公开(公告)号：US20170273609A1

公开(公告)日：2017-09-28

申请号：US15466751

申请日：2017-03-22

Applicant: Indiana University Research and Technology Corporation

Inventor： Luke G. Gutwein ,  Clinton D. Bahler ,  Anthony S. Kaleth

IPC: A61B5/1455 ,  A61B5/0205 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0075 ,  A61B5/4519 ,  A61B5/6804

Abstract: A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one near-infrared light source and at least one photodetector-and measuring oxygen saturation in at least one of a skin dermis layer, an adipose layer and a muscular fascial layer of a user.

公开(公告)号：US20170266197A1

公开(公告)日：2017-09-21

申请号：US15310070

申请日：2015-05-11

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： Adam Zlotnick ,  William W. Turner ,  Lee Daniel Arnold

IPC: A61K31/5377 ,  A61K31/506 ,  G01N33/50 ,  A61K31/445 ,  G01N33/576 ,  A61K45/06 ,  A61K31/18

CPC classification number: A61K31/5377 ,  A61K31/18 ,  A61K31/445 ,  A61K31/506 ,  A61K31/713 ,  A61K45/06 ,  G01N33/5023 ,  G01N33/5032 ,  G01N33/5762 ,  G01N2500/04

Abstract: Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.

公开(公告)号：US20170261518A1

公开(公告)日：2017-09-14

申请号：US15529595

申请日：2015-11-23

Applicant: Indiana University Research and Technology Corporation

Inventor： Sophie Paczesny

IPC: G01N33/68

Abstract: A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cGVHD) and methods of prognosing and/or diagnosing cGVHD using the biomarker panel are disclosed.

公开(公告)号：US09750481B2

公开(公告)日：2017-09-05

申请号：US14751458

申请日：2015-06-26

Applicant: Indiana University Research and Technology Corporation

Inventor： Saurabh S. Thosar ,  Janet P. Wallace ,  Chad C. Wiggins

IPC: G06K9/00 ,  A61B8/08 ,  A61B8/06

CPC classification number: A61B8/5223 ,  A61B8/06 ,  A61B8/0891 ,  G06T2207/30104

Abstract: A computer-implemented method for simultaneously analyzing antegrade and retrograde blood flow is provided. The method is implemented using a computing device including a processor in communication with a memory. The method includes receiving a first plot of blood velocities over time and determining a first amount of blood flow based on the first plot. The first amount is associated with antegrade blood flow. The method additionally includes determining a second amount of blood flow based on the first plot. The second amount is associated with retrograde blood flow. Additionally, the method includes determining a mean amount of blood flow based at least in part on the first amount of blood flow and the second amount of blood flow, and storing at least one of the first amount, the second amount, and the mean amount of blood flow in the memory.

公开(公告)号：US20170239225A1

公开(公告)日：2017-08-24

申请号：US15440727

申请日：2017-02-23

Applicant: Indiana University Research and Technology Corporation ,  The Brigham and Women's Hospital, Inc.

Inventor： Elliot J. Androphy ,  Kevin Hodgetts ,  Alyssa Nicole Calder

IPC: A61K31/437 ,  A61K31/4704 ,  A61K31/501 ,  A61K31/444 ,  A61K31/506

CPC classification number: A61K31/437 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/7125 ,  A61K45/06 ,  A61K48/00 ,  A61K2300/00

Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

公开(公告)号：US20170231548A1

公开(公告)日：2017-08-17

申请号：US15518732

申请日：2015-10-29

Applicant: Indiana University Research and Technology Corporation

Inventor： Charles R. Powell

IPC: A61B5/20 ,  A61B5/07 ,  A61B5/00

CPC classification number: A61B5/205 ,  A61B5/076 ,  A61B5/6874 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2560/063 ,  A61B2562/0247 ,  A61B2562/222

Abstract: A tissue sensing device and a method for placing the device. The device including a first electrically conductive needle; a non-conductive sheath receiving the first needle therein and allowing exposure of a portion the first needle at a distal end thereof; a second electrically conductive needle; and electronics coupled to the first and second needle, the electronics providing for sensing of capacitance between the first and second needles so as to provide an indication of a tissue in which the exposed portion of the first needle is located.

公开(公告)号：US09730942B2

公开(公告)日：2017-08-15

申请号：US15396978

申请日：2017-01-03

Applicant: Indiana University Research and Technology Corporation

Inventor： John J. Turchi ,  Sarah Shuck

IPC: A01N43/00 ,  A61K31/33 ,  A61K31/5377 ,  A61K31/4709 ,  A61K9/00 ,  A61K47/38 ,  A61K47/26 ,  A61K45/06

CPC classification number: A61K31/5377 ,  A61K9/0053 ,  A61K31/415 ,  A61K31/4709 ,  A61K33/24 ,  A61K45/06 ,  A61K47/26 ,  A61K47/38 ,  C07D401/04 ,  A61K2300/00

Abstract: Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a protein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment.

公开(公告)号：US09707276B2

公开(公告)日：2017-07-18

申请号：US14648752

申请日：2013-11-22

Applicant: Merck Sharp & Dohme Corp. ,  Indiana University Research and Technology Corporation

Inventor： Michael Meehl ,  Richard D. DiMarchi ,  Pengyun Li

IPC: A61K38/28 ,  A61K38/22

CPC classification number: A61K38/28 ,  A61K38/22

Abstract: Compositions and formulations comprising insulin or insulin analogs comprising a carboxy terminal portion (CTP) peptide comprising amino acids 112-118 to 145 of the beta subunit of human chorionic gonadotropin (hCGβ) or a partial variant thereof that includes at least one O-glycosylation site of the CTP peptide, wherein the CTP peptide of the CTP peptide-based insulin or insulin analog is O-glycosylated are described. In particular embodiments, the O-glycosylated insulin analogs are produced in vivo and in further embodiments, the O-glycosylated CTP-based insulin analogs comprise predominantly mannotriose and mannotetrose O-glycans or predominantly mannose O-glycans.

公开(公告)号：US09701621B2

公开(公告)日：2017-07-11

申请号：US14767570

申请日：2014-02-13

Applicant: Indiana University Research and Technology Corporation

Inventor： Amar H. Flood ,  Semin Lee ,  Kevin McDonald

IPC: C07C255/47 ,  C07D213/57 ,  C07D249/04 ,  C07F7/08 ,  C07F7/18

CPC classification number: C07C255/47 ,  C07C2603/90 ,  C07C2603/92 ,  C07D213/57 ,  C07D249/04 ,  C07F7/081 ,  C07F7/1804

Abstract: The present disclosure concerns synthesis and anion binding features of poly-cyanostilbene macrocycles of Formula (I):

公开(公告)号：US20170189362A1

公开(公告)日：2017-07-06

申请号：US15501905

申请日：2015-08-04

Applicant: Indiana University Research and Technology Corporation

Inventor： Jeffrey A. Kline ,  Nathan J. Alves ,  Daren M. Beam

IPC: A61K31/196 ,  A61K45/06 ,  A61K38/48

CPC classification number: A61K31/196 ,  A61K9/127 ,  A61K38/482 ,  A61K38/4833 ,  A61K38/484 ,  A61K38/4846 ,  A61K38/4853 ,  A61K38/486 ,  A61K38/4866 ,  A61K38/49 ,  A61K45/06 ,  A61K47/544 ,  A61K47/6909 ,  A61K47/6911 ,  A61K47/6929 ,  B82Y5/00 ,  C12Y304/21 ,  C12Y304/21001 ,  C12Y304/21004 ,  C12Y304/21005 ,  C12Y304/21007 ,  C12Y304/21008 ,  C12Y304/21027 ,  C12Y304/21034 ,  C12Y304/21036 ,  C12Y304/21069 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.