公开(公告)号：US11377506B2

公开(公告)日：2022-07-05

申请号：US16762221

申请日：2018-11-14

Applicant: TOKUSHIMA UNIVERSITY ,  SEKISUI CHEMICAL CO., LTD.

Inventor： Koichi Ute ,  Tomohiro Hirano ,  Miyuki Oshimura ,  Yasunari Kusaka ,  Yohei Nishimura ,  Misaki Senoo

IPC: C08F8/14 ,  C08F216/06 ,  C08F218/08

Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and capable of providing a film having high flexibility, high mechanical strength, and high adhesion, and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a triad unit chain ratio TOO of 7.5 or less, where the triad unit chain ratio TOO is obtained using the following formula (1): [ Math . ⁢ 1 ] T OO = [ Vac ⁢ ⁢ content ] × [ OOO ⁢ ⁢ proportion ] × 2 [ VOH ⁢ ⁢ content ] × [ AOO ⁢ ⁢ proportion ] ( 1 ) wherein the VOH content ratio represents the amount of the unit of vinyl alcohol, the Vac content ratio represents the amount of the unit of vinyl acetate, the OOO proportion represents the proportion of a triad OOO, and the AOO proportion represents the proportion of a triad AOO.

公开(公告)号：US20210363520A1

公开(公告)日：2021-11-25

申请号：US16640521

申请日：2018-08-20

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA, encoding said guide RNA.

公开(公告)号：US20210246560A1

公开(公告)日：2021-08-12

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. ,  Tokushima University

Inventor： Shoichi YAMADA ,  Toshio HYUGA ,  Hisao NEMOTO

IPC: C23F11/12 ,  C07D319/06 ,  C07D317/20 ,  C07C327/22 ,  C23F11/16

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n +1 valent linker group, n is an integer of 1 or more and 5 or less.

公开(公告)号：US10928303B2

公开(公告)日：2021-02-23

申请号：US16320002

申请日：2017-07-25

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Takashi Fukawa ,  Taiki Hattori ,  Masaaki Nagase ,  Kazuteru Tanaka ,  Kouji Nishino ,  Nobukazu Ikeda

IPC: G01N21/59 ,  G01N21/05 ,  G01N21/03 ,  G01N21/33

Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.

公开(公告)号：US20190271636A1

公开(公告)日：2019-09-05

申请号：US16320002

申请日：2017-07-25

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Takashi FUKAWA ,  Taiki HATTORI ,  Masaaki NAGASE ,  Kazuteru TANAKA ,  Kouji NISHINO ,  Nobukazu IKEDA

IPC: G01N21/05 ,  G01N21/59 ,  G01N21/03

Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.

公开(公告)号：US10324029B2

公开(公告)日：2019-06-18

申请号：US15748261

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Michio Yamaji ,  Nobukazu Ikeda ,  Kouji Nishino ,  Masayoshi Kawashima ,  Kazuteru Tanaka

IPC: G01N21/31 ,  G01N21/33 ,  G01J3/42 ,  G01N21/59 ,  G01N21/27 ,  G01J3/10 ,  G01J3/28 ,  G01J3/433 ,  G01J3/02 ,  G01N21/3504 ,  G01J1/42

Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.

公开(公告)号：US20190150463A1

公开(公告)日：2019-05-23

申请号：US16317684

申请日：2017-08-15

Applicant: Meiji Co., Ltd. ,  Tokushima University

Inventor： Hiroshi KIDO ,  Etsuhisa TAKAHASHI ,  Seiya MAKINO ,  Hiroshi KANO ,  Jun HENMI

IPC: A23C9/123 ,  A23L33/135 ,  A61K35/20 ,  A61P31/16 ,  A61P37/04

Abstract: A composition for suppressing deterioration of an acquired immune function according to the present invention includes, as an active ingredient, lactic acid bacteria products from lactic acid bacteria of the genus Lactobacillus. This composition for suppressing deterioration of the acquired immune function suppresses deterioration of the acquired immune function due to the use of an anti-influenza drug. The lactic acid bacteria of the genus Lactobacillus is preferably a bulgaricus bacterium. For example, the lactic acid bacteria of the genus Lactobacillus may be Lactobacillus delbrueckii subsp. bulgaricus. In the production method according to the present invention, a milk raw material is supplied to lactic acid bacteria of the genus Lactobacillus in order to produce the composition for suppressing deterioration of the acquired immune function to suppress deterioration of the acquired immune function due to the use of an anti-influenza drug.

公开(公告)号：US20180217054A1

公开(公告)日：2018-08-02

申请号：US15748264

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Michio YAMAJI ,  Nobukazu IKEDA ,  Kouji NISHINO ,  Masayoshi KAWASHIMA ,  Kazuteru TANAKA

IPC: G01N21/31 ,  G01N21/59 ,  G01J3/42 ,  G01J3/10

CPC classification number: G01N21/3103 ,  G01J3/10 ,  G01J3/42 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/59 ,  G01N2021/157 ,  G01N2021/3133 ,  G01N2201/0627 ,  G01N2201/08 ,  G01N2201/1211

Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.

公开(公告)号：US20180064073A1

公开(公告)日：2018-03-08

申请号：US15551791

申请日：2016-02-18

Applicant: Masakazu HASHIMOTO ,  Tokushima University ,  BEX Co., Ltd.

Inventor： Masakazu Hashimoto ,  Tatsuya Takemoto

IPC: A01K67/027 ,  C12N15/09 ,  C12N9/16

CPC classification number: A01K67/0275 ,  A01K67/027 ,  C12N9/16 ,  C12N15/09

Abstract: The disclosure relates to a method of introducing mRNA encoding Cas9 protein (Cas9 mRNA) into a mammalian embryo, comprising the steps of; (a) placing a mixture of the mammalian embryo and a solution comprising Cas9 mRNA in the gap between a pair of electrodes, and (b) applying a voltage to the electrodes for a voltage application duration, wherein the voltage and the voltage application duration achieve the efficiency of mRNA introduction (R) higher than the minimum required efficiency of mRNA introduction (Rmin) that is calculated on the basis of the concentration of Cas9 mRNA (ng/μl).

公开(公告)号：US20170199117A1

公开(公告)日：2017-07-13

申请号：US15321398

申请日：2015-07-23

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Nobukazu IKEDA ,  Michio YAMAJI ,  Tadayuki YAKUSHIJIN

IPC: G01N21/27 ,  G01N21/15 ,  G01N21/05

CPC classification number: G01N21/27 ,  G01N21/05 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/08

Abstract: An inline concentration measurement device comprises: a measurement cell main body with a gas flow path formed; a light incident part with a window member connected to the main body; and a light receiving part with a window member connected to the main body, wherein the gas flow path includes a gas flow path for an optical path extending straight between the window members of the light incident part and the light receiving part, a first communication part making a gas inlet formed in the main body communicate with the gas flow path part for the optical path, and a second communication part making a gas outlet formed in the main body communicate with the gas flow path part for the optical path, and the first communication part obliquely extends from the gas inlet towards the window member of the light incident part.