公开(公告)号：US11851446B2

公开(公告)日：2023-12-26

申请号：US17353627

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: C07D519/00 ,  C07D471/04 ,  A61K51/04

CPC classification number: C07D519/00 ,  A61K51/0455 ,  A61K51/0459 ,  C07D471/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20220409615A1

公开(公告)日：2022-12-29

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4985 ,  C07D487/04 ,  C07D403/14 ,  A61K31/506 ,  A61K31/501 ,  C07D413/14 ,  A61P25/28

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20220372045A1

公开(公告)日：2022-11-24

申请号：US17729881

申请日：2022-04-26

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Vinod Khetarpal ,  Ashley Jarvis ,  Sarah Hayes ,  John E. Mangette

IPC: C07D498/04 ,  A61K51/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11421007B2

公开(公告)日：2022-08-23

申请号：US16386885

申请日：2019-04-17

Applicant: Sangamo Therapeutics, Inc. ,  CHDI Foundation, Inc.

Inventor： Steven Froelich ,  Ignacio Munoz-Sanjuan ,  Edward J. Rebar ,  Bryan Zeitler ,  H. Steve Zhang

IPC: C12N15/11 ,  C07K14/47 ,  A61P25/00 ,  C12N7/00 ,  A61K38/00

Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.

公开(公告)号：US20210380608A1

公开(公告)日：2021-12-09

申请号：US17353627

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Michael Edward Prime ,  Peter David Johnson ,  Daniel Clark-Frew

IPC: C07D519/00 ,  C07D471/04 ,  A61K51/04

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20210379211A1

公开(公告)日：2021-12-09

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krulle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/14 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11173156B2

公开(公告)日：2021-11-16

申请号：US16898239

申请日：2020-06-10

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Vinod Khetarpal ,  Travis Lee Houston ,  Stephan D. Parent ,  Jian-xie Chen ,  Charles H. Montgomery ,  Geetha Banda

IPC: A61K31/505 ,  C07D239/28

Abstract: Forms of 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I and salts or co-crystals thereof.

公开(公告)号：US20210017522A1

公开(公告)日：2021-01-21

申请号：US16988862

申请日：2020-08-10

Applicant: IONIS PHARMACEUTICALS, Inc. ,  CHDI Foundation, Inc.

Inventor： Gene Hung ,  C. Frank Bennett ,  Janet M. Leeds ,  Susan M. Freier

IPC: C12N15/113

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

公开(公告)号：US20190322711A1

公开(公告)日：2019-10-24

申请号：US16386885

申请日：2019-04-17

Applicant: Sangamo Therapeutics, Inc. ,  CHDI Foundation, Inc.

Inventor： Steven Froelich ,  Ignacio Munoz-Sanjuan ,  Edward J. Rebar ,  Bryan Zeitler ,  H. Steve Zhang

IPC: C07K14/47 ,  C12N7/00 ,  A61P25/00

Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.

公开(公告)号：US20190185463A1

公开(公告)日：2019-06-20

申请号：US16046268

申请日：2018-07-26

Applicant: CHDI Foundation, Inc.

Inventor： Michel C. Maillard ,  Perla Breccia ,  Celia Dominguez ,  Alan F. Haughan ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Andrew J. Stott ,  Amanda Van de Poël ,  Michael Wall ,  Grant Wishart

IPC: C07D413/12 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D491/107

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.