公开(公告)号：US07767798B2

公开(公告)日：2010-08-03

申请号：US11366687

申请日：2006-03-02

Applicant: Suman Preet Singh Khanuja ,  Santosh Kumar Srivastava ,  Ankur Garg ,  Merajuddin Khan ,  Mahendra Pandurang Dardokar ,  Anirban Pal

Inventor： Suman Preet Singh Khanuja ,  Santosh Kumar Srivastava ,  Ankur Garg ,  Merajuddin Khan ,  Mahendra Pandurang Dardokar ,  Anirban Pal

IPC: C07H15/00

CPC classification number: C07H17/04

Abstract: The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.

Abstract translation: 本发明提供新的类胡萝卜素类似物及其制备方法。 本发明还提供了从Strychnos nux-vomica的果实果肉中分离出的Iridoid苷苷和其生物活性半合成类似物对体外生长的各种人类癌细胞系的用途。

公开(公告)号：US07501443B2

公开(公告)日：2009-03-10

申请号：US10540062

申请日：2002-12-23

Applicant: Anita Mehta ,  Sanjay Kumar Srivastava ,  Jang Bahadur Gupta

Inventor： Anita Mehta ,  Sanjay Kumar Srivastava ,  Jang Bahadur Gupta

IPC: A61K31/46 ,  C07D211/18

CPC classification number: C07D209/52 ,  A61K31/352 ,  C07D405/12

Abstract: This invention generally relates to the derivatives of 3.6-disubstituted azabicyclo [3.1.0] hexanes of the following formula [IA]. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the :h1ethods for treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及下式[IA]的3.6-二取代的氮杂二环[3.1.0]己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和：用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20080293682A1

公开(公告)日：2008-11-27

申请号：US11883753

申请日：2005-12-29

Applicant: Rama Mukherjee ,  Kumar Srivastava ,  Mohammad Jamshed Ahmed Siddioui ,  Manu Jaggi ,  Anu T. Singh ,  Anand Vardhan ,  Manoj Kumar Singh ,  Praveen Rajendran ,  Hemant Kumar Jajoo ,  Anand C. Burman ,  Vivek Kumar ,  Nidhi Rani ,  Shiv Kumar Agarwal

Inventor： Rama Mukherjee ,  Kumar Srivastava ,  Mohammad Jamshed Ahmed Siddioui ,  Manu Jaggi ,  Anu T. Singh ,  Anand Vardhan ,  Manoj Kumar Singh ,  Praveen Rajendran ,  Hemant Kumar Jajoo ,  Anand C. Burman ,  Vivek Kumar ,  Nidhi Rani ,  Shiv Kumar Agarwal

IPC: A61K31/58 ,  A61P35/04

CPC classification number: C07J71/0005 ,  C07J71/0047

Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.

Abstract translation: 本发明涉及式（I）的新型桦木酸衍生物，其中R为C（-CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基， 烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。

公开(公告)号：US20080139574A1

公开(公告)日：2008-06-12

申请号：US11998448

申请日：2007-11-29

Applicant: Brijesh Kumar Srivastava ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

Inventor： Brijesh Kumar Srivastava ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

IPC: A61K31/496 ,  C07D401/10 ,  A61P31/04

CPC classification number: C07D401/04 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention relates to novel compounds of general formula (I), their tautomeric forms, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process for preparing compounds of general formula (I), their tautomeric forms, their pharmaceutically acceptable salts and pharmaceutical compositions containing them.

Abstract translation: 本发明涉及通式（I）的新化合物，其互变异构形式，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（I）的化合物，其互变异构形式，其药学上可接受的盐和含有它们的药物组合物的方法。

公开(公告)号：US07200588B1

公开(公告)日：2007-04-03

申请号：US10209612

申请日：2002-07-29

Applicant: Alok Kumar Srivastava ,  Ivan Tinlung Lam ,  Sunil Kumar

Inventor： Alok Kumar Srivastava ,  Ivan Tinlung Lam ,  Sunil Kumar

IPC: G06F17/30

CPC classification number: G06F17/30595 ,  G06F11/3636 ,  Y10S707/99933 ,  Y10S707/99943

Abstract: The present invention provides a method and mechanism for analyzing trace data using a database management system (DBMS). According to an embodiment, trace data may be loaded onto one or more databases within a DBMS. With this aspect of the invention, several advantages are gained, including the ability to use the query tool of the DBMS to analyze the trace data and the ability to build a trace repository to analyze the history of the trace data.

Abstract translation: 本发明提供了一种使用数据库管理系统（DBMS）分析跟踪数据的方法和机制。 根据实施例，跟踪数据可以被加载到DBMS内的一个或多个数据库上。 通过本发明的这个方面，获得了几个优点，包括使用DBMS的查询工具来分析跟踪数据和构建跟踪存储库以分析跟踪数据的历史的能力。

公开(公告)号：US20070044077A1

公开(公告)日：2007-02-22

申请号：US11209515

申请日：2005-08-22

Applicant: Alok Kumar Srivastava ,  Dipak Saggi ,  Babak Hamadani ,  Sambit Mishra

Inventor： Alok Kumar Srivastava ,  Dipak Saggi ,  Babak Hamadani ,  Sambit Mishra

IPC: G06F9/44

CPC classification number: G06F9/44589

Abstract: A verification infrastructure uses a verification tool with a user interface with which a user may interact to verify an application and/or its platform. The user may enter the same set of commands to verify instances of the application on different platforms. Furthermore, the verification tool is data driven in a way that allows the verification tool to be easily extended to new platforms. Finally, details of a particular configuration are stored persistently and are used by the verification tool to perform verification. Thus, much of the complex work of acquiring knowledge about the configuration and applying the knowledge to the results of various checks made for verification is performed by the verification tool and not a human user.

Abstract translation: 验证基础设施使用具有用户界面的验证工具，用户可以与用户界面进行交互以验证应用程序和/或其平台。 用户可以输入相同的命令集来验证不同平台上应用程序的实例。 此外，验证工具是以允许验证工具轻松扩展到新平台的方式进行数据驱动的。 最后，特定配置的细节被永久存储，由验证工具用来执行验证。 因此，获取关于配置的知识和将知识应用于用于验证的各种检查的结果的许多复杂工作由验证工具而不是人类用户来执行。

公开(公告)号：US06893667B2

公开(公告)日：2005-05-17

申请号：US10104062

申请日：2002-03-22

Applicant: Rajender Singh Sangwan ,  Neelam Singh Sangwan ,  Bali Ram Tyagi ,  Avdhesh Kumar Srivastava ,  Usha Yadav

Inventor： Rajender Singh Sangwan ,  Neelam Singh Sangwan ,  Bali Ram Tyagi ,  Avdhesh Kumar Srivastava ,  Usha Yadav

IPC: C12Q1/28 ,  C12Q1/44 ,  C12Q1/52 ,  A61K35/78 ,  A01N37/18

CPC classification number: C12Q1/52 ,  C12Q1/28 ,  C12Q1/44 ,  G01N2550/00

Abstract: The present invention relates to a method for profiling of protein extract from hyper-acidic aerial parts of plant Scented Geranium (Pelargonium sp.), said method comprising steps of selecting effective extraction medium, with extraction medium consisting of 0.2 M sodium carbonate increasing percentage extract by about 600%, selecting effective medium to determine polypeptide pattern in said extract, with polypeptide pattern medium consisting of Sodium Carbonate ranging between 0.2 to 0.4 M, and 0.2 M Sodium Carbonate along with 50% dimethylsulfoxide, selecting effective media to determine enzyme multimolecular forms in said extract, with enzyme multimolecular forms media consisting of 0.2 M Tris-HCl buffer at pH 7.5, and optionally 50% dimethylsulfoxide; Sodium Carbonate at concentration ranging between 0.2 to 0.4 M and optionally 50% dimethylsulfoxide, and using biochemical and biophysical techniques comprising gel electrophoresis, spectrophotometry, centrifugation, protein estimation in said method to determine quantitative, qualitative, structural and functional facets of the proteins from said extract, and extraction compositions thereof.

Abstract translation: 本发明涉及一种用于从植物香味天竺葵（天竺葵属）的高酸性地上部分分析蛋白质提取物的方法，所述方法包括以下步骤：选择有效的提取介质，用0.2M碳酸钠提取百分比提取物 选择有效培养基以确定所述提取物中的多肽模式，多肽模式培养基由碳酸钠组成，范围在0.2至0.4M之间，0.2M碳酸钠与50％二甲基亚砜组成，选择有效培养基以确定酶多分子形式 在所述提取物中，用酶多分子形式的培养基由pH7.5的0.2M Tris-HCl缓冲液和任选的50％二甲基亚砜组成; 碳酸钠的浓度范围为0.2至0.4M，任选的50％的二甲基亚砜，并且使用生物化学和生物物理技术，包括凝胶电泳，分光光度法，离心，所述方法中的蛋白质估计，以确定所述蛋白质的定量，定性，结构和功能方面 提取物及其提取组合物。

公开(公告)号：US06579862B1

公开(公告)日：2003-06-17

申请号：US09280448

申请日：1999-03-30

Applicant: Ram Pratap ,  Ram Chandra Gupta ,  Ramesh Chander ,  Ashok Kumar Khanna ,  Arvind Kumar Srivastava ,  Deepak Raina ,  Satyavan Singh ,  Savita Srivastava ,  Anil Kumar Rastogi ,  Omkar Prasad Asthana ,  Swarn Nityanand ,  Nitya Anand ,  Ashim Ghatak ,  Narinder Kumar Kapoor ,  Sukh Dev

Inventor： Ram Pratap ,  Ram Chandra Gupta ,  Ramesh Chander ,  Ashok Kumar Khanna ,  Arvind Kumar Srivastava ,  Deepak Raina ,  Satyavan Singh ,  Savita Srivastava ,  Anil Kumar Rastogi ,  Omkar Prasad Asthana ,  Swarn Nityanand ,  Nitya Anand ,  Ashim Ghatak ,  Narinder Kumar Kapoor ,  Sukh Dev

IPC: A61K3158

CPC classification number: A61K31/573 ,  C07J13/005 ,  C07J13/007

Abstract: The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I): containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals wherein X═OH or O and the olefinic bonds are at 4(5); 5(6); 16(17); or 17(20) or various combinations, and wherein the compounds contain at lest one olefinic bond in or on their D-ring. The method comprises administering an effective amount of said compounds to recipient mammals.

Abstract translation: 本发明提供了一种使用由结构式（I）表示的孕ad酮和孕二烯醇的方法：在D环中或其D环上含有至少一个烯键，用于治疗哺乳动物中的高脂血症和高血糖病症，其中X = OH或O， 烯键为4（5）; 5（6）; 16（17）; 或17（20）或各种组合，并且其中所述化合物在其D环中或其上含有至少一个烯键。 该方法包括向受体哺乳动物施用有效量的所述化合物。

公开(公告)号：US06473212B1

公开(公告)日：2002-10-29

申请号：US09253259

申请日：1999-02-19

Applicant: Andrew Roman Chraplyvy ,  Robert Meachem Jopson ,  Atul Kumar Srivastava ,  James William Sulhoff ,  Yan Sun

Inventor： Andrew Roman Chraplyvy ,  Robert Meachem Jopson ,  Atul Kumar Srivastava ,  James William Sulhoff ,  Yan Sun

IPC: H04J1402

CPC classification number: H04B10/296 ,  H04B10/2914

Abstract: Substantially error-free communications is achieved in an optical communication system that includes optical amplifiers by detecting bits transmitted in the amplified optical signal using a detection threshold that is derived as a function of a maximum power level associated with a first bit value, e.g., bit “0”, and a minimum power level associated with a second bit value, e.g., bit “1”. Importantly, this detection scheme can be used to accurately detect bit patterns in the amplified signal even in the presence of nonlinear distortions caused by gain variations, such as inter-modal distortion and saturation induced crosstalk. In a wavelength division multiplexed (WDM) system comprising semiconductor optical amplifiers, for example, the detection threshold can be set at a level corresponding to PTOTAL/2N, where PTOTAL represents the total power in the WDM signal and N represents the number of optical channels in the WDM signal. According to another aspect of the invention, the effect of gain fluctuations becomes smaller as the number of channels increase. In particular, a smoothing effect is realized for the total effective saturation power as gain variations decrease as a function of an increase in the number of channels. As such, the performance of a semiconductor optical amplifier according to the principles of the invention approaches the linear performance of fiber amplifiers as the number of channels increases.

Abstract translation: 在包括光放大器的光通信系统中实现基本无差错的通信，所述光通信系统使用检测阈值来检测放大的光信号中发送的位，所述检测阈值作为与第一位值相关联的最大功率电平的函数导出，例如位 “0”，以及与第二位值相关联的最小功率电平，例如位“1”。 重要的是，即使存在由诸如模态间失真和饱和感应串扰的增益变化引起的非线性失真，该检测方案也可用于精确地检测放大信号中的位模式。 在包括半导体光放大器的波分复用（WDM）系统中，例如，检测阈值可以被设置在与PTOTAL / 2N相对应的电平，其中PTOTAL表示WDM信号中的总功率，N表示光信道数 在WDM信号中。 根据本发明的另一方面，增益波动的效果随着信道数量的增加而变小。 特别地，当增益变化随着通道数量的增加而减小时，实现总有效饱和功率的平滑效果。 因此，根据本发明原理的半导体光放大器的性能随着信道数量的增加而接近光纤放大器的线性性能。

公开(公告)号：US6049418A

公开(公告)日：2000-04-11

申请号：US89863

申请日：1998-06-03

Applicant: Atul Kumar Srivastava ,  James William Sulhoff ,  Yan Sun ,  Paul Francis Wysocki

Inventor： Atul Kumar Srivastava ,  James William Sulhoff ,  Yan Sun ,  Paul Francis Wysocki

IPC: H01S3/067 ,  H01S3/16 ,  H01S3/23 ,  H01S3/00

CPC classification number: H01S3/06754 ,  H01S3/0675 ,  H01S3/06766 ,  H01S3/0677 ,  H01S3/1608 ,  H01S3/2383 ,  H04B2210/258

Abstract: A wideband optical amplifier employs split-band architecture in which an optical signal passes through a common amplification stage and is then split to pass through parallel gain stages, each of which may be optimized for a particular band being traversed. A broadband grating reflector is used after the input gain section to reflect the signals of one of the bands so that they again will pass through the common input gain section before passing through gain section of the split structure dedicated to their particular wavelength. Meanwhile, the other signals pass through the reflector and move on through the gain section pertinent to their wavelength.

Abstract translation: 宽带光放大器采用分波段结构，其中光信号通过公共放大级，然后被分割以通过并行增益级，其中的每一级可以针对被遍历的特定频带进行优化。 在输入增益部分之后使用宽带光栅反射器以反射其中一个频带的信号，使得它们在通过专用于其特定波长的分割结构的增益部分之前再次通过公共输入增益部分。 同时，其他信号通过反射器并且通过与它们的波长有关的增益部分。