公开(公告)号：US20060084842A1

公开(公告)日：2006-04-20

申请号：US11245709

申请日：2005-10-07

Applicant: Charles Hart ,  Edward Pingleton

Inventor： Charles Hart ,  Edward Pingleton

IPC: A61B1/32

CPC classification number: A61B17/0293 ,  A61B17/3423 ,  A61B17/3498 ,  A61B2017/00265

Abstract: The invention is directed to a hand access system that provides hand access to a surgical area while maintaining pneumoperitoneum during laparoscopic surgery. The hand access system comprises a sheath retractor adapted to dilate a wound stretchable to a desired diameter, the sheath retractor includes a first ring being adapted for disposition interiorly of the wound, a second ring being adapted for disposition exteriorly of the wound, and a sheath being disposed in a generally cylindrical form between the first ring and the second ring and operable to exert a radial retraction force on the wound. The hand access system further comprises a detachable hand seal adapted to be removable from the second ring of the sheath retractor. The sheath retractor may be formed of an elastomeric material, and the hand seal may be formed of a gel material and includes a slit providing an instrument seal in the presence of an instrument or hand and a zero seal in the absence of the instrument or hand. In another aspect, there is disclosed a surgical access device adapted for disposition relative to an incision in a patient comprising a valve including a plurality of overlapping sheets defining an access channel, and a ring having an inner diameter for holding the valve by fixing each of the overlapping sheets along a portion of the perimeter, the access channel extends into communication with the incision in the patient. Each of the overlapping sheets includes a portion of the perimeter that is not fixed to the inner diameter of the ring, which provide open edges defining the access channel. The open edges slightly overlap at the center of the ring. The open edges may have different shapes including at least one of a straight edge, concave, convex and a cross-configuration. The hand access device may further comprise a septum seal formed at the proximal and distal ends of the ring.

Abstract translation: 本发明涉及一种手动进入系统，其在腹腔镜手术期间提供手术进入手术区域同时保持气腹。 手动进入系统包括一个适合于将可拉伸到所需直径的伤口扩张的护套牵开器，所述护套牵开器包括适于在伤口内部配置的第一环，适于在伤口外部配置的第二环， 在第一环和第二环之间以大致圆柱形的形式设置并可操作以在伤口上施加径向缩回力。 手动进入系统还包括适于从皮带牵开器的第二环移除的可拆卸手动密封件。 护套牵开器可以由弹性体材料形成，并且手动密封件可以由凝胶材料形成，并且包括在没有仪器或手的情况下在仪器或手的存在下提供仪器密封的狭缝和零密封 。 另一方面，公开了一种外科进入装置，其适于相对于患者的切口进行配置，该装置包括阀，所述阀包括限定出入通道的多个重叠片，以及具有用于通过固定每个 沿着周边的一部分重叠的片材，进入通道延伸成与患者的切口连通。 每个重叠片材包括未固定到环的内径的周边的一部分，其提供限定接入通道的开口边缘。 开口边缘在环的中心稍微重叠。 开口边缘可以具有不同的形状，包括直边，凹形，凸形和交叉构型中的至少一个。 手动进入装置还可以包括形成在环的近端和远端的隔膜密封件。

公开(公告)号：US20060076071A1

公开(公告)日：2006-04-13

申请号：US10942360

申请日：2004-09-16

Applicant: Wassim Ali-Ahmad ,  Charles Hart

Inventor： Wassim Ali-Ahmad ,  Charles Hart

IPC: F16L9/14 ,  B29C47/20

CPC classification number: F16L11/12 ,  B29C48/0022 ,  B29C48/09 ,  B29C48/12 ,  B29C48/19 ,  B29C48/20 ,  B29C48/23 ,  B29K2023/06 ,  B29K2023/065 ,  B29K2075/00 ,  B29K2077/00

Abstract: The invention is directed to open-channel extrusions of plastic materials. In one aspect, an open-channel tubing is formed by extruding a first plastic material forming an elongate tube having the open channel; and extruding a second plastic material filling the open channel such that the second plastic material forms a weak bond with the first plastic material, and the weak bond is then selectively broken or dissolved to yield the open channel in the first plastic material. The first and second plastic materials are different from one another and each comprises at least one of polyester, polyethylene, nylon, polyurethane, HDPE, plastic elastomers (TPE) and Kraton. The first and second plastic materials are preferably extruded at about the same time. In another aspect, at least one of the first and second plastic materials may be doped with an additive to form the weak bond. The process of the invention may further comprise the step of mechanically stripping or removing the second plastic material from the first plastic material, chemically dissolving the second plastic material using a chemical solvent, or separating the second plastic material in a thermal melting process. Mechanically stripping the second plastic material may further comprise pressuring or evacuating the extruded elongate tube. To chemically dissolve the second plastic material, the first plastic material may include an aramid plastic, the second plastic material may include a styrene plastic, and the chemical solvent may be acetone or MEK. High and low-temperature plastics may be used to separate in the thermal melting process.

Abstract translation: 本发明涉及塑料材料的开放通道挤压。 一方面，通过挤出形成具有开放通道的细长管的第一塑料材料形成开放通道管道; 以及挤出填充所述开放通道的第二塑料材料，使得所述第二塑料材料与所述第一塑料材料形成弱结合，然后所述弱键被选择性地破碎或溶解，以产生所述第一塑料材料中的开放通道。 第一和第二塑料材料彼此不同，并且每个包括聚酯，聚乙烯，尼龙，聚氨酯，HDPE，塑料弹性体（TPE）和Kraton中的至少一种。 第一和第二塑料材料优选在大约同时挤出。 在另一方面，第一和第二塑料材料中的至少一个可以掺杂有添加剂以形成弱键。 本发明的方法还可以包括从第一塑料材料机械剥离或除去第二塑料材料，使用化学溶剂化学溶解第二塑料材料或在热熔融过程中分离第二塑料材料的步骤。 机械地剥离第二塑料材料还可以包括加压或排空挤出的细长管。 为了化学溶解第二塑料材料，第一塑料材料可以包括芳族聚酰胺塑料，第二塑料材料可以包括苯乙烯塑料，化学溶剂可以是丙酮或MEK。 高温和低温塑料可用于在热熔融过程中分离。

公开(公告)号：US20050216028A1

公开(公告)日：2005-09-29

申请号：US10807974

申请日：2004-03-24

Applicant: Charles Hart ,  John Brustad

Inventor： Charles Hart ,  John Brustad

IPC: A61B17/28 ,  A61B17/34 ,  A61F11/00

CPC classification number: A61B17/3462 ,  A61B17/3417 ,  A61B17/3439 ,  A61B17/3498 ,  A61B2017/2905 ,  A61B2017/3441

Abstract: The present invention relates to a surgical access device comprising an elongate tubular member having a working channel and an axis extending between a proximal end and a distal end, a septum seal integrally formed at the distal end of the tubular member, and a zero seal disposed at the distal end of the tubular member and distal to the septum seal, the zero seal being sized and configured to seal when no instrument is in place within the working channel of the tubular member, and the zero seal being coupled to the septum seal and having properties to float with the septum seal relative to the tubular member. The tubular member may be formed from an elastomeric material. The tubular member has a wall that may be rigid or semi-rigid, and the tubular member may be reinforced with a coil along a portion of the tubular member. The tubular member may include a distal, mechanically deployable shielding portion. The zero seal may be a duckbill seal constructed with one or more intersecting sealing portions. The duckbill seal may comprise of opposing lip portions separated by a slit portion. The opposing lip portions are coated with or attached to a soft or occlusive material. The occlusive material is one of Kraton, polyurethane or the like. The occlusive lip portions allow a surgical item such as a suture to extend through the slit portion without disrupting the seal. In one aspect, the tubular member and the septum seal are molded together as a single unit and the zero seal is then bonded or fused to the septum seal. In another aspect, the tubular member, the septum seal and the zero seal are all molded together or integrally formed as a single unit. The tubular member may further comprise flexibility enhancing features to allow the tubular member to flex in response to a motion of a surgical instrument within the working channel of the tubular member.

Abstract translation: 本发明涉及一种外科进入装置，其包括细长管状构件，该细长管状构件具有工作通道和在近端和远端之间延伸的轴线，一体地形成在管状构件的远端处的隔膜密封件以及零密封件 在管状构件的远端处并且远离隔膜密封件，零密封件的尺寸和构造被设计成在管状构件的工作通道内没有仪器就位时密封，并且零密封件联接到隔膜密封件 具有相对于管状构件以隔垫密封件浮动的性质。 管状构件可以由弹性体材料形成。 管状构件具有可以是刚性或半刚性的壁，并且管状构件可以沿着管状构件的一部分用线圈加强。 管状构件可以包括远侧机械展开的屏蔽部分。 零密封可以是由一个或多个相交的密封部分构成的鸭嘴形密封件。 鸭嘴形密封件可以包括由狭缝部分分开的相对的唇部。 相对的唇部被涂覆或附着到柔软或闭塞的材料上。 封闭材料是Kraton，聚氨酯等之一。 闭合唇部允许诸如缝合线的手术物品延伸穿过狭缝部分而不破坏密封。 在一个方面，管状构件和隔膜密封件作为单个单元一起模制，然后将零密封件粘合或熔合到隔膜密封件。 在另一方面，管状构件，隔膜密封件和零密封件全部模制在一起或整体地形成为单个单元。 管状构件还可以包括柔性增强特征，以允许管状构件响应于外科器械在管状构件的工作通道内的运动而弯曲。

公开(公告)号：US20050209619A1

公开(公告)日：2005-09-22

申请号：US10805864

申请日：2004-03-22

Applicant: Gary Johnson ,  John Brustad ,  Charles Hart

Inventor： Gary Johnson ,  John Brustad ,  Charles Hart

IPC: A61B17/00 ,  A61B17/34 ,  A61B17/32

CPC classification number: A61B17/3417 ,  A61B17/34 ,  A61B2017/00473 ,  A61B2017/3482 ,  A61B2017/3484 ,  A61M39/02

Abstract: The present invention relates to a surgical access port for insertion into a body cavity having an elongate tubular body extending along an axis between a proximal end and a distal end, and a tip disposed at the distal end of the tubular body for penetrating through a body wall and into the body cavity. The distal tip operates to move from a first, penetrating position to a second, retaining position when the body wall has been traversed. The surgical access port may further comprise a seal housing operably connected to the proximal end of the tubular body, the seal housing having an access port providing an opening into the tubular body to allow passage of surgical instruments. The distal tip may be sharp, pointed or bladed. The distal tip may also be substantially blunt or have a conical surface. The access port may further comprise a retention member for connecting the tubular body and the distal tip. The retention member may be biased to hold the distal tip in an off-axis position when there is no axial load, or it may be lightly held in axial alignment and subsequently deflected in the presence of an instrument within the tubular body. The distal tip, which may comprise one or more parts or petals, may reposition to the side of the tubular body in a substantially right-angled condition in the second, retaining position. The repositioned tip remains in an off-axis condition until removal of the access port, at which time the distal tip automatically realigns with the axis of the tubular body as the access port is withdrawn from the body wall. The tubular body may be a thin walled tube. The distal tip may comprise a conical, tapered or rounded shape to separate tissue layers. The distal tip may be solid or hollow, which may act as a specimen bag by closing on a specimen and pulled inside the tip during removal of the access port. The distal tip may be formed from a clear material to allow viewing through an endoscope during placement of the surgical access port.

公开(公告)号：US20050165366A1

公开(公告)日：2005-07-28

申请号：US10766138

申请日：2004-01-28

Applicant: John Brustad ,  Said Hilal ,  Nabil Hilal ,  Charles Hart ,  Gary Johnson ,  Serene Hilal ,  Ghassan Sakakine ,  Donald Gadberry ,  Edward Pingleton ,  Matthew Petrime ,  Payam Adlparvar ,  Carl Hadley ,  Kenneth Vu

Inventor： John Brustad ,  Said Hilal ,  Nabil Hilal ,  Charles Hart ,  Gary Johnson ,  Serene Hilal ,  Ghassan Sakakine ,  Donald Gadberry ,  Edward Pingleton ,  Matthew Petrime ,  Payam Adlparvar ,  Carl Hadley ,  Kenneth Vu

IPC: A61B17/00 ,  A61B17/34 ,  A61M25/00 ,  A61M5/00

CPC classification number: A61M25/0012 ,  A61B1/0011 ,  A61B1/0055 ,  A61B17/3421 ,  A61B2017/003 ,  A61M25/0043

Abstract: The invention primarily is directed to a medical tubing adapted for insertion into a body tissue or cavity and method of manufacturing different variations of the tubing along a length of the tubing. The tubing comprises a plurality of individual, discrete, generally ring-shaped elements arranged in series and fused or bonded together forming a continuous tubular structure. The ring-shaped elements may be formed of a thermoplastic or a thermoset material. The ring-shaped elements may include plastic rings, metallic rings, un-reinforced plastic rings and/or metal reinforced plastic rings assembled along the length of the tubular structure to provide variable flexibility and kink-resistance. The tubular structure may have a cross-section of any geometric shape and it may be bent, twisted or curved without kinking. The ring-shaped elements may have different flexural modulus. The ring-shaped elements may include a combination of flexible and rigid ring-shaped elements assembled along different portions or sections of the tubular structure. The ring-shaped elements may be metallic and may be bonded with a resilient, flexible elastomeric adhesive, wherein the ring-shaped elements may have different lengths and may be fused closer or further apart to one another depending on the characteristics of a portion or section of the tubing. In another aspect of the invention, the medical tubing may further comprise a secondary lumen and a pull wire to control the tubular structure. The ring-shaped elements may be truncated to provide a bending bias. In another aspect of the invention, the ring-shaped elements may vary in diameter and/or composition in different portions or sections of the tubular structure. In yet another aspect of the invention, some of the ring-shaped elements may be radiopaque, or the ring-shaped elements may comprise of different colors to operate as indicators along the tubular structure.

Abstract translation: 本发明主要针对适于插入身体组织或空腔的医用管道以及沿管道长度制造管道的不同变化的方法。 管道包括多个单独的离散的大体环形元件，其串联布置并且熔合或粘合在一起形成连续的管状结构。 环形元件可以由热塑性材料或热固性材料形成。 环形元件可以包括沿着管状结构的长度组装的塑料环，金属环，未增强塑料环和/或金属增强塑料环，以提供可变的柔性和抗扭结性。 管状结构可以具有任何几何形状的横截面，并且其可以弯曲，扭曲或弯曲而没有扭结。 环形元件可以具有不同的弯曲模量。 环形元件可以包括沿着管状结构的不同部分或部分组装的柔性和刚性环形元件的组合。 环形元件可以是金属的并且可以用弹性的柔性弹性体粘合剂粘合，其中环形元件可以具有不同的长度，并且可以根据部分或部分的特性彼此靠近或更远地彼此熔合 的管道。 在本发明的另一方面，医疗管道还可包括用于控制管状结构的次管腔和拉线。 环形元件可以被截断以提供弯曲偏压。 在本发明的另一方面，环形元件可以在管状结构的不同部分或部分中的直径和/或组成变化。 在本发明的另一方面，一些环形元件可以是不透射线的，或者环形元件可以包括不同颜色以作为沿着管状结构的指示器。

公开(公告)号：US20050164937A1

公开(公告)日：2005-07-28

申请号：US11080803

申请日：2005-03-15

Applicant: Teresa Gilbert ,  Charles Hart ,  Paul Sheppard ,  Debra Gilbertson

Inventor： Teresa Gilbert ,  Charles Hart ,  Paul Sheppard ,  Debra Gilbertson

IPC: A61K38/00 ,  A61K38/18 ,  A61K38/19 ,  C07K14/52 ,  C07K14/475

CPC classification number: C04B38/06 ,  A61K38/177 ,  A61K38/18 ,  A61K38/1866 ,  A61K38/22 ,  C04B2111/00224 ,  C04B2111/00612 ,  C07K14/52 ,  C07K2319/00 ,  C12N2799/022 ,  C04B20/008 ,  C04B35/2641 ,  C04B35/50 ,  C04B35/64 ,  C04B38/0054 ,  C04B38/007 ,  C04B41/4578 ,  A61K2300/00

Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Abstract translation: 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

公开(公告)号：US20050049217A1

公开(公告)日：2005-03-03

申请号：US10938041

申请日：2004-09-10

Applicant: Charles Hart ,  Stavros Topouzis

Inventor： Charles Hart ,  Stavros Topouzis

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/18 ,  A61K48/00 ,  A61P13/02 ,  A61P13/12 ,  C07K14/49 ,  C12N15/85

CPC classification number: A61K38/1875 ,  A61K38/1858

Abstract: Materials and methods for improving kidney function or enhancing proliferation or survival of kidney tubule epithelial cells or epithelial cell precursors in a mammal are disclosed. The methods comprise administering to the mammal a composition comprising a therapeutically effective amount of a zvegf4 protein or a zvegf4 protein-encoding polynucleotide in combination with a pharmaceutically acceptable delivery vehicle. Zvegf4 proteins include, for example, disulfide-bonded dimers of two polypeptide chains, each comprising residues 258-370 of SEQ ID NO:2.

Abstract translation: 公开了用于改善哺乳动物中肾小管上皮细胞或上皮细胞前体的肾功能或增强增殖或存活的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4蛋白或编码zvegf4蛋白的多核苷酸与药学上可接受的递送载体组合的组合物。 Zvegf4蛋白包括例如两个多肽链的二硫键连接的二聚体，每个包含SEQ ID NO：2的残基258-370。

公开(公告)号：US20050004602A1

公开(公告)日：2005-01-06

申请号：US10612631

申请日：2003-07-02

Applicant: Charles Hart ,  Matthew Wixey

Inventor： Charles Hart ,  Matthew Wixey

IPC: A61B17/04

CPC classification number: A61B17/0487 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0488

Abstract: The invention is directed to a suture clinch that may be placed upon suture extensions of a placed suture to securely lock the extensions in a desired location. The clinch operates to replace a tied knot and retain the suture in a fixed relationship with little or no damage to the suture itself. The clinch comprises a mating pair of interlocking members that restrict movements of the suture. The interlocking members may be placed upon the suture extensions from alongside the suture extensions and compressed to a first condition where the interlocking members may be advanced, retracted or adjusted, and subsequently further compressed to a second condition where the interlocking members are fully engaged to fully restrict the movement of the suture. In another aspect, the clinch may be provided in a flat form comprising a first component and a second component. The first and second components fit together in a mating relationship that entraps at least a portion of the suture between tractive faces of the first and second components, respectively. Each end of the first and second components may have a recessed central portion that leaves two extensions along the sides of each end of the components. The extensions of the second component are subsequently folded over the first component to provide secure entrapment of the suture between the tractive faces of the first and second components. The tractive faces operate to engage the suture and hold it securely in place without damaging or challenging the suture. The clinch may comprise of plastic, metallic materials such as stainless steel or titanium, or a combination of both where the plastic is chosen for its value as an atraumatic interface and the metal for its radiopacity or durability.

Abstract translation: 本发明涉及可以放置在放置的缝合线的缝线延伸部上以将延伸部牢固地锁定在期望位置的缝合线夹。 该钳子用于替换结扎，并将缝合线保持固定的关系，对缝合线本身几乎没有或没有损坏。 钳子包括限制缝合线运动的一对互锁构件。 互锁构件可以从缝合线延伸部旁边放置在缝合线延伸部上并被压缩到第一状态，其中互锁构件可以前进，缩回或调节，并且随后被进一步压缩到第二状态，其中互锁构件完全接合到完全 限制缝合线的运动。 在另一方面，钳口可以以包括第一部件和第二部件的平坦形式提供。 第一和第二部件以匹配关系装配在一起，分别在第一和第二部件的牵引面之间截留缝合线的至少一部分。 第一和第二部件的每个端部可以具有凹入的中心部分，其沿着部件的每个端部的侧面留下两个延伸部。 随后将第二部件的延伸部折叠在第一部件上，以提供在第一和第二部件的牵引面之间的缝合线的牢固的截留。 牵引面用于接合缝合线并将其牢固地固定在适当的位置，而不会损伤或挑战缝合线。 夹子可以包括塑料，诸如不锈钢或钛的金属材料，或两者的组合，其中选择塑料作为无创伤界面的价值，并且金属用于其不透射线性或耐久性。

公开(公告)号：US20050004515A1

公开(公告)日：2005-01-06

申请号：US10832867

申请日：2004-04-26

Applicant: Charles Hart ,  John Brustad ,  Nabil Hilal

Inventor： Charles Hart ,  John Brustad ,  Nabil Hilal

IPC: A61M31/00

CPC classification number: A61B17/3421 ,  A61B2017/003 ,  B29C53/58 ,  B29C63/18 ,  B29D23/18 ,  B29K2019/00 ,  B29K2083/00 ,  B29L2031/7546 ,  B32B1/08

Abstract: A steerable kink resistant access device is provided having an elongated body and a steerable portion. The access sheath has an outside diameter sufficiently small so that it may be inserted into a body cavity or conduit. The access sheath typically has two internal lumen, a first lumen sized and configured as an access to a surgical site and a second lumen sized and configured to contain a tensioning device that, when acted upon, will deflect the steerable portion. The tensioning device may be directly or remotely attached to an actuation device that operates to control the tensioning and loosening of the tensioning device.

Abstract translation: 提供了一种具有细长主体和可转向部分的可转向扭结接近装置。 进入护套具有足够小的外径，使得其可以插入体腔或导管中。 进入护套通常具有两个内腔，第一腔的尺寸和构造为进入手术部位，第二腔具有尺寸和构造成容纳张紧装置，所述张紧装置在作用时将使可转向部分偏转。 张紧装置可以直接或远程地附接到操作以控制张紧装置的张紧和松动的致动装置。