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公开(公告)号:US06831080B2
公开(公告)日:2004-12-14
申请号:US10160582
申请日:2002-05-31
申请人: Yong-Jin Wu , Li-Quang Sun , Jie Chen , Huan He , Alexandre L'Heureux , Pierre Dextraze , Jean-Paul Daris , Gene G. Kinney , Steven I. Dworetzky , Piyasena Hewawasam
发明人: Yong-Jin Wu , Li-Quang Sun , Jie Chen , Huan He , Alexandre L'Heureux , Pierre Dextraze , Jean-Paul Daris , Gene G. Kinney , Steven I. Dworetzky , Piyasena Hewawasam
IPC分类号: C07C23720
CPC分类号: C07D213/40 , C07C233/11 , C07C235/34 , C07D209/08 , C07D213/56 , C07D215/04 , C07D215/12 , C07D217/06 , C07D239/26 , C07D241/12 , C07D265/30 , C07D265/36 , C07D295/135 , C07D307/79 , C07D311/58 , C07D317/58 , C07D317/60 , C07D319/18 , C07D333/24 , C07D407/12 , C07D491/08
摘要: There is provided novel cinnamide derivatives of Formula I: wherein R is C1-4 alkyl or trifluoromethyl; R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl in which said substituted phenyl is substituted with one or two substituents each independently selected-from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy and nitro; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, and halogen; R4 is selected from the group consisting of di(C1-4 alkyl)amino, trifluoromethoxy and optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl with one or two substituents in which said substituent is independently selected from the group consisting of C1-4 alkyl, aminomethyl, hydroxymethyl, chloro or fluoro; R5 is hydrogen, chloro or fluoro; or R4 and R5 taken together are —CH═CH—CH═CH— or —X(CH2)mY— in which X and Y are each independently selected from the group consisting of CH2, (CH2)nN(R9)— and O, wherein m is 1 or 2; n is 0 or 1; and R6, R7, and R8 are each independently selected from hydrogen, chloro and fluoro; and R9 is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxyethyl, C1-4 alkoxyethyl, cyclopropylmethyl, —CO2(C1-4alkyl), and —CH2CH2NR10R11 in which R10 and R11 are each independently hydrogen or C1-4 alkyl, which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
摘要翻译: 提供式I的新颖的肉桂酰胺衍生物:其中R是C 1-4烷基或三氟甲基; R 1选自吡啶基,喹啉基,噻吩基,呋喃基,1,4-苯并二恶烷基,1,3-苯并二恶唑基,苯并二氢吡喃基,茚满基,联苯基,苯基和取代的苯基,其中所述取代的苯基被一个 或两个各自独立地选自卤素,C 1-4烷基,C 1-4烷氧基,三氟甲基,三氟甲氧基和硝基的取代基; R 2和R 3各自独立地选自氢,C 1-4烷基和卤素; R 4选自二(C 1-4烷基)氨基,三氟甲氧基和任选取代的吗啉-4-基,吡啶基,嘧啶基,哌嗪基和吡嗪基,其中一个或两个取代基独立地选自所述取代基 由C1-4烷基,氨基甲基,羟甲基,氯或氟组成的基团; R 5是氢,氯或氟; 或R 4和R 5一起为-CH = CH-CH = CH-或-X(CH 2)mY-,其中X和Y各自独立地选自CH 2,(CH 2)n N (R 9) - 和O,其中m为1或2; n为0或1; 和R 6,R 7和R 8各自独立地选自氢,氯和氟; 并且R 9选自氢,C 1-4烷基,羟乙基,C 1-4烷氧基乙基,环丙基甲基,-CO 2(C 1-4烷基)和-CH 2 CH 2 NR 10 R 11, 10>和R 11各自独立地是氢或C 1-4烷基,其是KCNQ钾通道的开放剂,并且可用于治疗对开放KCNQ钾通道有响应的病症。
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公开(公告)号:US5994306A
公开(公告)日:1999-11-30
申请号:US752852
申请日:1996-11-21
申请人: Conway C. Chang , Chee Liang Gu , Jie Chen , Deborah A. Steinberg , Robert I. Lehrer , Sylvia S.L. Harwig, deceased
发明人: Conway C. Chang , Chee Liang Gu , Jie Chen , Deborah A. Steinberg , Robert I. Lehrer , Sylvia S.L. Harwig, deceased
IPC分类号: A61K38/00 , A01N63/02 , A61K38/10 , A61K38/17 , A61P31/00 , A61P31/04 , C07K4/00 , C07K7/00 , C07K7/08 , C07K14/00 , C07K16/18 , C12N15/12 , A61K38/04 , A01N25/00 , C12N15/13
摘要: The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections.
摘要翻译: 本发明涉及与天然存在的整合素肽相关的抗微生物肽,以及在各种情况下使用肽的方法,包括治疗或预防感染。
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公开(公告)号:US5887024A
公开(公告)日:1999-03-23
申请号:US780145
申请日:1996-12-26
申请人: Xiaoling Qin , Kunihiko Suzuki , Guoliang Shou , Changming Zhou , Jie Chen
发明人: Xiaoling Qin , Kunihiko Suzuki , Guoliang Shou , Changming Zhou , Jie Chen
摘要: The present invention provides a matched filter which can refresh an entire while keeping the speed of a calculation comparable to a small sized circuit. The first and second addition circuits of a matched filter of the present invention are classified into a plurality of groups, the first and second auxiliary adders replace functions for the groups of the first and second adders respectively. The outputs of the first and second adders are then inputted to the first and second subtractors, respectively, and the refreshing means appropriately refreshes the groups replaced by the first and second auxiliary adders. Further, the present invention decreases the number of auxiliary sapling and holding circuits to be used, and decides the refreshing intervals by considering the change of the voltage caused by leakage and other permissible errors of output voltage.
摘要翻译: 本发明提供了一种匹配滤波器,其可以保持与小尺寸电路相当的计算速度的整体刷新。 本发明的匹配滤波器的第一和第二加法电路分为多个组,第一和第二辅助加法器分别代替第一和第二加法器的组的功能。 然后,第一和第二加法器的输出分别输入到第一和第二减法器,并且刷新装置适当地刷新由第一和第二辅助加法器替换的组。 此外,本发明减少了要使用的辅助树苗和保持电路的数量,并且通过考虑由漏电引起的电压的变化和输出电压的其他允许误差来决定刷新间隔。
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公开(公告)号:USD998994S1
公开(公告)日:2023-09-19
申请号:US29893663
申请日:2023-06-01
申请人: Jie Chen
设计人: Jie Chen
摘要: FIG. 1 is a front perspective view of a shelf, showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a left side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines in the drawings illustrate the portions of the shelf, which form no part of the claimed design.-
公开(公告)号:US20180128528A1
公开(公告)日:2018-05-10
申请号:US15348571
申请日:2016-11-10
申请人: Jie Chen , Jan Pottinger
发明人: Jie Chen , Jan Pottinger
IPC分类号: F25B45/00
CPC分类号: F25B45/00 , F25B49/02 , F25B2345/001 , F25B2500/19 , F25B2500/24 , F25B2600/2513 , F25B2700/195 , F25B2700/197 , F25B2700/21163 , F25B2700/21175
摘要: A method for charging a field refrigeration system including an evaporator, a condenser, a compressor, and an expansion device includes calculating a target superheat as a function of one or more of a measured field outdoor dry bulb temperature, and a measured field indoor wet bulb temperature. A charge adjustment percentage can be calculated as a function of the target superheat. A refrigerant adjustment weight can be determined based on the charge adjustment percentage. A field refrigeration system charge can be adjusted by the refrigerant adjustment weight.
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公开(公告)号:US09611259B2
公开(公告)日:2017-04-04
申请号:US14772040
申请日:2014-03-13
申请人: Janssen Pharmaceutica NV , Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu
发明人: Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu , Yong Gong
IPC分类号: C07D405/14
CPC分类号: C07D405/14
摘要: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
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公开(公告)号:US09177178B2
公开(公告)日:2015-11-03
申请号:US13811734
申请日:2011-05-16
申请人: Chaoyang Liu , Dongxing Zhao , Jie Chen
发明人: Chaoyang Liu , Dongxing Zhao , Jie Chen
IPC分类号: G06K7/01 , G05B19/042 , G05B19/14
CPC分类号: G06K7/01 , G05B19/042 , G05B2219/25187 , G05B2219/25196 , H04W4/80
摘要: The disclosure provides a Radio Frequency Identification (RFID) control device, system and method. The RFID control device includes a base station controller (40). The base station controller (40) includes a base service module (402), a peripheral service module (401) and a control logic module (403), wherein the base service module (402) controls a base service device (50) and reports a control result information; the peripheral service module (401) controls a peripheral equipment (80) and reports a control result information; and the control logic module (403) receives the control result information reported by the base service module (402) and the peripheral service module (401), controls the base service device (50) through the base service module (402) and controls the peripheral equipment (80) through the peripheral service module (401) according to a control logic rule. When a use scene is changed, only the control logic rule of the control logic module (403) needs to be overwritten.
摘要翻译: 本公开提供了射频识别(RFID)控制装置,系统和方法。 RFID控制装置包括基站控制器(40)。 基站控制器(40)包括基本服务模块(402),外围服务模块(401)和控制逻辑模块(403),其中基本服务模块(402)控制基本服务设备(50) 控制结果信息; 外围服务模块(401)控制外围设备(80)并报告控制结果信息; 控制逻辑模块(403)接收由基本服务模块(402)和外围服务模块(401)报告的控制结果信息,通过基本服务模块(402)控制基本服务装置(50),并控制 外围设备(80)根据控制逻辑规则通过外围服务模块(401)。 当使用场景改变时,只需要覆盖控制逻辑模块(403)的控制逻辑规则。
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公开(公告)号:US09012192B2
公开(公告)日:2015-04-21
申请号:US13238978
申请日:2011-09-21
申请人: Jie Chen , James Xing , Woon T. Ang
发明人: Jie Chen , James Xing , Woon T. Ang
IPC分类号: C12P1/00 , C12N13/00 , C12N1/14 , C12N1/18 , C12P7/06 , C12P17/04 , C12P19/02 , C12P19/14 , C12M1/42
CPC分类号: C12N13/00 , C12M35/04 , C12N1/14 , C12N1/18 , C12P7/06 , C12P17/04 , C12P19/02 , C12P19/14 , Y02E50/17
摘要: A method of increasing the rate of growth, useful product production, or protein expression of a microorganism includes the step of exposing the microorganism to ultrasound having a frequency greater than about 1 MHz.
摘要翻译: 提高微生物生长速率,有用产物产生或蛋白质表达的方法包括将微生物暴露于频率大于约1MHz的超声波的步骤。
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公开(公告)号:US09000876B2
公开(公告)日:2015-04-07
申请号:US13419272
申请日:2012-03-13
申请人: Hao-Yi Tsai , Hsien-Wei Chen , Hung-Yi Kuo , Jie Chen , Ying-Ju Chen , Tsung-Yuan Yu
发明人: Hao-Yi Tsai , Hsien-Wei Chen , Hung-Yi Kuo , Jie Chen , Ying-Ju Chen , Tsung-Yuan Yu
IPC分类号: H01F5/00 , H01F27/28 , H01F27/36 , H01L31/107 , H01L23/522 , H01L23/552 , H01L23/00 , H01L49/02 , H01L23/58
CPC分类号: H01L23/5227 , H01L21/768 , H01L23/5225 , H01L23/552 , H01L23/585 , H01L24/03 , H01L24/11 , H01L28/10 , H01L2224/02351 , H01L2224/0401 , H01L2224/06515 , Y10T29/4902
摘要: An inductor device and method of forming the inductor device are provided. In some embodiments the inductor device includes a post passivation interconnect (PPI) layer disposed and an under bump metallization (UBM) layer, each disposed over a substrate. The PPI layer forms a coil and dummy pads. The dummy pads are disposed around a substantial portion of the coil to shield the coil from electromagnetic interference. A first portion of the UBM layer is electrically coupled to the coil and configured to interface with an electrical coupling member.
摘要翻译: 提供一种形成电感器件的电感器件和方法。 在一些实施例中,电感器件包括设置在衬底上的后钝化互连(PPI)层和凸块下金属化(UBM)层。 PPI层形成线圈和虚拟垫。 虚拟焊盘围绕线圈的大部分设置,以屏蔽线圈免受电磁干扰。 UBM层的第一部分电耦合到线圈并且被配置为与电耦合构件相接合。
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公开(公告)号:US08952823B2
公开(公告)日:2015-02-10
申请号:US13355320
申请日:2012-01-20
CPC分类号: G01R31/3606 , G01R31/3651 , G01R31/3675
摘要: An early warning and monitoring system is disclosed for battery cells and battery packs. During normal cycling of a battery, surface temperature, voltage, current and impedance may be monitored to determine if abnormalities exist in the battery and/or battery structure. The abnormalities may be advantageously detected using battery temperature characteristics, where the characteristics are subject to rule-based processing to determine impending battery failure. By receiving advance notice of failure, a warning signal may be transmitted to provide notice and/or allow corrective action to be taken.
摘要翻译: 公开了用于电池单元和电池组的早期预警和监视系统。 在电池的正常循环期间,可以监测表面温度,电压,电流和阻抗,以确定电池和/或电池结构中是否存在异常。 可以使用电池温度特性有利地检测异常,其中特性经受基于规则的处理以确定即将发生的电池故障。 通过收到事故通知,可以发送警告信号以提供通知和/或允许采取纠正措施。
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