids. The reaction is carried out in at least one reactor having a mixing device, into which glyoxal, urea, and mineral acid are continuously fed, and from which a suspension of acetylene diurea in mother liquor is discharged. The acetylene diurea is mechanically removed from the mother liquor, and the remaining mother liquor is recycled back into the reactor, in whole or in part.

    摘要翻译： 乙炔二脲的连续生产通过在无机酸存在下乙二醛与脲的反应进行。 该反应在具有混合装置的至少一个反应器中进行，其中连续加入乙二醛，尿素和无机酸，并从中排出乙醇二脲在母液中的悬浮液。 乙炔二脲从母液中机械除去，剩余的母液全部或部分循环回到反应器中。

    Process for producing optically active hemiesters
    69.
    发明申请
    Process for producing optically active hemiesters 失效
    光学活性半成品的制造方法

    公开(公告)号：US20030045729A1

    公开(公告)日：2003-03-06

    申请号：US10224392

    申请日：2002-08-21

    申请人： Sumitomo Chemical Company, Limited

    发明人： Kazunori Iwakura ,  Hiroshi Souda

    IPC分类号： C07D233/28 ,  C07C069/34 ,  C07C069/52

    CPC分类号： C07D233/32

    摘要： There is disclosed a process for producing an optically active hemiester of formula (1): 1 wherein R1, R2 and R5 represent the same meanings as described below, which comprises reacting a cyclic acid anhydride of formula (2): 2 wherein R1 and R2 are different and independently represent a hydrogen atom, a halogen atom, an alkyl group optionally substituted with an alkoxy group or a halogen atom, and the like, with a hydroxy compound of formula (3):R3OHnullnull(3)wherein R3 represents an alkyl group optionally substituted with an alkoxy group, a phenoxy group, a dialkylamino group or a halogen atom and the like, in the presence of an asymmetric catalyst.

    摘要翻译： 公开了一种制备式（1）的光学活性半酯的方法：其中R1，R2和R5表示与下述相同的含义，其包括使式（2）的环状酸酐反应：其中R1和R2不同 和独立地表示氢原子，卤素原子，任选被烷氧基或卤素原子取代的烷基等与式（3）的羟基化合物反应：R3OH（3）其中R3表示任选的烷基 在不对称催化剂的存在下被烷氧基，苯氧基，二烷基氨基或卤素原子等取代。

    Concentrated amphocarboxylpropionate surfactants produced from methyl acrylate and 2-alkyl imidazoline
    70.
    发明授权
    Concentrated amphocarboxylpropionate surfactants produced from methyl acrylate and 2-alkyl imidazoline 失效
    由丙烯酸甲酯和2-烷基咪唑啉生产的浓缩的两性羧酸丙酯表面活性剂

    公开(公告)号：US5942627A

    公开(公告)日：1999-08-24

    申请号：US829079

    申请日：1997-03-31

    申请人： Daniel Wayne Lemke

    发明人： Daniel Wayne Lemke

    IPC分类号： B01F17/00 ,  C07D233/18 ,  C07D233/26 ,  C07D233/28

    CPC分类号： C11D1/88 ,  C11D1/90

    摘要： A method for producing amphocarboxylpropionate comprising initiating the reaction of methyl acrylate with 2-alkyl imidazoline in the substantial absence of water; adding from 0.3 to 2 moles of water per mole of 2-alkyl imidazoline to the reaction products after at least 1.3 moles of the methyl acrylate reacts with one mole of the 2-alkyl imidazoline, so as to form a reaction product having a molar ratio of at least 1.8:1 of methyl acrylate to imidazoline. The products of the method can be formulated in highly concentrated form and do not have the gelling problems of the prior art formulation. These products are useful and beneficial in personal care products.

    摘要翻译： 一种生产二羧酸丙酯的方法，包括在基本上不含水的情况下引发丙烯酸甲酯与2-烷基咪唑啉的反应; 在至少1.3摩尔丙烯酸甲酯与1摩尔的2-烷基咪唑啉反应后，向每个反应产物中加入0.3至2摩尔水/摩尔2-烷基咪唑啉，以形成摩尔比 至少1.8:1的丙烯酸甲酯至咪唑啉。 该方法的产物可以以高度浓缩的形式配制，并且不具有现有技术制剂的凝胶化问题。 这些产品在个人护理产品中是有用的和有益的。